RU2381796C2 - Preparation "diaron" for treatment of acute gastrointestinal diseases of newborn calves - Google Patents

Abstract

FIELD: veterinary.

SUBSTANCE: preparation of treatment of gastrointestinal diseases in newborn calves, includes zeolite, tetracycline, sodium acetate and flour of dried leather bergenia rhizome (Bergenia crassifolia), at the following ratio of components, wt %: Zeolite 44.5-48.5; Sodium acetate 44.5-48.5; Flour from dried rhizome of leather bergenia (Bergenia crassifolia) 4.2-8.2; Tetracycline 1.0-2.0. Preparation is fed in dose of 35 g per head 2 times per day until recovery.

EFFECT: therapeutic efficiency makes 100%.

1 tbl, 4 ex

Description

The invention relates to veterinary medicine, namely to the treatment of acute gastrointestinal diseases of newborn calves.

Acute gastrointestinal diseases of newborn calves (OZHKBNT) - the most common forms of pathology of young animals, observed in almost all farms involved in dairy farming. In many farms during the period of mass calving of cows, which usually take place during the winter-stall period of keeping animals, OZHKBNT are in the nature of this epizootic, affecting all nascent calves. If you do not carry out effective preventive and therapeutic measures, then the mortality among diseased calves reaches up to 90-100%.

OZHKBNT include a large number of diseases that occur with signs of indigestion, and can be of infectious or non-infectious origin. They belong to intractable diseases, which is explained not only by their polyetiologicity, but also by the complexity of pathogenesis - they develop a disease of the whole organism, accompanied by a violation of the functions of almost all internal organs.

It should be noted that a huge number of methods and tools have been proposed for the fight against OZHKBNT, especially with regard to treatment. In recent years, more and more expensive imported drugs have been offered, but many farms are not able to purchase them because of the high cost.

No one doubts that treatment with OZHKBNT can be successful with the use of a complex of drugs, and not just some kind of "wonderful" monocomponent drug. Success in treatment can be achieved by the simultaneous use of antimicrobial agents, anti-dehydration and intoxication agents that increase tone, normalize digestion, heal the intestinal mucosa, etc. The use of various means separately requires the implementation of many therapeutic procedures (injections and drinks) on each sick calf. Therefore, veterinarians are physically unable to perform all procedures, especially with a massive calf disease, which is why they unwittingly simplify the treatment regimen, reducing the number of drugs or manipulations, thereby reducing its effectiveness.

The number of therapeutic manipulations is best reduced by the use of drugs in the form of combined mixtures used by drinking.

Of the combined analog preparations, startin, rehydraltan, eryprim, thromexin, radar and others are known. However, when using these drugs, a consistently high therapeutic effect is not always achieved due to the insufficient spectrum of their medicinal properties. In addition, their significant disadvantage is the high cost.

The closest technical solution, selected as a prototype of this invention, is gastrovetin, containing in its composition the same zeolite of the Shivyrtuysky field - Shivyrtuin (patent No. 2145502). Gastrovetin was used in a number of farms in the Chita region.

However, the effectiveness of gastrovetin is low, since it does not have antimicrobial, tonic and anti-dehydrating agents.

The aim of the present invention is to increase the effectiveness of the treatment of VLBI while reducing its cost.

This goal is achieved by the fact that the preparation diaron contains the following components, wt.%: Zeolite - 44.5-48.5, sodium acetic acid - 44.5-48.5, flour from the dried rhizome of frankincense Bergenia crassifolia - 4 , 2-8.2, tetracycline - 1.0-2.0.

All components of the diaron are powdery, easily mixed with each other, not scarce, not expensive, each of them has healing properties. In combined use, the healing properties of each component enhance the properties of the remaining components.

Diaron does not require preliminary preparation before use, that is, it is immediately fed to sick calves in the form of a suspension with water, which calves can easily cope with.

Shivyrtuin (TU 10 RSFSR 359-88) with a particle size of 0.1 to 0.3 mm is pre-dried in an oven at 110 ° C for 8 hours.

The rhizomes of badass thick-leaved (Bergenia crassifolia) are harvested in the autumn in the cedar forests of Transbaikalia, dried in the shade to a moisture content of not more than 14% and crushed using a crushing plant. Then turn into flour in special mills.

Sodium acetic acid and tetracycline are acquired through the Zoovetsnab system and other organizations selling veterinary drugs.

The components sifted through a sieve are placed in the required proportions in an enameled container and mixed with wooden spatulas. Then the resulting mixture is stirred in an electric mixer for 20 minutes until a homogeneous powder is obtained. The dosage form in the form of a gray powder is packaged in 0.5 kg plastic bags.

Scientific and industrial experiments on the study of the effectiveness of diarone were carried out according to the following scheme:

Example 1. Used the drug "Diaron" with a minimum ratio of the main ingredients, wt.%: Zeolite - 48.5; sodium acetate - 46.3; flour from the dried rhizome of the frankincense Bergenia crassifolia - 4.2, tetracycline - 1.0.

The test of the therapeutic effectiveness of diarone was carried out in a production environment on a farm during the period of mass calving of cows. The experiment was carried out on newborn calves with well-defined clinical signs of a gastrointestinal disease. According to the principle of analogues, they were divided into two groups - the experimental and control 10 goals in each in the following order: the first sick calf was included in the experimental group, the second in the control, the third in the experimental, the fourth in the control, etc.

The experimental calves were treated with diarone at a dose of 30-35 g per head, depending on the live weight of the calf. The drug was administered twice a day with an interval of about 12 hours, excluding colostrum: the first time completely, then little by little they began to drink it with boiled water.

Control calves were treated with gastrovetin as directed. The following indicators were taken into account: the duration of the disease, the nature of its course during the treatment period, the frequency of drug administration, and the outcome of the disease.

In the experimental group, already after twice drinking the diaron, 50% of calves recovered, 30% - after three times, 10% - five times and 10% - after eight times (after 4 days). The therapeutic efficacy of diarone was 100%. And in the control group one calf fell, the rest recovered in the period from 48 to 120 hours. The therapeutic efficacy of gastrovetin was 90%.

Example 2. Diaron was used in average ratios of ingredients, wt.%: Zeolite - 46.15; sodium acetate - 46.15; flour from the dried rhizome of frankincense Bergenia crassifolia - 6.16; tetracycline - 1.54.

The design of the experiment was similar to that in the first experiment. The duration of the disease in calves of the experimental group ranged from 48 to 72 hours, the effectiveness of treatment was 100%, and in control calves, respectively, 4-5 days and 90%.

Example 3. Diaron was used in the maximum ratios of the main ingredients, wt.%: Zeolite - 44.5; sodium acetate - 45.3; flour from the dried rhizome of frankincense Bergenia crassifolia - 8.2; tetracycline - 2.0.

The experiment was carried out according to the same methodology as in previous experiments. The duration of the disease in calves of the experimental group ranged from 48 to 72 hours, the effectiveness of treatment was 100%, and in control calves, respectively, 4-6 days and 90%.

Example 4. Of the calves suffering from acute gastrointestinal disorders, 4 experimental and one control groups were formed by the principle of analogues. For the treatment of calves, a diaron was used, consisting of the following ingredients, wt.%: Zeolite - 46.15; sodium acetate - 46.15; flour from the dried rhizome of frankincense Bergenia crassifolia - 6.16; tetracycline - 1.54. All experimental calves were treated with diarone 2 times a day in the following doses: in the first group 25 g per head, in the second 30, in the third 35 and in the fourth 40 g per head. Gastrovetin was administered to the control group of calves according to the instructions of 0.3 per 1 kg of body weight. The results are presented in table 1.

Thus, the experiments showed the high efficiency of diarone in acute gastrointestinal diseases of newborn calves.

In all experiments, all the calves that were treated with the diarone recovered. Slight differences in the results depended on the ratio of the ingredients in the preparation and the dose. The disease was cured within 2-4 days after giving the drug 4 to 7 times. The treatment efficiency was 100% in all experiments.

Table 1 Therapeutic efficacy of diarone in a dose-dependent manner Indicator Calf group The control one 2 3 four The number of calves, goal. 10 12 12 fifteen fifteen Single dose of diarone, g 25 thirty 35 40 - Single dose of gastrovetin, g - - - - 10.0 Duration of treatment, days 3.8 2,4 2.0 3.2 5.5 The multiplicity of treatment of calves during the treatment period, times 7 5 four 6 12 Recover, goal. 10 12 12 fifteen 10 Fallen goal - - - - 2 The effectiveness of treatment,% 100.0 100.0 100.0 100.0 86.7

Among the control calves there was a death, the duration of the disease ranged from 4 to 5.5 days. All experimental calves were ill in mild form, and control calves in severe and moderate forms.

Claims (1)

A preparation for the treatment of gastrointestinal diseases of newborn calves, including zeolite, characterized in that it additionally contains tetracycline, sodium acetate and flour from the dried rhizome of frankincense Bergenia crassifolia in the following ratio, wt.%:
Zeolite 44.5-48.5 Sodium Acetate 44.5-48.5 Dried Rhizome Flour bergenia crassifolia 4.2-8.2 Tetracycline 1.0-2.0