RU2376890C1 - Composition for providing preventive measures against calcic deficiency and normalisation of calcium metabolism (versions) - Google Patents

Abstract

FIELD: food industry. ^ SUBSTANCE: invention relates to food industry and can be used while producing biologically active supplements (BAS) for food and food products. Composition contains calcium, phosphor, magnesium sources and ascorbic acid, vitamins D3, B2, B6, extracts of John's wort, owa-tree fruits, Kurile tea, unossified antlers hematogen made of male maral blood and condimental substances. Composition components are used in certain ratio. Composition is proposed mostly for men. Composition contains calcium, phosphor, magnesium sources and ascorbic acid, vitamins D3, B2, B6, extracts of John's wort, rowa-tree fruits, Kurile tea, unossified antlers hematogen made of male maral blood and condimental substances. Composition also contains components in certain ratio and proposed for women. As a version composition contains sources of calcium, phosphor, magnesium, ascorbic acid, vitamins D3, B2, B6, rosehips extracts, black currant extracts, rowa tree fruits extracts, unossified antlers hematogen made of male maral blood and condimental substances and proposed for non-adults. ^ EFFECT: invention allows to obtain new balanced compositions used as preventive measures of calcic deficiency and normalisation of calcium metabolism. ^ 15 cl, 3 ex

Description

The invention relates to the food industry and can be used for the production of biologically active additives (BAA) for food and food products aimed at the prevention of calcium deficiency and normalization of calcium metabolism.

It is difficult to overestimate the role of calcium in the life of the body. Of the elements - metals, calcium is the main not only quantitatively, but also functionally. Of the total amount of calcium present in the body, 98.9% is deposited in the bone and cartilage, 0.51% in the teeth, 0.51% in the soft tissues and 0.08% in the blood plasma.

The optimal supply of calcium to the body is necessary during all periods of a person's life. A lack of calcium in the body increases the risk of rickets in children, osteoporosis in adults, disrupts the development of the skeleton and teeth.

Calcium performs various functions in the body, the main of which is participation in the creation of a rigid skeleton, achieved by the deposition of calcium phosphates on the collagen base in the bones.

During the period of intensive growth, adolescents increase up to 37% of the total bone mass, which emphasizes the intensity of calcium metabolism during this period.

With age (after 40 years), a natural decrease in bone mass occurs and after 60 years in men remains about 70%, in women - 60% of bone mass compared to the norm, and in women, a decrease in bone mass is exacerbated by hormonal changes in the body in the postmenopausal period, due to decrease in the level of sex hormones - estrogen. As you know, these hormones directly affect the state of metabolism in bone tissue, and when they are deficient, bone tissue is discharged due to calcium “leaching”.

But the process of growth and formation of the skeleton does not boil down to a simple increase in the mass of bone tissue and the degree of its mineralization. The skeleton, like any other organ or tissue, is in a state of constant self-renewal, remodeling, which is the result of two simultaneously occurring processes: - resorption - resorption of an existing, transformed bone and its formation, modeling.

As a result of these processes, during the period of intensive growth in children and adolescents, the skeleton is completely renewed in 1-2 years, in adults - in 10-12 years.

Resorption is enhanced whenever the level of calcium in the blood for one reason or another shows a tendency to decrease. Due to these peculiarities of calcium metabolism, the need for both growing and completed growth of the body in calcium is much higher than the average daily value of its absolute growth, deposition in the skeleton. And since a normal and stable concentration of calcium is a prerequisite for life, all changes in its balance are covered by bone tissue.

Due to the increased need for calcium, for the formation of the skeleton during the period of increased growth, the recommended rate of its consumption, according to the standards applicable in the Russian Federation, for children from 1 year to 3 years is 800 mg / day, for children aged 4-6 900 mg, 7-10 years - 1100 mg and 11-17 years - 1200 mg per day. For persons over 40, a dose of 800 to 1000 mg of calcium per day is recommended [7, 8].

High amounts of calcium are found in many foods. However, it should be borne in mind that not all forms of calcium contained in food are easily absorbed in the body. Calcium absorption is very difficult. Calcium compounds are insoluble in water, and therefore, getting into the human body with food, they only partially pass into soluble compounds under the influence of gastric juice and the alkaline environment of the small intestine, where it is absorbed.

It is believed that the most digestible forms of calcium are found in dairy products. The content of calcium in them reaches 100-150 mg per 100 g. Nevertheless, in order to get the necessary 800 or even 1200 mg of calcium from these products, you need to drink up to 1 liter of milk or eat 650-800 grams of cottage cheese per day. Eating so many dairy products daily for most people is not realistic. In addition, lactose (milk sugar) contained in milk is not absorbed in many people and causes discomfort in the digestive system, including diarrhea, pain and bloating, nausea and vomiting, after eating dairy products.

Since it is extremely difficult, and sometimes impossible at all, to ensure optimal calcium intake with diet through conventional foods, there is an urgent need to develop a composition aimed at preventing calcium deficiency and normalizing calcium metabolism.

A functional food product containing milk protein, a source of calcium, vitamins D, E with a certain ratio of components is known from the prior art (RF patent 2270586).

This product has a high digestibility of calcium and the ability to correct metabolic disorders in bone tissue, manifested by a disease such as osteoporosis.

BACKGROUND OF THE INVENTION Food supplements are known in the art for the prevention of calcium deficiency and the optimization of calcium metabolism, which contains a chemical compound of calcium, a mineral-organic complex consisting of compounds of magnesium, zinc, copper, potassium, a non-hormonal organic compound of iodine in covalently bound form, and vitamin D ₃ ascorbate, citrate, succinate, thiosulfate anions, amino acids lysine, arginine, tryptophan both in free and bound state, polyuronic acid compounds (RF patent 2255604). This invention can effectively solve the problems of eliminating calcium deficiency in the body.

The objective of the present invention is to expand the range of products that compensate for calcium deficiency by creating a new composition aimed at the prevention of calcium deficiency and normalization of calcium metabolism.

The problem is solved by a group of inventions, united by a single inventive concept.

The technical result obtained from the use of the claimed invention is the prevention of calcium deficiency and normalization of calcium metabolism by providing the body with easily absorbed (available) calcium and a balanced ratio of ingredients. It should be noted that it is not enough just to provide the necessary calcium to the body to solve the problem of deficiency and its prevention. As already mentioned, calcium belongs to hard-to-digest elements and its digestibility (availability) depends on its ratio with other micro- and macronutrients (phosphorus, magnesium), as well as vitamins [1].

Therefore, the problem is solved by the fact that the proposed composition for the prevention of calcium deficiency and normalization of calcium metabolism, which contains a source of calcium, a source of phosphorus, a source of magnesium, vitamins

D ₃ , B ₂ , B ₆ , ascorbic acid, St. John's wort extract, extract of Kuril tea, red rowan fruit extract, pantogematogen from the blood of a male deer and auxiliary substances, in the following ratio of components, wt.%:

Source of calcium 10,0-40,0 Phosphorus source 5.0-20.0 Magnesium source 5.0-28.0 Vitamin C 0.5-2.0 Vitamin D ₃ 0.00002-0.00007 Vitamin B ₂ 0.01-0.03 Vitamin B ₆ 0.01-0.03 Hypericum Extract 0.05-0.15 Rowan fruit extract 0.03-0.05 Kuril Tea Extract 0.09-0.11 Pantohematogen from the blood of a male deer 0.2-1.5 Excipients rest

The problem is also solved by the fact that the composition for the prevention of calcium deficiency and normalization of calcium metabolism contains a source of calcium, a source of phosphorus, a source of magnesium, vitamins D ₃ , B ₂ , B ₆ , ascorbic acid, St. John's wort extract, Kuril tea extract, rowan fruit extract red, pantohematogen from the blood of a female deer and auxiliary substances, in the following ratio of components, wt.%:

Source of calcium 10,0-40,0 Phosphorus source 5.0-20.0 Magnesium source 5.0-28.0 Vitamin C 0.5-2.0 Vitamin D ₃ 0.00002-0.00007 Vitamin B ₂ 0.01-0.03 Vitamin B ₆ 0.01-0.03 Hypericum Extract 0.05-0.15 Rowan fruit extract 0.03 - 0.05 Kuril Tea Extract 0.09-0.11 Pantohematogen from the blood of a female maral 0.2-1.5 Excipients rest

The problem is also solved by the fact that the composition for the prevention of calcium deficiency and normalization of calcium metabolism contains a source of calcium, a source of phosphorus, a source of magnesium, vitamins D ₃ , B ₂ , B ₆ , ascorbic acid, rosehip extract, blackcurrant fruit extract, extract red rowan fruits, pantohematogen from the blood of a male deer and auxiliary substances, in the following ratio of components, wt.%:

Source of calcium 7.0-25.0 Phosphorus source 3,5-12,5 Magnesium source 3,5-17,5 Vitamin C 0.5-2.0 Vitamin D ₃ 0.00002-0.00007 Vitamin B ₂ 0.01-0.03 Vitamin B ₆ 0.01-0.03 Rosehip extract 0.09-0.11 Rowan fruit extract 0.03-0.05 Blackcurrant Fruit Extract 0.03-0.05 Pantohematogen from the blood of a male deer 0.1-1.0 Excipients rest

In this case: - as a source of calcium, the composition contains mineral or organic salts of calcium;

- as a source of phosphorus, the composition contains calcium or magnesium phosphates;

- as a source of magnesium, the composition contains mineral or organic salts of magnesium;

- made in the form of tablets, dragees or capsules.

Excipients are standard excipients that are widely used in the pharmaceutical and food industries in the production of solid formulations in quantities that provide known manufacturing techniques.

In the preparation of tablets to eliminate changes in hygroscopicity and improve the ability to tabletting, auxiliary substances can be added to the composition: calcium or magnesium stearate, aerosil, talc, etc. in quantities that determine the technology of tabletting. Tablets are prepared in a known manner on tablet presses.

When performing the composition in the form of a dragee, molasses, powdered sugar, cocoa powder, etc. can be used as auxiliary substances. in the amount determined by the technology of pelleting.

Another more modern preparative form of the claimed composition is gelatin capsules containing the powder of the claimed composition.

The execution of the composition in the form of tablets, dragees or capsules gives an extension of the range of the drug in form and choice for customers the most convenient, acceptable form of the drug for him.

The inventive composition options contain:

- as a source of calcium - mineral salts, for example dicalcium phosphate, tricalcium phosphate, etc., organic salts - calcium lactate, calcium citrate, etc .;

- as a source of phosphorus - calcium phosphates, magnesium phosphates, etc .;

- as a source of magnesium - mineral salts, such as bisubstituted trihydrous magnesium phosphates, trisubstituted magnesium phosphates, etc., organic salts - magnesium citrate, magnesium lactate, etc.

All three of these elements are inextricably linked.

Phosphorus - phosphorus metabolism is closely related to calcium metabolism and significantly affects bone mineralization. The absorption efficiency of phosphorus depends on the ratio of calcium and phosphorus in the intestinal lumen. The scientific literature and practical recommendations on nutrition have repeatedly indicated that for optimal absorption and assimilation of these nutrients, the Ca: P ratio should be 1: 1 [3].

However, maintaining the optimal ratio of calcium and phosphorus in real conditions is difficult, since in a ratio close to optimal, calcium and phosphorus are found only in milk and dairy products, as well as in some vegetables, berries and fruits. In all other products, this ratio is strongly shifted towards excess phosphorus.

The results of numerous experimental studies, clinical and epidemiological observations indicate that limiting the consumption of phosphorus to the ratio Ca: P = 1: 0.5 allows you to prevent or significantly delay the development of disorders of phosphorus-calcium metabolism and bone changes in a number of pathological conditions [3].

Calcium intake should also be clearly balanced with the intake of another important alkaline-earth macronutrient - magnesium (Mg). Like calcium, magnesium is part of the mineral base of bone tissue. The human body contains about 25 g. Most of this amount is concentrated in the bones in the form of magnesium salts: phosphates and bicarbonate. Bones are a depot of magnesium, from where the body scoops it if necessary, like calcium. The magnesium content in staple foods is high enough. Since magnesium is a part of chlorophyll, they are especially rich in plant foods, which usually account for 2/3 of all magnesium that comes from food.

Unfortunately, the usual diet of a modern Russian is extremely poor in vegetables and does not always provide the body with the necessary amount of magnesium.

The lack of the latter enhances the deposition of calcium salts in the walls of blood vessels, kidneys, worsens the functioning of the heart muscle.

A lack of magnesium in children in their first years of life can be the cause of rickets that cannot be treated with vitamin D ₃ . In this case, it is necessary to prescribe this vitamin in combination with magnesium salts.

Recent studies have shown that enriching the diet with magnesium slows down the development of osteoporosis and helps increase bone density in older women. As with phosphorus, magnesium intake should be balanced with calcium intake. The optimum ratio is Mg: Ca = (0.5 ÷ 0.7): 1 [4].

In the claimed composition (options 1, 2, 3), the Ca: P: Mg ratio is optimally balanced and amounts to 1: 0.5: (0.5 ÷ 0.7), regardless of which salt each element is present in.

The quantitative ratio of these ingredients was calculated on the basis of the normative document “Norms of physiological requirements for food substances and energy for various groups of the population of the USSR” [7, 8]. For food products (to which the claimed composition relates) their content should be from 10 to 50% (GOST R 52349-2005). In this case, the upper and lower limits were calculated in such a way as to maintain the optimal ratio between calcium, phosphorus and magnesium.

As noted, the digestibility (availability) of calcium also depends on its ratio with vitamins, in particular with vitamin D, B ₂ , B ₆ and C.

Vitamin D ₃ - cholecalciferol D ₃ has the ability to regulate calcium-phosphorus metabolism. It maintains the level of phosphorus and calcium in the plasma above the threshold value and increases the absorption of calcium in the small intestine, thereby preventing the development of rickets and osteomalacia [6].

Along with this, a necessary condition for the full absorption and use of calcium is the optimal provision of the body with ascorbic acid (vitamin C), as well as other vitamins, in particular B ₂ (riboflavin) and B ₆ (pyridoxine hydrochloride). The role of ascorbic acid and vitamin B ₂ in these processes is due to their participation in the formation of hormone-active forms of vitamin D ₃ . In addition, ascorbic acid and vitamin B _{6 are} necessary to give proper spatial structure to collagen fibers, on which there is an orderly deposition of calcium during skeleton mineralization.

The results of numerous experimental studies confirm that the necessary condition for the implementation of vitamin D functions to maintain calcium homeostasis and skeleton remodeling is the optimal provision of the body with vitamins C and _B2 , which are directly involved in the formation of active forms of vitamin D. The lack of these vitamins even with normal supply of calcium and vitamin D makes it impossible to implement the function of maintaining the normal structure and mineral saturation of the skeleton [2].

The quantitative ratio of vitamins, as well as minerals, was calculated on the basis of the "Norms of physiological requirements for nutrients and energy for various groups of the population of the USSR" taking into account their influence on metabolic processes.

In addition, each of the three claimed compositions is equipped with additives of plant and animal origin, which also positively affect the absorption of calcium.

St. John's wort extract (Hyperici extract) contains catechins and tannins, which help the body absorb vitamin C, and also contribute to the synthesis of vitamin D ₃ in the skin under the influence of sunlight. The extract stimulates polyferative processes (cell reproduction) and tissue repair processes, including bone.

Fruits of red mountain ash (Fruits of service tree) are extremely rich in carotenoids, which are necessary for the growth, development, restoration and maintenance of bone, cartilage and connective tissue in good condition.

Kuril tea extract (Pentaphylloides fruticosa) in combination with St. John's wort extract limits lipid peroxidation processes, which helps to stabilize the rhythm of cortisol secretion into the blood, reduces hypercorticism and reduces calcium excretion from the body.

The fruits of blackcurrant (Ribes nigrunil) contain vitamins B ₂ , B ₆ , C, trace elements: calcium, magnesium, phosphorus, which give the proper spatial structure to collagen fibers, ordering calcium deposits during skeleton mineralization.

Rosehips (Frucfus Rosae) are rich in carotenoids, flavonoids, vitamins E, P and an extremely high content of vitamin C, which is necessary to improve calcium metabolism in the body [5].

Pantohematogen. Blood is an environmentally friendly complex of blood cells, proteins, amino acids, including irreplaceable minerals, trace elements, vitamins. Moreover, all these components are in the blood in balanced amounts necessary for life. Pantohematogen has the ability to activate the hormonal activity of both men and women. The nutritional value of blood is also known.

Dried blood - food albumin - is widely used in the food industry, dried plasma and blood serum are substitutes for egg white.

Antler animals have a high metabolic rate. By 4-5 months, the deer increases body weight by about 10 times. Blood sampling from antlers is performed during the period of antlers growth, i.e. during the period of greatest physiological activity, when the blood of the animal contains the maximum amount of biologically active substances.

Pantohematogen from the blood of a maral male enhances the energy supply of transport processes involved in the intake of most biologically active substances and ions, including calcium. In addition, pantohematogen has a pronounced specific effect on the process of calcium intake in bone tissue. This is due to an increase in the activity of osteoblasts actively using calcium to build new bones.

An important property of pantohematogen from the blood of a male deer is also its stabilizing effect on the autonomic nervous system and an increase in the concentration of adrenocorticotropic hormone (ACTH) in the blood, which leads to a decrease in cortisol and stabilization of its secretion. This eliminates the aggravating effect of stress on the state of bone tissue [5].

Plant extracts provide significant support and enhance the indicated properties of pantohematogen due to their flavonoids and anthocyanins. In addition, pantohematogen from the blood of a male deer increases the activity of sex hormones (testosterone), which is of great importance in men for calcium metabolism at a young age, and also prevents the development of osteoporosis at an older age. Therefore, a composition containing pantohematogen from the blood of a male deer (option 1) is intended primarily for men and:

- compensates for calcium deficiency;

- normalizes calcium metabolism;

- helps strengthen teeth and bone tissue;

- normalizes hormonal metabolism.

And the composition (option 3) is focused on actively growing children and adolescents in whom calcium deficiency is determined by rapid bone growth and increased muscle mass. This composition:

- compensates for the calcium deficiency of children and adolescents during the period of their intensive growth;

- normalizes calcium metabolism;

- helps strengthen teeth and bone tissue;

- normalizes hormonal metabolism.

Increased calcium loss is also observed with a decrease in the activity of sex hormones, which are indirectly involved in bone formation processes. Pantohematogen from the blood of a female maral contributes to the normalization of hormonal function in women, and also has a specific ability to improve calcium metabolism.

In addition, pantohematogen from the blood of a maral female enhances the activity of osteoblasts (cells - “builders” of the bone), and also positively affects the pituitary-adrenal system. Stabilization of its activity helps to reduce the level of cortisol in blood plasma and eliminate the influence of this pathogenesis factor of osteoporosis [5].

Therefore, the main consumer of the composition containing pantohematogen from the blood of a female maral (option 2) are women over the age of 40 years. This composition:

- compensates for calcium deficiency;

- normalizes calcium metabolism;

- Regulates the hormonal background in women.

Thus, extracts of St. John's wort, Kuril tea, fruits of red mountain ash, rosehip, blackcurrant and pantohematogen are well combined with calcium, phosphorus, magnesium, ascorbic acid, vitamins D ₃ , B ₂ , B ₆ , complementing each other and enhancing the positive effect of the composition as a whole .

The effectiveness of the composition is due to the fact that, in addition to purely substrate delivery of calcium to the body, it provides all the conditions for its successful assimilation.

The claimed composition takes into account the interplay between calcium, phosphorus, magnesium, as well as vitamins C, D, B ₂ , B ₆ , which are directly known in science and practice, which directly affect the digestibility (availability) of calcium.

The simultaneous administration of these ingredients together with additives of plant and animal origin ensures the active absorption of calcium in the intestine and its incorporation from internal fluid media into bone structures, i.e. compensates for calcium deficiency and normalizes calcium metabolism in the body.

The inventive composition is optimized by the quantitative indicators of additives of plant and animal origin.

An increase in the total amount of additives in excess of the declared is impractical, since, on the one hand, in terms of the total number of biologically active substances, the composition will approach drugs in action, and, on the other hand, the processes of drazhirovany, tabletting or encapsulation are difficult because additives are formulated in the form of natural finely divided components. The decrease in the number of additives below the stated is also impractical, because actually negate their positive effect on the composition as a whole.

Thus, the components included in the composition of the claimed composition and their quantitative ratio make it possible to provide the body with easily digestible calcium and normalize calcium metabolism, i.e. solve the problem.

In more detail, the proposed technical solution is described using an example of a specific implementation, not limiting the invention.

Example 1 Composition (option 1) as an example of a dragee. Loading rates per 100 kg: 1. Ascorbic acid 1.33 kg 2. Vitamin B ₂ 0.02 kg 3. Vitamin B ₆ 0.02 kg 4. Vitamin D ₃ 0.000033 kg 5. Magnesium lactate (source of magnesium) 1.2 kg 6. Pantohematogen from the blood of a male deer 0.6 kg 7. Trimagnesium phosphate (source of phosphorus and magnesium) 11.2 kg 8. Calcium citrate (source of calcium) 26.7 kg 9. Kuril tea extract 0.1 kg 10. Rowan fruit extract 0.04 kg 11. Hypericum extract 0.1 kg 12. Cocoa Powder 4.2 kg 13. Sugar cases 13.3 kg 14. Sugar and syrup 9.2 kg 15. Powdered sugar up to 100 kg

The preparation of the composition in the form of dragees is carried out according to known technology using standard excipients. In this example, it can be: powdered sugar, sugar syrup, cocoa powder.

Sugar casings are loaded into the pan. Then, when the boiler is rotated, sugar-syrup syrup is introduced and rotated until the entire surface of the shells is completely wetted. Then add 1/3 of calcium citrate in a mixture with powdered sugar and roll away for 12-15 minutes. All citrate is added in 3 divided doses. Then, in stages, through irrigation with syrup, vitamins, pantohematogen, ascorbic acid, plant extracts, trimagnesium phosphate, magnesium lactate mixed with powdered sugar are added. Each layer rolls for 12-15 minutes. For the last three layers take a mixture of powdered sugar with cocoa powder. Processing is carried out until a dragee of a given size is obtained. The finished semi-finished product is unloaded into trays and stand in the workshop for at least 12 hours.

After curing, the semi-finished product is glossy, i.e. coated with gloss to give the surface dragee shine and increase its durability during storage. Panning boilers are used for glossing. As a gloss, a wax-fat mixture is used. Ready dragees are packed and packaged in accordance with the requirements of regulatory documents.

Example 2 Composition (option 2) on the example of a tablet. Loading rates per 100 kg of finished products. 1. Ascorbic acid 1.33 kg 2. Vitamin B ₂ 0.02 kg 3. Vitamin B ₆ 0.02 kg 4. Vitamin D ₃ 0.000033 kg 5. Magnesium lactate (source of magnesium) 1.2 kg 6. Pantohematogen from the blood of a female deer 0.6 kg 7. Trimagnesium phosphate (source of phosphorus and magnesium) 11.2 kg 8. Calcium citrate (source of calcium) 26.7 kg 9. Hypericum extract 0.1 kg 10.Kuril tea extract 0.1 kg 11. Red rowan fruit extract 0.04 kg 12. Cocoa Powder 4.0 kg 13. Maltose 0.4 kg 14. Calcium stearate 0.5 kg 15. Talc 1,5 kg 16. Fructose 3.0 kg 17. Milk powder substitute up to 100 kg

The preparation of the composition in the form of tablets is carried out according to known technology using standard excipients. In this example, it can be: milk powder substitute, fructose, talc, calcium stearate, maltose and cocoa powder.

Ingredients are loaded into the mixer, sifted through a sieve with a hole diameter of 1.0 mm. The mass is stirred for at least 30 minutes. Next, the resulting material is poured into special containers and sent for tabletting. Tableting is carried out on tablet presses.

Example 3 Composition (option 3) on the example of capsules. Loading rate per 100 kg 1. Ascorbic acid 0.8 kg 2. Vitamin B ₂ 0.02 kg 3. Vitamin B ₆ 0.02 kg 4. Vitamin D ₃ 0.000033 kg 5. Magnesium lactate (source of magnesium) 0.8 kg 6. Pantohematogen from the blood of a male deer 0.2 kg 7. Trimagnesium phosphate (source of phosphorus and magnesium) 7.0 kg 8. Calcium citrate (source of calcium) 16.7 kg 9. Red rowan fruit extract 0.032 kg 10. Blackcurrant fruit extract 0.032 kg 11. Rosehip Extract 0.1 kg 12. Fructose up to 100 kg

The preparation of the composition in the form of capsules is carried out according to known technology using standard excipients. In this example, it may be fructose.

The calculated amount of ingredients is loaded into a micromill and the mass is ground to a homogeneous bulk material, which is then Packed in hard gelatin capsules.

As can be seen from the examples, the preparation of the composition is carried out on known equipment, using known means, therefore, the technical solution has industrial applicability.

The effect obtained from the use of the invention consists in expanding the range of domestic biologically active food additives and functional products aimed at preventing calcium deficiency and normalizing calcium metabolism.

Information sources

1. Pilate T.A., Ivanov A.A. Biologically active food additives. - M.: Avvalon, 2002, p.221-223.

2. Spirichev VB Vitamins and minerals in the comprehensive prevention and treatment of osteoporosis // Nutrition issues. - 2003. - No. 1. - p. 34-43.

3. Spirichev VB, Belakovsky MS Phosphorus in the diet of modern man and the possible consequences of consumption unbalanced with calcium // Nutrition Issues. - 1989. - No. 1. - p. 4-9.

4. Spirichev VB et al. Food fortification with vitamins and minerals // Science and Technology. Siberian University Publishing House. - Novosibirsk. - 2004 .-- p.109-121.

5. Suslov N.I. and other products based on pantohematogen. Mechanisms of action and application features. - Novosibirsk: Siberian University Publishing House. - 2004 .-- 144 p.

6. Shikh E.A. The role of vitamin complexes in the prevention and treatment of diseases of internal organs. // Russian Medical Journal. - 2007. - Volume 15, No. 5.

7. Norms of physiological needs for nutrients and energy for various groups of the population of the USSR (approved by the Chief Sanitary Doctor of the USSR on May 28, 1991 No. 5786-91). - M .: M-in the health of the USSR, 1991. - 24 p.

8. Recommended levels of consumption of food and biologically active substances (approved by the Head of the Federal Service for Supervision of Consumer Rights Protection and Human Well-being, Chief State Sanitary Doctor July 2, 2004).

Claims (15)

1. Composition for the prevention of calcium deficiency and normalization of calcium metabolism, containing a source of calcium, a source of phosphorus, a source of magnesium, ascorbic acid, vitamin D ₃ , vitamin B ₂ , vitamin B ₆ , St. John's wort extract, red rowan fruit extract, Kuril tea extract, pantohematogen from the blood of a male deer and auxiliary substances in the following ratio of components, wt.%:
Source of calcium 10.0-40.0 Phosphorus source 5.0-20.0 Magnesium source 5.0-28.0 Vitamin C 0.5-2.0 Vitamin D ₃ 0.00002-0.00007 Vitamin B ₂ 0.01-0.03 Vitamin B ₆ 0.01-0.03 Hypericum Extract 0.05-0.15 Rowan fruit extract 0.03-0.05 Kuril Tea Extract 0.09-0.11 Pantohematogen from the blood of a male deer 0.2-1.5 Excipients rest 2. The composition according to claim 1, characterized in that as a source of calcium it contains mineral or organic salts of calcium. 3. The composition according to claim 1, characterized in that as a source of phosphorus it contains calcium or magnesium phosphates. 4. The composition according to claim 1, characterized in that as a source of magnesium it contains mineral or organic salts of magnesium. 5. The composition according to claim 1, characterized in that it is made in the form of tablets, or dragees, or capsules. 6. Composition for the prevention of calcium deficiency and normalization of calcium metabolism, containing a source of calcium, a source of phosphorus, a source of magnesium, ascorbic acid, vitamin D ₃ , vitamin B ₂ , vitamin B ₆ , St. John's wort extract, red rowan fruit extract, Kuril tea extract, pantohematogen from the blood of a female deer and auxiliary substances in the following ratio of components, wt.%:
Source of calcium 10.0-40.0 Phosphorus source 5.0-20.0 Magnesium source 5.0-28.0 Vitamin C 0.5-2.0 Vitamin D ₃ 0.00002-0.00007 Vitamin B ₂ 0.01-0.03 Vitamin B ₆ 0.01-0.03 Hypericum Extract 0.05-0.15 Rowan fruit extract 0.03-0.05 Kuril Tea Extract 0.09-0.11 Pantohematogen from the blood of a female maral 0.2-1.5 Excipients rest 7. The composition according to claim 6, characterized in that it contains mineral or organic calcium salts as a source of calcium. 8. The composition according to claim 6, characterized in that it contains calcium or magnesium phosphates as a source of phosphorus. 9. The composition according to claim 6, characterized in that as a source of magnesium it contains mineral or organic salts of magnesium. 10. The composition according to claim 6, characterized in that it is made in the form of tablets, or dragees, or capsules. 11. Composition for the prevention of calcium deficiency and normalization of calcium metabolism, containing a source of calcium, a source of phosphorus, a source of magnesium, ascorbic acid, vitamin D ₃ , vitamin B ₂ , vitamin B ₆ , rosehip extract, blackcurrant fruit extract, red rowan fruit extract pantogematogen from the blood of a male deer and auxiliary substances in the following ratio of components, wt.%:
Source of calcium 7.0-25.0 Phosphorus source 3,5-12,5 Magnesium source 3,5-17,5 Vitamin C 0.5-2.0 Vitamin D ₃ 0.00002-0.00007 Vitamin B ₂ 0.01-0.03 Vitamin B ₆ 0.01-0.03 Rosehip extract 0.09-0.11 Rowan fruit extract 0.03-0.05 Blackcurrant Fruit Extract 0.03-0.05 Pantohematogen from the blood of a male deer 0.1-1.0 Excipients rest 12. The composition according to claim 11, characterized in that it contains mineral or organic calcium salts as a source of calcium. 13. The composition according to claim 11, characterized in that it contains calcium or magnesium phosphates as a source of phosphorus. 14. The composition according to claim 11, characterized in that as a source of magnesium it contains mineral or organic salts of magnesium. 15. The composition according to claim 11, characterized in that it is made in the form of tablets, or dragees, or capsules.