RU2297178C1 - Method for detecting human biological age - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: the present innovation is based upon measuring electroconductivity of skin parts of biologically active Su-points of twelve paired bel-meridians. In case of the first and the second variants one should detect biological age (BA) by the following formula:

where KB₀ in males is 8.38, and 3.63 in females. E_r0 and E_l0 in males are 36.33 and 35.91, and in females - 34.74 and 34.31; the values

in males correspond to 3.7 and 3.57, and in females - 4.0 and 3.84; E_r and E_l - mean arithmetic values of electroconductivity of right and left bel-meridians. Moreover, in case of the second variant human biological age should be estimated as mean arithmetic value of BA values of separate systems and organs not taking into consideration the BA values of systems and organs with pathological deviations.

EFFECT: higher accuracy of detection.

2 cl, 4 ex, 4 tbl

Description

The invention relates to medicine, namely to gerontology and geriatrics.

Currently, to determine the biological age (BV) of a person, many morphological, physiological, biochemical and mental tests have been proposed. All of them are practically in arbitrary combinations used by various schools according to the definition of BV (A. A. Podkolzin, V. N. Krutko, V. I. Dontsov and others. "Quantitative assessment of mortality, aging, life expectancy and biological age" methodical manual for doctors. M.: MGMSU, 2001, p.16).

The information content and quality of BV assessment using these tests largely depend on the following conditions.

The indicators used to determine BV should be highly correlated with calendar age (KB), change intensively and continuously with age so that differences between consecutive age groups can be detected. Tests should be independent of ongoing activities and the pathological processes that accompany aging (diseases should not mimic a change in BV). Testing should be safe, not tiring for the subject, simple for the experimenter, and not take much time.

During testing, a set of quantitative indicators (aging biomarkers) is recorded for each subject. Further, these indicators are mathematically processed using formulas obtained as a result of statistical data analysis (linear regression method).

A known method for determining the biological age of a person (RF patent No. 2228137, MKI 7 AB 5/16, application. 04.11.2002), which for the assessment of BV as biomarkers of aging uses anthropometric indicators, namely height, body weight, chest circumference on inhalation, chest circumference on exhalation, chest circumference on pause, chest excursion, lung capacity, compression force of the right hand, compression force of the left hand.

A significant drawback of this method is that it does not take into account the ever-increasing acceleration of development, which undoubtedly distorts its results.

The method of determining the aging rate (RF patent No. 2144381, MKI 7 AB 10/00, application. March 10, 1999), for the assessment of BV uses a battery of tests from the following physiological and neuropsychiatric indicators: stroke volume of the heart, index of the efficiency of the heart, vegetative index , general conjunctival index, systolic indicator, time of skin thermal restoration during a “cold” test, duration of spasm of skin vessels on norepinephrine, duration of breath holding after a deep breath, muscle strength of a hand, duration of statis matic balancing character - digital Wechsler test, questionnaires on their health self-assessment system.

Physiological tests, due to the age-related decline in the functions of a number of organs and systems, have ample opportunities for the selection of simple indicators characterizing BV. However, in many of them, indicators are used that vary significantly depending on the severity of pathological processes in people of the same age group. For example, in this method, the indicators "vegetative index" and "systolic indicator", which are calculated respectively on the basis of blood pressure and an electrocardiogram (ECG), are strongly affected by the severity of atherosclerosis for the examined people of old age. In addition, it is known that blood pressure indicators change substantially nonlinearly with age, and, therefore, estimating the biological age from this aging biomarker using the linear regression method will have serious errors.

Another way to determine the biological age of a person (RF patent No. 2102924, MKI 6 AB 5/16, application. 12.10.94) uses indicators of mental performance: short-term memory according to Muchnik-Smirnov, mental productivity according to Anfimov's tables, thinking (classification, interpretation of proverbs, selection of synonyms and antonyms, exclusion method, associative experiment), attention (Schulte-Platonov tables, tachistocopy).

The disadvantage of this method is that its results can be distorted due to the pronounced uneven nature of the aging of mental functions.

The considered methods for determining the biological age of a person and others currently operating are complex for the experimenter, require a lot of time, expensive special equipment and do not provide the required comfort conditions for the subjects. In addition, they do not allow you to see the whole picture of aging, reflect the process of age-related changes immediately in all the basic systems of the human body, using a single measurement scale. And this is of great importance not only for accurate integral assessment of BV, but also for identifying systems and organs with the highest degree of deterioration.

The objective of the invention is to develop a simple method for determining the biological age of a person based on indicators of electropuncture measurements, ensuring the speed of the procedure and calculating BV for both individual systems and the whole organism, increasing the accuracy of determining BV due to the breadth of coverage of body systems and excluding systems from calculation with pathological abnormalities, increasing the comfort of the procedure.

The technical result is achieved by the fact that in the proposed method, according to the invention, conduct electropuncture measurements at biologically active Su-points of paired byol-meridians, by applying an electric current of up to 10 μA on both hands to biologically active points: A9. I11 (7), E11 (6), L3 (5), D3 (5), H10, B1 (3), J6, F5, C35, K32, G69 (68), and when measuring the Su-points of the white meridians, located on one arm, for the right meridians use Su-points located on the index and middle fingers, and for the left meridians use Su-points located on the little finger and ring fingers, then determine the biological age by the formula:

where BV is the value of biological age,

E _n and E _l - arithmetic mean values of the electrical conductivity of the right and left byel-meridians of a particular person;

- статистические величины, вычисленные с помощью метода линейной регрессии, при этомKV ₀ , E _n0 and E _l0 ,

- statistical values calculated using the linear regression method, while

KV ₀ in men is 8.38, and in women is 3.63;

E _n0 and E _l0 in men are 36.33 and 35.91, and in women - 34.74 and 34.31;

у мужчин равны 3,7 и 3,57, а у женщин - 4,0 и 3,84.

in men they are equal to 3.7 and 3.57, and in women - 4.0 and 3.84.

Also, according to the invention, to increase the accuracy of the method, the biological age of individual systems and organs is preliminarily determined, while in men:

for the respiratory system:

for the large intestine:

for the stomach

for the pancreas:

for spleen:

for heart:

for the small intestine:

for the genitourinary system:

for the kidneys:

for the vascular system:

for the endocrine system:

for gall bladder:

for the liver:

and in women:

for the respiratory system:

for the large intestine:

for the stomach:

for the pancreas:

for spleen:

for heart:

for the small intestine:

for the genitourinary system:

for the kidneys:

for the vascular system:

for the endocrine system:

for gall bladder:

for the liver:

where _{n n} , _{л l} are the electrical conductivities of the corresponding byel meridians,

then determine the biological age of the body, as the arithmetic average of the values of the biological ages of individual systems and organs, not taking into account the values of the biological ages of systems or organs with pathological deviations.

Thanks to the method described above, it is possible to quickly obtain electropuncture indices and, based on them, it is possible to accurately determine the biological age, taking into account gender, both the whole organism and its individual systems and organs. The method can be used in the practice of medical, health and gerontological centers, rehabilitation departments of the sanatorium-resort profile.

The method is as follows.

Using the device for electropunctural testing, the electrical conductivity of the skin areas is measured, which are projections of biologically active Su points of twelve pair of white meridians.

Measured biologically active points (BAPs) of Bel-Meridians have the following information and functional connections with classical Meridians and body systems (organs): A9 - with the Meridian of the lungs and respiratory system; I11 (7) - with the pericardial meridian and the vascular system; E11 (6) - with the meridian of the heart and heart; L3 (5) - with the meridian of the liver and liver; D3 (5) - with the meridian of the pancreas-spleen and the corresponding organs, moreover, the right branch of the meridian is connected with the pancreas, and the left branch - with the spleen; H10 - with the meridian of the kidneys and kidneys; B1 (3) - with the meridian of the large intestine and large intestine; J6 - with a triple heater and endocrine system; F5 - with the meridian of the small intestine and small intestine; C35 - with the meridian of the stomach and stomach; K32 - with the meridian of the gallbladder and gall bladder; G69 (68) - with the meridian of the bladder and the genitourinary system.

The indicated numbers of points in brackets are substitute and are used if it is impossible to make measurements on the main ones (skin lesions, etc.).

The choice of points for examination is based on the universal correspondence system developed by Dr. Park Joo-woo (Lac Ji-Woo “Guide to Su Jok (wrist and foot) acupuncture.” Moscow, Pechatny Dvor, 1993).

When examining Su-points on both hands, biologically active points A9, I11 (7), E11 (6), L3 (5), D3 (5), H10, B1 (3), J6, F5, C35, K32, G69 (68). When measuring Su-points of the byel-meridians located on one arm, Su-points located on the index and middle fingers of the hand are used for the right meridians, and Su-points located on the little finger and ring fingers are used for the left meridians. The measurement of Su-points on one arm is used to speed up the examination procedure, as well as in the absence of one limb of the hands or fingers used in the measurement.

After the selection of the Su-points, they act with a constant electric current of up to 10 μA on the areas of the skin that are projections of these points and measure the relative electrical conductivity.

The measurement is made by a digital measuring device for electropunctural testing, which contains active and passive electrodes, a power source, and a measurement unit. The active electrode is made in the form of a tip with a diameter of 2 mm, and the passive electrode is in the form of a plate. The active electrode is applied with a tip to the area of the skin where the BAP is located, and pressed, and at this time the passive electrode is held by the patient with fingers in the opposite hand.

Measurement is carried out for up to 3 seconds until the maximum digital indicator appears on the instrument panel. If necessary, the measurement can be repeated. Before measuring, it is necessary to moisten the tip of the active electrode with physiological saline. If excessive sweating is detected in the studied area of the skin (mainly the palmar surface), it is necessary to dry it with a paper towel, and then make a measurement.

After conducting electropuncture measurements, the biological age is calculated according to the obtained indicators using mathematical formulas (1-27), taking into account gender, both for the whole organism and for its individual systems. Moreover, a quantitative assessment of BV in this method is made in two ways.

The first option for calculating BV is the simplest and fastest, and the second option requires more time to calculate, but is more accurate and allows you to identify body systems with pathological abnormalities and with an accelerated rate of aging.

For the first option, it is enough to calculate the arithmetic mean values of the measured values of the right and left byel-meridians and, substituting them into formula (1), determine the BV for men or women, respectively. To find BV according to the second option, it is first necessary to determine BV separately for each system or organ in men according to formulas (2-14), and for women according to formulas (15-27). Then, based on the calculated BV values of individual systems and organs, the biological age of the whole organism in men and women is determined by the formula:

where BV _i - the value of BV of a separate system or body;

n is the number of studied systems and organs.

One of the necessary conditions for improving the quality of BV assessment is independence from the pathological processes that accompany aging. This method of determining BV provides this condition by identifying systems and organs with pathological abnormalities and excluding them from the calculation.

The following option is proposed for identifying pathological abnormalities:

where S _nami is the degree of pathological deviations;

BV _i - BV value of a specific system or body;

BV _c - average of all BV values of individual systems and organs (without exceptions);

σ is the root-mean-square deviation for a number of all BV values of the studied systems and organs;

n is the number of all analyzed systems and organs (n = 13).

If the degree of degree of pathological deviations is greater than or equal to 1.5 (S _nami ≥1.5), then it is considered that the analyzed system or organ has pathological deviations that can affect the assessment of BV, distorting its values.

The exclusion of the BV value of such a system or organ from formula (28) significantly increases the accuracy of the integral estimation of a person’s biological age.

Consider specific examples of determining biological age based on indicators of electropuncture measurements for men and women. BV assessment for them was carried out in two options.

When analyzing the results of determining BV, preference is given to the value of BV calculated using the second option. In the examples, the conclusions are given for this option.

Example 1. Patient B., gender - male, examination date: 08/23/2005, calendar age: 41.5 years

Table 1. Measured values of electrical conductivity in arbitrary units (cu) Mer. R Gl E RP FROM IG V R MS TR Vb F Rights 25 22 36 27 31 27 twenty 24 22 thirty 22 33 Left 21 23 34 thirty 26 21 25 22 twenty 22 24 32

1st option:

a) we find the arithmetic mean values of the measured values of the electrical conductivity of the right and left byel-meridians:

E _n = 26.58 (c.u.);

E _l = 25.0 (c.u.).

b) substituting the calculated average values of electrical conductivity (E _n and E _l ) in the formula (1), we find the value of the biological age for a given person

BV = 45.89 (years)

2nd option:

Substituting the measured values of the right and left meridians (Table 1) in formulas 2-14, corresponding to these meridians and certain systems and organs, we obtain the following BV values for them.

a) for the respiratory system: BV = 66.37 (years);

b) for the large intestine: BV = 44.74 (years);

c) for the stomach: BV = 15.41 (years);

g) for the pancreas: BV = 48.53 (years);

d) for the spleen: BV = 40.94 (years);

e) for the heart: BV = 42.47 (years);

g) for the small intestine: BV = 43.84 (years);

h) for the genitourinary system: BV = 50.97 (years);

i) for the kidneys: BV = 39.44 (years);

j) for the vascular system: BV = 71.31 (years);

l) for the endocrine system: BV = 44.61 (years);

m) for the gallbladder: BV = 37.83 (years);

m) for the liver: BV = 34.89 (years);

n) We determine the value of BV _with , as the arithmetic average of all calculated values of BV of the studied systems and organs according to the formula (28):

BV _c = 44.72 (years).

n) For the whole series of BV values of the studied systems and organs, using the Excel 2000 program, we find the root mean square deviations (σ):

σ = 13.79

p) For each body system, using the formula (29), the degree of pathological deviations (S _nami ) is determined.

for the respiratory system:

for the genitourinary system:

for the large intestine:

for the kidneys:

for the stomach:

for the vascular system:

for the pancreas:

for the endocrine system:

for spleen:

for gall bladder:

for heart:

for the liver:

for the small intestine:

c) Having excluded from formula (28) the values of BV of the respiratory system, vascular system and stomach, which have pathological deviations (S _{nam i} ≥1.5), we find the value of the integral BV for this person -

BV = 42.83 (years)

Conclusion: The biological age of this person is 1.33 years more than the calendar, which reflects the physiological (natural) aging of the body.

Pathological abnormalities are detected in the stomach, respiratory and vascular systems.

Example 2. Patient T., gender - female, examination date: 08/24/2005, calendar age: 58.1 years

Table 2 Measured values of electrical conductivity (cu) Mer. R Gl E RP FROM IG V R MS TR Vb F Rights 26 16 22 28 twenty 22 twenty eighteen 27 eighteen 21 33 Left twenty 13 21 29th twenty 16 twenty 16 29th fourteen eighteen 29th

1st option

a) we find the arithmetic mean values of the electrical conductivity of the right and left byel meridians:

E _n = 22.58 (c.u.)

E _l = 20.41 (c.u.)

b) substituting the calculated average values of electrical conductivity (E _n and E _l ) in the formula (1), we find the value of the biological age for a given person

BV = 54.62 (years)

2nd option:

Substituting the measured values of the right and left meridians (Table 2) in formulas 15-27, corresponding to these meridians and certain systems and organs, we obtain the following BV values for them.

a) for the respiratory system: BV = 59.32 (years);

b) for the large intestine: BV = 72.85 (years);

c) for the stomach: BV = 55.97 (years);

g) for the pancreas: BV = 41.47 (years);

d) for the spleen: BV = 36.23 (years);

e) for the heart: BV = 57.35 (years);

g) for the small intestine: BV = 61.04 (years);

h) for the genitourinary system: BV = 52.61 (years);

i) for the kidneys: BV = 86.83 (years);

j) for the vascular system: BV = 45.82 (years);

l) for the endocrine system: BV = 76.35 (years);

m) for the gallbladder: BV = 53.30 (years);

m) for the liver: BV = 30.13 (years).

n) We determine the value of BV _with , as the arithmetic average of all calculated values of BV of the studied systems and organs according to the formula (28):

BV _s = 56.09 (years)

o) For the whole series of BV values of individual systems and organs, using the Excel 2000 program, we find the mean square deviations (σ):

σ = 16.02

p) For each studied system or organ, the degree of pathological deviations (S _{nam i} ) is determined using formula (29).

for the respiratory system:

for the genitourinary system:

for the large intestine:

for the kidneys:

for the stomach:

for the vascular system:

for the pancreas:

for the endocrine system:

for spleen:

for gall bladder:

for heart:

for the liver:

for the small intestine:

c) Having excluded from the formula (28) the values of BV of the kidneys and liver having pathological deviations (S _nami ≥1.5), we find the value of the integral BV for a given person.

BV = 55.66 (years)

Output. The biological age of this person is less than the calendar by 2.44 years, which corresponds to the physiological aging of the body. Pathological abnormalities were found in the kidneys and liver. Accelerated pace of aging - in the endocrine system and large intestine.

Example 3. Patient A., gender - female, examination date: 09/18/2005, calendar age: 41.2 years

Table 3. Measured values of electrical conductivity (cu) Mer. R Gl E RP FROM IG V R MS TR Vb F Rights 32 eighteen 22 33 24 22 twenty twenty 34 23 eighteen twenty Left twenty 21 21 thirty 22 22 22 twenty 35 19 19 27

1st option

a) we find the arithmetic mean values of the measured values of the electrical conductivity of the right and left byel-meridians:

E _n = 23.83 (c.u.)

E _l = 23.16 (c.u.)

b) substituting the calculated average values of electrical conductivity (E _n and E _l ) in the formula (1), we find the value of the biological age for a given person

BV = 46.84 (years)

2nd option:

Substituting the measured values of the right and left meridians (Table 3) in formulas 15-27, corresponding to these meridians and certain systems and organs, we obtain the following BV values for them.

a) for the respiratory system: BV = 46.84 (years);

b) for the large intestine: BV = 50.35 (years);

c) for the stomach: BV = 55.97 (years);

g) for the pancreas: BV = 26.32 (years);

d) for the spleen: BV = 33.29 (years);

e) for the heart: BV = 48.88 (years);

g) for the small intestine: BV = 46.76 (years);

h) for the genitourinary system: BV = 47.85 (years);

i) for the kidneys: BV = 63.46 (years);

j) for the vascular system: BV = 26.44 (years);

l) for the endocrine system: BV = 55.55 (years);

m) for the gallbladder: BV = 58.42 (years);

m) for the liver: BV = 52.95 (years).

n) We determine the value of BV _c as the arithmetic average of all the calculated values of BV systems and organs according to the formula (28):

BV _c = 47.16 (years)

p) For the whole series of BV values of the studied systems and organs, using the Excel 2000 program, we find the mean square deviations (σ):

σ = 11.7

p) For each system or organ, the degree of pathological deviations (S _nami ) is determined using formula (29)

for the respiratory system:

for the genitourinary system:

for the large intestine:

for the kidneys:

for the stomach:

for the vascular system:

for the pancreas:

for the endocrine system:

for spleen:

for gall bladder:

for heart:

for the liver:

for the small intestine:

c) Having excluded from the formula (28) the values of the BV of the pancreas and the vascular system with pathological deviations (S _nami ≥1.5), we find the value of the integral BV for this person.

BV = 50.94 (years)

Output. The biological age of this person exceeds the calendar

by 9.74 years, which reflects a moderately accelerated rate of aging of the body. Pathological abnormalities were found in the pancreas and vascular system. Accelerated pace of aging - in the kidneys, gall bladder and stomach.

Example 4. Patient K., gender - male, date of examination: 04/22/2005,

calendar age: 38.0 years

Table 4. Measured values of electrical conductivity (cu) Mer. R Gl E RP FROM IG V R MS TR Vb F Rights 35 25 37 38 28 22 21 25 38 35 23 31 Left 31 25 34 35 thirty 25 26 26 38 thirty 28 35

1st option

a) we find the arithmetic mean values of the measured values of the electrical conductivity of the right and left byel-meridians:

E _n = 33.24 (c.u.)

E _l = 27.89 (c.u.)

b) substituting the calculated average values of electrical conductivity (E _n and E _l ) in

formula (1), we find the value of biological age for a given person

BV = 30.56 (years)

2nd option:

Substituting the measured values of the right and left meridians (Table 4) in formulas 2-14, corresponding to these meridians and certain systems of the body, we obtain the following BV values for them.

a) for the respiratory system: BV = 30.67 (years);

b) for the large intestine: BV = 33.06 (years);

c) for the stomach: BV = 13.33 (years);

g) for the pancreas: BV = 22.35 (years);

d) for the spleen: BV = 27.79 (years);

e) for the heart: BV = 41.12 (years);

g) for the small intestine: BV = 47.26 (years);

h) for the genitourinary system: BV = 44.87 (years);

i) for the kidneys: BV = 28.26 (years);

j) for the vascular system: BV = 27.77 (years),

l) for the endocrine system: BV = 14.72 (years);

m) for the gallbladder: BV = 27.01 (years);

m) for the liver: BV = 33.58 (years).

n) We determine the value of BV _with , as the arithmetic average of all the calculated values of BV of individual systems and organs according to the formula (28):

BV _s = 30.14 (years)

p) For the whole range of BV systems and organs values, using the Excel 2000 program, we find the mean square deviations (σ):

σ = 10.23

p) For each studied system or organ, the degree of pathological deviations (S _nami ) is determined using formula (29).

for the respiratory system:

for the genitourinary system:

for the large intestine:

for the kidneys:

for the stomach:

for the vascular system:

for the pancreas:

for the endocrine system:

for spleen:

for gall bladder:

for heart:

for the liver:

for the small intestine:

c) Excluding from the formula (28) the values of BV of the small intestine, endocrine system and stomach, which have pathological deviations (S _nami ≥1.5), we find the value of the integral BV for a given person.

BV = 31.65 (years)

Conclusion: The biological age of this person is 6.35 years less than the calendar, which reflects moderately slow aging of the body. Pathological abnormalities are detected in the stomach, small intestine and endocrine system.

Claims (2)

1. A method for determining the biological age of a person, characterized in that conductivity measurements are carried out at biologically active Su points of paired byol-meridians, by applying an electric current of up to 10 μA on both hands to biologically active points: A9, I11 (7), E11 ( 6), L3 (5), D3 (5), H10, B1 (3), J6, F5, C35, K32, 069 (68), and when measuring the Su-points of the white meridians located on one arm, for the right Meridians use Su points located on the index and middle fingers, and for left meridians use Su points located on the little finger and ring fingers, then determine the biological age according to the formula

where BV is the value of biological age; KV ₀ in men is 8.38, and in women is 3.63; E _p0 and E _l0 in men are 36.33 and 35.91, and in women - 34.74 and 34.31;

in men they are equal to 3.7 and 3.57, and in women - 4.0 and 3.84; E _p and E _l - arithmetic mean values of the electrical conductivity of the right and left byel-meridians. 2. A method for determining the biological age of a person, characterized in that the biological age of individual systems and organs is determined first, while in men: for the respiratory system:

for the large intestine:

for the stomach

for the pancreas:

for spleen:

for heart:

for the small intestine:

for the genitourinary system:

for the kidneys:

for the vascular system:

for the endocrine system:

for the gastric bladder:

for the liver:

and in women: for the respiratory system:

for the large intestine:

for the stomach:

for the pancreas:

for spleen:

for heart:

for the small intestine:

for the genitourinary system:

for the kidneys:

for the vascular system:

for the endocrine system:

for the gastric bladder:

for the liver:

where E _p , E _l - the value of the electrical conductivity of the corresponding meridians, then determine the biological age of the body, as the arithmetic average of the values of the biological ages of individual systems and organs, not taking into account the biological ages of systems or organs with pathological deviations.