RU2373930C1 - Method for blood microvesicle correction in arterial hypertension and pancreatic diabetes type ii - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology, cardiology and endocrinology and concerns correction of blood microvesicle level in arterial hypertension (AH) and pancreatic diabetes type II (PD II). That is ensured by integrated therapy involving graduated physical exercises, as well as introduction of lisinopril in a dose 10 mg once in the morning, amlodipine in a dose 5 mg once in the morning and pioglitazone in a dose 30 mg once in the morning for therapeutic course at least 7 weeks.

EFFECT: complex of specific medical preparations and physical exercises combined with empirically specified duration of treatment provides effective correction of blood microvesicle level and, thereby, reduced risk of thrombotic complications in given group of patients.

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Description

The invention relates to medicine, namely to hematology, cardiology and endocrinology.

Analogues of the proposed method for correcting the level of microvesicles in the blood for arterial hypertension (AH) and type II diabetes mellitus (type II diabetes) do not exist.

It is known that an important feature of the cytoplasmic membrane is the asymmetry of the phospholipid and protein composition of two sheets of the bilayer, which occurs under the action of intracellular enzymes, differences in the ionic composition of the cytoplasm and extracellular fluid. The asymmetry of the bilayer determines the atrombogenicity and hemocoagulation properties of blood cells and the endothelium of blood vessels and, in addition, is involved in creating a gradient of curvature, folds, wrinkling, and in laminating portions of the membrane in the form of microvesicles.

Fragments of cell membranes formed during exocytosis, necrosis and apoptosis are able to close and form vesicles with a diameter of 0.05 to 3.0 microns. The size of the microvesicles depends on the nature of the agent acting on the target cell. Microvesicles are of platelet and non-platelet origin. They form on the cell surface, desquamating from the cytoplasmic membrane. Therefore, they contain various membrane glycoproteins, cytoskeletal proteins, microfilaments, myosin chains, etc.

Microvesicles not only represent the catalytic surface for internal “tenase” (a supramolecular complex consisting of factor IXa, factor VIIIa and phospholipids) and the prothrombinase complex, but they are also able to influence the proteolytic inactivation of factors Va and VIIIa by activated protein C in combination with protein S. Therefore, a decrease in the level of microvesicles in the blood leads to a decrease in the blood coagulation potential of platelet-free blood plasma.

In hypertension and type II diabetes, there is an increase in the level of microvesicles in the blood, causing an increase in plasma coagulation capabilities. At the same time, approaches to lowering the level of microvesicles in the blood in hypertension and type II diabetes remain very poorly developed. In patients with hypertension and type II diabetes, ACE inhibitors and calcium antagonists are used to lower blood pressure (BC Zadionchenko et al. “Arterial hypertension in the metabolic syndrome: pathogenesis, basics of therapy.” Consilium medicum 2004, v.6, no. 9, http : //www.voed.ru/art.gip.metab.sindr.htm). For correction of type II diabetes, pioglitazone and physical activity can be used.

However, never before has a treatment complex consisting of dosed physical activity, lisinopril, amlodipine and pioglitazone been used in patients with hypertension and type II diabetes to lower their microvesicle level.

The aim of the invention is to lower the level of blood microvesicles in patients with hypertension and type II diabetes.

The essence of the proposed method is that to correct the level of blood microvesicles in patients with hypertension and type II diabetes for at least 7 weeks, lisinopril 10 mg 1 time in the morning, amlodipine 5 mg 1 time in the morning and pioglitazone 30 mg 1 time in the morning against the background of dosed physical loads.

The method allows you to adjust the level of blood microvesicles in patients with hypertension and type II diabetes for at least 7 weeks, translating it to a level close to that for healthy people. If you follow the recommendations of the proposed method, it is possible to maintain the level of microvesicles at an optimal level, which will significantly reduce the risk of thrombotic complications, reduce the number of cases of temporary disability, speed up inpatient treatment and improve its quality, reduce disability, and also extend the life and reduce mortality of patients with hypertension and type II diabetes from heart attack and stroke.

The inventive method is as follows.

The level of blood microvesicles is determined by the activity of 5-nucleotidase in blood serum (L.D. Zubairova, D.M. Zubairov, I.A. Andrushko et al. Cellular microvesicles in the dynamics of experimental endotoxinemia. // Bulletin of experimental biology and medicine: monthly international scientific and theoretical journal / RAMS. - 2006. - Volume 142, No. 11. - S.517-520). Normally, its level is 63.8 ± 2.5 nkat. With an increase in the level of blood microvesicles, patients with hypertension and type II diabetes should be treated with lisinopril 10 mg 1 time in the morning, amlodipine 5 mg 1 time in the morning and pioglitazone 30 mg 1 time in the morning against a background of dosed physical activity. One possible example of the latter is given below.

Physical exercises in real life conditions are carried out in three forms: 1) morning hygienic gymnastics (exercise); 2) therapeutic and preventive gymnastics; 3) fractional physical exercises throughout the day.

1. Morning hygienic gymnastics (exercise).

Morning exercises should be done after sleep before breakfast in a ventilated room. Under the influence of classes, the body is freed from the state of inhibition of physiological processes that occurs during sleep.

The sequence of exercises involves alternating the load on various muscle groups (arms, legs, body). Exercises are performed with a gradually increasing excursion of breathing, stretching, limited use of force conditions. The breathing during exercises should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhalation (inhalation 2-3 s, exhalation 3-5 s).

With good health, the load can be increased by the number of repetitions, acceleration of the pace, an increase in the amplitude of movements and a reduction in pauses between exercises.

With fatigue, you should reduce the load, increase the duration of pauses between exercises, fill them with calm breathing.

After gymnastics, you need to go to a wipe or take a shower.

Morning exercises should cause a sense of vitality, increased activity, better health and performance.

If you feel unwell, develop shortness of breath or pain in the heart and behind the sternum, you should temporarily interrupt classes and consult a doctor.

During the day, patients are recommended therapeutic and prophylactic gymnastics. Depending on the initial training, it is possible to use a lightened version of physical activity at the beginning, and in the subsequent - a strengthened version.

2. Complexes of therapeutic and preventive gymnastics.

2.1. A lightweight version of therapeutic gymnastics.

Exercise 1. Standing. Walking is calm with a gradual acceleration and deceleration of 1-2 minutes. When performing the exercise, a gradual deepening of breathing.

Exercise 2. Circular movements in the shoulder joints. When breeding - inhale, while mixing - exhale with a slight tilt of the body and retraction of the abdominal wall - 6-8 times. Fingers touch shoulders, elbows pressed to the body.

Exercise 3. Standing, hands on the belt. Alternately transferring the severity of the body from one leg to the other with slight bending of the legs in the knee joint, without taking the feet off the floor. Do the exercise 10-16 times with muscle tension in the legs.

Exercise 4. Standing, legs spaced shoulder width apart, hands on the belt. Torso forward, touch left sock with your right hand. 4-6 times alternately. When the position is straightened, inhale; when tilted, exhale. Looking forward.

Exercise 5. Standing, arms along the torso. At the same time, take straight arms and one leg to the sides with alternating leg abductions. 4-6 times in each direction alternately. A wave of arms and legs, breathing free, do not hold.

Exercise 6. Standing, legs to the sides, hands in front of the chest, palms down. With the turn of the body, spread your arms to the sides with the turn of the palms up - inhale. Return to the starting position with a slight tilt of the body forward - exhale. 3-5 times in each direction alternately. Coordinate breathing with the movement of the body and hands. By the end of the exhalation, retract the wall of the abdomen.

Exercise 7. Standing, hands free. Walking freely - 1 min, then with high flexion of the hips - 10-20 movements, followed by a transition to a quiet walk - 1-2 minutes. Rhythmic breathing, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. Bending back and bending forward of the body. Repeat 6-10 times. Do not hold your breath.

Exercise 9. Sitting on the edge of the chair, focus with tassels on the edge of the chair, and with your feet somewhat in front of the chair. Squats with an emphasis on the edge of the chair - 4-6 times. When squatting, exhale.

Exercise 10. Standing sideways to the back of the chair, hold on to it with one hand. Swing your free straight arm with your legs back. Return to starting position. Repeat 4-6 times with each hand and foot. Do not hold your breath.

Exercise 11. Standing, legs apart, arms at the waist. Turns the body to the right and left - 6-10 times alternately. Do not turn your head, look forward.

Exercise 12. Standing, legs together, arms down. To spread your arms to the sides - inhale, bend your leg at the knee and press your hands to your stomach - exhale. 3-5 times each leg in turn. Strive to maintain balance; as you exhale, draw in your stomach.

Exercise 13. Standing, legs together, arms down. Lateral tilts of the body with bending of the opposite arm (“pump”). Do not hold your breath, strive for a greater excursion of movement.

Exercise 14. Standing. Walking is calm with uniform breathing of medium depth. 1-2 minutes

Exercise 15. Lying on a rug with a pillow placed under the head. Go to the half-sitting position and hug the bent hips - exhale, return to the starting position - inhale. Do not hold your breath. Strive in a half-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying, arms to the sides, legs apart. Semicircular movements with the right straight leg to the left with the turn of the pelvis - exhale - return to the starting position - inhale. 3-5 times in each direction. Alternately left and right with the greatest possible excursion of the leg movement, while maintaining the emphasis of the hands on the floor.

Exercise 17. Sitting on the floor; a) get on all fours; b) move to a kneeling position; c) raise your hands up - inhale, tilt the body, and take your hands back - exhale. When tilting, belly retract. Repeat 4-6 times; e) move to a standing position, and then to a prone position; e) self-massage of the abdomen with small semicircular movements in a clockwise direction -1-2 min. Rest 2 min; g) calm breathing; h) exercise in protruding (calm) and retracting (active) the abdominal wall. Combine abdominal retraction with expiration through the mouth. Repeat 4-6 times.

Exercise 18. Standing, arms bent. Vigorous walking on the spot or in a room with high flexion of the hips and waved arms - 20-30 steps. Do not hold your breath.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of the chair. Circular movements of the pelvis with retraction of the abdomen when the pelvis is brought back. 4-6 times in each direction.

Exercise 20. Standing. Calm walking with breathing of an average depth of 2-3 minutes.

With the initial sufficient training or exercise tolerance arising during the classes, the following set of exercises can be used.

2.2. A reinforced version of therapeutic gymnastics.

Exercise 1. Standing. Walking calm with rubbing the palms of the chest, abdomen, lower back. It takes 1-2 minutes.

Exercise 2. Standing, arms down. Simultaneous bending with tension and free “throwing” of arms forward, to the sides and upwards 12-16 times. When bending, exhale, while leveling, inhale.

Exercise 3. Standing, arms at the waist, legs shoulder width apart. Lateral movements of the pelvis to the right and left, back and forth. It is performed 6-10 times alternately. Breathing is free.

Exercise 4. Standing, feet shoulder width apart, arms down. Circular movements of straight arms in the shoulder joints, 6-10 times with maximum excursion, do not hold your breath.

Exercise 5. Standing, arms in front of the chest, bent at the elbows. Walking with high flexion of the hips, with the touch of hands. 6-10 times each leg in turn. The movements are vigorous, while flexing the thigh - exhale through the mouth.

Exercise 6. Walking calm 1-2 minutes.

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bending of the body. The exercise is performed 8-10 times. The movements are energetic. When straightening, inhale; when bent, exhale.

Exercise 8. Standing sideways to a chair, hold on to the back, the other hand at the waist. Alternating swings with a straight leg forward with the greatest possible excursion. Leg sweep combined with exhalation. It is carried out 4-6 times.

Exercise 9. Standing, legs apart, arms to the sides. Tilts the body forward with a touch of the right brush of the left toe of the foot, the other hand is pulled up. Return to starting position. Combine the slope with the exhale, while straightening, inhale 4-6 times.

Exercise 10. Walking calm with breathing of medium depth. 1-2 minutes

Exercise 11. Standing, hands in a fist and lowered: a) bending the arms at the elbows with force and unbending them with the back, with the greatest possible straightening and tension and a delay in tension for 2-3 seconds. Standing, hands on the waist; b) half-squats, followed by lifting on toes and straining the legs. The exercise is performed 4-6 times with the greatest possible rectification and tension and a delay in the stress state for 2-3 seconds.

Exercise 12. Sitting on the edge of a chair. In the position of the leg raised and bent at the knee joint, alternately shake the tibia and thigh muscles with the hands. Reduce muscle tension. 1-2 minutes

Exercise 13. Sitting on the edge of the chair, straight legs divorced. Breeding and mixing straight arms and legs. When breeding, inhale, while mixing, exhale. It is carried out 4-8 times.

Exercise 14. Standing. Walking is calm with the transition to a rhythmic calm run (jogging) in place or with movement. If tired, go for a walk with moderate breathing. 2-5 minutes

Exercise 15. Lying on the mat. Simultaneous lifting of the body and legs as you exhale. 4-6 times. Arms and legs straightened, keep balance.

Exercise 16. Lying on the mat, emphasis with brushes on the floor. Cross movement with straight legs - “scissors.” 4-8 times. Do not hold your breath.

Exercise 17. With a quick straightening of the legs, move to a sitting position, then lie down. You can help with a wave, 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breath 4-6 times.

Exercise 19. Lying on your back, arms spread apart with the emphasis of the hands on the floor. With the turn of the pelvis to the left, bend the legs, turn the pelvis with the legs crossed to the right and stretch the legs. Repeat such circular movements with legs 3-6 times in each direction alternately. Do not tear your hands off the floor. Do not hold your breath.

Exercise 20. Lying on your back, arms and legs apart. Alternate turns of the body to the right and left with the laying of one hand on the other. Do not move your legs. With arms apart, inhale, while turning, exhale. It is carried out 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) turn on the right side; c) go to the supine position; d) get on your knees; e) move to a standing position; f) walking in a place with high hip flexion and arm movement - 20-30 steps; g) sit on the mat; h) lie on your back, calm breathing. Repeat the whole complex 3-4 times.

Exercise 22. Standing. Walking calm with breathing of medium depth - 1-2 minutes.

Exercise 23. Standing, legs spaced the width of the foot, hands on the waist. Circular motion of the pelvis, right and left 6-8 times. Do not hold your breath.

Exercise 24. Standing with legs wide apart, hands in front of the chest. Alternately bending the leg with the transfer of body weight to it with stretching the arms to the toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - inhale, while tilting - exhale.

Exercise 25. Standing, legs spaced shoulder width apart, arms at the waist. Circular head movements 4-10 times in each direction.

Exercise 26. Standing, legs spaced shoulder-width apart, arms at the waist. Tilt the body to the right, pulling the left hand up - inhale. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same, arms to shoulders. Circular movements of the hands with the maximum excursion in the shoulder joints, when breeding - inhale, while reducing and retracting the walls of the abdomen - exhale. The breath is deep.

Exercise 28. Standing. Calm walking and breathing of medium depth. Reduced overall load. 1-2 minutes

3. Fractional exercise throughout the day.

A patient with hypertension and type II diabetes is a patient with a number of concomitant disorders and, above all, the cardiovascular system. This circumstance limits the simultaneous use of great physical activity in the process of morning gymnastics, as well as in the main occupation of therapeutic and prophylactic gymnastics. That is why the increase in physical activity of people suffering from hypertension and type II diabetes should be achieved by distributing physical activity in small doses throughout the day.

This method of increasing the physical activity of patients with hypertension and type II diabetes should be considered as a fractional load method.

Depending on the real life conditions of patients with hypertension and type II diabetes, various exemplary fractions of various loads can be recommended to increase physical (motor) activity throughout the day.

Option 1.

Exercise 1. Sitting - spread your elbows to the sides - inhale, stretch your arms forward with tension - exhale, 4-6 times.

Exercise 2. Sitting - stand up with the deflection of the body and sit down - 8-10 times.

Exercise 3. Sitting - an imitation of the movements of a boxer with a possibly large rotation of the body - 10-12 times.

Option 2

Exercise 1. Standing - walking with high flexion of the hips - 16-30 times.

Exercise 2. Standing - circular movements of the head to the right and left - 3-8 times in each direction.

Exercise 3. Standing - legs spread apart - imitation of the movement of the pigtail - 10-12 times.

Exercise 4. Sitting - transition to a standing position - 10-12 times.

Option 3

Exercise 1. Walking is calm - 1 min.

Exercise 2. Walking accelerated - 1 min.

Exercise 3. Walking with a high flexion of the hips and alternate wave of hands 20-30 times.

Exercise 4. Walking calm with breathing -1-2 min; the run is calm on the spot or with movement around the room - 2-5 minutes.

Option 4

Walking walk of various extent.

Option 5

Physical labor in various versions and of various durations depending on the conditions (cleaning the premises, home maintenance, work on cleaning the territory, garden works, etc.).

Example. Patient Zh., 51 years old, with AH of the 2nd degree, 2 stages (blood pressure 165/100 mm Hg) and type II diabetes (fasting glycemia 6.8 mmol / L) during the examination revealed an increase in the level of blood plasma microvesicles 224.1 nkat. The patient was prescribed lisinopril 10 mg 1 time in the morning, amlodipine 5 mg 1 time in the morning and pioglitazone 30 mg 1 time in the morning against a background of dosed physical activity. The patient was regularly examined after the start of treatment. Simultaneously with the examination, the level of blood microvesicles was determined.

After 7 weeks of treatment, the patient's blood pressure stabilized at 125/80 mm Hg, fasting glycemia was 5.4 mmol / L with normalization of the level of blood microvesicles of 61.2 nkat.

The patient was asked to follow the recommendations given to her in the future.

Using the proposed method for correcting the level of blood microvesicles in hematology, cardiology and endocrinology will help to avoid many vascular complications in patients with hypertension and type II diabetes, reduce the number of cases of temporary disability, reduce the duration of hospitalization, reduce disability and mortality.

Claims (1)

A method for correcting the level of microvesicles in the blood with arterial hypertension and type II diabetes mellitus by applying lisinopril 10 mg 1 time in the morning, amlodipine 5 mg 1 time in the morning, pioglitazone 30 mg 1 time in the morning and dosed physical activity for at least 7 weeks.