RU2384341C1 - Pharmaceutical composition for psoriasis treatment - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: there is offered a pharmaceutical composition for psoriasis treatment for external application, containing acetic acid, vegetable oil and extract of animal origin; as extract of animal origin it contains mussels acid hydrolysate in effective amount.

EFFECT: higher clinical effectiveness with respect to psoriasis, including severe erythroderma psoriaticum.

9 cl, 2 ex

Description

The invention relates to pharmaceutical compositions for the treatment of chronic dermatosis, in particular to a pharmaceutical composition based on a hydrolyzate from mussels and acetic acid for the treatment of psoriasis by external use.

It is known to use mussel hydrolyzate in cosmetics and medicine as part of compositions for external use. Acidic mussel hydrolyzate is made from the meat of marine mollusks, mussels of the Mytilidae family (for example, according to TU-15-1089-90, TU 9283-082-00472124-97 or TU 9265-001-13190640-94) and is a dark brown liquid, containing 30-38 wt.% solids. The therapeutic and preventive effect is due to the presence in the mussel hydrolyzate of a complex complex of amino acids, low molecular weight heptides, polyene fatty acids, phosphatides, humic acids, melansidines and trace elements. For example, it is known a means for cleaning the skin based on mussel hydralizate, with wound healing, tonic and cleansing effect with a disinfecting effect [patent RU 2134571, publ. 09/20/1999]. Also known is a pharmaceutical composition for the treatment of herpes viruses, comprising a mussel hydrolyzate and a pharmaceutically acceptable carrier [patent RU 2165264, publ. 04/10/2000]. This composition has antiviral activity against herpes viruses of types 1 and 2 and does not cause the formation of resistant strains of the herpes virus. Meanwhile, the use of mussel hydrolyzate for the treatment of psoriasis is not known in the art.

Known pharmaceutical compositions for the treatment of psoriasis, which include vinegar and various vegetable oils and / or salts as main components. For example, compositions are known including, among other components: strong vinegar and sesame oil [patent CN 1077117, publ. 10/13/1993]; vinegar and salt [application WO 98/25586, publ. 06/18/1998; CN Patent 1895412, publ. January 17, 2007]; rice vinegar and castor oil [patent CN 1408398, publ. 04/09/2003]; vegetable oil and diluted acetic acid [application US 2005/0281771, publ. 12/22/2005]; acetic acid and rose or lemon oil [application WO 2006/092151, publ. 08 09.2006]; olive oil and vinegar [application WO 2008/003130, publ. 01/10/2008].

As a prototype, one of the above compositions was selected, namely, an ointment composition for treating psoriasis by external use, containing powder of a fly fly along with strong vinegar, sesame oil and other components [patent CN 1077117, publ. 10/13/1993]. Meanwhile, the complex of biologically active substances contained in the powder of the fly is not effective enough in the treatment of severe forms of psoriasis such as psoriatic erythroderma.

The technical task to be solved is to increase the effect of using a pharmaceutical composition for the treatment of psoriasis based on acetic acid and vegetable oil due to the introduction of a complex complex of biologically active substances contained in marine hydrobionts.

To solve the technical problem, a pharmaceutical composition is proposed for the treatment of psoriasis for external use, which contains acetic acid, vegetable oil and animal extract with an effective ratio of components. What is new is that, as an extract of animal origin, the composition contains mussel hydrolyzate in an effective amount.

The composition may further comprise water to the desired consistency of the composition, an edible salt in an effective amount and / or an anesthetic in an effective amount, for example, an analgesic.

It is better when the content of the components of the composition is, parts by volume: 90% acetic acid - 1-2; sunflower oil - 2-3; mussel acid hydrolyzate - 2-3. Moreover, the composition may further comprise:

- analgin in an amount of 4-10 mg per 10 ml of mussel acid hydrolyzate;

- edible salt in an amount of 2-3 vol.h .;

- water up to 40 vol.h. total composition.

The invention is further explained in more detail using examples.

The following components are used to prepare the composition of the preferred embodiment of the invention: 90% food acetic acid — 10 ml; vegetable oil - 15 ml; mussel acid hydrolyzate - 15 ml; analginum - 10 mg; food salt (NaCl) - 30 g (15 ml); boiled and / or distilled water - up to 200 ml of the total amount of the composition.

All of the above components are mixed in the usual way under normal conditions until a viscous emulsion of light brown color is obtained.

It is possible to replace sunflower oil with any other suitable vegetable oil, such as corn, soybean, olive, etc.

Perhaps an exception to the composition of the salt of food and analgin at the stages of recovery or when prescribed for prophylactic purposes.

For use, the composition is applied to psoriasis affected areas of the skin by wiping these areas. Such rubbing is carried out 2-4 times a day until recovery. Testing the composition, which will be explained in more detail below, showed that recovery usually occurs after 4-6 months. It is assumed that mussel acid hydrodisate in combination with other components of the claimed composition significantly increases the intensity of free radical oxidation processes, in particular, stimulates lipid peroxidation, which leads to normalization of their level and recovery of the patient.

Further, the invention is illustrated by examples of extracts from medical records.

Example 1. Patient X, born in 1956

Asked for help in 2006

According to the patient, psoriasis began in the 1970s, after which he underwent courses of treatment in various medical institutions. For treatment, iodine solution was used for 6 months without any effect. After time, psoril was prescribed other drugs for the treatment of psoriasis, but they did not give any kind of positive effect. For a certain time, medicinal baths from hot natural springs were used, ointment based on solidol, various decoctions on an herbal basis, Betamethasone, Levamezol and other products were used without improvement.

With psoriatic erythroderma, the pathological process covers the entire (or almost all) skin. The skin becomes taut, rough, infiltrated, red, with abundant large and small plate peeling on the surface. The peripheral lymph nodes increase, subfebrile temperature appears, the general condition of patients (neurotic disorders, itching, weakness, sleep disturbance, appetite, etc.) is disturbed, changes in the blood are observed (leukocytosis, increased ESR, shifts in protein fractions, etc.), urine (the appearance of protein). The development of erythroderma contributes to irrational, irritating therapy of the progressive stage of psoriasis.

External examination: the pathological process covers most of the skin - the skin in the lesion is red, rough, infiltrated, with abundant peeling; peripheral lymph nodes are enlarged. Complaints: weakness, itching, impaired sleep and appetite. Revealed: increased ESR and the appearance of protein in the urine.

Diagnosis: psoriatic erythroderma as a result of previous irrational therapy of the progressive stage of psoriasis.

It was prescribed wiping 3 times a day with a new composition based on mussel acid hydrolyzate, acetic acid and vegetable oil (the preferred composition is described above). The improvement in general condition was noticeably manifested after 16 weeks, and full recovery occurred 24 weeks after the appointment of the composition (ESR - within normal limits; protein in urine - absent; low-grade temperature - normal; skin on the whole body is dry, natural, without color and signs) defeat).

Example 2. Patient U, b. 1971

Seeking help in 2007. Symptoms: the presence of bright psoriatic papules on the scalp, on the skin of the buttocks, elbows, knees, some of which have yellow crusts and small cavities with sterile exudate; "Stuck" of the nail plates; itching

Diagnosis: pustular psoriasis (diabetes mellitus).

Appointed: a new composition based on mussel acid hydrolyzate, acetic acid and vegetable oil (the preferred composition is described above) - rubbing up to 3 times a day; antiseborrhoeic shampoo; conventional therapy for diabetes. The improvement in general condition was noticeably manifested by the 18th week and related to the disappearance of papules on the skin of the scalp, and full recovery occurred 30 weeks after the appointment of the composition.

In addition to the above examples, the new composition has been successfully tested on patients suffering from palmar-plantar and seborrheic forms of psoriasis.

It should be understood that the above examples are used only to illustrate the possibility of carrying out the invention and do not limit the scope of legal protection presented in the claims, while a specialist in the art is relatively simple to implement other ways of carrying out the invention.

Claims (9)

1. Pharmaceutical composition for the treatment of psoriasis for external use, containing acetic acid, vegetable oil and animal extract with an effective ratio of components, characterized in that the extract of animal origin contains mussel acid hydrolyzate in an effective amount. 2. The composition according to claim 1, characterized in that it further comprises water to the desired consistency of the composition. 3. The composition according to claim 1, characterized in that it further comprises an edible salt in an effective amount. 4. The composition according to claim 1, characterized in that it further comprises an anesthetic in an effective amount. 5. The composition according to claim 1, characterized in that as an anesthetic contains an analgesic. 6. The composition according to claim 1, characterized in that the content of the components is, vol.h .: 90% acetic acid - 1-2; vegetable oil - 2-3; mussel acid hydrolyzate - 2-3. 7. The composition according to claim 6, characterized in that it further contains analgin in an amount of 4-10 mg per 10 ml of mussel acid hydrolyzate. 8. The composition according to claim 6, characterized in that it further comprises edible salt in an amount of 2-3 vol.h. 9. The composition according to claim 1, characterized in that it further comprises water up to 40 vol.h. total composition.