RU2466743C1 - Disinfectant - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: disinfectant containing a chlorinated derivative of isocyanuric acid and a gas-yielding mixture comprises a polymer ingredient specified in a group consisting of polyvinyl alcohol, polyacrylic acid and its copolymers, polyvinylpyrrolidone, water-soluble cellulose esters and their mixture in the following proportions, wt %: chlorinated derivative of isocyanuric acid 20-90, polymer ingredient 0.1-5, gas-yielding mixture - the rest. The gas-yielding mixture represents a mixture of base and acid ingredients. The base ingredient of the disinfectant contains alkaline or alkaline-earth salts of carbonic acid or their mixture. As the acid ingredient, the disinfectant contains organic acids, may contain anticorrosion additives, e.g. sodium benzoate, sodium nitrite, calcium formate, zinc compounds. The disinfectant may contain a builder that is a non-ionic surfactant on the basis of oxyethylated derivatives of alcohols, phenols or organic acids, complexons - salts of ethylenediaminotetraacetic acid, a neutral excipient, e.g. sodium phosphate, sodium sulphate, sodium tartrate, sodium acetate.

EFFECT: invention provides preparing the ready storage-stable disinfection solutions containing active chlorine.

6 cl, 15 ex

Description

The invention relates to the field of sanitation and hygiene, and in particular to means for disinfecting water, premises, any equipment, and can find application in various industries.

Disinfectants based on dichloroisocyanuric acid salts are sources of active chlorine and are widely used for disinfection (Guidelines for the use of potassium and sodium salts of dichloroisocyanuric acid for disinfection. Approved by the Ministry of Health of the USSR of 23.06.1977 n 1754-77). Working solutions of the product in water remain active for 3 days.

Non-proprietary preparations are produced in the form of a mixture of the sodium salt of dichloroisocyanuric acid with fillers (gas-releasing composition) consisting of a basic or acidic component, especially in a mixture with sodium bicarbonate and adipic acid, which ensure rapid dissolution of the tablet in water (self-mixing effervescent tablets). In particular, such effervescent tablets are manufactured under the trademarks of Sanivap (firms Nautimex Industry, Sweden), Javel-Clade (firms Clade, France), Aquatabs (Medentech Ltd., Ireland) , “ХТХ Жавель” (Arch Water Products, France) and others (Disinfectants. Part 1. Disinfectants. Reference / Edited by A. Monisov, M. G. Shandaly Publishing House "Rarog" LLP, Moscow, 1996. Handbook “Disinfectants 2010”. BINGO GRAND Publishing House, Moscow, 2010).

A disinfectant is also known (RF Patent 2243765, published January 10, 2005). The agent is based on a chlorine derivative of isocyanuric acid, and also contains a basic or acid component or a mixture thereof in certain ratios of components. As the main component, the product contains alkaline or alkaline earth salts of carbonic acid or a mixture thereof. As an acid component, the product contains alkali metal phosphates, or sodium bisulfite, or organic acids: citric, tartaric, fumaric, maleic, adipic, malic, sulfamic, oxalic or alkaline salts thereof, or a mixture thereof. The product contains a neutral filler — sodium sulfate, a detergent component — sodium lauryl sulfate or sulfonal, a binder — sodium benzoate, or alkaline earth metal stearate, or talc. Working solutions of the product in water remain active for 3 days.

HTX Javelin disinfectant (INSTRUCTIONS No. 1/06 and 2/06 on the use of XTH Javelin disinfectant (“hth JAVEL”) by Arch Water Products, France (“ARCH WATER PRODUCTS”, France) was taken as a prototype State Registration Certificate 77.99.36.2. U8049.8.06 dated 08/07/2006 issued by the Federal Service for Supervision of Consumer Rights Protection and Human Well-being).

The disinfectant in the form of tablets "ХТХ Javel" contains sodium dichloroisocyanuric acid (75%), sodium bicarbonate (12.5%) and adipic acid (12.5%) as the active substance. The working solution of the product in water remains active for 3 days.

The disadvantages of this tool are the lack of stability of its finished aqueous solutions during storage and the pronounced local irritating effect of the dry composition on the skin and mucous membranes.

The objective of the invention is to provide a chemically stable, effective disinfectant with improved consumer properties, low toxicological hazard, increased stability of prepared aqueous solutions, as well as reduced dust formation in the production of the composition.

The technical result of the invention is to obtain instant, self-mixing when dissolved in water mixtures with a given content of active chlorine, a neutral pH obtained from these formulations of aqueous solutions and their storage stability up to 20 days. An additional effect is a significant reduction in the local irritant effect on the skin and mucous membranes of a dry composition due to the enveloping effect of the polymer.

The essence of the proposed technical solution lies in the fact that the means for disinfection, including the chlorine derivative of isocyanuric acid and a gas-generating mixture, according to the invention further comprises a polymer component selected from the group comprising polyvinyl alcohol, polyacrylic acid or its copolymers, polyvinylpyrrolidone, water-soluble cellulose ethers or a mixture thereof in the following ratio of components, wt.%:

Isocyanuric Acid Chloride 20-90 Polymer component 0.1-5 Gas evolving mixture rest

The introduction of a chlorine derivative of isocyanuric acid into a disinfectant allows you to get a disinfectant with a high degree of exposure to microorganisms.

An additional introduction to the disinfectant of the polymer component can significantly increase the stability of the finished working aqueous solutions, as well as significantly reduce the local irritant effect on the skin and mucous membranes of the dry formulation.

As a gas-evolving mixture, the agent contains a mixture, for example, an equimolar or approximate ratio of the main component in the form of an alkaline salt of carbonic acid and an acid component in the form of an organic acid selected from the group consisting of adipic, tartaric, citric, fumaric, maleic, malic, succinic acid or a mixture of the listed acids. With this ratio of the main and acid components, a neutral pH of the gas-evolving mixture is ensured when it is dissolved. Due to the self-mixing effect, the gas-evolving mixture accelerates the dissolution of the product.

Additionally, the tool may contain anti-corrosion additives, for example, sodium benzoate, sodium nitrite, calcium formate, zinc compounds or mixtures thereof, wt.%: 0.1-5. The additional introduction of anti-corrosion additives allows the processing of a wide range of metal products.

Additionally, the tool may contain a nonionic surfactant based on ethoxylated derivatives of alcohols (syntanols), phenols (neonols) or organic acids (for example, twins), or mixtures thereof, wt.%: 0.5-10. The additional introduction of nonionic surfactants facilitates the dissolution of the product and imparts detergent properties to ready-made solutions, facilitates wettability and improves the disinfection of contaminated surfaces.

Additionally, the tool may contain complexones, for example, salts of ethylenediaminetetraacetic acid, polyphosphates. The additional introduction of complexones reduces the hardness of the water used, which in turn allows the use of water of any hardness for the preparation of solutions, wt.%: 0.1-5.

Additionally, the tool may contain a neutral filler based on salts of both inorganic and organic acids, for example sodium phosphate, sodium sulfate, sodium tartrate, sodium acetate and others, wt.%: 1-50%. The additional introduction of a neutral filler allows you to adjust the concentration of active components in a wide range.

The invention meets the criterion of "novelty", as in the well-known scientific, technical and patent literature there is no complete set of features characterizing the invention. There are no data in the literature on the effect of the proposed polymer component on increasing the stability of ready-made solutions based on isocyanuric acid chloro derivatives. Such a property was discovered for the first time and it does not follow explicitly from the prior art for a specialist, which meets the criterion of "inventive step", the invention is industrially applicable, so it can be used to disinfect water, rooms and any equipment.

One way to obtain a disinfectant is to mix the calculated components in wt.% And then mix them to obtain a homogeneous mass. The mixture can be used in powder form or for convenience in the form of granules, tablets, capsules, etc. When dissolved in water for 1-5 minutes, the solid components dissolve completely without sediment. It turns out a clear solution that does not require filtration. Neutral pH (6.0-7.0) of prepared aqueous solutions and low volatility of the components do not require additional protection of the respiratory system and skin of the hands. Prepared working solutions can be used within 5-20 days. The required dose of the drug may vary depending on the type and degree of contamination of the object.

The stability of the finished aqueous solutions is determined by the content of active chlorine. For disinfection purposes, solutions with an active chlorine content of 0.005-1% are used depending on specific objects (Guidelines for the use of potassium and sodium salts of dichloroisocyanuric acid for disinfection purposes. Approved by the Ministry of Health of the USSR of 23.06.1977 n 1754-77).

The invention is illustrated by examples of the obtained disinfectants with different contents of the components.

Example 1. Received a disinfectant containing 5.25 g of sodium dichloroisocyanuric acid (75%), 0.007 g of polyvinyl alcohol (0.1%), 0.90 g of sodium bicarbonate (12.9%) and 0.84 g adipic acid (12%). A sample of 3.5 g of the obtained product is dissolved in 1.5 l of water, the content of active chlorine is 0.1%. The stability of the finished working solution is 7 days.

Example 2. Similarly obtained a disinfectant containing 5.25 g of sodium salt of dichloroisocyanuric acid (75%), 0.35 g of polyvinyl alcohol (5%), 0.74 g of sodium bicarbonate (10.5%) and 0.67 g adipic acid (9.5%). A sample of 3.5 g of the obtained product is dissolved in 1.5 l of water, the content of active chlorine is 0.1%. The stability of the finished working solution is 15 days.

Example 3. Received a disinfectant containing 5.25 g of sodium dichloroisocyanuric acid (75%), 0.007 g of polyacrylic acid (0.1%), 0.90 g of sodium bicarbonate (12.9%) and 0.84 g of adipic acid (12%). A sample of 3.5 g of the obtained product is dissolved in 1.5 l of water, the content of active chlorine is 0.1%. The stability of the finished working solution is 9 days.

Example 4. Similarly obtained a disinfectant containing 5.25 g of sodium dichloroisocyanuric acid (75%), 0.35 g of polyacrylic acid (5%), 0.74 g of sodium bicarbonate (10.5%) and 0.67 g adipic acid (9.5%). A sample of 3.5 g of the obtained product is dissolved in 1.5 l of water, the content of active chlorine is 0.1%. The stability of the finished working solution is 20 days.

Example 5. Similarly, a disinfectant was prepared containing 5.25 g of sodium dichloroisocyanuric acid (75%), 0.35 g of polyvinylpyrrolidone (5%), 0.74 g of sodium bicarbonate (10.5%) and 0.67 g adipic acid (9.5%). Sample 3.5 g of the obtained product. dissolved in 1.5 l of water, the content of active chlorine is 0.1%. The stability of the finished working solution is 14 days.

Example 6. Similarly obtained a disinfectant containing 5.25 g of sodium dichloroisocyanuric acid (75%), 0.35 g of carboxymethyl cellulose (5%), 0.74 g of sodium bicarbonate (10.5%) and 0.67 g adipic acid (9.5%). A sample of 3.5 g of the obtained product is dissolved in 1.5 l of water, the content of active chlorine is 0.1%. The stability of the finished working solution is 10 days.

Example 7. Analogously to example 1, a disinfectant was prepared containing 6.3 g of dichloroisocyanuric acid sodium salt (90%), 0.007 g pemulene (acrylic acid copolymer) (0.1%), 0.35 g potash (5%), 0.34 g of tartaric acid (4.9%). A sample of 4.0 g of the obtained product is dissolved in 200 ml of water, the content of active chlorine is 1%. The stability of the finished working solution is 14 days.

Example 8. Similarly, a disinfectant was prepared containing 6.3 g of sodium dichloroisocyanuric acid (90%), 0.35 g of polyvinyl alcohol (5%), 0.21 g of sodium bicarbonate (3%) and 0.14 g of lemon acid (2%). A sample of 4.0 g of the obtained product is dissolved in 200 ml of water, the content of active chlorine is 1%. The stability of the finished working solution is 12 days.

Example 9. Similarly, a disinfectant was prepared containing 1.4 g of dichloroisocyanuric acid sodium salt (20%), 0.007 g of polyvinylpyrrolidone (0.1%), 0.28 g of sodium bicarbonate (40%) and 2.79 g of fumaric acid (39.9%). A sample of 4.46 g of the obtained product is dissolved in 10 l of water, the content of active chlorine is 0.005%. The stability of the finished working solution is 10 days.

Example 10. Similarly obtained a disinfectant containing 1.4 g of sodium dichloroisocyanuric acid (20%), 0.35 g of carboxymethyl cellulose (5%), 2.59 g of sodium bicarbonate (37%) and 2.66 g of maleic acid (38%). A sample of 4.46 g of the obtained product is dissolved in 10 l of water, the content of active chlorine is 0.005%. The stability of the finished working solution is 7 days.

Example 11. Similarly, a disinfectant was prepared containing 6.3 g of sodium dichloroisocyanuric acid (90%), 0.007 g of polyacrylic acid (0.1%), 0.007 g of sodium nitrite (0.1%), 0.035 g of ALM syntanol ( nonionic surfactant) (0.5%), 0.007 g of disodium salt of ethylenediaminetetraacetic acid (0.1%), 0.07 g of sodium sulfate (1%), 0.29 g of sodium bicarbonate (4.2%) and 0.28 g malic acid (4%). A sample of 4.0 g of the obtained product is dissolved in 2 l of water, the content of active chlorine is 0.1%. The stability of the finished working solution is 10 days.

Example 12. Similarly obtained a disinfectant containing 1.40 g of sodium dichloroisocyanuric acid (20%), 0.35 g of polyvinyl alcohol (5%), 0.35 g of sodium benzoate (5%), 0.7 g of tween -20 (nonionic surfactant) (10%), 0.35 g of sodium polyphosphate (5%), 3.5 g of sodium phosphate (50%), 0.21 g of sodium bicarbonate (3%), 0.14 g of succinic acid (2 %). A sample of 4.46 g of the obtained product is dissolved in 10 l of water, the content of active chlorine is 0.005%. The stability of the finished working solution is 7 days.

Example 13. Similarly, a disinfectant was prepared containing 5.25 g of dichloroisocyanuric acid sodium salt (75%), 0.35 g of polyvinylpyrrolidone (5%), 0.35 g of calcium formate (5%), 0.035 g of OP-10 ( neonol, nonionic surfactant) (0.5%), 0.007 g of disodium salt of ethylenediaminetetraacetic acid (0.1%), 0.07 g of sodium acetate (1%), 0.49 g of sodium bicarbonate (7%), 0.45 g malic acid (6.4%). A sample of 3.5 g of the obtained product is dissolved in 1.5 l of water, the content of active chlorine is 0.1%. The stability of the finished working solution is 10 days.

Example 14. Similarly, a disinfectant was prepared containing 1.4 g of dichloroisocyanuric acid sodium salt (20%), 0.007 g of carboxymethyl cellulose (0.1%), 0.35 g of zinc acetate (5%), 0.7 g of tween 80 (nonionic surfactant) (10%), 0.35 g of sodium polyphosphate (5%), 0.07 g of sodium tartrate (1%), 2.09 g of sodium bicarbonate (29.9%), 0.35 g of fumaric acid ( 29%). A sample of 4.46 g of the obtained product is dissolved in 10 l of water, the content of active chlorine is 0.005%. The stability of the finished working solution is 7 days.

Example 15. A comparative example that does not contain a polymer component. A disinfectant was obtained containing 5.25 g of dichloroisocyanuric acid sodium salt (75%), 0.91 g of sodium bicarbonate (13%) and 0.84 g of adipic acid (12%). A sample of 3.5 g of the obtained product is dissolved in 1.5 l of water, the content of active chlorine is 0.1%. The stability of the finished working solution is 3 days.

As can be seen from the above examples, the introduction of the polymer component into the composition made it possible to significantly increase the stability of the finished working solutions from 5 to 20 days, depending on the type and amount of the introduced polymer component.

Claims (6)

1. A means for disinfection, including a chlorine derivative of isocyanuric acid and a gas-evolving mixture, characterized in that it further comprises a polymer component selected from the group consisting of polyvinyl alcohol, polyacrylic acid or its copolymers, polyvinylpyrrolidone, water-soluble cellulose ethers or a mixture thereof in the following ratio of components , wt.%:
Isocyanuric Acid Chloride 20-90 Polymer component 0.1-5 Gas evolving mixture Rest 2. The disinfectant according to claim 1, characterized in that as a gas-emitting mixture it contains a mixture of the main component in the form of an alkaline salt of carbonic acid and an acid component in the form of an organic acid selected from the group consisting of adipic, citric, fumaric, maleic, malic, tartaric acid or a mixture of the listed acids. 3. The disinfectant according to claim 1, characterized in that it further comprises an anticorrosion component selected from the group consisting of sodium benzoate, sodium nitrite, calcium formate, zinc compounds, wt.%: 0.1-5. 4. The disinfectant according to claim 1, characterized in that it further comprises a wetting component in the form of a nonionic surfactant based on ethoxylated derivatives of alcohols, phenols or organic acids, wt.%: 0.5-10. 5. The disinfectant according to claim 1, characterized in that it further comprises complexones in the form of a salt of ethylenediaminetetraacetic acid or polyphosphates, wt.%: 0.1-5. 6. The disinfectant according to claim 1, characterized in that it further comprises a neutral filler selected from the group consisting of sodium phosphate, sodium sulfate, sodium tartrate, sodium acetate, wt.%: 1-50%.