RU2317819C2 - Фармацевтическая композиция для применения в терапии злокачественных новообразований, включающая комбинацию бифосфоната, ингибитора сох-2 и таксола - Google Patents
Фармацевтическая композиция для применения в терапии злокачественных новообразований, включающая комбинацию бифосфоната, ингибитора сох-2 и таксола Download PDFInfo
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- RU2317819C2 RU2317819C2 RU2004115337/15A RU2004115337A RU2317819C2 RU 2317819 C2 RU2317819 C2 RU 2317819C2 RU 2004115337/15 A RU2004115337/15 A RU 2004115337/15A RU 2004115337 A RU2004115337 A RU 2004115337A RU 2317819 C2 RU2317819 C2 RU 2317819C2
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- Prior art keywords
- cox
- inhibitor
- phenyl
- methylsulfonyl
- bisphosphonate
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Classifications
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
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- A61K31/66—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US34592101P | 2001-10-19 | 2001-10-19 | |
| US60/345,921 | 2001-10-19 |
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| RU2004115337A RU2004115337A (ru) | 2005-04-20 |
| RU2317819C2 true RU2317819C2 (ru) | 2008-02-27 |
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| RU2004115337/15A RU2317819C2 (ru) | 2001-10-19 | 2002-10-18 | Фармацевтическая композиция для применения в терапии злокачественных новообразований, включающая комбинацию бифосфоната, ингибитора сох-2 и таксола |
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|---|---|
| US (1) | US7345088B2 (enExample) |
| EP (1) | EP1443942B1 (enExample) |
| JP (1) | JP2005506371A (enExample) |
| KR (1) | KR20040066103A (enExample) |
| CN (1) | CN100372539C (enExample) |
| AT (1) | ATE382347T1 (enExample) |
| AU (1) | AU2002363089B2 (enExample) |
| BR (1) | BR0213410A (enExample) |
| CA (1) | CA2461085A1 (enExample) |
| CO (1) | CO5570672A2 (enExample) |
| DE (1) | DE60224429T2 (enExample) |
| DK (1) | DK1443942T3 (enExample) |
| EC (1) | ECSP045054A (enExample) |
| ES (1) | ES2301710T3 (enExample) |
| HU (1) | HUP0402061A3 (enExample) |
| IL (2) | IL161090A0 (enExample) |
| MX (1) | MXPA04003671A (enExample) |
| NO (1) | NO20042056L (enExample) |
| NZ (1) | NZ532282A (enExample) |
| PL (1) | PL367707A1 (enExample) |
| PT (1) | PT1443942E (enExample) |
| RU (1) | RU2317819C2 (enExample) |
| SI (1) | SI1443942T1 (enExample) |
| WO (1) | WO2003035081A1 (enExample) |
| ZA (1) | ZA200402089B (enExample) |
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| GB0204756D0 (en) * | 2002-02-28 | 2002-04-17 | Novartis Ag | Organic compounds |
| GB0328040D0 (en) * | 2003-12-03 | 2004-01-07 | Coleman Robert E | Pharmaceutical uses of bisphosphonates |
| FR2939314A1 (fr) * | 2008-12-04 | 2010-06-11 | Univ Victor Segalen Bordeaux 2 | Nouvelles compositions et methodes pour la potentialisation des signaux d'apoptose dans les cellules tumorales |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| KR101813728B1 (ko) * | 2009-07-31 | 2017-12-29 | 그뤼넨탈 게엠베하 | 결정화 방법 및 생체이용률 |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
Citations (2)
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| WO2000038730A2 (en) * | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Use of a cyclooxygenase-2 inhibitor and one or more antineoplastic agents for combination therapy in neoplasia |
| WO2001054688A1 (en) * | 2000-01-28 | 2001-08-02 | Merck & Co., Inc. | Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug |
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| CN1187130A (zh) * | 1995-06-06 | 1998-07-08 | 麦克公司 | 用二磷酸盐预防与免疫抑制疗法有关的骨损失 |
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2002
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- 2002-10-18 CA CA002461085A patent/CA2461085A1/en not_active Abandoned
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- 2002-10-18 PT PT02801899T patent/PT1443942E/pt unknown
- 2002-10-18 RU RU2004115337/15A patent/RU2317819C2/ru not_active IP Right Cessation
- 2002-10-18 NZ NZ532282A patent/NZ532282A/en unknown
- 2002-10-18 JP JP2003537648A patent/JP2005506371A/ja active Pending
- 2002-10-18 AU AU2002363089A patent/AU2002363089B2/en not_active Ceased
- 2002-10-18 US US10/493,042 patent/US7345088B2/en not_active Expired - Fee Related
- 2002-10-18 DE DE60224429T patent/DE60224429T2/de not_active Expired - Fee Related
- 2002-10-18 MX MXPA04003671A patent/MXPA04003671A/es active IP Right Grant
- 2002-10-18 IL IL16109002A patent/IL161090A0/xx unknown
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- 2002-10-18 AT AT02801899T patent/ATE382347T1/de not_active IP Right Cessation
- 2002-10-18 DK DK02801899T patent/DK1443942T3/da active
- 2002-10-18 KR KR10-2004-7005630A patent/KR20040066103A/ko not_active Ceased
- 2002-10-18 ES ES02801899T patent/ES2301710T3/es not_active Expired - Lifetime
- 2002-10-18 WO PCT/EP2002/011696 patent/WO2003035081A1/en not_active Ceased
- 2002-10-18 BR BR0213410-1A patent/BR0213410A/pt not_active IP Right Cessation
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2004
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- 2004-03-25 IL IL161090A patent/IL161090A/en not_active IP Right Cessation
- 2004-04-08 EC EC2004005054A patent/ECSP045054A/es unknown
- 2004-04-15 CO CO04034537A patent/CO5570672A2/es not_active Application Discontinuation
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000038730A2 (en) * | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Use of a cyclooxygenase-2 inhibitor and one or more antineoplastic agents for combination therapy in neoplasia |
| WO2001054688A1 (en) * | 2000-01-28 | 2001-08-02 | Merck & Co., Inc. | Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug |
Non-Patent Citations (1)
| Title |
|---|
| SENARATNE S.G. et al. Bisphosphonates induce apoptosis in human breast cancer cell lines. Br. J. Cancer. 2000 Apr.; 82(8):1459-68, реферат. JAGDEV S.P. et al. The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel. Br. J. Cancer. 2001 Apr. 20; 84(8):1126-34, реферат. ARIEL F. SORIANO et al. Synergetic effect of new chemopreventive agents and convectional cytotoxyc agents against human lung cancer cell lines. Canser research 59, 6178-6184, December 15, 1999. * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL161090A0 (en) | 2004-08-31 |
| PT1443942E (pt) | 2008-04-07 |
| SI1443942T1 (sl) | 2008-08-31 |
| ECSP045054A (es) | 2004-05-28 |
| HUP0402061A3 (en) | 2007-05-29 |
| NZ532282A (en) | 2006-02-24 |
| DK1443942T3 (da) | 2008-05-19 |
| CN100372539C (zh) | 2008-03-05 |
| WO2003035081A1 (en) | 2003-05-01 |
| HK1080733A1 (en) | 2006-05-04 |
| CO5570672A2 (es) | 2005-10-31 |
| HUP0402061A2 (hu) | 2005-02-28 |
| NO20042056L (no) | 2004-05-18 |
| CN1703226A (zh) | 2005-11-30 |
| KR20040066103A (ko) | 2004-07-23 |
| BR0213410A (pt) | 2004-11-03 |
| DE60224429D1 (de) | 2008-02-14 |
| DE60224429T2 (de) | 2008-12-18 |
| ES2301710T3 (es) | 2008-07-01 |
| MXPA04003671A (es) | 2005-06-20 |
| IL161090A (en) | 2010-04-15 |
| ZA200402089B (en) | 2005-06-22 |
| CA2461085A1 (en) | 2003-05-01 |
| ATE382347T1 (de) | 2008-01-15 |
| PL367707A1 (en) | 2005-03-07 |
| AU2002363089B2 (en) | 2006-02-16 |
| EP1443942B1 (en) | 2008-01-02 |
| EP1443942A1 (en) | 2004-08-11 |
| US20050014726A1 (en) | 2005-01-20 |
| US7345088B2 (en) | 2008-03-18 |
| RU2004115337A (ru) | 2005-04-20 |
| JP2005506371A (ja) | 2005-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20091019 |