RU2419628C2 - Immunogenic composition for use in vaccination against staphylococci - Google Patents

Immunogenic composition for use in vaccination against staphylococci Download PDF

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RU2419628C2
RU2419628C2 RU2007110024/10A RU2007110024A RU2419628C2 RU 2419628 C2 RU2419628 C2 RU 2419628C2 RU 2007110024/10 A RU2007110024/10 A RU 2007110024/10A RU 2007110024 A RU2007110024 A RU 2007110024A RU 2419628 C2 RU2419628 C2 RU 2419628C2
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protein
group
immunogenic
immunogenic composition
composition according
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RU2007110024/10A
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RU2007110024A (en
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Синди КАСТАДО (BE)
Синди Кастадо
Никола Пьер Фернан ЛЕКРЕНЬЕ (BE)
Никола Пьер Фернан ЛЕКРЕНЬЕ
Сесиль Анна НЕЙТ (BE)
Сесиль Анна НЕЙТ
Ян ПУЛМАН (BE)
Ян Пулман
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ГлаксоСмитКлайн Байолоджикалз с.а.
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Abstract

FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to biotechnology. Immunogenic composition is described comprising an effective amount of a combination of at least two different proteins or their immunogenic fragments selected from at least two groups of proteins or immunogenic fragments selected from the following groups: group (a): at least one staphylococcal protein binding an extracellular component, or its immunogenic fragment; group (b): at least one staphylococcal transport protein or its immunogenic fragment; group (c): at least one staphylococcal regulator of virulence, toxin or its immunogenic fragment, wherein at least one protein or an immunogenic fragment is selected from the group (a), and at least one protein or immunogenic fragment is selected from the group (b). A vaccine against staphylococcal infection is proposed, which comprises an effective amount of the immunogenic composition described. Also the method to obtain the vaccine is offered.
EFFECT: method for preventing or treating staphylococcal infection is proposed, comprising the introduction of the proposed vaccine, as well as method of producing immunoglobulin, comprising the steps of immunisation of the recipient by the proposed vaccine.
17 cl, 7 dwg, 8 tbl, 8 ex

Description

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Claims (17)

1. Иммуногенная композиция, содержащая эффективное количество комбинации по меньшей мере двух разных белков или их иммуногенных фрагментов, выбранных из по меньшей мере двух групп белков или иммуногенных фрагментов, выбранных из следующих групп:
Группа (а): по меньшей мере один стафилококковый белок, связывающий внеклеточный компонент, или его иммуногенный фрагмент, выбранный из группы, состоящей из SdrG, рецептора ламинина, EbhA, EbhB, эластин-связывающего белка (EbpS), EFB (FIB), SBI, аутолизина, ClfA, SdrC, SdrH, липазы GehD, FnbA, FnbB, Cna, ClfB, FbpA, Npase (нейтральной фосфатазы), IsaA/PisA, SsaA, EPB, SSP-1, SSP-2, HBP, витронектин-связывающего белка, коагулазы и MAP;
Группа (б): по меньшей мере один стафилококковый транспортный белок или его иммуногенный фрагмент, выбранный из группы, состоящей из иммунодоминантного АВС-транспортера, IsdA, IsdB, Mg2+ транспортера, SitC и Ni АВС-транспортера;
Группа (в): по меньшей мере один стафилококковый регулятор вирулентности, токсин или его иммуногенный фрагмент, выбранный из группы, состоящей из альфа-токсина (Н1а), мутанта альфа-токсина H35R, РНК III-активирующего белка (RAP);
где по меньшей мере один белок или иммуногенный фрагмент выбран из группы (а), и по меньшей мере один белок или иммуногенный фрагмент выбран из группы (б).1. An immunogenic composition comprising an effective amount of a combination of at least two different proteins or immunogenic fragments thereof selected from at least two groups of proteins or immunogenic fragments selected from the following groups:
Group (a): at least one staphylococcal protein that binds the extracellular component, or an immunogenic fragment thereof, selected from the group consisting of SdrG, laminin receptor, EbhA, EbhB, elastin binding protein (EbpS), EFB (FIB), SBI , autolysin, ClfA, SdrC, SdrH, lipases GehD, FnbA, FnbB, Cna, ClfB, FbpA, Npase (neutral phosphatase), IsaA / PisA, SsaA, EPB, SSP-1, SSP-2, HBP, vitronectin-binding protein , coagulases and MAP;
Group (b): at least one staphylococcal transport protein or immunogenic fragment thereof selected from the group consisting of immunodominant ABC transporter, IsdA, IsdB, Mg2 + transporter, SitC and Ni ABC transporter;
Group (c): at least one staphylococcal virulence regulator, toxin or immunogenic fragment thereof selected from the group consisting of alpha-toxin (H1a), mutant alpha-toxin H35R, RNA III-activating protein (RAP);
where at least one protein or immunogenic fragment is selected from group (a), and at least one protein or immunogenic fragment is selected from group (b). 2. Иммуногенная композиция по п.1, где по меньшей мере один белок или иммуногенный фрагмент выбран из группы (в).2. The immunogenic composition according to claim 1, where at least one protein or immunogenic fragment is selected from group (c). 3. Иммуногенная композиция по п.1, где по меньшей мере один белок или иммуногенный фрагмент, выбранный из группы (б), представляет собой IsdA.3. The immunogenic composition according to claim 1, where at least one protein or immunogenic fragment selected from group (b) is IsdA. 4. Иммуногенная композиция по п.1, где по меньшей мере один белок или иммуногенный фрагмент, выбранный из группы (б), представляет собой IsdB.4. The immunogenic composition according to claim 1, where at least one protein or immunogenic fragment selected from group (b) is IsdB. 5. Иммуногенная композиция по п.1, содержащая по меньшей мере один белок или иммуногенный фрагмент из Staphylococcus aureus.5. The immunogenic composition according to claim 1, containing at least one protein or immunogenic fragment from Staphylococcus aureus. 6. Иммуногенная композиция по п.1, содержащая по меньшей мере один белок или иммуногенный фрагмент из Staphylococcus epidermidis.6. The immunogenic composition according to claim 1, containing at least one protein or immunogenic fragment from Staphylococcus epidermidis. 7. Иммуногенная композиция по п.1, дополнительно содержащая PIA полисахарид или олигосахарид.7. The immunogenic composition of claim 1, further comprising a PIA polysaccharide or oligosaccharide. 8. Иммуногенная композиция по п.1, дополнительно содержащая капсульный полисахарид или олигосахарид типа V и/или типа VIII из Staphylococcus aureus.8. The immunogenic composition according to claim 1, additionally containing a capsular polysaccharide or oligosaccharide type V and / or type VIII from Staphylococcus aureus. 9. Иммуногенная композиция по п.1, дополнительно содержащая капсульный полисахарид или олигосахарид типа I, и/или типа II, и/или типа III из Staphylococcus epidermidis.9. The immunogenic composition according to claim 1, additionally containing a capsular polysaccharide or oligosaccharide of type I, and / or type II, and / or type III from Staphylococcus epidermidis. 10. Иммуногенная композиция по п.8, где стафилококковый капсульный полисахарид конъюгирован с белком-носителем.10. The immunogenic composition of claim 8, wherein the staphylococcal capsular polysaccharide is conjugated to a carrier protein. 11. Иммуногенная композиция по п.10, где белок-носитель выбран из группы, состоящей из столбнячного анатоксина, дифтерийного анатоксина, CRM197, протеина D Haemophilus influenzae, пневмолизина и альфа-анатоксина.11. The immunogenic composition of claim 10, wherein the carrier protein is selected from the group consisting of tetanus toxoid, diphtheria toxoid, CRM197, protein D Haemophilus influenzae, pneumolysin, and alpha-toxoid. 12. Иммуногенная композиция по любому из пп.1-11, способная вызывать эффективный иммунный ответ как против Staphylococcus aureus, так и против Staphylococcus epidermidis.12. The immunogenic composition according to any one of claims 1 to 11, capable of eliciting an effective immune response against both Staphylococcus aureus and Staphylococcus epidermidis. 13. Вакцина против стафилококковой инфекции, содержащая эффективное количество иммуногенной композиции по любому из пп.1-12 и фармацевтически приемлемый эксципиент.13. A vaccine against staphylococcal infection, containing an effective amount of the immunogenic composition according to any one of claims 1 to 12 and a pharmaceutically acceptable excipient. 14. Способ получения вакцины, включающий стадии смешивания антигенов с получением иммуногенной композиции по любому из пп.1-12 и добавления фармацевтически приемлемого эксципиента.14. A method of producing a vaccine, comprising the steps of mixing antigens to obtain an immunogenic composition according to any one of claims 1 to 12 and adding a pharmaceutically acceptable excipient. 15. Способ предупреждения или лечения стафилококковой инфекции, включающий стадию введения вакцины по п.13 пациенту, нуждающемуся в этом.15. A method of preventing or treating staphylococcal infection, comprising the step of administering the vaccine of claim 13 to a patient in need thereof. 16. Применение иммуногенной композиции по любому из пп.1-12 в изготовлении вакцины для лечения или предупреждения стафилококковой инфекции.16. The use of the immunogenic composition according to any one of claims 1 to 12 in the manufacture of a vaccine for the treatment or prevention of staphylococcal infection. 17. Способ получения иммуноглобулина для применения в предупреждении или лечении стафилококковой инфекции, включающий стадии иммунизации реципиента вакциной по п.13 и выделения иммуноглобулина из реципиента. 17. A method for producing immunoglobulin for use in the prevention or treatment of staphylococcal infection, comprising the steps of immunizing a recipient with the vaccine of claim 13 and isolating the immunoglobulin from the recipient.
RU2007110024/10A 2004-09-22 2005-09-20 Immunogenic composition for use in vaccination against staphylococci RU2419628C2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB0421081.1 2004-09-22
GB0421078A GB0421078D0 (en) 2004-09-22 2004-09-22 Immunogenic composition
GB0421079.5 2004-09-22
GB0421078.7 2004-09-22
GB0421082.9 2004-09-22
GB0421079A GB0421079D0 (en) 2004-09-22 2004-09-22 Immunogenic composition
GB0421082A GB0421082D0 (en) 2004-09-22 2004-09-22 Immunogenic composition
GB0503143.0 2005-02-15

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RU2009139185/10A Division RU2521501C2 (en) 2004-09-22 2009-10-20 Immunogenic composition applicable for staphylococcus vaccination

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RU2419628C2 true RU2419628C2 (en) 2011-05-27

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RU2009139185/10A RU2521501C2 (en) 2004-09-22 2009-10-20 Immunogenic composition applicable for staphylococcus vaccination

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CA3037070A1 (en) * 2016-10-21 2018-04-26 Socpra Sciences Et Genie S.E.C. Vaccine constructs and uses thereof against staphylococcus infections

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US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
EP1096952B1 (en) * 1998-07-15 2008-05-21 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
WO2003020875A2 (en) * 2001-06-17 2003-03-13 D-Squared Biotechnologies, Inc. Staphylococci surface-exposed immunogenic polypeptides

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