RU2328879C2 - Composition for producing biologically active food additive - Google Patents

Abstract

FIELD: food processing.

SUBSTANCE: invention relates to the biologically active food additives (BAFA). BAFA includes (in mass percent): 5-60 of the maidenhair tree (Ginkgo biloba) leaves, 10-60 of the hawthorn (Crataegus) fruits, 10-60 of the sedge grass (Equisetum arvense), 10-60 of hips (Rosa), 5-55 of Hibiscus flowers and 5-55 of motherwort (Leonurus) grass.

EFFECT: biologically active food additive has nice organoleptic properties and improves cardiovascular fitness.

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Description

The invention relates to the food industry, namely to the production of biologically active additives (BAA) of plant origin, and relates to a composition for the preparation of BAA - a source of flavonoids used to improve the functional state of the cardiovascular system.

The food and medical industries produce products of various compositions containing plant components. Known compositions that include, among other components, the leaves of ginkgo biloba (bilobate) [Prokopyeva L.A., Gavinsky Yu.V., Kalachikova L.G. Biologically active food supplement for the prevention and reduction of weather dependence, sensitivity to solar and geomagnetic storms. Patent for invention RU 02188564 C1 20020910; Prokopieva L.A., Vinogradov A.K., Kungurtseva N.V. etc. Biologically active food supplement for the prevention of disorders and correction of vision. Patent for invention RU 02270583 C2 20060227], hibiscus flowers [Scherbakov O.N. Phytotea. Patent for invention (19) RU (11) 2000123799 (13) A; Beletskaya I.G. Composition for making a tea drink. Patent for invention (19) RU (11) 2169480 (13) C2; Shcherbakov O.N. Composition for making a tea drink. Patent for the invention (19) RU (11) 2163448 (13) C1; Shcherbakov O.N. Method for the production of herbal tea, herbal tea-dietary supplement. Patent for the invention of (19) RU (11) 2162644 (13) C1; Shebalin D. D. Method for the production of a drink. Patent for the invention of (19) RU (11) 2173339 (13) C1; Zhuk V.V., Stepanova E.F., Andreeva I.N. and others. Means with hypocholesterolemic and antihypoxic action. Patent for invention (19) RU (11) 2144373 (13) C1; Kazachenko A.G. Herbal tea to cleanse the body and reduce weight. Patent for the invention RU (11) 02215424 C2 20031110], rose hips [Ponomareva A.G. Medicinal collection to cleanse the body. Patent for invention RU 94035971 A1 19960927; Ponomareva A.G. Medicinal collection to cleanse the body. Patent for invention RU 02097052 C1 19971127; Tsoi G.A. Compositions "Ginrozin" with a restorative and adaptogenic effect. Patent for invention RU 02189243 C1 2020920; Ponomareva A.G., Poverin D.I. The collection of medicinal plants with a restorative effect, "Tenderness", "Autumn", "Natasha". Patent for invention RU 02012348 C1 19940515; Buraga L.P. Means for the prevention and treatment of malignant neoplasms. Patent for invention RU 02044547 C1 19950927], hawthorn fruit [Ponomareva A.G. Medicinal collection to cleanse the body. Patent for invention RU 02097052 C1 19971127; Konovalov V.N., Konovalova Yu.V. Multivitamin collection (options). Patent for invention RU 02195301 C1 20021227; Dulkis M.D. An agent with a sedative effect "Fitosedin". Patent for invention RU 02185847 C1 20020727; Malov V.A. A method for the treatment of hypothalamic syndrome in women. RU 02101024 C1 19980110; Tsybulko E.I., Yudina T.P., Nikitina I.N. Herbal tea composition. Patent for invention RU 95102566 A1 19970527; Nikolaeva G.G., Nikolaev S.M., Tsyrenzhapova O.D. and others. A method of obtaining funds with adaptogenic activity. Patent for invention RU 02135198 C1 19990827; Dorofeev D.N., Dorofeeva D.V. A method for the treatment of asthenoneurotic conditions. Patent for invention RU 02101025 C1 19980110; Trutaev I.V., Fedorin G.F. A composition that has a sedative effect. Patent for invention RU 02138280 C1 19990927; Konovalov V.N., Konovalova Yu.V. Collection No. 3 of medicinal herbs with a restorative effect. Patent for invention RU 02119798 C1 19981010; Prokopieva L.A., Gavinsky Yu.V., Kalachikova L.G. Dietary supplement for the prevention of diseases and the improvement of the cardiovascular system. Patent for invention RU 02163134 Cl 20010220; Ponomareva A.G., Poverin D.I. The collection of medicinal plants with a restorative effect, "Tenderness", "Autumn", "Natasha". Patent for invention RU 02012348 C1 19940515; Buraga L.P. Means for the prevention and treatment of malignant neoplasms. Patent for invention RU 02044547 C1 19950927; Prokopieva L.A., Gavinsky Yu.V., Kalachikova L.G. Biologically active food supplement for the prevention and reduction of weather dependence, sensitivity to solar and geomagnetic storms. Patent for invention RU 02188564 C1 20020910; Tsybulko E.I., Yudina T.P., Nikitina I.N. Herbal tea composition. Patent for invention RU 95102566 A1 19970527], horsetail of field grass [Konovalov V.N., Konovalova Yu.V. Multivitamin collection (options). Patent for invention RU 02195301 C1 20021227; Malov V.A. A method for the treatment of hypothalamic syndrome in women. Patent for invention RU 02101024 C1 19980110; Buraga L.P. Means for the prevention and treatment of malignant neoplasms. Patent for invention RU 02044547 C1 1995 0927], motherwort herb [Ponomareva A.G. Medicinal collection to cleanse the body. Patent for invention RU 02097052 C1 19971127; Dulkis M.D. An agent with a sedative effect "Fitosedin". Patent for invention RU 02185847 C1 20020727; Malov V.A. A method for the treatment of hypothalamic syndrome in women. Patent for invention RU 02101024 C1 19980110; Dorofeev D.N., D.V. Dorofeeva. A method for the treatment of asthenoneurotic conditions. Patent for invention RU 02101025 C1 19980110; Trutaev I.V., Fedorin G.F. A composition that has a sedative effect. Patent for invention RU 02138280 C1 19990927; Prokopieva L.A., Gavinsky Yu.V., Kalachikova L.G. Biologically active food supplement for the prevention and reduction of weather dependence, sensitivity to solar and geomagnetic storms. Patent for the invention RU 02188564 C1 20020910]. Some of these dietary supplements have an effect improving the functional state of the cardiovascular system, but do not always achieve high quality of organoleptic properties, exhibit a less pronounced therapeutic effect and are not considered as a source of flavonoids. In addition, various combinations of medicinal plants in dietary supplements provide different pharmacological effects and are sources of various groups of biologically active substances.

The closest analogue of the proposed composition is a composition intended for exposure to the cardiovascular system and containing motherwort, hawthorn and valerian [Malov V.A. A method for the treatment of hypothalamic syndrome in women. Patent for the invention RU 02101024 C1 19980110]. This composition provides an improving effect on the functional state of the cardiovascular system. However, since it contains motherwort (of bitter taste) and valerian (whose smell often causes unpleasant sensations), it does not provide pleasant organoleptic properties of the resulting infusion. In addition, the additional introduction of ginkgo biloba into the leaves helps improve blood circulation and antithrombotic action (which is important for patients with cardiovascular diseases).

An advantage of the present invention is that in the developed composition it is proposed to use, in addition to the named hawthorn and rosehip, additional ginkgo, rosehip, hibiscus, which makes it possible to use a biologically active additive as a source of flavonoids with an effect improving the central and peripheral circulation and generally improving the functional state of the cardio vascular system action with pleasant organoleptic properties, which in turn contributes to the expansion NIJ range of this type of product.

The aim of the invention is to improve the functional state of the cardiovascular system, organoleptic properties of dietary supplements, providing an adequate level of flavonoids when used.

This goal is achieved by the fact that as part of dietary supplements, medicinal plant raw materials are used that are approved for use in medical practice, containing flavonoids and manifesting together improving the functional state of the cardiovascular system (in parts by weight): ginkgo biloba leaves ( bilobate) - 5-60, hawthorn fruits - 10-60, field horsetail grass - 10-60, rose hips - 10-60, hibiscus flowers - 5-55, motherwort grass - 5-55.

The introduction of ginkgo biloba (bilobate) into the leaf composition enriches dietary supplements with flavonoids (glycosides of kempferol, quercetin, luteolin, amentoflavon, bilobetin, ginkgetin, isoginkgetin, sciadopitisin), terpenoids (ginkgolides and bicoriboids, etheric acids, bilobalides, ethereal acids, biloberic acids, and other fatty acids) oils, sugars, macro- and microelements (calcium, iron, phosphorus) and provides antihypoxic, antioxidant, normalizes blood circulation, antiatherosclerotic, nootropic, hypoglycemic, angiop rotor, venotonic action [State register of medicines. T.1. - M .: Ministry of Health of the Russian Federation, 2002 .-- 1300 p .; Encyclopedia of drugs. Register of medicines of Russia. Issue 9. - M .: RLS-2002 LLC, 2002. - 1504 p .; Encyclopedic dictionary of medicinal plants and animal products: Textbook. allowance / Ed. G.P. Yakovleva and K.F. Blinova, 2nd ed., Rev. and add. - St. Petersburg: SpetsLit, Publishing House of SPKhFA, 2002. - 407 p .; dark WM et al. Therapeutic efficacy of Ginkgo biloba in transient focal ischemia / Poster presented at: 52 ^nd annual meeting of the American Academy of Neurology. - May 2, 2000, San Diego, Ca.]

Rose hips contain flavonoids (vitamin P); vitamins: ascorbic acid, carotene, phylloquinone, riboflavin, tocopherol and have a general strengthening, choleretic effect (due to the organic acids and carotenoids contained in them), P-vitamin effect (improve vascular permeability), multivitamin, anti-inflammatory activity, enhance tissue regeneration body resistance to harmful environmental influences, infections and other adverse factors, increase redox processes in the body, activate a number of enzyme Istemi [GF XI, Ch.2. - 1990; Plants for us. Reference publication / K.F. Blinova, V.V. Vandyshev, M.N. Komarova and others; Ed. G.P. Yakovleva and K.F. Blinova. - 1996. - 652 s .; Muravyova D.A., Samylina I.A., Yakovlev G.P. Pharmacognosy: A Textbook. - 4th ed., Revised. and add. - M .: Medicine, 2002. - 656 p .; Sokolov S.Ya. Herbal medicine and phytopharmacology. A guide for doctors. - M.: Medical News Agency, 2000. - 970 p.]. In addition, rose hips improve the taste, color and smell of the final product.

Hawthorn fruits contain flavonoids, organic acids, carotenoids, tannins, fatty oils, triterpene glycosides, sugars, vitamins. They have P-vitamin (improve vascular permeability), anti-atherosclerotic, vasodilator, blood circulation enhancing, antihypoxant, cardiotonic, sedative, hypotensive effect. They have pleasant organoleptic characteristics. [GF XI, Part 2. - 1990; Plants for us. Reference publication / K.F. Blinova, V.V. Vandyshev, M.N. Komarova and others; Ed. G.P. Yakovleva and K.F. Blinova. - 1996. - 652 s .; Muravyova D.A., Samylina I.A., Yakovlev G.P. Pharmacognosy: A Textbook. - 4th ed., Revised. and add. - M .: Medicine, 2002. - 656 p .; Sokolov S.Ya. Herbal medicine and phytopharmacology. A guide for doctors. - M.: Medical News Agency, 2000. - 970 p.].

Hibiscus flowers increase the organoleptic properties of dietary supplements, and also add flavonoids, organic acids, vitamins, polysaccharides (pectins), amino acids and improve the general condition of the body, exhibit antispasmodic, antibacterial, P-vitamin (strengthen the walls of blood vessels), choleretic effect, promote the release of metabolic products, toxins and heavy metals from the intestine [Atlas of medicinal plants of the USSR. / Ed. N.V. Tsitsina. M., 1962; Render A. Manual of Cultivated Tress and Shrubs. New York, 1949, p 830-844].

Horsetail grass enriches the composition of dietary supplements with flavonoids, phenolcarboxylic acids, ascorbic acid, carotene, mineral salts, silicic acid (up to 25% in dry grass). Contributes to the overall pharmacological action of dietary supplements due to the manifestation of diuretic, hemostatic, anti-inflammatory, antimicrobial, detoxification (in particular, removes lead from the body) activities. Horsetail grass is usually used as a diuretic for congestive cardiac events (heart defects, heart failure), for edema associated with pulmonary heart disease, for diseases of the urinary tract (pyelitis, cystitis, urethritis), etc. [GF XI, Part 2. - 1990; Plants for us. Reference publication / K.F. Blinova, V.V. Vandyshev, M.N. Komarova and others; Ed. G.P. Yakovleva and K.F. Blinova. - 1996. - 652 s .; Muravyova D.A., Samylina I.A., Yakovlev G.P. Pharmacognosy: A Textbook. - 4th ed., Revised. and add. - M .: Medicine, 2002. - 656 p .; Sokolov S.Ya. Herbal medicine and phytopharmacology. A guide for doctors. - M.: Medical News Agency, 2000. - 970 p.].

Motherwort grass contains flavonoids, tannins, saponins, iridoids, provitamin A, ascorbic acid, essential oil, mineral salts, etc. It has a calming, cardiotonic, hypotensive effect. It is used as a calming, cardiotonic, cardiac rhythm regulating agent for cardiovascular neurosis, angina pectoris, hypertension, vegetative-vascular dystonia, etc. [GF XI, Part 2. - 1990; Plants for us. Reference publication / K.F. Blinova, V.V. Vandyshev, M.N. Komarova and others; Ed. G.P. Yakovleva and K.F. Blinova. - 1996. - 652 s .; Muravyova D.A., Samylina I.A., Yakovlev G.P. Pharmacognosy: A Textbook. - 4th ed., Revised. and add. - M .: Medicine, 2002. - 656 p .; Sokolov S.Ya. Herbal medicine and phytopharmacology. A guide for doctors. - M.: Medical News Agency, 2000. - 970 p.].

In general, with this combination of plant components, the potentiating effect of the biologically active substances contained in them is achieved: the sum of flavonoids, organic acids, vitamins, etc., which provides small doses of mild pharmacological activity, manifested by an improvement in the functional state of the cardiovascular system. In addition, the addition of hibiscus flowers, rose hips, hawthorn fruits give the finished product a pleasant taste, color, smell.

Examples of specific formulations of dietary supplements (in parts by weight)

Example 1

Ginkgo biloba (biloba) leaves - 10

Hawthorn fruit - 10

Horsetail grass 10

Rose hips - 10

Hibiscus Flowers - 5

Motherwort Herbs - 55

The resulting dietary supplement in terms of flavonoid content corresponds to the recommended adequate level, has positive organoleptic properties and exhibits activity that improves the functional state of the cardiovascular system.

Example 2

5 leaves of ginkgo biloba (biloba)

Hawthorn fruit - 10

Horsetail grass 10

Rose hips - 10

Hibiscus Flowers - 55

Motherwort Herbs - 10

Example 3

Ginkgo biloba (biloba) leaf - 60

Hawthorn fruit - 10

Horsetail grass 10

Rose hips - 10

Hibiscus Flowers - 5

Motherwort Herbs - 5

Example 4

Ginkgo biloba (biloba) leaves - 10

Hawthorn fruit - 10

Horsetail grass 10

Rose hips - 60

Hibiscus Flowers - 5

Motherwort Herbs - 5

Example 5

Ginkgo biloba (biloba) leaves - 10

Hawthorn fruit - 10

Horsetail Grass 60

Rose hips - 10

Hibiscus Flowers - 5

Motherwort Herbs - 5

Example 6

Ginkgo biloba (biloba) leaves - 10

Hawthorn fruit - 60

Horsetail grass 10

Rose hips - 10

Hibiscus Flowers - 5

Motherwort Herbs - 5

The production of dietary supplements includes the following technological operations: acceptance of raw materials; preparation of medicinal plant materials; grinding of raw materials; sieving the crushed mass and obtaining a powder; mixing the components that make up the dietary supplement; prefabrication and rejection of filter bags; labeling, packaging; delivery of finished products to the warehouse.

Raw materials are scanned and removed by extraneous inclusions: pieces of paper, pieces of twine, parts of other plants, metal objects, stones and other impurities. Viewed and refined raw materials are ground (by cutting or crushing). The following raw materials are subjected to cutting: hibiscus flowers, ginkgo bilobate leaves, motherwort grass, horsetail field grass. The following raw materials are subject to crushing: ginkgo bilobate leaves, rosehip fruits, hawthorn fruits. The ground mass is sieved and a powder is obtained. The fraction passed through a sieve with holes with a diameter of 2 mm, but not passed through a sieve of 0.18 mm, is weighed, packaged, labeled and transferred to the mixing area of the components. The fraction that has not passed through a sieve with holes with a diameter of 2 mm is collected, weighed, packaged, labeled and returned to the cutting and crushing site. The components in accordance with the recipe are weighed and mixed. The resulting composition is Packed in filter bags of 2.0 g. The plant mixture packaged in filter bags is a mixture of heterogeneous crushed particles of plant materials passing through a sieve with openings of 2 mm in size and has the following physicochemical and organoleptic characteristics: mass fraction moisture not more than 14%, total ash content not more than 15%, mineral impurities not more than 1%, mass fraction of particles not passing through a sieve with holes of 2 mm, not more than 10%, mass fraction of particles passing through a sieve with holes p size 0.18 mm, not more than 10%, color - brownish-green with light yellow, yellow-orange, gray-green, reddish-violet blotches, aroma - weak, fruity.

When brewing the thus obtained filter bag with the herbal mixture, a reddish-pink to reddish-brownish aromatic infusion is obtained with a sour-tart taste and fruity odor.

To confirm the correspondence of the number of dietary supplement flavonoids to the adequate consumption level, the content of this group of biologically active substances in the dry dietary supplement raw material and in the finished infusion was studied. The amount of flavonoids was determined in terms of rutin (flavonoids are found in all used types of medicinal plant materials, and their glycosides are more present in the final product (tea)). The determination of the amount of flavonoids was carried out by differential spectrophotometry after the complexation reaction with aluminum chloride. According to experimental data, the amount of flavonoids in terms of rutin and absolutely dry raw materials in dietary supplements for Cardiaginkgo food is at least 0.5% and is in the range of 0.5-1.2%. Based on the obtained experimental data, in 1 filter packet (2 g) of dietary supplement for food “Ginkgoechinal” contains a maximum of 24 mg of flavonoids in terms of rutin. When determining the amount of flavonoids in the water extract obtained from 1 filter bag (2 g) per glass of boiling water (200 ml) with an infusion of 15 minutes, the maximum content of flavonoids was 6.1 mg, which corresponds to the recommended levels of consumption of food and biologically active substances, given that 3 cups of infusion are used per day, prepared at the rate of 1 filter bag per 1 cup of boiling water (an adequate level of consumption of flavonoids is 85 mg; the upper allowable level of consumption is 120 mg, including flavonols and their glycosides 30 mg and 100 mg respectively naturally [Methodical levels of consumption of food and biologically active substances / Methodical recommendations MP 2.3.1.1915 - 04. - M., 2004. - 36 p.]).

Clinical studies were conducted in the Department of Cardiovascular Pathology of the Clinic of the Research Institute of Nutrition RAMS. Under observation were 40 patients with coronary heart disease and hypertension with overweight and hyperlipoproteinemia. Patients were divided into two representative groups of 20 people: the main and the comparison group. All patients received a hyponatrium anti-atherogenic diet Ap containing 75 g of protein, 60 g of fat and 190 g of carbohydrates with an energy value of 1600 kcal during a 3-week study period. The amount of sodium in the diet was 2-3 g and was supplied only due to the sodium in the foods. Salt was not added during cooking. Patients of the main group during 3 weeks of testing on the background of diet Ar received dietary supplement "Cardiaginkgo". Patients in the comparison group received only diet Ar. Cardiaginkgo dietary supplement was used in 1 filter bag, brewed in 1 glass of water, 3 times a day with meals. A comprehensive study of patients included a study of the dynamics of objective signs of the disease: blood pressure, heart rate, daily ECG monitoring. Biochemical parameters (total protein, uric acid, glucose, total bilirubin, ALT, ACT, total cholesterol, triglycerides, HDL cholesterol, fibrinogen, prothrombin index, fibrinolysis time) were determined using a Spectrum analyzer from ABBOTT, USA. The results of studies showed that the tolerance of dietary supplements was good. Over the entire period of clinical trials, not a single case of its intolerance, dyspeptic symptoms, allergic reactions, or other side effects was noted. Assessment of the organoleptic properties of dietary supplements was carried out by questionnaire-survey method. Its good organoleptic properties were noted. None of those participating in the tasting noted any unpleasant “aftertaste”. The use of dietary supplements "Cardiaginkgo" on the background of a hyponatrium antiatherogenic diet in patients with coronary artery disease and GB 1-11 tbsp. has a beneficial effect on the clinical picture of these diseases and the dynamics of clinical and instrumental indicators characterizing the functional state of the cardiovascular system. There was a more significant decrease in serum levels of total cholesterol, LDL cholesterol and the value of the atherogenic coefficient in patients of the main group. An increase in thrombolytic effect was observed when using the Cardiaginkgo dietary supplement, which was manifested by a significant decrease in the prothrombin index and an increase in fibrinolytic activity. In general, the results of studies showed that the studied dietary supplement improves the functional state of the cardiovascular system.

Thus, as a result of the implementation of the proposed invention, a dietary supplement is obtained, which is a source of flavonoids, which has pleasant organoleptic properties, improves the functional state of the cardiovascular system, which helps to expand the range of this type of product.

Information sources

1. Atlas of medicinal plants of the USSR / Ed. N.V. Tsitsina. M., 1962.

2. Beletskaya I.G. Composition for making a tea drink. Patent for invention (19) RU (11) 2169480 (13) C2.

3. Buraga L.P. Means for the prevention and treatment of malignant neoplasms. Patent for invention RU 02044547 C1 19950927.

4. The state register of medicines. Volume 1. - M .: Ministry of Health of the Russian Federation, 2002. - 1300 S.

5. GFH1, Part 1. - 1989; Part 2. - 1990.

6. Dorofeev D.N., D.V. Dorofeeva A method for the treatment of asthenoneurotic conditions. Patent for invention RU 02101025 C1 19980110.

7. Dulkis M.D. The remedy with the sedative effect "Fitosedin", Patent for the invention RU 02185847 C1 20020727.

8. Zhuk V.V., Stepanova E.F., Andreeva I.N. and others. Means with hypocholesterolemic and antihypoxic action. Patent for invention (19) RU (11) 2144373 (13) C1

9. Kazachenko A.G. Herbal tea to cleanse the body and reduce weight. Patent for invention RU (11) 02215424 C2 20031110.

10. Konovalov V.N., Konovalova Yu.V. Multivitamin collection (options). Patent for invention RU 02195301 C1 20021227.

11. Konovalov V.N., Konovalova Yu.V. Collection No. 3 of medicinal herbs with a restorative effect. Patent for invention RU 02119798 C1 19981010.

12. Malov V.A. A method for the treatment of hypothalamic syndrome in women. RU 02101024 C1 19980110.

13. Methodical levels of consumption of food and biologically active substances / Methodical recommendations MP 2.3.1.1915 - 04. - Moscow, 2004. - 36 p.

14. Muravyova D.A., Samylina I.A., Yakovlev G.P. Pharmacognosy: A Textbook. - 4th ed., Revised. and add. - M .: Medicine, 2002 .-- 656 p.

15. Nikolaev G.G., Nikolaev S.M., Tsyrenzhapova O.D. and others. A method of obtaining funds with adaptogenic activity. Patent for invention RU 02135198 C1 19990827.

16. Ponomareva A.G., Poverin D.I. The collection of medicinal plants with a restorative effect, "Tenderness", "Autumn", "Natasha". Patent for invention RU 02012348 C1 19940515.

17. Ponomareva A.G. Medicinal collection to cleanse the body. Patent for invention RU 9403 5971 A1 19960927.

18. Ponomareva A.G. Medicinal collection to cleanse the body. Patent for invention RU 02097052 C1 19971127.

19. Prokopieva L.A., Gavinsky Yu.V., Kalachikova L.G. Dietary supplement for the prevention of diseases and the improvement of the cardiovascular system. Patent for invention RU 02163134 C1 20010220.

20. Prokopieva L.A., Gavinsky Yu.V., Kalachikova L.G. Biologically active food supplement for the prevention and reduction of weather dependence, sensitivity to solar and geomagnetic storms. Patent for invention RU 02188564 C1 20020910.

21. Prokopieva L.A., Vinogradov A.K., Kungurtseva N.V. etc. Biologically active food supplement for the prevention of disorders and correction of vision. Patent for invention RU 02270583 C2 20060227.

22. Plants for us. Reference publication / K.F. Blinova, V.V. Vandyshev, M.N. Komarova and others; Ed. G.P. Yakovleva and K.F. Blinova. - 1996. - 652 p.

23. Sokolov S.Ya. Herbal medicine and phytopharmacology. A guide for doctors. - M.: Medical News Agency, 2000. - 970 p.

24. Trutaev I.V., Fedorin G.F. A composition that has a sedative effect. Patent for invention RU 02138280 C1 19990927.

25. Tsoi G.A. Compositions "Ginrozin" with a restorative and adaptogenic effect. Patent for invention RU 02189243 C1 2020920.

26. Tsybulko E.I., Yudina T.P., Nikitina I.N. Herbal tea composition. Patent for invention RU 95102566 A1 19970527.

27. Shebalin D.D. Method for the production of a beverage. Patent for invention (19) RU (11) 2173339 (13) C1.

28. Scherbakov O.N. Composition for making a tea drink. Patent for invention (19) RU (11) 2163448 (13) C1.

29. Scherbakov O.N. Method for the production of herbal tea, herbal tea-dietary supplement. Patent for the invention (19) RU (11) 2162644 (13) C1.

30. Scherbakov O.N. Phytotea. Patent for invention (19) RU (11) 2000123799 (13) A.

31. Encyclopedia of drugs. Register of medicines of Russia. Issue 9. - M .: LLC “RLS-2002”, 2002. - 1504 p.

32. Encyclopedic Dictionary of medicinal plants and animal products: Textbook. allowance / Ed. G.P. Yakovleva and K.F. Blinova, 2nd ed., Rev. and add. - St. Petersburg: SpetsLit, Publishing House of SPKhFA, 2002. - 407 p.

33. Clark WM et al. Therapeutic efficacy of Ginkgo biloba in transient focal ischemia / Poster presented at: 52 ^nd annual meeting of the American Academy of Neurology. - May 2, 2000, San Diego, Ca.

34. Rehder A. Manual of Cultivated Tress and Shrubs. New York, 1949, p. 830-844.

Claims (1)

Composition for preparing a biologically active food supplement - a source of flavonoids, used to improve the functional state of the cardiovascular system, including motherwort grass and hawthorn fruits, characterized in that it additionally contains rose hips, ginkgo biloba leaves, field horsetail grass, hibiscus flowers, in the following ratio of components, parts by weight: Ginkgo biloba leaves 5-60 Hawthorn fruit 10-60 Grass horsetail 10-60 Dog-rose fruit 10-60 Hibiscus flowers 5-55 Motherwort herb 5-55