RU2322999C2 - Method for preventing and treating complications at radiation and/or chemotherapy of cancer of different localization - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: it is necessary to prepare a patient to therapy due to local treatment of skin and available mucosa of organs subjected to chemo- and/or radiation impact, with butyric extracts of medicinal plants; and introduction of immunomodulating preparation (IMP) and an adsorbent in the course and after the course of radiation and/or chemotherapy. Additionally, one should perorally introduce protective species comprised out of compatible pharmacopoeic medicinal plants matched with possibility for their combined protector action upon tumor-unaffected tissues of sick organ and upon the tissue of all healthy organs being in area of chemo- and/or radiation impact. As IMP and adsorbent mentioned one should apply, correspondingly, a plant adaptogen and a plant adsorbent. Introduction of species, adaptogen and adsorbent should be started while preparing a patient to chemo- and/or radiation therapy to introduce them daily in the course of therapy conducted. Local treatment of skin and mucosa should be fulfilled after each seance of radiation and/or chemotherapy. Species, plant adaptogen and plant adsorbent should be introduced at certain intervals between each other. The innovation enables to decrease traumatism of chemo- and/or radiation therapy.

EFFECT: higher efficiency of prophylaxis and therapy.

14 cl, 7 ex

Description

The invention relates to medicine, namely to a method for the prevention and treatment of complications of radiation and / or chemotherapy of cancer of various localization, and can be used in oncology to reduce the morbidity of radiation and / or chemotherapy.

A known method for the prevention and treatment of cancer of various localization, including the collection of medicinal plants. See patent No. 2008001, RU, A61K 31/00. The disadvantage of this method is that the collection is taken by people 50-80 years old, without a diagnosis of "cancer", for the prevention of its occurrence and inoperable patients to improve the general condition.

There is also known a method of treating cancer, which includes the collection of medicinal plants in the period before radical treatment and after treatment. See patent No. 2137495, RU, A61K 35/78. In this method, the collection of medicinal plants, taken in therapeutic doses, is aimed at destroying the tumor itself, and not at supporting healthy organs.

Closest to the claimed (prototype) is a method for the prevention and treatment of complications of radiation and / or chemotherapy of cancer of various localization. See M.S. Bardychev, A.F. Tsyb. - Local radiation damage. - Moscow. - "The medicine". - 1985, p. 58, 208, 216.

The known method includes preparing the patient for radiation and / or chemotherapy, performing local treatment of the skin and the mucous membranes of organs exposed to chemo and / or radiation exposure with oil extracts of medicinal plants, administering an immunomodulating drug and an adsorbent.

In the known method, preradiation preparation of patients consists only in specifying the size, shape and position of the tumor, choosing the most beneficial for damage to the tumor and sparing healthy tissue of the radiation field and the direction of the beam. In this method, there is completely no preparation for radiation and / or chemotherapy of non-tumor-affected tissues of a diseased organ and tissues of healthy organs falling into the area of chemo and / or radiation exposure. It is also known that due to the small interval of differences in the radiosensitivity of the tumor and the surrounding healthy tissues, the occurrence of radiation injuries of the skin, other organs and tissues that fall into the irradiation zone is almost inevitable. Local radiation injuries can lead not only to disability of patients, but also to fatal outcomes. In addition, in the known method, the administration of an immunomodulating preparation and an adsorbent and local treatment of the skin and mucous membranes with oil extracts is carried out only during radiation therapy and only according to indications, i.e., for example, when skin pigmentation, radiation cystitis, leukopenia, etc. item, i.e. treat already existing complications, sometimes interrupting the main treatment for this, which negatively affects its result. It should also be noted that the development of local radiation damage depends on the functional state of the whole organism, pathological processes occur under the neurohumoral control of the whole organism, which is why it is necessary to take drugs aimed at stimulating the body's defenses. In the known method, vitamins (A, B, C, E, F), folic and nicotinic acids, non-specific stimulation agents, for example, aloe, chamomile, sea buckthorn oil, rosehip oil, are used as such immunomodulating preparations. However, these vitamins are synthesized and insufficiently absorbed by the body, and nonspecific stimulation agents are mainly used locally, for example, for skin lubrication, bladder instillation, intestinal microclyster, while these agents are used only according to indications, i.e. with the onset of symptoms of a particular complication, such as adjuvants, with conventional drug therapy.

In the known method, sea buckthorn oil and rosehip oil are used as oil extracts. These oils, along with the regenerative effect, dry the mucous membranes (they must be diluted before use), which can lead to damage. Thus, the main disadvantage of this method is the focus of all actions only on the defeat of the tumor and, to a small extent, on strengthening the body's defenses. Organs that fall into the area of exposure to radiation and / or chemotherapy are not protected, but are treated according to indications, i.e. with the onset of symptoms of a disease. All this significantly increases the morbidity of radiation or chemotherapy.

The objective of the invention is to reduce the morbidity of radiation and chemotherapy for cancer of various localization.

This problem is solved by the fact that in the known method for the prevention and treatment of complications of radiation and / or chemotherapy of cancer of various localization, including preparing the patient for radiation and / or chemotherapy, performing local treatment of the skin and located in the access zone of the mucous membranes of organs undergoing chemo- and / or radiation exposure, oil extracts of medicinal plants, the introduction of an immunomodulating drug and an adsorbent during and after a course of radiation and / or chemotherapy, according to the invention they administer a peroral administration of a collection, which is composed of compatible pharmacopoeial medicinal plants, selected with the possibility of their combined protective effect on non-tumorous tissues of the diseased organ and tissues of all healthy organs falling into the zone of chemo- and / or radiation exposure, while being immunomodulating the plant and the adsorbent use the plant adaptogen and the plant adsorbent, respectively, the introduction of collection, adaptogen and adsorbent begin during the preparation of the patient to chemo and / or radiation therapy, and during the course of chemo and / or radiation therapy they are administered daily, and local treatment of the skin and mucous membranes is carried out after each radiation and / or chemotherapy session, moreover, collection, plant adaptogen and plant the adsorbent is carried out in therapeutic doses, with intervals between the introduction of each of them. Wherein:

- in radiation therapy for cancer of any of the pelvic organs, a collection containing components in the following ratio (wt.%) is used as a tread collection:

Chamomile 10-20 Yarrow 20-25 Plantain 10-20 Bearberry 15-25 St. John's wort 20-25 Licorice 10-15

- for lung cancer, as a tread collection, a collection containing components is used in the following ratio (wt.%):

Eucalyptus 15-20 Elecampane 15-20 Licorice 20-25 Thyme 20-25 Chamomile 15-20 Plantain 10-15

- in breast cancer, as a tread collection, a collection containing components is used in the following ratio (wt.%):

Immortelle 20-25 Milk thistle 10-20 Golden root 15-20 Solyanka hill 10-20 Chamomile 10-25 Licorice 10-15

- as a plant adsorbent use alcohol extract Eleutherococcus;

- as a plant adaptogen use a decoction of flax seeds, prepared at the rate of 1-2 tablespoons of seeds per 1 cup of boiling water;

- oil extracts selected from the group including extract of birch buds, fruit blossom extract;

- the introduction of collection, plant adaptogen and plant adsorbent begin 3-10 days before the start of radiation and / or chemotherapy;

- the interval between the introductions of the tread collection and the extract of Eleutherococcus is 5-10 minutes;

- the adsorbent is administered at least 20 minutes after the introduction of tread collection and plant adaptogen;

plants for sacrificial collections are pre-dried, ground to a particle size of 1.5-2.5 mm, mixed in the indicated proportions and compressed by compression in a single dose, mainly 2 g per 1 tablet;

- tread charges are administered in the form of a decoction prepared in a single dose of 1 tablet per 1 cup of boiling water, 2 times a day 20-30 minutes before eating;

- alcohol extract Eleutherococcus is administered in a single dose of 15-25 drops 1-2 times a day;

- a decoction of flax seeds is administered 1-2 tablespoons at least three times a day;

- continue the introduction of tread collection, plant adaptogen and plant adsorbent in half doses 1-3 months after the end of the course of radiation and / or chemotherapy.

The method is as follows:

Upon admission to the hospital, depending on the diagnosis, it is determined which of the healthy organs will fall into the area of exposure to radiation and / or chemotherapy and constitute a collection of protective action, which includes herbs traditionally used in official medicine to improve these organs, choose compatible ones , i.e. not having a neutralizing effect on each other and possessing a strong protective effect in the complex. The composition of the charges and the ratio of the components in them are determined experimentally. These fees cover the entire spectrum of possible radiation and / or chemodiagnostics of organs that fall into the exposure zone, and prepare non-tumor-affected tissues of the diseased organ and tissues of healthy organs for radiation and / or chemotherapy. Tread charges begin to be administered orally 3-10 days before the start of radical treatment in therapeutic doses. In less than 3 days, introducing fees is impractical because there will be practically no therapeutic effect. More than 10 days to enter is also impractical, because the main treatment is delayed. During this period, the patient begins to orally administer a plant adaptogen, namely, alcohol extract of Eleutherococcus and a plant adsorbent - a decoction of flax seeds. Eleutherococcus is chosen as an immunomodulating drug because it strengthens the immune system by acting through the cerebral cortex, enhancing the mild immunomodulating effect of immunoprotective herbs that are part of the collections and acting through the adrenal cortex (for example, licorice, golden root, plantain, St. John's wort). This is especially important with chemotherapy for breast cancer, when the liver and immunity are most affected. Eleutherococcus is administered orally 15-25 drops twice a day. Less than 15 drops is impractical to enter, because the effect is insufficient, more than 25 drops is also impractical, due to the lack of an adequate response of the immune system. Charges are used in the form of tablets from dried and ground herbs mixed in the required ratio. The volume of the tablet is 2 g, is a single dose. Because finely dispersed, the active substances pass well into water simply when brewing with boiling water, without standing in a water bath, which greatly improves usability. The volume of tablets is equal to the volume of a single dose of the tread collection, which allows you to use them after a course of radiation therapy on an outpatient basis, without violating the dosage.

The introduction of tread collection, plant adaptogen and adsorbent in the period of preradiation preparation of the patient makes it possible to improve, prepare the tissues of organs for radiation and / or chemical effects and increase the resistance of the whole organism. Tread collection, plant adaptogen and adsorbent are administered orally one after another, while the interval between the introduction of tread collection and plant adaptogen is 5-10 minutes, because although these drugs do not have a neutralizing effect on each other, it is difficult for the patient to take them without a break.

The interval between the introduction of the tread collection, the plant adaptogen and the introduction of the plant adsorbent is 20-30 minutes, in order to avoid adsorption of the active principle of the indicated collection and the adaptogen.

As a plant adsorbent, flax seed is used in the form of a decoction prepared at the rate of 1-2 tablespoons of seeds per glass of boiling water. A single dose - 1-2 tablespoons of the decoction. The choice of flax seed as an adsorbent is also due to the fact that the broth additionally protects the mucous membranes of the gastrointestinal tract, because contains mucus, which creates a protective film throughout the gastrointestinal tract, especially suffering from radiation and chemotherapy. A decoction of flax seeds is administered orally at least three times a day. It is undesirable to enter less than three times, because the protective film on the mucous membranes will disappear. It is most advisable to introduce a decoction after 2-2.5 hours, i.e. 3 or more times. After the start of the course of radiation and / or chemotherapy, patients continue to receive tread collection, plant adaptogen and plant adsorbent daily according to this scheme. The introduction is not interrupted at the weekend. Charges of protective action are administered orally in a single dose of 1 tablet (2 g) per glass of boiling water, twice a day, in the morning and at lunch, 20-30 minutes before meals. It is not advisable to administer less than two times in the indicated dose, because collection action will be weakened. Enter more than 2 times (2 tablets) per day is also impractical, because collection expense increases without causing an adequate response. In addition, after each session of radiation and / or chemotherapy, the skin and the mucous membranes of organs entering the chemo and / or radiation exposure zone, for example, the intestines, bladder, etc., are treated with oil extracts of birch buds or gingerbread. . These extracts have a good anti-burn effect, contribute to the epithelization of the mucous membranes, the restoration of blood microcirculation, and do not dry the mucous membranes.

The use of protective actions during the preparatory period and the period of radiation and / or chemotherapy can prevent the occurrence of complications, especially late radiation and chemical complications, the most severe and not always treatable. Traditional pharmacopeia herbs used in official medicine were used in the collections, but the composition of the collection and the ratio of the components in it were selected experimentally, they have a protective effect on all healthy organs, while at the same time preventing from the very first session the risk of developing traditional mucosal lesions during normal therapy membranes and tissues of healthy organs. In cervical cancer, radiation therapy is the main treatment. At the same time, the bladder, lower colon, vagina, skin, fatty tissue, urinary tract, etc. enter the irradiation zone. To prepare these organs for radiation therapy, a collection was chosen consisting of yarrow, which has anti-inflammatory and astringent effects, chamomile, as an anti-inflammatory agent, plantain, which has a mild immunomodulating, anti-inflammatory effect, bearberry, as a uroseptic agent, St. John's wort, antidepressant, and immunomodule licorice - an expectorant and immunomodulatory effect. On the whole, the collection covers the entire spectrum of possible radiation and chemo-injuries, possessing anti-inflammatory astringent, antiseptic, uroseptic, mild immunomodulatory (through the adrenal cortex) action. In this case, the collection has a directed protective effect on healthy tissues. Herbs in the collection reinforce each other's action. Taking them separately does not give such an effect.

In lung cancer, the lung tissue, the esophagus, trachea, bronchi, and nasopharynx, which are not affected by the tumor, enter the irradiation zone. To prepare them for radiation therapy, a general protective action is used, which uses herbs such as eucalyptus, which has a strong anti-inflammatory effect, elecampane - an anti-inflammatory and analgesic effect, licorice - an expectorant effect and immunomodulatory (through the adrenal cortex), thyme - expectorant spasm , chamomile - anti-inflammatory effect.

In breast cancer, the main treatment method is chemotherapy, while the liver and the immune system are particularly affected, and the gastrointestinal tract also suffers. To prepare them for chemotherapy and to prevent complications, a collection was used containing immortelle - hepatoprotective effect, milk thistle - antioxidant, choleretic, hepatoprotective effect, golden root - immunomodulator, acting through the adrenal cortex, chamomile - anti-inflammatory effect, licorice - expectorant and immunomod - choleretic, antioxidant, hepatoprotective effect. In this collection, the effect of immunomodulators is enhanced. All herbs in collections have a pronounced treading effect in the complex, due to the combination of the above properties, while when taken separately, the herbs do not have such an effect. When searching, no known methods were found specifically aimed at preparing healthy organs for radiation and / or chemotherapy, all the fees used are aimed at destroying or suppressing tumor growth. Moreover, with radiation and / or chemotherapy, lethal outcomes are noted precisely because of complications arising (especially later, more than 3 months after treatment).

The following are examples of specific applications of the method:

Example 1

The method was applied to a group of 12 patients with a diagnosis of cervical cancer. The control group is 10 people. 5 days before the start of radiation therapy, the patients were given an oral oral protective collection at a dose of 2 g (1 tablet) per 1 cup of boiling water twice a day in the morning and at lunch, 30 minutes before meals. The collection contained (in% per 1 tablet) 20% yarrow, 15% chamomile, 15% plantain, 20% bearberry, 20% hypericum, 10% licorice. 5 minutes after the introduction of the specified collection was administered perorally alcohol extract of Eleutherococcus 15 drops. 20 minutes after the introduction of Eleutherococcus, the patients were given an oral decoction of flax seeds, two tablespoons of the decoction prepared at the rate of 1 tablespoon of seeds per glass of boiling water. A flax broth was administered four times a day. During radiation therapy, patients daily, including weekends, entered data collection, adaptogen and adsorbent in the indicated doses. In addition, after each session of radiation therapy, the patients were lubricated with abdominal oil by birch kidney oil, the vagina was also treated, microclysters were performed to treat the mucous membrane of the colon and instillation of the bladder 1 hour after the session. Earlier than an hour, it is difficult for patients to take these procedures. After a course of radiation therapy, patients independently took the collection and adaptogen in half doses, twice a day, a decoction of flax seeds was taken 1 tablespoon (0.5 dose) 3 times a day, for 3 months.

Example 2

The technique is similar to example 1. (Used for 12 patients), only herbs in the collection were used in equal proportions of 20%, Eleutherococcus - 20 drops. Flax seed - every 2 hours. After the course of radiation therapy, the patients continued the introduction of tread collection, plant adaptogen and adsorbent in half doses 2 times a day, a decoction of flax seeds was administered orally 3 times a day, 1 tablespoon each. After a course of radiation therapy, only one out of 24 patients with uterine cancer developed radiation cystitis, because according to cytoscopy, the patient had a history of chronic cystitis. In the control group of 10 patients, five had radiation cystitis, for the relief of which they had to temporarily interrupt radiation therapy and conduct a course of drug treatment. After 3 months, 5 out of 10 patients in the control group were hospitalized for rehabilitation for post-radiation cystitis. Of the study group, only two out of 24 patients.

Example 3

The method was used for 10 patients with lung cancer (control group - 10 patients). In this example, 10 patients, 7 days before the start of radiation therapy, began to administer perorally protective collection, plant adaptogen and adsorbent. Tread collection at a dose of 1 tablet (2 g) per glass of boiling water twice a day, in the morning and at lunch 30 minutes before meals. The collection contained (% per 1 tablet) 15% eucalyptus, 25% licorice, 20% elecampane, 25% thyme, 15% chamomile. 10 minutes after taking this collection, patients were orally administered 15 drops of Eleutherococcus alcohol extract. 20 minutes after the introduction of Eleutherococcus, 2 tablespoons of decoction prepared from 1 tablespoon of flax seeds per 1 cup of boiling water was orally administered. A decoction of flax seeds was also introduced in the evening 20 minutes before meals. During the course of radiation therapy, patients continued to be administered the perorally named collection, adaptogen and adsorbent in the indicated doses daily. The introduction was not interrupted at the weekend. In addition, after each session of radiation therapy, patients were lubricated with skin with gingerbread. And flax seed was administered orally every two hours. After the end of the course of radiation therapy, patients continued to take tread collection on their own for three months, plant adaptogen and plant adsorbent 2 times a day in half doses, only a decoction of flax seeds was taken 3 times a day, in half dose.

Example 4. (10 patients)

The technique and doses are similar to example 3, only the tread collection was in the following percentage: 20% eucalyptus, 15% elecampane, 20% licorice, 20% thyme, 15% chamomile, 10% plantain. Eleutherococcus was used in a dose of 15 drops, a decoction of flax seeds - 2 tablespoons each.

Example 5. (10 patients)

The method and doses are analogous to example 3, only herbs in the tread collection were used in equal proportions (in% per 1 tablet).

After the course, radiation esophagitis occurred in four of 30 patients with lung cancer and radiation pulmonitis in 6 patients. Whereas in the control group, a radiation burn of the mucous membrane of the esophagus (Esophagitis) occurred in all patients and in 6 patients, radiation pulmonitis also occurred during the course of radiation therapy, after which the course was interrupted and drug treatment was carried out. After 3 months, only 4 out of 30 patients developed pulmonary fibrosis. In the control group, 4 out of 10 people were hospitalized for rehabilitation for pulmonary fibrosis.

Example 6

The method was used for 10 patients with breast cancer (control group - 10 people). The technique is similar to an example of a specific implementation of the method. 10 days before the start of chemotherapy, the patients were given the perorally indicated tread collection to prepare the liver and gastrointestinal tract and strengthen the immune system. The collection contained (in% per 1 dose) immortelle - 25%, milk thistle - 15%, hodgepodge - 20%, golden root - 15%, chamomile - 10%, licorice - 15%. At a dose of 2 g (1 tablet) per 1 cup of boiling water twice a day, morning and evening, 20 minutes before meals. 7 minutes after the introduction of the tread collection, patients were orally administered alcoholic extract of Eleutherococcus 20 drops. 30 minutes after the introduction of Eleutherococcus, the patients were administered orally decoction of flax seeds, 2 tablespoons three times a day. The broth was prepared at the rate of 1 tablespoon of seeds per 1 cup of boiling water. After the initiation of chemotherapy, patients continued to be administered orally tread collection, plant adaptogen and adsorbent in the indicated doses, only a decoction of flax seeds was reintroduced two hours after the introduction of tread collection and plant adaptogen and in the evening, after dinner. After each chemotherapy session, patients were lubricated with birch bud oil. After a course of chemotherapy, breast cancer patients undergo radiation therapy. They continued to be treated according to the above scheme during the entire course of radiation therapy and for 3 months after the end of the course, independently taking the half-dose collection and adaptogen, flax seed decoction was taken 3 times a day.

Example 7

The method was used for 12 patients with breast cancer. The methodology and doses correspond to example 6, only the percentage of components in the tread assembly is changed, within the above ranges. One tablet (2 grams) contains 20% immortelle, 20% milk thistle, 10% hill hodgepodge, 20% golden root, 15% chamomile, 15% licorice. Eleutherococcus extract was administered orally 25 drops. After a course of chemo- and radiation therapy in a group of 22 patients, dry epidermitis developed in 7 patients and leukopenia in 2 patients. Before the end of the course, in the control group, 6 people developed dry and 2 people developed wet epidermitis; special treatment was required, because of which the main treatment was interrupted. 3 patients had leukopenia, because the bone marrow of the spine also enters the affected area. After 3 months, 1 patient from the study group (22 people) and 3 patients from the control group (10 people) were hospitalized for rehabilitation for leukopenia

Thus, the application of the proposed method allows in most cases to prevent the occurrence of early and late complications in radiation and / or chemotherapy of cancer of various localization, thereby reducing the invasiveness of treatment.

Claims (15)

1. A method for the prevention and treatment of complications of radiation and / or chemotherapy of cancer of various localization, including preparing the patient for radiation and / or chemotherapy, performing local treatment of the skin and the mucous membranes of the organs exposed to chemo and / or radiation exposure with oil extracts of medicinal plants, the introduction of an immunomodulatory drug and an adsorbent during and after a course of radiation and / or chemotherapy, characterized in that they additionally carry out the oral administration of the tread sb ora, which is composed of compatible pharmacopoeial medicinal plants, selected with the possibility of their combined protective effect on the diseased tissues of the diseased organ and on the tissues of all healthy organs that fall into the zone of chemo- and / or radiation exposure, while as an immunomodulating drug and adsorbent use respectively plant adaptogen and plant adsorbent; the introduction of the collection, adaptogen and adsorbent begins during the preparation of the patient for chemo and / or radiation therapy, and during the course of chemo and / or radiation therapy they are administered daily, with local treatment of the skin and mucous membranes after each radiation session and / or chemotherapy, and the introduction of the collection, plant adaptogen and plant adsorbent is carried out in therapeutic doses, with intervals between the introduction of each of them. 2. The method according to claim 1, characterized in that during radiation therapy for cancer of any of the pelvic organs, a collection containing components in the following ratio, wt.%: chamomile 10-20 yarrow 20-25 plantain 10-20 bearberry 15-25 St. John's wort 20-25 licorice 10-15 3. The method according to claim 1, characterized in that for lung cancer as a tread collection, a collection containing components is used in the following ratio, wt.%: eucalyptus 15-20 elecampane 15-20 licorice 20-25 thyme 20-25 chamomile 15-20 plantain 10-15 4. The method according to claim 1, characterized in that in breast cancer, as a tread collection, a collection containing components is used in the following ratio, wt.%: immortelle 20-25 milk thistle 10-20 Golden root 15-20 hodgepodge 10-20 chamomile 10-25 licorice 10-15 5. The method according to claim 1, characterized in that the alcohol extract of Eleutherococcus is used as a plant adaptogen. 6. The method according to claim 1, characterized in that as a plant adsorbent use a decoction of flax seeds, prepared at the rate of 1-2 tablespoons per glass of boiling water. 7. The method according to claim 1, characterized in that the oil extracts are selected from the group comprising extract of birch buds, fruit blossom extract. 8. The method according to claim 1, characterized in that the introduction of the collection, plant adaptogen and plant adsorbent begin 3-10 days before the start of radiation and / or chemotherapy. 9. The method according to claim 1, characterized in that the interval between the introduction of the tread collection and the extract of Eleutherococcus is 5-10 minutes 10. The method according to claim 1, characterized in that the adsorbent is administered at least 20 minutes after the introduction of tread collection and plant adaptogen. 11. The method according to claim 1, characterized in that the plants for sacrificial collections are pre-dried, ground to a particle size of 1.5-2.5 mm, mixed in the indicated proportions and compressed by compression in a single dose, mainly 2 g per 1 tablet. 12. The method according to claim 1, characterized in that the tread collection is administered in the form of a decoction in a single dose of 1 tablet per 1 glass of boiling water, 2 times a day 20-30 minutes before eating. 13. The method according to claim 5, characterized in that the alcohol extract of Eleutherococcus is administered in a single dose of 15-25 drops 2 times a day. 14. The method according to claim 6, characterized in that a decoction of flax seeds is administered 1-2 tablespoons at least three times a day. 15. The method according to claim 1, characterized in that the introduction of tread collection, plant adaptogen and plant adsorbent in half doses 1-3 months after the end of the course of radiation and / or chemotherapy is continued.