RU2311891C1 - Experimental biological clinic - Google Patents

Abstract

FIELD: medical engineering.

SUBSTANCE: clinic has pre-barrier zone room, feed-through transfer units, hygiene and sanitary barriers, and post-barrier zones. Some of them are exposed to overpressure action under standard air changes per hour.

EFFECT: higher reliability of barrier protection systems.

7 cl, 1 dwg

Description

The invention relates to medical, pharmaceutical and microbiological equipment.

The known design of the experimental biological clinic (hereinafter referred to as EBK). The disadvantage of this design is that it does not solve the complex problem presented to modern EBCs at the domestic and international level. Basically, this design is designed to work with conventional animals.

The closest technical solution is the design of the EBC, containing administrative premises, a reception area for animals, a service (dirty) area and an aseptic ("clean") area.

This technical solution has several disadvantages:

- there are no regulatory dividing sanitary-hygienic barriers for entry and exit from the barrier (aseptic) zone;

- there are no air locks blocking the barrier zone from the pre-barrier zone;

- there is no transfer gateway for transferring sterile feed and materials from one barrier zone to another;

- there is no provision for a common interzonal isolated room for the collection of waste removed from the premises for keeping animals from the barrier zone and their heat treatment;

- there are no isolated rooms for transferring animals to quarantine rooms;

- there are no autonomous barrier zones allowing simultaneous experimental work with both conventional and non-microbial (SPF) animals.

The essence of the EBC utility model is as follows - providing a high degree of reliability of the EBC barrier protection systems. This goal is achieved by the following technical solutions.

Separating sanitary-hygienic barriers are equipped with autonomous entrance sanitary inspection rooms, consisting of the following rooms located in series: an isolated room of a “clean” locker room, which is under excess pressure and the standard rate of air exchange of clean air created in it by regular EBC ventilation systems (supply and exhaust ventilation systems); an isolated room of an air lock providing protection of the barrier zone both from outside contamination and blocking of the internal air of the barrier zone due to the normative air exchange of clean air and its increased overpressure in relation to the air pressure inside the “clean” locker room and “clean” corridor .

In addition, the dividing sanitary-hygienic barriers of the ECB are equipped with exit sanitary inspection rooms, consisting of successively located rooms: an isolated locker room for removing “dirty” technological clothes under vacuum and standard air exchange of clean air; the isolated room of the air lock, which is under regulatory air exchange and excess pressure of clean air; shower rooms.

Between the "clean" corridors located at the entrance to the premises for keeping animals and quarantine and the "dirty" corridors located at the exit of the rooms for keeping animals and quarantine, isolated transitional vestibules-locks are made, while the pressure in them is less than in the "clean" corridors, but more rarefaction than in the "dirty" corridors. Transitional vestibules-locks ensure the normative orientation of human flows, localization of any contingency that occurs in the corridors and rooms of the EBC, perform the functions of additional barrier devices and compensators for pressure drops in the corridors and rooms of the EBC.

To clean the cells and collect waste coming from the barrier zones, separate, zonal, isolated rooms were made at the border between the dirty sink and the transition vestibule of the common corridor, interconnected by a common untreated waste room, inside of which in an isolated partition, on the border with the transition tambour of a common corridor; a plant for heat treatment of waste was mounted.

The EBC contains isolated rooms for transferring newly arrived animals to their quarantine rooms, located between the "dirty" quarantine corridors and the "clean" animal quarantine rooms, while the rarefaction in the rooms for transferring animals is less than in the border with them "dirty" quarantine corridors. The EBK is additionally equipped with an interzonal transfer lock installed in the partition between the temporary storage room for sterile feed and materials of one barrier zone and the “clean” corridor with an arc of the barrier zone.

The provision of sterile food, bedding, cages and other materials of both autonomous barrier zones has become possible from one common room for temporary storage of sterile food and materials of the barrier zone. The areas of "clean" locker rooms of autonomous entrance sanitary inspection rooms are divided into two parts by transverse separation-barrier benches, one for removing transitional clothes, and the other for putting on clean technological clothes, while the height of the separation-barrier benches prevents them from overstepping. The drawing shows a plan of a General view of the experimental biological clinic. The premises of the experimental biological clinic are divided into three zones.

I. Autonomous dividing sanitary-hygienic barriers containing:

Common areas:

- a wardrobe room for outerwear 1, toilets 2, locker rooms for home and transitional clothes 3, a transitional room 4, showers 5.

Autonomous premises:

- for one autonomous separation sanitary-hygienic barrier: the premises of the “clean” locker room 6 with the separation barrier 63, the air lock 7, the locker room for removing “dirty” technological clothing 18, the air lock 19, the shower room 20;

- for another autonomous separation sanitary-hygienic barrier: the premises of the “clean” locker room 22 with the transverse separation and barrier bench 63, the air lock 23, the locker room for removing “dirty” technological clothes 36, the air lock 37, the shower room 38.

II. A pre-barrier zone (“dirty”), containing: rooms for cleaning the cells and collecting waste 31 and 41, a transitional vestibule of the common corridor 40, a dirty washing room 42, a laundry room 43, a room for transmitting devices 44 with passage autoclaves 58 and 59 and a transfer a lock 60, an untreated waste room 45, equipped with a waste heat treatment plant 61, a common corridor 46 room, a locker room for workers in the pre-barrier zone 47, a toilet room 48, a shower room 49, a warehouse for temporary storage treated waste 50 with a refrigerator for storing treated animal bodies 62, premises for storing feed, bedding, cages, disinfectants, work clothing and other materials 51, an entrance hall 52, a room for receiving animals 53, administrative rooms 54, a toilet room 55, premises of power plants 56, premises of standard ventilation units 57.

III. Barrier (aseptic) zones containing:

- for one autonomous barrier zone: premises of a “clean” corridor 8, rooms for keeping animals 9, rooms for handling 10, rooms for quarantine animals 11, rooms for transferring animals 12, temporary storage of sterile feed, bedding, cages and other materials 13, room transitional vestibule-gateway 14, the premises of the "dirty" corridor 15, the premises of the "dirty" quarantine corridor 16, the premises of the transitional vestibule-gateway 17, the premises of the "dirty" corridor 17A, the storage room for cleaning equipment 21;

- for another autonomous barrier zone: the premises of the “clean” corridor 25 with the interzonal transfer lock 24, the premises for keeping animals 26, the rooms for the handling 27, the rooms for transferring animals 28, the premises for quarantine animals 29, the transitional vestibule-lock 30, the “dirty” corridor quarantine 32, “dirty” corridor 33, transitional vestibule-lock 34, “dirty” corridor 35, storage room for cleaning equipment 39.

The principle of the EBC is as follows. Entrance and exit of working and maintenance personnel to the premises of the ECB barrier zone is carried out through the premises of the sanitary and hygienic separation barriers. The passage of personnel through the premises of one of the autonomous entrance sanitary inspection rooms is carried out in the following sequence - 1 → 3 → 4 → 6 → 7 → 8; the passage of personnel through the premises of another input autonomous sanitary inspection room - 1 → 3 → 4 → 22 → 23 → 25. The personnel exit from autonomous barrier zones through the sanitary inspection rooms and is carried out in the following sequence, through one of them 17A → 18 → 19 → 20 → 4 → 3, through the other - 35 → 36 → 37 → 38 → 4 → 3.

The sequence of personnel performing transitional and clean technological clothing dressing operations is as follows: in a “clean” locker room, personnel removes transitional clothes, sits on a separation-barrier bench, removes transitional shoes, throws their legs to the other side of the bench, changes into clean technological shoes, and then changes clothes in clean technological clothes.

All “clean” rooms and “clean” corridors of the barrier zone are under excess pressure and the norm of air exchange of clean air, and “dirty” rooms and “dirty” corridors are under vacuum, which ensures reliability of cleanliness of the premises for keeping animals and quarantine and at the same time environmental protection from possible emissions and unpleasant odors.

The movement of working personnel and material flows inside the EBC barrier zone is strictly unidirectional - from “clean” rooms to “dirty” ones. Counterflow - not permissible.

Dirty process clothing is washed in laundry room 43 and sterilized in autoclave 59.

Fodder, bedding, cages, technological clothes and other materials transferred to the premises of the barrier zone from storage rooms 51 of the pre-barrier zone undergo sterilizing heat treatment in the passage of the autoclave 58, after which they are transferred to room 13 for temporary storage of a three-day supply. From room 13, sterile feed and other materials, according to the schedule, are transferred to animals and quarantine rooms through the “clean” corridor 8. In similar rooms of the neighboring autonomous barrier zone, sterile feed and materials are transferred through the interzonal transfer lock 24 directly to the “clean” corridor 25 .

Wastes coming from the barrier zone are to be incinerated in incineration chambers, having previously undergone heat treatment in installation 61.

All cells coming from the barrier zones are cleaned of waste in rooms 31 or 41, from where the cells go to the sink in room 42, and the untreated waste from them is transferred to room 45. From room 45, the waste goes to installation 61 for heat treatment, and then to the room their temporary storage 50. Heat-treated animal corpses are stored separately in the refrigerator compartment 62, installed in the warehouse 50.

Animals that enter the EBC from nurseries are accepted indoors 53.

Animals enter the “clean” quarantine rooms 11 and 29 through animal transfer rooms 12 and 28.

The proposed design of the experimental biological clinic will find application in the medical, pharmaceutical and microbiological industries. A comprehensive technical solution allows for simultaneous work with both conventional and microbial (SPF) laboratory animals in autonomous barrier zones of EBCs.

Claims (7)

1. Experimental-biological clinic (EBC), containing the premises of the pre-barrier zone, the premises of regular ventilation systems, the premises of transmission devices with passage autoclaves, the premises of sanitary-hygienic barriers, the rooms of locker rooms, the premises of barrier zones, the premises of “dirty” and “clean” corridors , characterized in that to ensure a high degree of reliability of the barrier systems of EBC, the separation sanitary-hygienic barriers are equipped with entrance sanitary inspection rooms, consisting of a sequence of but located Improvement: isolated room "pure" cloakrooms, under overpressure and regulatory multiplicity of ventilation of clean air generated therein by regular ventilation systems; an isolated room of an air lock with a standard rate of air exchange and an excess pressure of clean air, the value of which is greater than in the premises of the "clean" locker room and the "clean" corridor of the barrier zone. 2. EBC according to claim 1, characterized in that the dividing sanitary-hygienic barriers are equipped with exit sanitary inspection rooms, consisting of successively located rooms: an isolated locker room for removing “dirty” technological clothes and under clean air and normative air exchange; an isolated room of an air lock with a standard rate of air exchange and clean air under excess pressure; shower rooms. 3. EBC according to claim 1, characterized in that the "clean" and "dirty" corridors are equipped with transitional vestibules, which serve as additional barrier devices and compensators for pressure drops in the corridors and premises of the EBC barrier zone. 4. EBC according to claim 1, characterized in that the EBC is additionally equipped with an interzonal transfer gateway installed in the partition between the temporary storage room for sterile feed and materials of one barrier zone and the “clean” corridor of another barrier zone. 5. EBC according to claim 1, characterized in that for cleaning the cells and collecting waste coming from the barrier zones, at the border between the “dirty” sink and the transitional vestibule from the common corridor, separate, zoned, isolated rooms are combined, interconnected by an untreated room waste, inside of which in an isolated partition, on the border with the transitional vestibule from a common corridor, a plant for heat treatment of waste was mounted. 6. EBC according to claim 1, characterized in that the ESC further comprises isolated rooms for transferring animals to their quarantine rooms, located between the "dirty" quarantine corridors and the "clean" rooms for quarantine animals, while the amount of vacuum inside the premises for transfer there are fewer animals than in the “dirty” quarantine corridors bordering with them. 7. EBC according to claim 1, characterized in that the area of the "clean" locker room of the entrance sanitary inspection room is divided into two parts by the transverse separation and barrier bench, one to remove transitional clothing, and the other to put on clean technological clothing, while the height of the transverse separation barrier bench prevents its free stepping.