RU2388799C2 - Cleaning composition containing organic catalyst with improved compatibility with enzymes - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: cleaning compositions contain organic catalysts having the formula (i), (ii) given in the formula of invention, or mixtures thereof. In the formula G is selected from -O-, -CH₂O-, -(CH₂)₂- and -CH₂-, R¹ is selected from H or C₁-C₄ alkyl, each R² is independently selected from C₄-C₈ alkyl, benzyl, 2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 4-ethylbenzyl, 4-isopropylbenzyl and 4-tert-butylbenzyl.

EFFECT: improved compatibility of organic catalysts with enzymes.

18 cl, 18 ex

Description

FIELD OF THE INVENTION

The present invention relates to cleaning compositions containing organic catalysts, and to methods for producing and using such cleaning products.

State of the art

Oxygen bleaches, such as hydrogen peroxide, are usually used to facilitate the removal of stains and dirt from clothing and various surfaces. Unfortunately, such bleaches are extremely temperature dependent. As a result, when such bleaches are used in colder solutions, the whitening effect of such solutions is markedly reduced.

In an effort to solve the aforementioned efficiency problem, a class of materials known as “whitening activators” has been developed in industry. However, since such materials quickly lose their effectiveness in solution at temperatures less than 40 ° C, new organic catalysts have been developed, such as the internal salts of 3,4-dihydro-2- [2- (sulfooxy) decyl] isoquinolinium. In general, although such state-of-the-art catalysts are effective in low water temperatures, they can inactivate certain enzymes. Since most laundry detergents and cleaning compositions are made with enzymes, formulating cleaning products with such catalysts can be problematic.

Thus, there is a need for an inexpensive cleaning composition containing an organic catalyst that can provide a combined effect of versatility, bleaching efficiency at low water temperatures, and enzyme compatibility.

SUMMARY OF THE INVENTION

The present invention relates to cleaning compositions containing organic catalysts having improved compatibility with enzymes, and to methods for their preparation and use.

DETAILED DESCRIPTION OF THE INVENTION

Definitions

As used herein, the term “cleaning composition” includes, unless otherwise indicated, a granular or powder form of universal or “heavy duty” detergents, especially laundry detergents; liquid, gel or paste-like form of universal or “heavy duty” detergents, especially the so-called heavy duty liquid types; liquid detergents for delicate fabrics; compositions for manual washing dishes and lightweight compositions for washing dishes, especially compositions with copious foaming; compositions for machine washing dishes, including various tableted, granular, liquid types and types with the addition of rinse aid for domestic and industrial use; liquid detergents and disinfectants, including antibacterial cleansers, washing bars, mouthwashes, dental cleaners, shampoos for cars and carpets, bath cleaners; shampoos and hair rinses; shower gels and bath foams, and metal surface cleaners; as well as auxiliary cleaning agents, such as bleaching additives and stain removers or pre-treatment substances.

As used in this application, the phrase "independently selected from the group consisting of ..." means that the fragments or elements that are selected from the specified Markush formula may be the same, different, or any mixture of elements.

To determine the appropriate values of the parameters of the inventions of the applicant should use the test methods disclosed in the section "Testing methods" of this application.

Unless otherwise indicated, all components or contents of the compositions are based on the active content of these components or compositions and do not take into account impurities, such as residual amounts of solvents or by-products that may be present in commercially available products.

All percentages and ratios are given by weight unless otherwise indicated. All percentages and ratios are based on the entire composition, unless otherwise indicated.

It should be understood that any maximum numerical limitation given in the present description includes any lower numerical value, as if such lower values would be specifically indicated. Each minimum numerical limitation given in the framework of the present description will include any larger numerical limitation, as if such large limitations would be specifically indicated. Any numerical range described herein will include any narrower range falling within it, as if such narrower ranges would be specifically indicated.

All cited documents, in their relevant part, are incorporated into this application by reference; citing any source may not be construed as recognition of it relating to the prior art regarding the present invention.

Organic Catalyst Cleaning Compositions

Applicant has found that a judicious selection of the R ¹ and R ² fragments of the organic catalyst of the present invention leads to improved enzyme compatibility. Without being bound by theory, the applicant believes that this is due to the favorable decomposition of the catalyst in aqueous media as a result of the aforementioned thoughtful selection of the mentioned fragments.

In one aspect of the invention, the cleaning compositions comprise an organic catalyst having an enzyme compatibility value of 70 or more, or even 80 or more.

In one aspect of the invention, the cleaning compositions comprise an organic catalyst having an enzyme compatibility value of 70 or more, and one or more auxiliary compounds.

In one aspect of the invention, the cleaning compositions comprise an organic catalyst having an enzyme compatibility value of 80 or more, and said composition comprises the following auxiliary ingredients: an activated source of peroxygen, an enzyme, and a surfactant.

In one aspect of the invention, the cleaning compositions comprise an organic catalyst represented by Formula 1 or Formula 2, or mixtures thereof.

where G is selected from —O—, —CH ₂ O—, - (CH ₂ ) ₂ -, and —CH ₂ -. R ^{1 is} selected from H or C ₁ -C ₄ alkyl. Suitable C ₁ -C ₄ alkyl moieties include, but are not limited to, methyl, ethyl, isopropyl, and tert-butyl. Each R ^{2 is} independently selected from C ₄ -C ₈ alkyl, benzyl, 2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 4-ethylbenzyl, 4-isopropylbenzyl and 4-tert-butylbenzyl. Suitable C ₄ -C ₈ alkyl moieties include, but are not limited to, n-butyl, n-pentyl, cyclopentyl, n-hexyl, cyclohexyl, cyclohexylmethyl, n-heptyl and octyl.

In one aspect of the present invention, G is selected from —O— and —CH ₂ -. R ¹ selected from H, methyl, ethyl, isopropyl and tert-butyl. Each R ^{2 is} independently selected from C ₄ -C ₆ alkyl, benzyl, 2-methylbenzyl, 3-methylbenzyl and 4-methylbenzyl.

In yet another aspect of the present invention, G is —CH ₂ -, R ¹ is H, and each R ^{2 is} independently selected from n-butyl, n-pentyl, n-hexyl, benzyl, 2-methylbenzyl, 3-methylbenzyl and 4 methylbenzyl.

The composition of the above cleaning compositions, for any object, is brought to a balance (up to 100%) using one or more auxiliary materials.

Methods for preparing suitable organic catalysts

Suitable organic catalysts can be prepared using a variety of reaction reactors and processes, including a batch, semi-batch, and continuous process. A suitable imine-containing modification of the catalyst (formula 1) can be obtained in accordance with the General Protocol described in the examples and references herein. A modification of said catalyst containing an oxaziridinium ring can be obtained by contacting an iminium-containing modification of this catalyst with an oxygen carrier, for example, peroxycarboxylic acid or peroxymonosulfuric acid. Such substances can be formed in situ and used without purification.

Cleaning compositions and cleaning composition additives containing organic catalysts of the applicant

The cleaning composition of the present invention can be successfully used, for example, when washing clothes, cleaning hard surfaces, in automatic dishwashers, as well as in cosmetic use, for example for dentures, teeth, hair and skin. However, in view of the unique advantages of both improved efficiency at lower solution temperatures and excellent compatibility with enzymes, the organic catalysts of the present invention are ideally suited for use in washing, for example when bleaching fabrics using detergents containing a bleaching agent, or detergents containing bleach. In addition, the organic catalysts of the present invention can be used in both granular and liquid formulations.

The organic catalysts of the present invention can also be used in cleaning additives. A cleaning agent comprising the organic catalysts of the present invention is ideally suited to be added to the washing process if additional whitening effectiveness is desired, for example, but not limited to, when cleaning in solution at low temperature. In its simplest form, the additive may be an organic catalyst of the applicant. Preferably, the additive may be packaged in a dosage form for addition in a cleaning process where a source of peroxygen is used and it is desirable to increase the whitening efficiency. Such a unit dosage form may comprise a pill, tablet, gel measure or other separate dosage unit, such as pre-measured powders or liquids. To increase the volume, such a composition may include a filler or carrier. Suitable carrier or filler material includes, but is not limited to, various salts of sulfate, carbonate, and silicate, as well as talc, alumina, and the like. The carrier or filler materials for liquid compositions may be water or low molecular weight primary or secondary alcohols, including diols and polyols. Examples of such alcohols include, but are not limited to, methanol, ethanol, propanol and isopropanol. Compositions may contain from about 5% to about 90% of such materials. Acidic excipients may be used to lower the pH. Alternatively, the cleaning additive may include an activated source of peroxygen, as defined hereinafter, or auxiliary ingredients, as fully defined below.

Applicant's cleaning compositions and cleaning additives require a catalytically effective amount of an applicant's organic catalyst. The required level of such a catalyst can be achieved by adding one or more of the applicant's organic catalyst substances. In practice, but not for the purpose of limiting, the compositions and cleaning methods disclosed herein may comprise of the order of at least 0.001 ppm (ppm), from about 0.001 ppm to about 500 ppm, from about 0.005 ppm to about 150 ppm, or even from about 0.05 ppm to about 50 ppm of the applicant's organic catalyst in a washing liquid. To obtain such levels in a washing liquid, typical compositions of interest may contain from about 0.0002% to about 5%, or even from about 0.001% to about 1.5% of an organic catalyst by weight of the cleaning compositions.

When the applicant’s organic catalyst is used in a granular composition, it may be desirable for the applicant’s organic catalyst to be in the form of encapsulated particles to protect the applicant’s organic catalyst from moisture and / or other components of the granular composition during storage. In addition, encapsulation is also a means of controlling the availability of the applicant’s organic catalyst during the cleaning process and can enhance the whitening efficiency of the applicant’s organic catalyst. In this regard, the applicant’s organic catalyst may be encapsulated by any known encapsulating material.

The encapsulating material typically encapsulates at least a portion, and preferably the entire organic catalyst of the applicant. Typically, the encapsulating material is a water-soluble and / or water-dispersible material. The encapsulating material may have a glass transition temperature (T _g ) of 0 ° C. or higher.

Preferably, the encapsulating material is selected from the group consisting of carbohydrates, natural or artificial resins, chitin and chitosan, cellulose and its derivatives, silicates, phosphates, borates, polyvinyl alcohol, polyethylene glycol, paraffin waxes, and combinations thereof. Preferably, the encapsulating material is a carbohydrate, usually selected from the group consisting of monosaccharides, oligosaccharides, polysaccharides and combinations thereof. More preferably, the encapsulating material is starch. Preferred starches are described in EP 0922499, US 4.977.252, US 5.354.559 and US 5.935.826.

The encapsulating material may be microspheres made of plastic, for example, from thermoplastics, acrylonitrile, methacrylonitrile, polyacrylonitrile, polymethacrylonitrile, and mixtures thereof; commercially available microspheres sold under the Expancel® brand from Expancel from Stockviksverken, Sweden, and microspheres sold under the PM 6545, PM 6550, PM 7220, PM 7228, Extendospheres®, Luxsil®, Q-cel® and Sphericel® brands from PQ Corp. ., Valley Forge, Pennsylvania, USA.

The cleaning compositions of the present invention will preferably be formulated so that during use in an aqueous medium, the pH of the water is between about 6.5 and about 11, or even between about 7.5 and 10.5. Liquid dishwashing compositions may have a pH between about 6.8 and about 9.0. Laundry products typically have a pH of from about 9 to about 11. Techniques for controlling pH within the recommended ranges of use include the use of buffers, alkalis, acids, etc., and are well known to those skilled in the art.

Supporting materials

Although not essential for the purposes of the present invention, the following is a non-limiting list of excipients that are suitable for use in the compositions of the present invention and may, if desired, be included in some embodiments of the invention, for example to facilitate or enhance the cleaning effect, to treat the subject cleaning the substrate or to change the aesthetic component of the cleaning composition, as is the case with fragrances, dyes, coloring agents, etc. The exact nature of such additional components and their levels of content will depend on the physical form of the composition and the nature of the cleaning operation in which they are used. Suitable auxiliary materials include, but are not limited to, surfactants, major components, chelating agents, color transfer inhibitors, dispersants, enzymes and enzyme stabilizers, catalytic materials, bleaching activators, hydrogen peroxide, hydrogen peroxide sources, preformed peracids , polymer dispersants, anti-redeposition agents for removing mineral soil contaminants, brighteners, defoamers, dyes, perfumes and, agents for structure elasticity, fabric softeners, carriers, hydrotropes, processability additives, solvents and / or pigments. In addition to what is described below, suitable examples of other such excipients and their levels of use are given in US patent No. 5.576.282, 6.306.812 B1 and 6.326.348 B1, which are incorporated herein by reference.

As mentioned earlier, auxiliary ingredients are not required for the compositions of the applicant. Therefore, some embodiments of the applicant’s compositions do not contain one or more of the following auxiliary materials: surfactants, main components, chelating agents, color transfer inhibitors, dispersants, enzymes and enzyme stabilizers, catalytic materials, bleaching activators, hydrogen peroxide, peroxide sources hydrogen, pre-formed peracids, polymer dispersants that prevent the re-deposition of mineral removal agents soil contaminants, brighteners, defoamers, dyes, perfumes, agents for elasticity of the structure, fabric softeners, carriers, hydrotropes that improve the workability of additives, solvents and (or) pigments. However, when one or more auxiliary materials are present, such one or more auxiliary materials may be presented, as described in detail below.

Bleaching agents: The cleaning compositions of the present invention may contain one or more bleaching agents. Suitable bleaches other than bleach catalysts include photo bleaches, bleach activators, hydrogen peroxide, sources of hydrogen peroxide, preformed peracids, and mixtures thereof. In general, when using bleach, the compositions of the present invention may contain from about 0.1% to about 50%, or even from about 0.1% to about 25% of bleach, based on the weight of the cleaning composition in question. Examples of suitable bleaches include:

(1) photobleaches, for example zinc sulfonated phthalocyanine;

(2) pre-formed peracids. Suitable preformed peracids are selected from the group consisting of percarboxylic acids and salts, perugaric acids and salts, perimidic acids and salts, peroxymonosulfuric acids and salts, for example Oxzone®, and mixtures thereof. Suitable percarboxylic acids include hydrophobic and hydrophilic peracids having the formula R- (C = O) O-O-M, where R is an alkyl group, optionally branched, having, if the peracid is hydrophobic, from 6 to 14 carbon atoms, or from 8 to 12 carbon atoms, and if the peracid is hydrophilic, less than 6 carbon atoms, or even less than 4 carbon atoms; and M is a counterion, for example, sodium, potassium or hydrogen;

(3) sources of hydrogen peroxide, for example, inorganic perhydrates, including alkali metal salts, for example sodium perborates (usually mono- or tetrahydrates), percarbonates, persulfates, perphosphates, persilicates and mixtures thereof. In one aspect of the invention, inorganic perhydrates are selected from the group consisting of sodium salts of perborate, percarbonate, and mixtures thereof. Typically, inorganic perhydrates are used in an amount of from 0.05 to 40 wt.%, Or 1 to 30 wt.% Of the total weight of the composition and, as a rule, are included in such compositions in the form of a crystalline solid phase, which can be coated. Suitable coatings include inorganic salts, for example silicates, carbonates or borates of alkali metals or mixtures thereof, or organic materials, for example, water-soluble or water-dispersible polymers, waxes, oils or fatty soaps; and

(4) bleaching activators having R- (C = O) -L, where R is an alkyl group, optionally branched, having, if the bleaching activator is hydrophobic, from 6 to 14 carbon atoms, or from 8 to 12 carbon atoms, and if hydrophilic bleaching activator, less than 6 carbon atoms, or even less than 4 carbon atoms; and L is a leaving group. Examples of suitable leaving groups are benzoic acid and its derivatives, in particular benzenesulfonate. Suitable whitening activators include dodecanoyloxybenzene sulfonate, decanoyloxybenzene sulfonate, decanoyloxybenzoic acid and its salts, 3,5,5-trimethylhexanoylbenzene sulfonate, tetraacetyl diamine (TAED) and nonanoyloxybenzene sulfonate (NOBS). Suitable whitening activators are also disclosed in WO 98/17767. Although any whitening activator is allowed, in one aspect of the present invention, the cleaning compositions in question may contain NOBS, TAED, or mixtures thereof.

The peracid and / or bleach activator, if any, is typically present in the composition in an amount of from about 0.1 to about 60 wt.%, From about 0.5 to about 40 wt.%, Or even from about 0.6 up to about 10 wt.% based on the composition. One or more hydrophobic peracids or their precursors may be used in combination with one or more hydrophilic peracids or their precursor.

The amount of the source of hydrogen peroxide and peracid or bleach activator can be selected so that the molar ratio of available oxygen (from the source of peroxide) to peracid is from 1: 1 to 35: 1, or even from 2: 1 to 10: 1.

Surfactants: cleaning compositions in accordance with the present invention may contain a surfactant or a surfactant system, the surfactant may be selected from nonionic, anionic, cationic, ampholytic, zwitterionic, semi-polar nonionic surfactants and mixtures thereof. If present, the surfactant is usually present in an amount of from about 0.1% to about 60%, from about 1% to about 50%, or even from about 5% to about 40% by weight of the composition in question.

Main components: the cleaning compositions of the present invention may contain one or more main components or main detergent systems. When using the main component, its content in the composition in question is usually at least about 1%, from about 5% to about 60%, or even from about 10% to about 40% by weight of the composition in question.

Key components include, but are not limited to, alkali metal salts, ammonium and alkanolammonium salts of polyphosphates, alkali metal silicates, alkaline earth and alkali metal carbonates, aluminosilicate components and polycarboxylate compounds, hydroxypolycarboxylate ethers, copolymers of maleic anhydride with ethylene ether or vinyl methylene , 1,3,5-trihydroxybenzene-2,4,6-trisulfonic acid, and carboxymethyloxy succinic acid, salts of various alkali metals, ammonium and substituted ammonium salts of poly susne acids, for example ethylenediaminetetraacetic acid and nitrotriuksusnoy acid, as well as polycarboxylates such as mellitic acid, succinic acid, citric acid, oxydisuccinic acid, polymaleic acid, benzene 1,3,5-tricarboxylic acid, carboxymethyloxysuccinic acid, and soluble salts thereof.

Chelating Agents: The cleaning compositions in question may contain a chelating agent. Suitable chelating agents include chelating agents of copper, iron and (or) manganese, as well as mixtures thereof. When using a chelating agent, its content in the composition in question can be from about 0.005% to about 15%, or even from about 3.0% to about 10% by weight of the composition.

Dye Transfer Prevention Agents: The cleaning compositions in question may also include one or more dye transfer inhibiting agents. Suitable polymeric agents include, but are not limited to, polyvinylpyrrolidone polymers, N-polyprolamine polymers, N-vinyl pyrrolidone and N-vinylimidazole copolymers, polyvinyl oxazolidones and polyvinylimidazoles, as well as mixtures thereof. When using anti-dye transfer agents, their content in the composition may be from about 0.0001% to about 10%, from about 0.01% to about 5%, or even from about 0.1% to about 3% by weight of the composition .

Gloss formers: the considered cleaning compositions of the present invention may also contain additional components that change the color intensity of the products to be cleaned, for example, fluorescent brighteners. The levels of suitable fluorescent brighteners include lower limits from more than about 0.01, from about 0.05 to about 0.1 wt.%, Or even from about 0.2 wt.% To an upper limit of 0.5 or even 0.75 wt.%.

Dispersing agents: the compositions of the present invention may also contain dispersing agents. Suitable water-soluble organic materials include homo- or copolymer acids or their salts, in which the polycarboxylic acid contains at least two carboxyl radicals separated from each other by no more than two carbon atoms.

Enzymes: cleaning compositions may contain one or more enzymes that provide a cleaning effect and / or tissue care benefits. Examples of suitable enzymes include, but are not limited to, hemicellulase, peroxidase, protease, cellulase, xylanase, lipase, phospholipase, esterase, cutinase, pectinase, mannanase, pectate lyase, keratinase, reductase, oxidase, phenol oxidase, lipoxygenase, pullulanases, tannases, pentosanases, malanases, β-glucanases, arabinosidases, gualuronidases, chondroitinases, laccases, amylases and mixtures thereof. The usual combination is a mixture of enzymes, which may contain, for example, a protease and a lipase in combination with amylase. If the above enzymes are present in the cleaning composition, the protein content of the above enzymes can be from about 0.00001% to about 2%, from 0.0001% to about 1%, or even from about 0.001% to about 0.5% by weight of the composition .

Enzyme Stabilizers: For use in detergents, enzymes can be stabilized by various methods. The enzymes used in the present invention can be stabilized in the presence of water-soluble sources of calcium and / or magnesium ions in the final compositions containing these ions. In the case of aqueous compositions containing a protease, a reversible protease inhibitor, for example, a boron compound, can be added to further increase stability.

Catalytic metal complexes: Applicant's cleaning compositions may include catalytic metal complexes. One type of metal-containing bleaching catalysts is a catalytic system containing a transition metal cation with a specific bleaching activity, for example, copper, iron, titanium, ruthenium, tungsten, molybdenum or manganese, an auxiliary metal cation with little or no bleaching activity, for example , zinc or aluminum cation, and a binder having certain stability constants for the catalytic and auxiliary metal cations, in particular ethylenediaminetetrauk acetic acid, ethylene diamine tetra (methylenephosphonic) acid and their water soluble salts. Such catalysts are described in US patent No. 4.430.243.

If desired, the compositions of the present invention can be catalyzed using a manganese compound. Such compounds and their levels are well known in the art and include, for example, manganese-based catalysts described in US Pat. No. 5,576,282.

Known cobalt whitening catalysts suitable for the present invention, and are described, for example, in US patent No. 5.597.936 and 5.595.967. Such cobalt catalysts are readily prepared by known procedures, such as, for example, as described in US Pat. Nos. 5,597,936 and 5,595,967.

The compositions of the present invention may also include a transition metal complex with ligands such as bispidones (see WO 05/042532 A1) and / or macrocyclic rigid ligands, referred to as “MRL”. In practice - but not by limitation - the compositions and methods of the present invention can be adjusted to contain at least one part per million active MRL component in a washing aqueous medium, and, as a rule, provide from about 0.005 ppm to about 25 ppm, from about 0.05 ppm to about 10 ppm, or even from about 0.1 ppm to about 5 ppm of MRL in the washing solution.

Suitable transition metals in the whitening catalysts of the present invention include, for example, manganese, iron and chromium. Suitable MRLs include 5,12-diethyl-1,5,8,12-tetrazabicyclo- [6.6.2] hexadecane.

Suitable transition metal MRLs are readily prepared using known procedures, for example, as described in WO 00/32601 and US 6,225,464.

Solvents: Suitable solvents include water and other solvents such as lipophilic liquids. Examples of suitable lipophilic liquids include siloxanes, other silicones, hydrocarbons, glycol ethers, glycerol derivatives, for example glycerol esters, perfluorinated amines, perfluorinated and hydrofluoroether solvents, low volatile non-fluorinated organic solvents, diol solvents, other environmentally friendly solvents, and also from mixtures.

Methods for the manufacture of cleaning compositions and (or) processing compositions

The cleaning compositions of the present invention can be formulated in any suitable form and prepared by any method selected by the experimenter; non-limiting examples of such methods are given in the examples of the applicant and in US patent No. 5879.584, 5.691.297, 5.574.005, 5.569.645, 5.565.422, 5.516.448, 5.489.392, 5.486.303, which are all included here by reference.

Mode of application

The present invention includes a method of cleaning including a surface area or fabric. The method includes the steps of contacting the applicant's cleaning composition, in pure form or as a dilute aqueous solution, with at least a portion of a surface or fabric, and then optionally rinsing said surface or fabric. The surface or fabric may undergo a washing step prior to the indicated rinsing step. For the purposes of the present invention, washing includes, but is not limited to, wiping and mechanical agitation. As will be appreciated by one skilled in the art, the cleaning compositions of the present invention are ideally suited for washing laundry. Accordingly, the present invention includes a method of washing a fabric. This method comprises the steps in which: the fabric to be washed is contacted with said cleaning detergent solution containing at least one embodiment of a cleaning composition of the applicant, a cleaning additive of the applicant or a mixture thereof. The fabric may contain virtually any fabric capable of being washed under normal consumer conditions. The solution preferably has a pH of from about 8 to about 10.5. These compositions can be used at concentrations in solution of from about 500 ppm to about 15,000 ppm. The water temperature usually ranges from 5 ° C to 90 ° C. The water / fabric ratio is usually from about 1: 1 to about 30: 1.

Organic Catalyst and Enzyme Compatibility Test

The test below uses an alpha amylase activity test to measure the effect of an organic catalyst on an enzyme.

Equipment: UV / Vis spectrophotometer capable of measuring at 415 nm; magnetic stirrer heated to 40 ° C, 5 ml syringe with Luer nozzle and filters (Acrodisc 0.45 μm), pH meter and balance (analytical, 4 digits).

Reagents: amylase kit from Merck (Merck Eurolab, cat. No. 1.19718.0001); Trizma base (Sigma, Cat. No. T-1503 or equivalent); two-water calcium chloride (Sigma, cat. No. C-5080 or equivalent); quaternary sodium thiosulfate (Sigma, Cat. No. S-6672 or equivalent); hydrochloric acid (VWR cat. No. JT9535-0 or equivalent); stiffness solution (STS group, 3.00 g / cm ³ or equivalent); sodium percarbonate; peracetic acid (Aldrich, cat. No. 26933-6 or equivalent); amylase enzymes: termamyl, natalase and duramyl (Novozymes, Denmark); a matrix of granular detergent that does not contain an enzyme, organic catalyst or bleaching agents.

1) Preparation of the solution:

a) TRIS test buffer. Prepare 1 liter of 0.1 M TRIS buffer, 0.5% sodium thiosulfate (w / v), 0.11% calcium chloride (w / v) at pH 8.3.

b) Control solution of detergent. Prepare 1 liter of 0.5% enzyme and bleach-free granular detergent in deionized water (w / v), which is 250 ppm H ₂ O ₂ (0.77 g percarbonate), and hardness 10 gpg (rigidity 880 U1).

c) The stock of termamyl, duralyl and natalase. 100 ml of solutions are prepared containing 0.1633 mg of active termamyl per ml of TRIS buffer, 0.1159 mg of active natalase per ml of TRIS buffer, and 0.1596 mg of active duramil per ml of TRIS buffer.

d) Stocks of organic catalyst. Prepare 500 ppm in a solution of methanol in µm.

e) Stock of peracetic acid. A solution of 3955 ppm peracetic acid in deionized water is prepared.

e) Amylase reagent. Follow the instructions of the Merck kit to prepare vials (containers) 1 and 2, use vial 3, followed by mixing vials 1 and 2 to obtain the final reagent used in the analysis of amylase activity.

2) Sample analysis:

a) Analysis of a sample containing only the enzyme: add 100 ml of a control solution of the detergent in a 150 ml measuring cup. Place the beaker on a heated stirrer and adjust the temperature to 40 ° C with stirring. Add to the glass Y μl of the enzyme supply, where Y = 612 μl of duramil, 306 μl of thermamil or 918 μl of natalase. Only the enzyme of interest is labeled. Stir the sample for 1 minute. Start the timer. After 7 min 45 sec, a sample is taken out and filtered using a 0.45 μm syringe filter (5 ml syringe). 6 μl of the filtered sample is mixed with 250 μl of amylase reagent in a cuvette and the cuvette is placed in UV / view. spectrophotometer and observed changes in absorption at 415 nm. The duration of time (t _E ) required to obtain an absorbance reading of 1.0 for each enzyme is determined to within a second. Use the obtained t _E for each enzyme in steps 2b) and 2c) shown below.

b) Analysis of the sample only with the enzyme and peracetic acid. Step 2a) is repeated, except that after adding the enzyme, the solution is allowed to mix for 1 minute, then 127 μl of the stock of peracetic acid is added and the timer is started. Take out the sample after 7 min 45 sec, as in step 2a). When the sample and reagent are mixed, the absorption at t _{E is} recorded for the corresponding enzyme. Such absorption is denoted by A _b .

c) Analysis of a sample with an enzyme, peracetic acid and an organic catalyst. Step 2a) is repeated except that after adding the enzyme, the solution is allowed to stir for 1 minute, then a supply of 127 μl of peracetic acid and a supply of 100 μl of organic catalyst are added and the timer is started. After 7 minutes and 45 seconds, the sample was removed, as in step 2a). By mixing the sample and reagent, the absorption at t _{E is} recorded for the corresponding enzyme. Designate such an absorption as A _with .

3) Calculation of the value of the compatibility of the enzyme (ECV):

a) Calculation of ECV for each specific enzyme: Thermamyl (ECV _ter ), Duramyl (ECV _dur ) and Natalase (ECV _nat ). The ECV value for any particular enzyme is (A _c / A _b ) × 100, where A _c and A _b are the values determined in steps 2c) and 2b), respectively, for a given enzyme.

b) ECV for the selected organic catalyst is the average of the individual ECV values for these three enzymes. Therefore, ECV = (ECV _ter + ECV _dur + ECV _nat ) / 3.

EXAMPLES

Unless otherwise indicated, materials may be obtained from Aldrich, P.O. Box 2060, Milwaukee, WI53201, USA.

Example 1: preparation of the internal salt of 3,4-dihydro-4,4-dibenzyl-2- (3-sulfopropyl) isoquinolinium

Step 1. Preparation of α, α-dibutylbenzeneacetonitrile (2): 5.0 g (0.043 mol) of benzyl cyanide (1) and 100 ml of tetrahydrofuran are added to a 500 ml three-necked round-bottom flask equipped with a dry argon inlet, magnetic stirrer and thermometer . 7.2 g (0.1075 mol) of sodium hydride (60% in oil) are slowly introduced into the reaction over an hour. Upon completion of the addition, the reaction mixture was stirred at room temperature for 1 hour. To the reaction mixture was added 18.4 g (0.043 mol) of benzyl bromide and stirred at 50 ° C for 18 hours. The mixture was evaporated to dryness, the residue was dissolved in toluene and washed with 1N HCl. The organic phase was dried over Na ₂ SO ₄ , filtered and evaporated to give α, α-dibutylbenzeneacetonitrile (2), yield 7.7 g (65%).

Step 2. Preparation of 1-amino-2,2-dibutyl-2-phenylethane (3): 7 g (0.0237 mol) of α, α-dibutylbenzeneacetonitrile (2) was dissolved in 1.1 equiv. complex borane-THF at room temperature for 18 hours. At the end of the reaction, 50 ml of ethanol are added and the mixture is evaporated to dryness. After evaporation, the residue was suspended in 100 ml of 1N HCl, and the suspension was evaporated to dryness on a rotary evaporator. This procedure is repeated three times. After the last evaporation, the white residue was dissolved in 100 ml of 1N NaOH and extracted with diethyl ether (2 × 150 ml). The extracts were combined, dried over Na ₂ SO ₄ , filtered and evaporated to dryness to give 6.4 g of 1-amino-2,2-dibutyl-2-phenylethane (3) (yield 90%).

Step 3. Preparation of 3,4-dihydro-4,4-dibenzylisoquinoline (5): into a 100 ml calcined three-necked round bottom flask equipped with an additional funnel, dry argon inlet, magnetic stirrer, thermometer, Dean-Stark trap and heating bath, 5.0 g (0.0166 mol) of 1-amino-2,2-dibutyl-2-phenylethane (3) and 25 ml of toluene are added. 5.0 g of formic acid is added to an additional funnel. Formic acid is added slowly to the stirred reaction mixture over a period of more than 60 minutes to form a solid. After complete addition, the reaction mixture is distilled under reflux and water is removed using a Dean-Stark trap. Upon completion of the reaction, toluene is removed and 4.9 g of N-formyl-β, β-dibutyl-β-phenethylamine (4) are obtained (90% yield). Formamide (4) is then reacted with 30 g of polyphosphoric acid / 6 g of phosphorus pentoxide, using Bischler-Naperalsky conditions, for 18 hours at 170 ° C. Then the reaction mixture is neutralized with an aqueous solution of NaOH, maintaining the temperature between 60 and 80 ° C. After neutralization, the product is extracted with toluene to give 3,4-dihydro-4,4-dibenzylisoquinoline (5). Subsequently, the product can be purified on silica gel.

Step 4. Preparation of the internal salt of 3,4-dihydro-4,4-dibenzyl-2- (3-sulfopropyl) isoquinolinium (6): 3.0 g (0.010 mol) of 3.4 are added to a calcined three-necked round-bottom flask with a capacity of 100 ml -dihydro-4,4-dibenzylisoquinoline (5) and 25 ml of acetonitrile. The solution was stirred at room temperature under argon, and 1.34 g (0.011 mol) of 1,2-oxathiolane-2,2-dioxide was added to the solution. The mixture is heated to 50 ° C and stirred for 18 hours. The reaction mixture was cooled to room temperature and left overnight at room temperature. The resulting solid was separated by filtration and washed with cold acetonitrile to give 3,4-dihydro-4,4-dibenzyl-2- (3-sulfopropyl) isoquinolinium (6).

Example 2: preparation of an internal salt of 3,4-dihydro-4,4-dipentyl-2- (3-sulfopropyl) isoquinolinium

The desired product is obtained in accordance with Example 1, replacing in stage 1 benzyl chloride pentyl chloride.

Example 3: preparation of an internal salt of 3,4-dihydro-4,4-dihexyl-2- (3-sulfopropyl) isoquinolinium

The desired product is obtained in accordance with Example 1, replacing in step 1 benzyl chloride with hexyl chloride.

Example 4: preparation of an internal salt of 3,4-dihydro-4,4-dibutyl-2- (3-sulfopropyl) isoquinolinium

The desired product is obtained in accordance with Example 1, replacing benzyl chloride with butyl chloride in step 1.

Example 5: preparation of an internal salt of 3,4-dihydro-4,4-di (2-methylphenylmethyl) -2- (3-sulfopropyl) isoquinolinium

The desired product is obtained in accordance with Example 1, replacing the benzyl chloride in step 1 with 2-methylbenzyl chloride.

Example 6: preparation of the internal salt of 3,4-dihydro-4,4-di (3-methylphenylmethyl) -2- (3-sulfopropyl) isoquinolinium

The desired product is obtained in accordance with Example 1, replacing in step 1 benzyl chloride with 3-methylbenzyl chloride.

Example 7: preparation of an internal salt of 3,4-dihydro-4,4-di (4-methylphenylmethyl-2- (3-sulfopropyl) isoquinoline

The desired product is obtained in accordance with Example 1, replacing the benzyl chloride in step 1 with 4-methylbenzyl chloride.

Example 8: preparation of the internal salt of 3,4-dihydro-4,4-di (cyclohexylmethyl) -2- (3-sulfopropyl) isoquinolinium

The desired product is obtained in accordance with Example 1, replacing benzyl chloride with chloromethylcyclohexane (obtained from cyclohexanemethanol according to Coe et al., Polyhedron 1992, 11 (24), pp. 3123-8) in step 1.

Example 9: preparation of the internal salt of 3,4-dihydro-4,4-di (phenylmethyl) -2- (3-sulfobutyl) isoquinolinium

The desired product is obtained in accordance with Example 1, replacing in step 4 1,2-oxathian-2,2-dioxide 1,2-oxathiolane-2,2-dioxide.

Example 10: preparation of an internal salt of 3,4-dihydro-4,4-di (phenylmethyl) -2- [3- (sulfoxy) ethyl] isoquinolinium

The desired product is obtained in accordance with Example 1, replacing in step 4 1,3,2-dioxathiolan-2,2-dioxide 1,2-oxathiolan-2,2-dioxide.

Example 11: preparation of an internal salt of 3,4-dihydro-4,4-di (phenylmethyl) -2- [3- (sulfoxy) propyl] isoquinolinium

The desired product is obtained in accordance with Example 1, replacing in step 4 1,3,2-dioxathian-2,2-dioxide 1,2-oxathiolane-2,2-dioxide.

Example 12: preparation of the internal salt of 3,4-dihydro-4,4-di (4-methylphenylmethyl) -7-methyl-2- (3-sulfopropyl) isoquinoline

Step 1: Preparation of 4-methyl-α- (4-methylphenyl) -α - [(4-methylphenyl) methyl] benzenepropanenitrile.

Part a. Preparation of a silicon-containing catalyst: silicon oxide (MKS-500, specific surface area 497 m ² / g, from Nikki Chemical) was activated by treatment with 6N HCl and dried in vacuum at 120 ° C. A mixture of 7.0 g of activated silica gel and 80 ml of toluene was placed in a flask and stirred for 1 hour. Then, 25 ml of N- (2-aminoethyl) -3-aminopropyltrimethoxysilane (SH-6020, from Troy Silicone) was injected with a syringe and the resulting mixture was distilled under reflux in an oil bath for 8 hours. After cooling, the silica gel is filtered off and washed with benzene in a soxhlet for 12 hours. The purified silica is washed 3 more times with diethyl ether and left in the air overnight. One gram of purified silica is then suspended in 1.5 ml of dioxane for 8 hours, after which 4.3 ml of 1,10-dibromodecane are added and the mixture is stirred at 80 ° C. overnight in an oil bath. Then, silica is filtered off on a glass filter and washed with dioxane, acetone and 1% NH ₄ OH, and then washed successively with acetone and diethyl ether. The silica thus obtained was dried at 50 ° C. under reduced pressure overnight.

Part b. Preparation of 4-methyl-α- (4-methylphenyl) -α - [(4-methylphenyl) methyl] benzenepropanenitrile. 0.3 g of a silica-based catalyst is added to a flask containing 1.0 g (2 mmol) of sodium cyanide (95%) dissolved in 5 ml of a 50% aqueous NaOH solution, then 6.8 mmol of 4-methylbenzyl chloride and 1 ml of toluene. The flask was placed in an oil bath and heated for 48 hours at 40 ° C with stirring, after which 10 ml of toluene was added. The organic layer was filtered off and the filtrate was evaporated to give 4-methyl-α- (4-methylphenyl) -α - [(4-methylphenyl) methyl] benzenepropanenitrile.

Step 2. Preparation of 4-methyl-α- (4-methylphenyl) -α - [(4-methylphenyl) methyl] benzene propanenitrile: the desired product is obtained according to Example 1, step 2, replacing 4, methyl, α, α-dibutylbenzeneacetonitrile -α- (4-methylphenyl) -α - [(4-methylphenyl) methyl] benzenepropanenitrile.

Step 3. Preparation of 3,4-dihydro-4,4-di (4-methylphenylmethyl) -7-methyl-isoquinoline: The desired product is obtained according to Example 1, step 3, replacing 1-amino-2,2-dibutyl- 2-phenylethane 4-methyl-α- (4-methylphenyl) -α - [(4-methylphenyl) methyl] benzenepropanamine.

Step 4. Preparation of the internal salt of 3,4-dihydro-4,4-di (4-methylphenylmethyl) -7-methyl-2- (3-sulfopropyl) isoquinoline: the desired product is obtained according to Example 1, step 4, replacing 3 , 4-dihydro-4,4-dibenzyl-isoquinoline 3,4-dihydro-4,4-di (4-methylphenylmethyl) -7-methylisoquinoline.

Example 13: preparation of the internal salt of 3,4-dihydro-4,4-di (4-isopropylphenylmethyl) -7-isopropyl-2- (3-sulfopropyl) isoquinoline

The desired product is obtained in accordance with Example 1, replacing 4-methylbenzyl chloride with 4-isopropylbenzyl chloride.

Example 14: the simultaneous preparation of a mixture of an organic catalyst containing catalysts of the formula 3, where R ¹ independently represents H, methyl, ethyl and mixtures thereof

The desired mixture is formed according to Example 12 by replacing 4-methylbenzyl chloride with a mixture of benzyl chloride (source for R ¹ = H), 4-methylbenzyl chloride (source R ¹ = methyl) and 4-ethylbenzyl chloride (Oakwood Products Inc., West Columbia, SC 29172 , USA; source for R ¹ = ethyl). This leads to a mixture of 18 compounds of various organic catalysts.

Example 15

The bleaching detergent compositions in the form of a granular washing detergent are represented by the following compositions:

BUT AT FROM D E F Linear alkylbenzenesulfonate twenty 22 twenty fifteen twenty twenty C ₁₂ dimethylhydroxyethylammonium chloride 0.7 one one 0.6 0,0 0.7 AE3S 0.9 0,0 0.9 0,0 0,0 0.9 AE7 0,0 0.5 0,0 one 3 one Sodium Tripolyphosphate 23 thirty 23 17 12 23 Zeolite A 0,0 0,0 0,0 0,0 10 0,0 1.6R Silicate 7 7 7 7 7 7 Sodium carbonate fifteen fourteen fifteen eighteen fifteen fifteen Polyacrylate MW 4500 one 0,0 one one 1,5 one Carboxymethyl cellulose one one one one one one Savinase 32.89 mg / g 0.1 0,07 0.1 0.1 0.1 0.1 Natalase 8.65 mg / g 0.1 0.1 0.1 0,0 0.1 0.1 Brightener 15 0.06 0,0 0.06 0.18 0.06 0.06 Brightener 49 0.1 0.06 0.1 0,0 0.1 0.1 Diethylene triamine pentaacetic acid 0.6 0.3 0.6 0.25 0.6 0.6 MgSO ₄ one one one 0.5 one one Sodium percarbonate 0,0 5.2 0.1 0,0 0,0 0,0 Photo bleach 0.0030 0.0015 0.0015 0.0020 0.0045 0.0010 Sodium Perborate Monohydrate 4.4 0,0 3.85 2.09 0.78 3.63 NOBS 1.9 1.9 1,66 1.77 0.33 0.75 TAED 0.58 0.58 0.51 0,0 0.015 0.28 Organic catalyst * 0.0185 0.0185 0.0162 0.0162 0.0111 0.0074 Sulphate / Wet up to 100% up to 100% up to 100% up to 100% up to 100% up to 100% * Organic catalyst obtained in accordance with Examples 1-14, or mixtures thereof

Any of the above composition is used for washing fabrics at a concentration in water of 3500 ppm, 25 ° C and a water: clothing ratio of 25: 1. Typically, the pH is about 10, but can be adjusted by changing the ratio of acid to alkylbenzenesulfonate in the form of a Na salt.

Example 16

The bleaching detergent compositions in the form of a granular washing detergent are represented by the following compositions:

BUT AT FROM D Linear alkylbenzenesulfonate 8 7.1 7 6.5 AE3S 0 4.8 0 5.2 Alkyl Sulfate one 0 one 0 AE7 2.2 0 3.2 0.1 C _10-12 dimethylhydroxyethylammonium chloride 0.75 0.94 0.98 0.98 Crystalline Layered Silicate (δ-Na ₂ Si ₂ O ₅ ) 4.1 0 4.8 0 Zeolite A twenty 0 17 0 Lemon acid 3 5 3 four Sodium carbonate fifteen twenty fourteen twenty Silicate 2R (SiO ₂ : Na ₂ O in a 2: 1 ratio) 0.08 0 0.11 0 Dirt repellent agent 0.75 0.72 0.71 0.72 Acrylic Acid / Maleic Acid Copolymer 1,1 3,7 1,0 3,7 Carboxymethyl cellulose 0.15 1.4 0.2 1.4 Protease (56.00 mg of active substance / g) 0.37 0.4 0.4 0.4 Amylase (21.55 mg of active substance / g) 0.3 0.3 0.3 0.3 Lipase (11.00 mg of active substance / g) 0 0.7 0 0.7 Tetraacetylethylenediamine (TAED) 3.6 4.0 3.6 4.0 Percarbonate 13 13,2 13 13,2 Organic catalyst * 0.04 0.02 0.01 0.06 Na-salt of ethylenediamip-N, N′-di-succinic acid, (S, S-isomer) (EDDS) 0.2 0.2 0.2 0.2 Hydroxyethane diphosphonate (HEDP) 0.2 0.2 0.2 0.2 MgSO ₄ 0.42 0.42 0.42 0.42 Perfume 0.5 0.6 0.5 0.6 Foam suppressor agglomerate 0.05 0.1 0.05 0.1 Soap 0.45 0.45 0.45 0.45 Sodium sulfate 22 33 24 thirty Sulfonated Zinc Phthalocyanine 0,07 0.12 0,07 0.12 Photo bleach 0.0014 0.002 0.0014 0.001 Blotches 0,03 0.05 0,03 0.05 Water and stuff up to 100% up to 100% up to 100% up to 100% * Organic catalyst obtained in accordance with Examples 1-14, or mixtures thereof

Any of the above composition is used for washing fabrics at a concentration in water of 10,000 ppm, 20-90 ° C and a ratio of water: clothes 5: 1. Typically, the pH is about 10, but can be adjusted by changing the ratio of acid to alkylbenzenesulfonate in the form of a Na salt.

Example 17

The bleaching detergent compositions in the form of a granular washing detergent are represented by the following compositions:

BUT AT FROM D E F Linear alkylbenzenesulfonate 19.0 15.0 20,0 19.0 18.0 17.5 Alkyl Sulfate 1D 1,0 0.8 1,0 1,1 1,2 AE3S 0.3 0.2 0,0 OD 0.3 0.5 Partially neutralized polyacrylic acid 6.0 5.5 7.5 7.0 5.8 6.0 Sodium xylene sulfonate * 1,5 1.9 2.0 1.7 1,5 1,0 PEG 4000 0.3 0.25 0.35 0.15 0.2 0.10 Brightener 49 0 0 0.32 0.04 0.04 0.16 Brightener 15 0 0 0.68 0.08 0.08 0.32 Moisture 2,50 2.00 2.90 2.20 2.40 1.80 Sodium carbonate 20,0 17.5 21.0 20,2 19.0 18.0 Sodium sulfate 0.20 0.30 0.50 0.30 0.45 0.10 Sodium silicate 0.25 0.25 0.55 0.30 0.25 0.10 Crystalline layered silicate with the formula δ-Na ₂ Si ₂ O ₅ 2.7 3.0 2.2 3,7 1,5 1,0 Zeolite A 11.0 11.0 12.5 10,2 9.5 8.0 Protease 0.20 0.50 1,0 0.15 0.40 0,0 Silicone foam suppressor 0.40 0.35 1.00 0.60 0.50 0.00 Lumpy Sulphate 21.5 23.0 21.0 21.0 20,0 18.5 Amine reaction product containing δ-Damascon **** 0.40 0.25 0.10 0.35 0.60 0.00 Perfume 0.10 0.30 0.20 0.20 0.40 0.50 Sodium percarbonate 2,8 4,5 2.00 4.7 7.4 10.0 Traditional Activator (NOBS) 2.10 3,7 1.00 3.0 5,0 10.0 Organic catalyst ** 0.005 0.10 1.00 0.25 0.05 0.05 Subcendent *** 0.50 0.20 1.00 0.30 0.10 0.00 Filler up to 100% up to 100% up to 100% up to 100% up to 100% up to 100% * Other hydrotropes, such as toluenesulfonate, may also be used. ** Organic catalyst obtained in accordance with Examples 1-14, or mixtures thereof *** Such as Ultramarine Blue or Azo-CM-Cellulose (Megazyme, Bray, Co. Wicklow, Ireland) **** Received in accordance with WO 00/02991

Any of the above composition is used for washing fabrics at a concentration in water of 500-1500 ppm, 5-25 ° C and a water: clothing ratio of 15: 1-25: 1. Typically, the pH is about 9.5-10, but can be adjusted by changing the ratio of acid to alkylbenzenesulfonate in the form of a Na salt.

Example 18

The organic catalysts listed below were tested in accordance with the compatibility test of the organic catalyst of the present invention and the enzyme using: [peracetic acid] = 5.0 ppm; [organic catalyst] = 0.5 ppm, to obtain the following results:

Position* ** Fragments of the catalyst R ² ; G Enzyme Compatibility ECVter ECV _dur ECV _nat ECV one There is no data 51 86 58 65 2 There is no data 54 90 57 67 3 Benzyl; -O- 101 one hundred 103 101 four Benzyl; -CH ₂ - 102 99 104 102 5 4-methyl-benzyl; -CH ₂ - 103 99 99 one hundred * Positions 1 and 2 are the internal salt of mono [2- (3,4-dihydroisoquinolin-2-yl) -1 - ((1,1-dimethylethoxy) methyl) ethyl] sulfuric acid ester and the internal salt of mono [2- (3,4-dihydroisoquinolin-2-yl) -1- (2-ethylhexyloxymethyl) ethyl] sulfuric acid ester, respectively, which are not covered by the Applicant Formulas 1 and 2 ** R ¹ represents H for positions 3-5

It will be apparent to those skilled in the art that the described and illustrated particular embodiments of the present invention may be changed and modified without departing from the spirit and scope of the present invention. Therefore, all such changes and modifications falling within the scope of this invention are covered by the appended claims.

Claims (18)

1. A cleaning composition containing:
a) an organic catalyst selected from the group consisting of organic catalysts having the following formulas:
(i)

(ii)

(iii) and mixtures thereof;
where G is selected from —O—, —CH ₂ O—, - (CH ₂ ) ₂ -, and —CH ₂ -, R ^{1 is} selected from H or C ₁ -C ₄ alkyl, each R ^{2 is} independently selected from C ₄ -C ₈ alkyl, benzyl, 2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 4-ethylbenzyl, 4-isopropylbenzyl and 4-tert-butylbenzyl; and
b) one or more accessory ingredients. 2. The cleaning composition according to claim 1, characterized in that G is selected from —O— and —CH ₂ -; R ¹ selected from H, methyl, ethyl, isopropyl and tert-butyl; and each R ^{2 is} independently selected from C ₄ -C ₆ alkyl, benzyl, 2-methylbenzyl, 3-methylbenzyl and 4-methylbenzyl. 3. The cleaning composition according to claim 2, characterized in that G is —CH ₂ -; R ¹ represents H; and each R ^{2 is} independently selected from n-butyl, n-pentyl, n-hexyl, benzyl, 2-methylbenzyl, 3-methylbenzyl and 4-methylbenzyl. 4. The cleaning composition according to claim 1, characterized in that it contains an organic catalyst having the following formula:

where G is selected from —O—, —CH ₂ O—, - (CH ₂ ) ₂ -, and —CH ₂ -, R ^{1 is} selected from H or C ₁ -C ₄ alkyl, each R ^{2 is} independently selected from C ₄ -C ₈ alkyl, benzyl, 2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 4-ethylbenzyl, 4-isopropylbenzyl and 4-tert-butylbenzyl. 5. The cleaning composition according to claim 4, characterized in that G is selected from —O— and —CH ₂ -; R ¹ selected from H, methyl, ethyl, isopropyl and tert-butyl; and each R ^{2 is} independently selected from C ₄ -C ₆ alkyl, benzyl, 2-methylbenzyl, 3-methylbenzyl and 4-methylbenzyl. 6. The cleaning composition according to claim 5, characterized in that G is —CH ₂ -; R ¹ represents H; and each R ^{2 is} independently selected from n-butyl, n-pentyl, n-hexyl, benzyl, 2-methylbenzyl, 3-methylbenzyl and 4-methylbenzyl. 7. The cleaning composition according to claim 1, characterized in that it contains an organic catalyst having the following formula:

where G is selected from —O—, —CH ₂ O—, - (CH ₂ ) ₂ -, and —CH ₂ -, R ^{1 is} selected from H or C ₁ -C ₄ alkyl, each R ^{2 is} independently selected from C ₄ -C ₈ alkyl, benzyl, 2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 4-ethylbenzyl, 4-isopropylbenzyl and 4-tert-butylbenzyl. 8. The cleaning composition according to claim 7, characterized in that G is selected from —O— and —CH ₂ -; R ¹ selected from H, methyl, ethyl, isopropyl and tert-butyl; and each R ^{2 is} independently selected from C ₄ -C ₆ alkyl, benzyl, 2-methylbenzyl, 3-methylbenzyl and 4-methylbenzyl. 9. The cleaning composition of claim 8, wherein G is —CH ₂ -; R ¹ represents H; and each R ^{2 is} independently selected from n-butyl, n-pentyl, n-hexyl, benzyl, 2-methylbenzyl, 3-methylbenzyl and 4-methylbenzyl. 10. The cleaning composition according to claim 1, characterized in that at least one of the aforementioned one or more auxiliary ingredients is selected from activated sources of peroxygen, enzyme, surfactant and mixtures thereof. 11. The cleaning composition according to claim 4, characterized in that at least one of the aforementioned one or more auxiliary ingredients is selected from activated sources of peroxygen, enzyme, surfactant and mixtures thereof. 12. The cleaning composition according to claim 7, characterized in that at least one of the one or more auxiliary ingredients mentioned is selected from activated sources of peroxygen, enzyme, surfactant and mixtures thereof. 13. The cleaning composition according to claim 1, characterized in that it contains the following auxiliary ingredients: an activated source of peroxygen, an enzyme and a surfactant. 14. The cleaning composition according to claim 4, characterized in that it contains the following auxiliary ingredients: an activated source of peroxygen, an enzyme and a surfactant. 15. The cleaning composition according to claim 7, characterized in that it contains the following auxiliary ingredients: an activated source of peroxygen, an enzyme and a surfactant. 16. The cleaning composition according to claim 1, characterized in that G is —CH ₂ -; R ¹ represents H; and each R ^{2 is} independently selected from n-butyl, n-pentyl, n-hexyl, benzyl, 2-methylbenzyl, 3-methylbenzyl and 4-methylbenzyl, and said composition contains the following auxiliary ingredients: an activated source of oxygen, an enzyme and a surfactant. 17. The cleaning composition according to claim 1, characterized in that the said catalyst has a compatibility value with an enzyme of 70 or more and one or more auxiliary compounds. 18. A cleaning composition according to claim 17, characterized in that it contains an organic catalyst having an enzyme compatibility value of 80 or more, said composition comprising the following auxiliary ingredients: an activated source of peroxygen, an enzyme and a surfactant.