RU2347564C1 - Method for treatment of infiltrative suppurative forms of scalp trichophytosis - Google Patents

Abstract

FIELD: medicine; dermatology.

SUBSTANCE: antimycotic griseofulvin, sunflower seed oil and ascorbic acid are introduced per os. Powder of kerakol from crushed native cornea of neat cattle eyes is applied on infiltrative suppurative focus in amount of 25 mg 2 times per day for 7-8 days.

EFFECT: formation of tender cosmetic scar in focus of infiltrative suppurative trichophytosis, method simplification and reduction of treatment time.

2 ex

Description

The invention relates to medicine, namely to dermatovenerology, and can be used for external treatment of infiltrative suppurative forms of zooanthroponous trichophytosis of the scalp.

A known method using a 2% solution of furatsilin in the form of lotions on the foci (Yu.K. Skripkin. "Triad-farm". - M., 2001, "Skin and sexually transmitted diseases", p. 201) as a bactericidal agent. However, this drug for local treatment of wounds not only does not possess the necessary antimicrobial activity, but also does not provide a quick drying effect, which requires the use of aniline dyes in the future (as a drying agent). This limits the application of this method in practice.

The main drug in the treatment of patients with dermatophytosis (trichophytosis, microsporia) is the systemic antimycotic griseofulvin.

The prototype of this invention is a method consisting in the fact that the patient is prescribed griseofulvin, little sunflower, ascorbic acid, and as an external therapy, a Dalcex-trypsin napkin is applied to the infiltrative suppuration focus previously moistened with physiological saline (Patent RU 2276609, 2006). An absorbent layer of cotton wool is applied over the napkins and fixed with a gauze bandage. For 48 hours, the dressing is kept moist (wetting through a bandage). After 48 hours, the inflammatory infiltrate in the focus is sharply flattened, the purulent crusts soften and tear away, the hair follicles are released from pus, and the remaining hair in the focus easily and painlessly epilates. On the 3rd day after cleansing the focus, fungicidal ointments are applied (sulfur-tar, sulfuric 33%). By day 6, inflammation in the focus completely disappears, cicatricial atrophy forms from the peripheral departments. Recovery occurs by day 10. This method contributes to the rapid relief of inflammatory phenomena and resorption of infiltration in the outbreak in a shorter time than with commonly used external methods of treatment. However, the low regenerative ability of Dalcex-trypsin three-layer wipes does not prevent the development of a severe cosmetic defect in the form of a rough scar.

The technical result - the formation of a gentle cosmetic scar in the focus of infiltrative suppurative trichophytosis, simplification of the method, reducing the duration of treatment.

The proposed method is as follows. The patient is prescribed griseofulvin 0.125, 3.5 tablets per day (17 mg per kg body weight), 1/2 tablespoon sunflower oil 3 times a day, ascorbic acid 0.05 1 tablet 3 times a day. External therapy: apply keracol in an amount of 25 mg 2 times a day to the infiltrative suppurative focus for 7-8 days. At the first stage, which takes 1-3 days, keracol helps cleanse the wound from pus, and at the next stage provides skin regeneration.

Kerala (VFS 42-1895-89) is an amorphous powder of a slightly yellowish color from the crushed dried native cornea of cattle eyes.

It is known that keracol is used to stimulate repair processes in the pathology of the cornea and conjunctiva (copyright certificate SU 1602514, 1990). However, the study of the effectiveness of the external use of keracol in infiltrative suppurative forms of trichophytosis has not been conducted.

Using the proposed method of treatment in 28 patients with an infiltrative suppurative form of zooanthroponous trichophytosis contributed to the formation of a gentle cosmetic scar in the focus of trichophytosis.

The invention is illustrated by the following examples.

Example 1. Patient M., 8 years old. Upon admission to the RKVD, the mycological lesion process was focal in nature. In the occipital region of the scalp there was a tumor-like lesion with a size of 4.5 × 6.5 cm in diameter with clear even contours. The mouths of the hair follicles in the lesion were dilated, from which pus was secreted, the hair partially fell out, and the rest were easily removed (kerion Celsii). Microscopic examination of fungi in the hair from the lesion revealed spores of the fungus of the Tr.ectothrix type, Tr.verrucosum was culturally isolated. After the examination, the patient was diagnosed with Infiltrative suppuration trichophytosis of the scalp (1 outbreak), due to Tr.verrucosum.

Prescribed treatment: griseofulvin 0.125 to 3.5 tablets per day (17 mg per kg of body weight), little sunflower seeds 1/2 tablespoon 3 times a day, ascorbic acid 0.05 1 tablet 3 times a day. External therapy: keracol was applied in an amount of 25 mg 2 times a day to the infiltrative suppurative focus for 7-8 days. On the 3rd day of treatment, the focus was cleansed of pus, on the 7th day of treatment, a tender scar was formed in the patient.

Thus, the use of the drug keracol in the complex external treatment of infiltrative suppurative forms of trichophytosis of the scalp contributed to the formation of a tender scar in the lesion than with conventional external methods of treatment and reduction of healing time, which significantly improves the quality of treatment.

Example 2. Patient G., 10 years old, was admitted to the mycology department of the RKVD with a diagnosis of Infiltrative suppurative trichophytosis of the scalp (2 foci). When viewed in the temporal region of the scalp there was a tumor-like lesion with a size of 6.3 × 6.5 cm in diameter. In the focus of the mouth of the hair follicles were expanded, of which pus liberated (kerion Celsii). The hair in the focus partially fell out, the remaining ones were easily removed. Regional lymph nodes were enlarged. Microscopic examination of the hair from the lesion revealed spores of the fungus of the Tr.ectothrix type, Tr.verrucosum was culturally isolated. Prescribed treatment: griseofulvin 0.125, 4.5 tablets per day (17 mg per kg of body weight), little sunflower seeds 1/2 tablespoon 3 times a day, ascorbic acid 0.05 1 tablet 3 times a day, external therapy: keracol was applied in an amount of 25 mg 2 times a day to the infiltrative suppurative focus for 7-8 days. On the 4th day of treatment, the foci were cleansed of pus, on the 8th day of treatment, a tender scar was formed in the patient. Thus, the use of the drug keracola contributed to the formation of a more tender scar in the foci and a reduction in the duration of treatment than with commonly used external methods of treatment, which significantly improves the quality of treatment.

Thus, the authors' studies have proved the high therapeutic effect of keracol in the infiltrative suppuration forms of trichophytosis due to its pronounced adsorption and regenerating effect.

Claims (1)

A method of treating infiltrative suppurative forms of trichophytosis of the scalp, including the administration of a per os antimycotic griseofulvin, sunflower oil, ascorbic acid, the use of an external agent on an infiltrative-suppurative focus, characterized in that, as an external agent, keracol powder from the crushed large native cornea is applied cattle at a dose of 25 mg 2 times a day for 7-8 days.