RU2307657C2 - Method for treating patients for orl- organs inflammatory diseases - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves making use of 0.5-2% aqueous colloid silver solutions. The solutions combine silver and polyvinylpyrrolidon with 7-8% of silver and 92-93% of polyvinylpyrrolidon. The solutions are also usable in preparing water-soluble polymer gels.

EFFECT: enhanced effectiveness of treatment with greater total contact surface acting upon pathogenic flora; high silver introduction rate in pathological focus; no allergic responses observed.

Description

The invention relates to medicine, in particular to the treatment of inflammatory diseases of the nasopharynx: rhinopharyngitis, adenoiditis, sinusitis, granular pharyngitis, chronic tonsillitis, and otitis media.

The presence of the pharyngeal tonsil is a feature of childhood. About 65% of children under 7 years of age suffer from chronic adenoiditis, since the pharyngeal tonsil belongs to the peripheral organs of the immune system. Traditional surgical treatment (adenomotomy) is not always justified, since nasal breathing improves, but the state of local immunity does not improve, there are relapses of adenoid vegetation, side effects are noted, in particular, in the form of a neurotic child. The prevalence of chronic pathology of ENT organs in childhood determines the frequency and severity of chronic diseases of the adult population with all the consequences, including economic ones.

Known methods of treating inflammatory diseases of ENT organs, as a rule, are complex and include antibacterial, antihistamine, mucoregulatory, immunomodelling therapy, physiotherapy and biologics. This requires the use of various antiseptic drugs, which are often ineffective due to the low antimicrobial activity, the mismatch of the spectrum of the drug to the nature of the microflora of the inflammatory focus, and also due to the resistance of microorganisms to antibacterial agents.

As you know, silver preparations have high antiseptic activity and have a wide spectrum of antibacterial action. There are many different combinations using different forms and silver compounds.

For example, "Therapeutic agent", protected by RF patent No. 2172180, containing recombinant interferon, silver nitrate and aluminum hydroxide gel / 1 /.

The disadvantage of drugs containing AgNO ₃ is their high sensitivity to various inactivating factors. In particular, high sensitivity to the action of light. They readily react with the formation of inactive compounds, for example, with chlorine ions, which is always present in biological media, forms inactive silver chloride.

Closest to the proposed is a method of treating inflammatory diseases of ENT organs using aqueous solutions of stabilized colloidal silver, for example protargol, which is colloidal silver stabilized by gelatin. / Reference "Medicines. Properties. Applications. Contraindications" edited by M.A. Klyuev. Krasnoyarsk, "Grotesque", 1993, p.362 / 2 /.

The disadvantages of using protargol include side effects in the form of allergic reactions caused by the stabilizer, and insufficient therapeutic effect.

The objective of the invention is to provide a more effective method of treating inflammatory diseases of ENT organs using silver preparations.

The problem was achieved using both alone and in the complex treatment of 0.5-2% aqueous solutions or solutions of water-polymer gels of a complex of colloidal silver with polyvinylpyrrolidone (PVP), in which silver is 7-8%, polyvylpyrrolidone 92-93%.

The proposed method of treatment using a complex of colloidal silver with polyvinylpyrrolidone in the specified ratio of the components showed high efficiency due to the fact that the preferred particle size of silver is 10-15 Å, while in the closest particle size preparation, protargol has an average particle size of 25- 30 Å or more.

It is known that silver particles less than 20 Å have unique physicochemical and biological properties. They have a large total surface, which contributes to maximum contact with pathogenic microflora. In addition, they have a low silver ionization potential, which ensures a rather high rate of silver entry into the medium, and therefore its high efficiency. / Yu.P. Petrov, - Physics of Small Particles, M., Nauka, 1982./3/.

Another advantage of the proposed tool over protargol is that the stabilizer polyvinylpyrrolidone has detoxifying properties, which helps to reduce the toxic load on the body.

A solution of a complex of colloidal silver with polyvinylpyrrolidone in the claimed concentration does not cause dryness of the mucosa, which is important for prolonged use to normalize the physiological functions of the nose.

The effectiveness of the proposed method of treatment is confirmed by the following examples.

Example 1

Patient L., 4 years old, turned to the ENT office complaining of difficulty in nasal breathing, snoring in a dream.

During the examination, the diagnosis was established: hypertrophy of II-III degree adenoids, chronic adenoiditis, OIVDP (Acute upper respiratory tract infection).

The complex of therapeutic measures included local anti-inflammatory treatment by washing the nasopharynx with 0.5% aqueous solution of stabilized PVP colloidal silver, 200 ml per procedure. A total of 6 washes were carried out by moving along Proetz using an electric pump at low negative pressure.

After the course, the swelling of the nasal mucosa decreased, no signs of inflammation of the dome of the nasopharynx were observed, pathological content in the mucus was not found, the production of mucus was reduced, adenoids decreased in size to I-II degree. The general condition of the patient is satisfactory.

To maintain stability, it is recommended to continue the course of treatment with the drug 5 drops in the nose 3 times a day while taking antihistamines and homeopathic medicines for 2-3 weeks.

Example 2

Patient T., 9 years old, suffers from chronic tonsillitis from 6 years. The patient turned to the ENT office during an exacerbation of a chronic disease. As a result of a laboratory study of a nasopharyngeal swab, Staphylococc aureus grade III was found in combination with Streptococc pyogenus grade III.

Against the background of general and physiotherapy with a laser, a tonsil washing course was prescribed with a 0.5% aqueous solution of colloidal silver stabilized by PVP, 100 ml per procedure. A total of 6 procedures were performed.

After a course of washing, the tonsils decreased in volume, became clean, hyperemia and swelling of the arches disappeared, and the lymph nodes in the cervix decreased. The general condition of the patient in the observed period improved: fatigue decreased, pain and sore throat disappeared. The presence of Staphylococc aureus II degree was found in the control smear from the pharynx, therefore, to completely cleanse the pharynx from it, it is recommended at home to lubricate the tonsils with a 1% solution of a substance containing PVP stabilized colloidal silver during the week and take immunomodulators. After that, the smear on the pathogenic flora is negative.

It is recommended at home to lubricate the tonsils with a 1% solution of colloidal silver stabilized by PVP during the week and take immunomodulators.

Example 3

Patient M., 5 years old, turned to the ENT office on the fifth day of the disease with complaints of headache, difficulty in nasal breathing, weakness, low-grade fever, poor sleep and appetite.

Based on the data of examination, R-graphy and laboratory tests, a diagnosis of the disease is established - catarrhal sinusitis.

Inspection data: severe swelling of the nasal mucosa. X-ray of the paranasal sinuses: swelling of the mucosa of the maxillary sinuses and ethmoid labyrinth cells.

Smear on the microflora from the nose: Streptococus pyogenus III degree isolated.

The patient was prescribed antibiotic therapy: Amoxiclav suspension 125 mg 3 times a day, 7 days.

Local treatment was carried out using 1% aqueous solution of colloidal silver, stabilized by PVP, 75 ml by washing the nasopharynx 5 times with Proetz transfer method. Vasodilators in the nose, laser therapy of the nasal cavity and pharynx, biologically active points were also prescribed.

As a result of complex therapeutic treatment, the duration of recovery was reduced from 14 to 7 days. Clinical recovery was confirmed by the absence of complaints from the patient, normalization of the rhinoscopic picture: no pathological flora was found in the smear from the nasopharynx.

Example 4

Patient V., 10 years old, suffers from chronic external otitis media for 2 years. I went to the ENT office with a diagnosis of recurrent otitis externa.

On examination: a boil in the left ear canal. The patient's condition is satisfactory. Complaints of pain in the left ear, aggravated by chewing and swallowing.

Treatment: under local anesthesia of a 10% lidocaine solution, a boil was opened. Ear toilet with a 2% solution of H ₂ O ₂ , turunda with a 2% aqueous solution of colloidal silver, stabilized by PVP. Laser therapy of the left ear cavities was carried out, autohemotherapy (excellin 1.0 once).

General condition improved on the 3rd day.

Example 5

Patient M., 6 years old, attends kindergarten for 2 years. History of frequent colds.

ChDB, chronic adenoiditis, hypertrophy of adenoids of the II degree, hypertrophy of tonsils of the II degree, granular pharyngitis.

Complains of difficulty in nasal breathing, dryness and sore throat in the morning, coughing, constantly breathing through the mouth, and snoring in a dream.

Along with generally accepted methods of treatment, the child was prescribed a course of local therapy with a 0.5% aqueous solution of stabilized colloidal silver, 3 drops 3 times a day, lying down and for quenching the posterior pharyngeal wall 1% solution 2 times a day, 10 days.

On the 5th day of treatment, improvement in nasal breathing was noted, a sore throat and coughing passed.

Objectively: the mucous membrane of the nasopharynx is pink, moist. Adenoids and tonsils decreased in volume. It is recommended to continue the course for up to 14 days with drugs of general strengthening effect: vitamin therapy and hardening for one month.

Example 6

Patient M., 14 years old, turned for prophylactic treatment of chronic tonsillitis. A history of two purulent sore throats, frequent colds. Objectively: tonsils are hypertrophied III degree, friable, scarred, on the tonsils pinpoint plaque, in the lacunae liquid pus. In a throat swab sown St. Pyogenus II degree and revealed fungal infection of the tonsils. Then tonsils were treated using the Tonsillor apparatus.

At the second stage of treatment for ultrasonic applications, a 2% solution of the colloidal silver composition with PVP in a gel of polyethylene oxide - 1500 was used. 10 sessions were performed. Tonsils cleared of pathological contents, decreased in volume. It is recommended to repeat the course of treatment after 6 months.

Thus, the complex of colloidal silver stabilized by PVP, having anti-inflammatory and astringent effects, reduces the volume of adenoids and inflammation, does not cause mucous dryness, optimizes treatment regimens, and can be recommended for treatment with long and repeated courses without the risk of the formation of multiresistant microorganisms.

Information sources

1. RF patent 2172180, MKI A61K 38/24 BI 23 (2001).

2. Reference "Medicines. Properties. Applications. Contraindications", ed. M.A. Klyueva. Krasnoyarsk, "Grotesque", 1993, p. 362.

3. Yu.P. Petrov. The physics of small particles. M., Science, 1982.

Claims (1)

A method of treating inflammatory diseases of ENT organs, characterized in that 0.5-2% aqueous solutions of colloidal silver are used in the form of a complex of silver and polyvinylpyrrolidone (PVP), in which silver is 7-8%, polyvinylpyrrolidone 92-93% or use these solutions in water-soluble polymer gels.