RU2333757C2 - Фармацевтические композиции - Google Patents
Фармацевтические композиции Download PDFInfo
- Publication number
- RU2333757C2 RU2333757C2 RU2003100507/15A RU2003100507A RU2333757C2 RU 2333757 C2 RU2333757 C2 RU 2333757C2 RU 2003100507/15 A RU2003100507/15 A RU 2003100507/15A RU 2003100507 A RU2003100507 A RU 2003100507A RU 2333757 C2 RU2333757 C2 RU 2333757C2
- Authority
- RU
- Russia
- Prior art keywords
- valsartan
- tablet
- filler
- tablet according
- oral solid
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title description 12
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- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims abstract description 8
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Images
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- A61K31/33—Heterocyclic compounds
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- Neurology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59968700A | 2000-06-22 | 2000-06-22 | |
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| IL143233A0 (en) * | 1998-12-23 | 2002-04-21 | Novartis Ag | Use of at-1 receptor antagonist or at-2 receptor modulator for treating diseases associated with an increase of at-1 or at-2 receptors |
| US7468390B2 (en) | 2002-01-17 | 2008-12-23 | Novartis Ag | Methods of treatment and pharmaceutical composition |
| WO2003059345A1 (en) * | 2002-01-17 | 2003-07-24 | Novartis Ag | Pharmaceutical compositions comprising valsartan and nep inhibitors |
| GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| TWI299663B (en) * | 2002-05-14 | 2008-08-11 | Novartis Ag | Methods of treatment |
| KR20080083071A (ko) * | 2003-08-08 | 2008-09-12 | 아지노모토 가부시키가이샤 | 나테글리니드 함유 제제 |
| WO2006021443A2 (en) * | 2004-08-26 | 2006-03-02 | Novartis Ag | Composition comprising an at1 receptor blocker and a macrolide t-cell immunomodulator |
| PL2033629T3 (pl) | 2004-12-24 | 2013-04-30 | Krka | Stała kompozycja farmaceutyczna zawierająca walsartan |
| JP2009001520A (ja) * | 2007-06-21 | 2009-01-08 | Kowa Co | ジフェンヒドラミン含有固形製剤 |
| WO2009048848A1 (en) | 2007-10-09 | 2009-04-16 | Novartis Ag | Pharmaceutical formulation of valsartan |
| WO2009059605A1 (en) * | 2007-11-08 | 2009-05-14 | University Of Copenhagen | Small scale solid state screening |
| EP2067470A1 (en) * | 2007-12-03 | 2009-06-10 | Laboratorios Lesvi, S.L. | Pharmaceutical compositions containing valsartan and process for its preparation |
| SI2536396T1 (sl) | 2010-02-16 | 2017-01-31 | KRKA, tovarna zdravil, d.d.,Novo mesto | Postopek za pripravo oralnih trdnih odmernih oblik, ki obsegajo valsartan |
| CN102362865B (zh) * | 2011-10-28 | 2013-06-26 | 山东司邦得制药有限公司 | 一种含有盐酸贝尼地平和缬沙坦的复方制剂及其应用 |
| WO2013098576A1 (en) | 2011-12-31 | 2013-07-04 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Immediate release pharmaceutical composition of valsartan |
| WO2013098578A1 (en) | 2011-12-31 | 2013-07-04 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Immediate release pharmaceutical composition of valsartan hydrochlorothiazide |
| CN103599084B (zh) * | 2013-11-22 | 2018-10-30 | 威海迪素制药有限公司 | 一种降压组合物 |
| CN112826806A (zh) * | 2021-01-20 | 2021-05-25 | 海南皇隆制药股份有限公司 | 一种缬沙坦片制备方法和缬沙坦片 |
| CN112807286A (zh) * | 2021-01-20 | 2021-05-18 | 海南皇隆制药股份有限公司 | 一种缬沙坦分散片制备方法和缬沙坦分散片 |
| EP4295839A1 (en) | 2022-06-20 | 2023-12-27 | KRKA, d.d., Novo mesto | Combination of valsartan and indapamide |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997049394A2 (en) * | 1996-06-27 | 1997-12-31 | Novartis Ag | Sold oral dosage forms of valsartan |
| RU98100250A (ru) * | 1995-06-07 | 1999-09-27 | Джи. Ди. Сирл Энд Ко. | Комбинация, содержащая антагонист рецептора ангиотензина ii и эпоксистероидный антагонист рецептора альдостерона |
| WO2000038676A1 (en) * | 1998-12-23 | 2000-07-06 | Novartis Ag | Use of at-1 receptor antagonist or at-2 receptor modulator for treating diseases associated with an increase of at-1 or at-2 receptors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE122007000050I1 (de) * | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
| JPH09510225A (ja) * | 1994-03-17 | 1997-10-14 | チバ−ガイギー アクチェンゲゼルシャフト | バルサルタンを用いる糖尿病性ネフロパシーの治療 |
| BR9609066A (pt) * | 1995-06-07 | 1999-01-26 | Searle & Co | Antagonista aldoesterone epoxi-esteroidal e terapia de combinação de antagonista angiotensina ii para tratamento de deficiência do coração |
| MY119312A (en) * | 1995-10-06 | 2005-05-31 | Novartis Ag | At 1-receptor antagonists for preventing and treating postischemic renal failure and for protecting ischemic kidneys |
| ES2189940T3 (es) * | 1996-02-29 | 2003-07-16 | Novartis Ag | Antagonista de receptor at1 para la estimulacion de la apoptosis. |
| IL124935A (en) * | 1996-05-20 | 2001-06-14 | Janssen Pharmaceutica Nv | Dispersible antifungal compositions comprising itraconazole with improved bioavailability |
| US6362371B1 (en) * | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| SE9802973D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
| US20040023840A1 (en) * | 2000-04-12 | 2004-02-05 | Marc De Gasparo | Combination of organic compounds |
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2001
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU98100250A (ru) * | 1995-06-07 | 1999-09-27 | Джи. Ди. Сирл Энд Ко. | Комбинация, содержащая антагонист рецептора ангиотензина ii и эпоксистероидный антагонист рецептора альдостерона |
| WO1997049394A2 (en) * | 1996-06-27 | 1997-12-31 | Novartis Ag | Sold oral dosage forms of valsartan |
| WO2000038676A1 (en) * | 1998-12-23 | 2000-07-06 | Novartis Ag | Use of at-1 receptor antagonist or at-2 receptor modulator for treating diseases associated with an increase of at-1 or at-2 receptors |
Non-Patent Citations (2)
| Title |
|---|
| G.T. MCINNES: «Clmical Advantage of Vqlsartan», CARDIOLOGY, vol.91, no suppl. 1, 1999, pages 14-18. * |
| Технология лекарственных форм. /Под ред. Л.А.Ивановой. - М.: Медицина, 1991, т.2, с.137. * |
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