RU2313352C2 - Method for treating purulent-necrotic wounds - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: the innovation in question deals with treating purulent-necrotic wounds due to adding 100 ml physiological solution into 25 ml xenosplenic homogenate to be mixed, decanted and centrifuged at 1500 rotations. Then it is important to mix the obtained supernatant liquid and 3 ml 100%-dimexid to apply the obtained curative mixture onto a filter cloth at 1 ml mixture/sq. cm wound surface area followed by fulfilling applications of a gauze filter cloth impregnated with the above-mentioned curative mixture onto a wound's purulent-necrotic surface once daily. The innovation enables to improve preparation's permeability into tissues and accelerates wound healing.

EFFECT: higher efficiency of therapy.

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Description

The invention relates to medicine, in particular to surgery, can be used to treat purulent necrotic wounds.

An analogue of the invention is the use of xenosepleen homogenate for the treatment of purulent wounds (Method for the treatment of purulent wounds. Patent SU 1801488 A1, co-author S.Yu. Safarov, M.A. Aliyev). The xenosplenic homogenate accelerates the purification of a purulent wound from toxic infectious agents, metabolic products and purulent-necrotic masses, and accelerates the granulation and epithelization of wounds, increasing local immunity. The disadvantage of analogues is that the xenosplenic homogenate weakly affects the deep sections of the purulent wound and enhances the pain syndrome in the wound.

It is known that the drug dimexide has the ability to quickly penetrate through biological membranes, mucous membranes, the membrane of microbes, improving the transportation of a number of drugs through them (V.V. Schetinin, E.A. Dimexide also has analgesic, anti-inflammatory (Balabanova P.M., Mach E.S., Astakhova T.A.), antiseptic and fibrinolytic properties (Khabirov F.A., Bilyalova G.Z.). In plastic surgery, the drug is used to preserve skin homotransplants (M.D. Mashkovsky, Medicines).

As a prototype of the proposed method for the treatment of purulent-necrotic wounds, a method for treating purulent wounds according to the patent for invention SU 1801488 A1, 03/15/93, et al. S.Yu.Safarov, M.A. Aliyev, according to which the essence of the method is as follows.

The spleen is taken in a meat processing plant immediately after slaughtering a pig in compliance with asepsis. After washing the vascular bed of the spleen with cold saline to clean water in a special container, they are taken to the clinic, where after decapsulation, its pulp is cut into pieces, ground in a mortar to obtain a cell mass used to apply purulent wounds and trophic ulcers. This achieves an increase in local immunity, accelerated cleansing of the wound surface from toxic infectious agents, metabolic products, and stimulates the development of granulation and epithelization of wounds. The disadvantages of the prototype include the fact that the xenosplenic homogenate does not affect the underlying infected layers, causes an increase in the pain syndrome, possibly due to its drying out or other local action of the drug.

The aim of the invention is to accelerate the healing of purulent-necrotic wounds. This goal is achieved by exposure to an xenosplenic extract, which has immunogenic properties in combination with dimexide, an anti-inflammatory, antimicrobial, anti-edematous drug, which also freely penetrates through cell membranes and microbial membranes, carrying medicinal and biologically active substances deep into cells and tissues.

SUMMARY OF THE INVENTION

The invention consists in the following.

The xeno-spleen homogenate is used, while the treatment mixture is prepared as follows: 100 ml of physiological saline is added to 25 ml of the xeno-spleen homogenate, mixed, decanted and centrifuged at 1500 rpm, the resulting supernatant is mixed with 3 ml of 100% dimexide, the resulting treatment mixture is applied to a tissue from calculating 1 ml of the mixture per 1 cm ^{2 of the} area of the wound surface, make an application on the purulent-necrotic surface of the wound of a gauze cloth soaked in the treatment mixture, once a day every day, the course of treatment with puts from 3 to 7 days.

Every day, once a day, on the purulent-necrotic surface of the wound, an application is made with a gauze napkin, abundantly soaked with a therapeutic mixture consisting of xenosepleen extract and dimexide at the rate of 1 ml of mixture per 1 cm ^{2 of} the wound surface. The course of treatment averages from 3 to 7 days, at which the abscess is cleansed and the wound surface decreases.

The therapeutic mixture is prepared as follows.

The spleen is taken in a meat factory with aseptic compliance, then it is placed in a sterile container and delivered to the clinic, where after washing the vascular bed from the blood, decapsulation and fragmentation, the pulp is passed through a sterile meat grinder. 100 ml of physiological saline are added to 25 ml of the resulting xenosplenic mass, mixed, decanted and centrifuged at 1500 rpm for 30 minutes. The resulting supernatant is mixed with 3 ml of 100% dimexide, so that a treatment mixture is obtained. The resulting treatment mixture is stored in the refrigerator at a temperature of +2 to + 4 ° C for up to 5 days. The source material (pig spleen) passes sanitary and veterinary control, the spleen is taken immediately after the slaughter of the pig.

An example of the clinical application of the method.

Example 1. Patient Magomedgadzhiev MA, born in 1957, was admitted to the Republican Coloproctology Department on June 12, 2004 with a diagnosis of Acute horseshoe-shaped ischiorectal suppurative paraproctitis. On the same day, the operation is an autopsy of paraproctitis, sagging and necrectomy. Despite an adequate autopsy, local treatment with traditional methods (Vishnevsky ointment, levomekol) did not provide for cleansing the abscess of the necrotic masses, the treatment was ineffective and long. In connection with this, on June 19, 2004, daily injections of gauze napkins moistened with a medical mixture of xenoseplenic extract and dimexide into the purulent cavity were started. Three days after this, the abscess cavity was mostly cleansed of necrotic masses, there were signs of granulation, hyperemia and perifocal edema decreased, and the pain syndrome stopped from the first day. On the fifth day after the start of treatment by the proposed method, the depth of the abscess cavity decreased, which allowed the patient to be discharged for outpatient treatment.

Example 2. Patient Kulchitsky F.F., born in 1974, was admitted to the hospital on October 25, 2004 with a diagnosis of Abscess of the epithelial-coccygeal passage. Diabetes mellitus, type 1, moderate. 10/25/2004, after a short preoperative preparation, an abscess and sagging in the gluteal region were opened, necrectomy. Due to the weak effect of the treatment with conventional methods, from 02.11.2004, gauze napkins soaked in a treatment mixture of xenosepleenza extract and dimexide were introduced into the abscess cavity. 3-5 days after the start of treatment according to the proposed method, the purulent surface almost cleared of detrital masses, there were traces of granulation, the wound surface turned pink, in places contact bleeding, perifocal edema and hyperemia significantly decreased. By November 9, 2004, the abscess was completely cleansed of purulent-necrotic masses, it began to fill with granulation tissue, marginal epithelization appeared and the patient was discharged for outpatient treatment.

The combination of xenosplenic extract and dimexide provides a mutually potent effect.

The usefulness of the proposed method:

The method allows to increase the efficiency of treatment of purulent-necrotic wounds: by 30%, sometimes and by 50%, the time for cleansing and healing of the wound surface is reduced due to the pronounced anti-inflammatory and antiseptic effect of the drug, increasing local immunity and stimulating the regenerative process. In a relatively short time, local processes that were difficult to treat with conventional methods were closed. Consequently, the need to saturate the body with drugs has disappeared. It is obvious that the combination of xenospleenica extract and dimexide provides a mutually potentizing effect.

The terms of treatment of purulent-necrotic wounds by reorganization and activation of regenerative processes in the wound are reduced.

Claims (1)

A method for treating purulent-necrotic wounds, including the use of xenosepleen homogenate, characterized in that the treatment mixture is prepared as follows: 100 ml of physiological saline are added to 25 ml of xenosepleen homogenate, mixed, decanted and centrifuged at 1500 rpm, the resulting supernatant is mixed with 3 ml of 100 % dimexide, the resulting treatment mixture is applied to a napkin at the rate of 1 ml of mixture per 1 cm ^{2 of} the wound surface, an application is made of a purulent-necrotic surface of the wound with a gauze napkin Ki impregnated with the treatment mixture daily once a day, the course of treatment is from 3 to 7 days.