RU2376037C1 - Disinfectant composition - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: invention relates to disinfection agents, specifically to disinfectant compositions based on halogenated 5,5-dimethylhydantoin, which are used for disinfecting objects (rooms, furniture, crockery, toys, sanitary equipment, objects used in caring for patients, etc) in centres of infection, as well as for protective purposes. The disinfectant composition contains the following in pts. wt: halogen substituted 5,5-dimethylhydantoin 100; anionic surfactant 4-8; non-ionic surfactant 4-10; corrosion inhibitor 14-26; inert additive 45-176; water 82-180. The composition can additionally contain 5,5-dimethylhydantoin in amount of 37-83 pts. wt per 100 pts. wt halogen substituted 5,5-dimethhylhydantoin and fragrance component. The composition is a homogeneous paste which does not form dust, does not flake with time and virtually does not lose the active halogen for a year under airtight storage conditions. Working aqueous solutions made from the paste have high disinfection activity: working concentration of the composition can range form 0.1 to 0.2% for killing bacteria and from 1 to 2.5% for killing highly dangerous infectious agents (tuberculosis, lues etc.).

EFFECT: effective, environmentally safe and stable disinfectant.

3 cl, 1 tbl, 6 ex

Description

The invention relates to disinfectants, in particular to disinfecting compositions based on halogenated 5,5-dimethylhydantoin, which are used to disinfect objects (premises, furnishings, dishes, toys, sanitary equipment, patient care items, etc.) in foci of infections as well as for preventive purposes.

In addition to high efficiency and stability during storage, disinfecting compositions are required to be free from dust, which is irritating to the mucous membranes of the eyes and upper respiratory tract.

To eliminate this drawback use the formation of disinfectants. Known disinfectant compositions based on halogenated 5,5-dimethylhydantoin obtained in the form of tablets, granules and other forms with sufficient strength (US 4427692, A01N 43/50, 1984; US 4621096, A01N 43/50, 1986). To accelerate the dissolution of such forms, special loosening additives are introduced into the composition. However, even the pressed forms of the compositions do not provide a complete absence of dusting, which means irritating effects on the respiratory organs, do not provide quick dissolution in water, and also do not eliminate the dusting problems in the production of press compositions.

Closest to the technical nature of the proposed disinfectant composition is a known disinfectant composition based on 1,3-dichloro-5,5-dimethylhydantoin (SU 552973, A61L 13/00, 1977), containing, wt.%:

1,3-dichloro-5,5-dimethylhydantoin 19-25; 5,5-dimethylhydantoin 10-18; corrosion inhibitor (sodium tripolyphosphate and / or anhydrous trisodium phosphate) 7-15; inert additive (sodium chloride and / or anhydrous sodium sulfate) 48-57; anionic surfactant - surfactant (alkylarylsulfonate) 2-5. The composition is prepared by mixing and grinding the components, for example, in a ball mill. The resulting composition does not spontaneously ignite when heated to 250 ° C. The composition is a fine powder with an active chlorine content of 13.7-18.0%. When stored for several years, it practically does not lose active chlorine. The composition has bactericidal and washing properties. The bactericidal composition is 5-10 times higher than that of the well-known disinfectant "chloramine B". The industry manufactures a sulfochlorantin powder disinfectant with a close composition, the properties of which have been comprehensively studied (Medical Journal, 1990, No. 2, pp. 108-111). The tool is used in the form of a 0.005-3% aqueous solution. Due to its high activity and a wide spectrum of antimicrobial activity, the drug is successfully used for disinfecting measures for massive intestinal and drip infections of bacterial and viral etiology, as well as for the prevention of nosocomial infections in medical institutions of various profiles.

Meeting most requirements for modern disinfectants, this tool, however, has a number of disadvantages. When preparing a working aqueous solution of a powder composition, dusting and the appearance of an irritating smell inevitably occur. A sufficiently long time for complete dissolution of the composition — 30-60 minutes — can be reduced to 5 minutes by preparing a composition with a greater dispersion (particle size less than 0.1 mm). However, the greater the dispersion of particles, the greater the tendency of the product to dust, which leads to the creation of irritating and dangerous concentrations of chlorine-containing products in the air. The prepared working solutions, when standing, lose active chlorine and at the same time become acidic and corrosive, as a result of which their long-term storage is impractical.

The problem to which the invention is directed, is to obtain an effective, environmentally friendly and stable disinfectant based on halogen-substituted 5,5-dimethylhydantoin.

To solve this problem, a disinfecting composition based on a halogen-substituted 5,5-dimethylhydantoin is proposed, containing an anionic surfactant, a corrosion inhibitor and an inert additive, characterized in that it additionally contains non-ionic surfactant and water in the following ratio, wt.h .:

halogen-substituted 5,5-dimethylhydantoin one hundred anionic surfactant 4-8 nonionic surfactant 4-10 corrosion inhibitor 14-26 inert additive 45-176 water 82-180

The disinfecting composition may further contain 5,5-dimethylhydantoin in an amount of 37-83 parts by weight per 100 parts by weight halogen-substituted 5.5-dimethylhydantoin, as well as perfume up to 0.5 wt.h.

The technical result that can be obtained using the proposed invention is the absence of delamination and loss of active halogen during storage of a disinfectant composition based on halogenated 5,5-dimethylhydantoin containing water.

Information on stable disinfectant compositions based on halogen-substituted 5,5-dimethylhydantoin containing water is not available.

The main active ingredient in the composition is halogen-substituted 5,5-dimethylhydantoin. The composition is obtained by mixing the basic substance with other components to a homogeneous state in a technical mixer or in a tank using a circulation pump-homogenizer. The components mixed with water are non-dusting homogeneous pastes that do not exfoliate over time and practically do not lose active halogen during the year under conditions of tight storage. The pastes have a very weak, non-irritating smell, with the addition of fragrances, the smell is practically not felt. In addition, for the preparation of pastes, it is possible to use components with natural humidity, while for the preparation of a powder composition, it is necessary to use only dry components.

For disinfecting purposes, an aqueous solution is prepared from a paste. The rate of dissolution of the paste is higher than that of powders, as the solids in the paste are smaller than 0.1 mm. When preparing working solutions, dusting is absent. Working aqueous solutions prepared from paste have a high disinfecting activity, as in the prototype: the working concentration of the composition can be 0.1-0.2% for killing bacteria and 1-2.5% for killing highly dangerous pathogens of infections (tuberculosis, plague, etc.).

To prepare the disinfectant composition, for example, 1,3-dichloro-5,5-dimethylhydantoin, 1-chloro-5,5-dimethylhydantoin, 1,3-dibromo-5,5-dimethylhydantoin are used as a halogen-substituted 5.5-dimethylhydantoin; as an anionic surfactant, for example, alkylaryl sulfonate (sulfonol), Na-salt of alkylpolyglycol sulfate (dysonyl FES 993-15), partially neutralized sulfated hydroxyalkylated alkylphenol (dysonyl FES-601S), sodium salts of C ₁₁ -C ₁₈ -alkyl sulfonic acids (alkyl sulfonates); as a nonionic surfactant, for example, ethoxylated alkyl phenols (neonol AF 9-12, emulsite 100), ethoxylated fatty alcohols (dysonyl AFX 3070); as a corrosion inhibitor, for example, sodium tripolyphosphate, trisodium phosphate; as an inert additive, for example, sodium chloride, sodium sulfate; as a perfume, any ether used in food and cosmetic products, for example, E 3212 Lemon Citric, ESS 3098 Fresh Florad Pine.

When the water content is less than 82 parts by weight a mixture of powdered components does not mix well with water, crumbles, warms up during mixing. With a water content of more than 180 parts by weight the finished composition exfoliates, the upper layer of water is separated.

When the content of nonionic surfactants is less than 4 parts by weight separation of the composition occurs, and the composition is less stable during storage. Exceeding the content of more than 10 parts by weight it is impractical, since it leads to a deterioration in the consumer (washing) properties of the working solutions - the solutions become cloudy, a film forms on the walls of the vessel.

The invention is illustrated by the following examples.

Example 1

The composition is prepared by mixing in the technical mixer the following components (parts by weight): 1,3-dichloro-5,5-dimethylhydantoin - 100, 5,5-dimethylhydantoin - 83, sulfonol - 6, neonol AF 9-12 - 10, tripolyphosphate sodium - 26, sodium chloride - 63, water - 180. Mixing is carried out until the mixture is completely homogenized. The finished disinfectant composition is a homogeneous white paste with a very weak, non-irritating chlorine odor. The content of active chlorine is 15.3 wt.%, PH is 6.

The time of complete dissolution of the paste is determined as follows: a portion of the composition of 2.5 g is placed in 100 ml of distilled water, vigorously shaken for 2 minutes, left in a stationary mode until completely dissolved and the total dissolution time, which for this composition is 5 minutes, is fixed. When dissolved, the paste does not dust.

To check the stability of the paste during storage, it is placed in an airtight container, the active chlorine content is determined after storage in airtight conditions for 30 days, six months and a year and the pH changes are monitored. During the entire shelf life, the paste does not separate, practically does not lose active chlorine, and the pH does not change. The test results are presented in table 1.

Examples 2-6

The compositions are prepared and tested analogously to example 1, the components and their ratios are shown in table 1. The complete dissolution of the resulting pastes is 5 minutes When dissolving pastes do not dust. During the entire shelf life, the pastes do not exfoliate, practically do not lose active halogen, and the pH practically does not change. The test results are presented in table 1.

Example 7 (for comparison)

The composition is prepared and tested analogously to example 1, only the paste is prepared without the addition of a nonionic surfactant. The components and their ratios are shown in table 1. The resulting paste has a tangible chlorine smell, the content of active chlorine is 15.0 wt.%, PH is 6. After storing the paste for 30 days, a significant decrease in the content of active chlorine, a decrease in pH, and bloating are already observed. packaging and exfoliation of pasta. After storage during the year, the content of active chlorine is only 10.5 wt.%, The pH drops to 2, and the paste has an unpleasant odor. The test results are presented in table 1.

To confirm the high disinfecting activity of the proposed composition, working aqueous solutions are prepared from the compositions according to examples 1 and 4 according to the invention and for comparison from the composition according to the prototype, with an active chlorine content in the solution of 0.015; 0.03 and 0.15 wt.%, As well as from the composition according to example 5 according to the invention with the content of active bromine in a solution of 0.034; 0.068 and 0.34 wt.%. The preparation of aqueous solutions from the composition according to example 5 is carried out taking into account that the content of active bromine of 36.8 wt.% Corresponds to the content of active chlorine of 16.3 wt.%. Then, the resulting solutions treat surfaces infected with pathogens of various infections for 60 minutes and determine the effective concentration of the solutions, which ensures complete disinfection of the surfaces. Table 2 shows the concentration of the obtained working aqueous solutions of disinfectant compositions and the results of verification of their disinfectant activity.

table 2 Example No. The concentration of working aqueous solutions, wt.% Concentrations ensuring complete eradication of infections by composition active halogen bacterial etiology infections viral infections tuberculosis candidiasis one 0.1 0.015 + 0.2 0,030 + + 1,0 0.150 + four 0.09 0.015 + 0.18 0,030 + + 0.90 0.150 + 5 0.09 0,034 + 0.18 0,068 + + 0.90 0.340 + According to the prototype 0.1 0.015 + 0.2 0,030 + + 1,0 0.150 +

Claims (3)

1. A disinfectant composition based on halogen-substituted 5,5-dimethylhydantoin containing an anionic surfactant, a corrosion inhibitor and an inert additive, characterized in that it additionally contains a non-ionic surfactant and water in the following ratio, wt.h .:
halogen-substituted 5,5-dimethylhydantoin one hundred anionic surfactant 4-8 nonionic surfactant 4-10 corrosion inhibitor 14-26 inert additive 45-176 water 82-180 2. The disinfecting composition according to claim 1, characterized in that it additionally contains 5.5-dimethylhydantoin in an amount of 37-83 parts by weight per 100 parts by weight halogen-substituted 5.5-dimethylhydantoin. 3. The disinfecting composition according to claim 1 or 2, characterized in that it further comprises a perfume.