RU2419434C1 - Cream for treatment of skin diseases in small pets - Google Patents

Abstract

FIELD: medicine. ^ SUBSTANCE: invention relates to veterinary and can be used for external application in treatment of dogs, cats, fur-bearing animals and other small pets with disease of bacterial-mycotic-mite etiology. Cream for treatment of skin disease of small pets, contains acaricidic, anti-mycotic-antimicrobial substances, wt %: 20% Roksacin 1.8-2.1; 1% Aversect-2 7.8-8.1; child's cream on grease base - the remaining part. ^ EFFECT: invention insures increasing of efficiency and reduction of treatment terms. ^ 1 tbl, 2 ex

Description

The invention relates to veterinary medicine and can be used for external use in the treatment of dogs, cats, fur animals, in the case of diseases of bacterial-mycotic-tick-borne etiology. Small pets, especially dogs, have always been of great importance in human life. Currently, more than 31.34% of cases of pet owners contacting veterinary specialists are related to skin disease.

However, this pathology is so diverse that even today there are quite a few "blank spots". The constantly changing ecological situation, unsystematic use of antibiotics create the prerequisites for the emergence of new, more advanced and resistant strains of microorganisms.

Mixed infections, manifested in the form of dermatitis in dogs, especially those found at home in the city, have become widespread and tend to increase.

Due to the widespread occurrence of skin diseases of dogs with low therapeutic efficacy of the drugs used and their high cost, the study of the etiological aspects of skin diseases of dogs and the search for new effective drugs for these pathologies is an urgent problem of modern veterinary science and practice.

Known tool "Oridermil gel" for the treatment of otodectosis of dogs and cats, complicated by a bacterial infection, containing: neomycin sulfate; nystatin; triamcinolone acetonide; lindane and lidocaine.

Neomycin sulfate is a compound of the aminoglycoside group that has an antimicrobial effect against gram-positive and some gram-negative microorganisms: Staph. albus; Staph. aureus; E. coli; Proteus; Corynebacterium pyogenes; Pseudomonas. Neomycin sulfate has a bactericidal effect. The mechanism of action is a violation of the synthesis of protein bacteria, which leads to damage to the cell membrane and the death of bacteria.

Nystatin is a compound of the polyene group. Depending on the concentration, it has a fungistatic and fungicidal effect. The mechanism of action is damage to the cell membrane of fungi. Nystatin is active against: Candida spp., Cryptococcus spp., Histoplasma spp., Blastomyces spp., Trichophyton spp., Epidermophyton spp. Pityrospomm canis.

Triamcinolone acetonide is a synthetic glucocorticosteroid, has an anti-inflammatory effect, the mechanism of which is based on the inhibition of phospholipase.

Lindane is an antiparasitic means of contact action. It acts on the nerve ganglia of insects and ticks, causing paralysis. Active against Demodex canis; Chorioptes bovis; Sarcoptes scabies and Otodectes cynotys.

Lidocaine is a compound of the amide group that has a local anesthetic effect. The mechanism of action is to block the passage of a nerve impulse by depolarization of the membrane of a neuron.

However, the composition does not provide sufficient effectiveness for the treatment and prevention of skin diseases in small domestic animals, since they affect only pathogens that cause pathological processes and the drug is very slowly absorbed from the skin surface. (Vetokvinol Biovet Sp.z.oz.o., Poland. Producer: Vetokvinol SA., France) Directory of veterinary medicines.

The closest analogue is Dermasept, consisting of griseofulvin (an antifungal component), neocidol (an acaricidal component) and levomycetin (an antibacterial component). To create a dosage form, solvents were selected that are compatible with each other - they turned out to be dimethyl sulfoxide, ethyl alcohol and glycerin. The created medicinal composition is a clear, colorless liquid with a specific odor (Terekhova, O.B. Staphyloderma of dogs: epizootology, clinical presentation and therapy: abstract of thesis ... Candidate of Veterinary Sciences: 16.00.03: protected 04.12.02 / O.B. Terekhova; KGAU. - Krasnodar, 2002 .-- 22 p.).

The disadvantage of the closest analogue is its dosage form, the content of ethyl alcohol in the preparation and a specific smell.

A significant novelty is acaricidal, antimycotic-antimicrobial substances, characterized in that the composition is included in the composition as target products in wt.%:

20% roxacin 1.8-2.1 1% Aversect-2 7.8-8.1 Baby cream rest

The technical result of the task is the treatment of skin diseases of small pets by creating a tool that has both antimicrobial, fungicidal, antiparasitic effect and positively affects the body of the animal as a whole, since it does not accumulate in the body and is biodegradable, which, accordingly, entails an increase therapeutic effect.

This object is achieved by the fact that in the tool intended for the treatment of skin diseases of small pets, including 20% Roxacin and 1% Aversect-2, additionally contains a baby cream. Thanks to this particular composition, the effectiveness of treatment is increased, the duration of the disease is reduced, the cost of the course of treatment is reduced, the drug quickly and deeply penetrates the tissues due to menthol, lanolin and many other components that are part of the baby cream, and itching and dryness of the skin are also reduced.

The signs that distinguish the claimed technical solution from the closest analogue are aimed at achieving the task and have not been identified in the study of this and related fields of science and technology, therefore, in our opinion, meet the criterion of "inventive step".

The manufacturing name of the product intended for the treatment of skin diseases in small pets is the word "Haboska".

The claimed tool "Haboska" is a complex preparation and includes components that can have acaricidal, antimycotic and antimicrobial effects on pathogenic agents. Each of the components of the drug is able to perform certain functions in a living organism. So “Aversect-2” is a preparation containing an avermectin complex (aversectin C), obtained on the basis of the vital products of the soil fungus Streptomyces avermitilis. A transparent, yellow, sterile solution containing 1% of the active substance on a water-alcohol-polymer basis. “Aversect-2” has a pronounced antiparasitic effect on nematodes and larvae of subcutaneous, nasopharyngeal, gastric gadfly, as well as on lice, bloodsucker and causative agents of animal sarcoptosis. The mechanism of action of the active ingredient, aversectin C, is its effect on the current of chlorine ions through the membranes of nerve and muscle cells of the parasite. The main targets are glutamate-sensitive chlorine channels, as well as gamma-aminobutyric acid receptors. A change in the current of chlorine ions disrupts the conduction of nerve impulses, which leads to paralysis and death of the parasite. The drug has low toxicity for warm-blooded animals. In recommended doses, it does not have a sensitizing, embryotoxic, teratogenic and mutagenic effect.

"Roxacin", a structural analogue - polyhexamethylene guanidine - refers to a limited range of biocidal drugs that can simultaneously act on both aerobic and anaerobic microflora, which is present among the pathogens of purulent infection. Roxacin does not accumulate in the body, is a biodegradable substance. It is soluble in water, Roxacin aqueous solutions are odorless, do not discolor tissues, and are not an allergen. Roxacin can be successfully used in areas where effective antimicrobial protection is required.

As a fat base, “Baby Cream” was used, which has a pronounced anti-inflammatory, antipruritic, moisturizing, wound-healing effect in eczema, dermatitis, psoriasis, pustular lesions, diaper rash. Eliminates skin itching. Moisturizes the skin and restores its elastic properties, prevents lichenization, restores the patency of the ducts of the sebaceous glands.

In this case, any cream for children can be used, in particular: cream "for children, with vitamins A, F and chamomile extract"; cream “for children, with vitamins A, F and chamomile extract”; cream "baby moisturizing"; cream for children JOHNSON'S BABY "From diaper rash", under the diaper; cream for children JOHNSON'S BABY "Special care", with baby oil; cream for children JOHNSON'S BABY "Tenderness of nature", protective for walking; cream TYPE-TOP "Children's", nutritious; cream "Children's" FREEDOM, and many others.

Baby cream with vitamins A, F and chamomile extract: mineral oil, water, ceresin, confectionery fats, paraffin, sorbitan oleate, lanolin, vitamin F, sodium tetraborate, eucalyptus oil, benzyl acetate, chamomile extract, benzyl alcohol, vitamin A, menthol.

The proposed Haboska cream is prepared as follows: take a clean glass container, add the necessary amount of fat base - Baby cream, slightly heat it in a water bath, then add the appropriate amount of medicinal components and mix thoroughly for 10-15 minutes until a homogeneous mass is formed .

The drug "Haboska" is obtained by mixing its constituent components in the indicated proportions. The substances used are 1% Aversect-2 (Farmbiomed LLC, Moscow), 20% Roxacin (Polyvit, Ufa), and baby cream.

The cream was tested on 148 dogs, 78 rats, 39 cats and 15 rabbits, during 2008-2009.

Testing the use of "Haboska" is presented in examples on animals.

Scientific and production experience was carried out in the conditions of clinics in Krasnodar. Animals with signs of baldness, eczema, redness and itching on the background of partial baldness on the body aged 3 to 5 years and weighing 4-6 kg were formed in 2 groups of 15 individuals each.

An experimental group of animals was treated with the claimed Haboska means once a day; in the control group, the drug Dermasept (containing griseofulvin, neocidol and chloramphenicol as DV) was used.

Therapeutic efficacy was evaluated by the number of recovered individuals, the duration and severity of the disease. The results of the experiment are presented in table 1.

Table 1. Therapeutic efficacy of the claimed means "Haboska" for skin diseases in small pets Groups Number of dogs Duration of the disease, days The number of recovered,% Experienced fifteen 3.4 one hundred Control fifteen 6.2 80

As can be seen from table 1, the proposed drug has a pronounced therapeutic activity in skin diseases in small pets, providing a versatile positive effect on their body. Animals receiving the claimed preparation according to the treatment regimen more easily tolerate the disease, their recovery period is reduced in relation to the group treated with the Dermasept drug.

Example 1

The Kuzya cat, 2 years old, with a body weight of 3.5 kg, with signs of dermatitis in the back of the head, was exposed to Khaboska cream once daily for 4 days. On day 2, a significant improvement in his condition was recorded: itching disappeared, peeling of the skin stopped. By the 4th day, the signs of dermatitis in the animal disappeared, the affected area of the skin began to overgrow with hair, appetite and behavioral reactions returned to normal.

Example 2

Bitch Dora, 3 years old, with a body weight of 21 kg, the animal is restless, there are itchy nodules in the back, with redness of the skin. Appetite, act of defecation and urination saved. The presence of fleas. was prescribed once daily for 5 days, the drug "Haboska." By the end of the course of treatment, the animal showed no signs of disease, the animal from the 2nd day of administration became more active, with a pronounced appetite, the daily increase in body weight increased.

Examples of obtaining funds.

Example 1

To obtain 100 g of Khaboska cream, they took a 20% solution of Roxacin, with a volume of 1.8%; 1% solution of Aversect-2 - 7.8%; the remaining 90.4% was the fat base. Mixing was carried out with continuous stirring.

Example 2

To obtain 100 g of Khaboska cream, they took a 20% solution of Roxacin, with a volume of 2.1%; 1% solution of Aversect-2 - 8.1%; the remaining 89.8% was the fat base. Mixing was carried out with continuous stirring.

The results of clinical trials allow us to recommend the claimed drug in veterinary practice.

Claims (1)

Cream for the treatment of skin diseases in small pets, containing acaricidal, antimycotic, antimicrobial substances, characterized in that the composition is included as target products, wt.%:
20% roxacin 1.8-2.11 Aversect-2 7.8-8.1 Fat-based baby cream Rest