RU2288701C2 - Composition for treatment of alveolitis - Google Patents

Abstract

FIELD: medicine, stomatology, pharmacy.

SUBSTANCE: invention proposes a composition used in treatment of alveolitis that comprises anesthetic, antiseptic and a hemostatic component wherein the composition comprises anaesthesinum as an anesthetic, crystalline iodine and potassium iodide an aqueous solution as an antiseptic and pectin as a hemostatic component. The composition comprises lanolin and vaseline as ointment base wherein components are taken in the definite ratio. Invention provides high effectiveness in treatment of alveolitis and its capacity to activate regenerative healing processes. Invention can be used in treatment of complications after teeth removal, in particular, alveolitis.

EFFECT: valuable medicinal properties of composition.

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Description

The invention relates to medicine, namely to surgical dentistry, and can be used to treat complications after tooth extraction, in particular alveolitis.

A special tool for the treatment of alveolitis is known - French-made Alvojill paste, which has antiseptic analgesic and hemostatic properties, of the following composition, wt.%:

Iodoform 10.0 Butyl salt of diaminobenzoic acid 16,2 Eugenol 8.6 Penghawar / Penghawar / 2.2 Excipient 63.0

It is possible to use flagella soaked with the Alvojill paste described above [Catalog "Medicines and preparations of the company SPECIALITES SEPTODOLKOT", publishing house of the company "OLMA-PRESS", 1995, p.7]. The disadvantages of the paste "Alvozhil" are:

- the use of a strong antiseptic iodoform, which has a local irritating and biotoxic effect;

- the use as constituents of inaccessible expensive components, for example, Penghawara, which has a hemostatic effect;

- when using a flagellum impregnated with Alvojill paste, it becomes necessary to remove it, because soaked flagellum does not have the property of resorption.

Also known composition for the treatment of alveolitis, containing, wt.%:

Iodoform 15.4 Glycerol 15.4 Ethanol 7.7 The ether is medical 61.5

For the treatment of alveolitis using tampons soaked in this composition [Surgical dentistry. The textbook, ed. TG Robustova, M .: Medicine, 1990, 576 p.].

The disadvantages of the known composition are:

- local toxicity due to the use of iodoform;

- the possibility of using it only in the form of a swab soaked with this composition, which determines the need for its removal;

- local irritant effect due to the use of ether and ethyl alcohol.

Closest to the claimed is a composition for the treatment of alveolitis "Alvostaz" of domestic production, with hemostatic and antiseptic properties, of the following composition:

Eugenol

Iodoform

Thymol

Calcium phosphate

Lidocaine

Butylparaaminobenzoate

Propolis

Iodoform used in Alvostasa is a strong antiseptic, lidocaine is an anesthetic, calcium phosphate is a hemostatic component. For the treatment of alveolitis, tampons are used that are saturated with this composition, which exert their effect for several hours, then are gradually rejected. The tampon needs to be changed several times [Instructions for use of Alvostaz, approved by the Ministry of Health of the Russian Federation No. 98/705 of 05/15/1998].

The disadvantages of the composition are:

- the use of a strong antiseptic iodoform, which has local irritating and biotoxic effects;

- when using a swab soaked with Alvojill paste, it becomes necessary to remove it, because the impregnated swab does not have the property of resorption;

- the free outflow of exudate from the site of infection is not ensured;

- the duration of treatment due to locally traumatic action when removing the used swab.

The objective of the invention is the creation of a composition for the treatment of alveolitis with reduced local irritant and biotoxic effects on an open wound surface, as well as expanding the range of compositions used to treat alveolitis.

The technical result is an increase in the effectiveness of treatment of alveolitis with the proposed composition, which does not have local irritating and biotoxic effects, exhibits sorption and hemostatic activity against toxins of microorganisms and tissue decay products in the alveolus and the ability to activate regenerative processes in the healing stage, while contributing to a reduction in the healing time.

The specified technical result is achieved by the fact that in the known composition for the treatment of alveolitis, including anesthetic, antiseptic and hemostatic component, the peculiarity lies in the fact that the composition contains anestezin as an anesthetic, crystalline and aqueous potassium iodide solution as an antiseptic, and as the hemostatic component is pectin, while the composition additionally contains lanolin-vaseline ointment in the following ratio of components, wt.%:

Lanolin-vaseline ointment 44.2-48.6 Crystalline iodine 0.2-0.6 Aqueous solution of potassium iodide 0.7-0.9 Pectin 44.2-48.6 Anestezin 3.8-5.8 Distilled water Rest

The introduction into the proposed composition for the treatment of alveolitis of a solution of iodine obtained by dissolving crystalline iodine in an aqueous solution of potassium iodide and pectin with the above ratio of these components leads to the formation of an iodine-containing organic substance, where iodine is in the so-called organically bound form, in which bactericidal activity is maintained organically bound iodine, but the locally irritating and biotoxic effects of elemental iodine on the wound surface are reduced, and it also increases rbtsionnuyu activity of the proposed composition against toxins, promotes stimulation of regenerative processes in the gingival tissues and hemostatic action.

The use of the proposed composition contributes to the free outflow of exudate while maintaining a constant concentration of the composition in the inflammation zone, which provides an adequate effect on all phases of the inflammatory process.

The introduction of lanolin-vaseline ointment gives plasticity to the composition, and this property makes it possible to fill the narrow sinuous apical sections of the alveolar hole.

The composition resolves, i.e. no medical intervention is required to remove it.

The duration of treatment is reduced due to the elimination of the locally traumatic effect of the swab used.

The proposed composition is obtained as follows.

In a solution of iodine obtained by dissolving 0.4% wt. crystalline iodine in an aqueous solution of 0.8% wt. potassium iodide, injected 46.4% wt. lanolin-vaseline ointment is thoroughly mixed, then 4.8 wt.% anestezin and 46.4 wt.% pectin are added to the resulting composition, followed by stirring with the addition of water until a homogeneous colloidal mass is formed.

The proposed composition has been tested in the dental clinic of Meleuzov Central District Hospital of the Republic of Belarus.

Example 1. Patient A., 27 years old, came to the dental clinic of the Meleuzov Central District Hospital two days after the removal of 27 teeth of the upper jaw on the left with complaints: severe constant pain in the socket of the extracted tooth radiating to the left temporal region, bad breath. Objectively: the general condition is satisfactory, t ° 36.6, when examining the oral cavity, swelling and inflammation of the soft tissues of the gums in the area of the socket of the removed 27 tooth are noted. The bone walls of the hole are exposed, covered with a whitish coating. Palpation of the transitional fold in the projection of the extracted tooth is sharply painful. On the control x-ray taken on the day of treatment of the patient, residual roots of the extracted tooth were not found. On the basis of the anamnesis, data of an objective examination, the diagnosis was made: post-extraction serous alveolitis of the hole 27 of the upper jaw tooth on the left. After that, a complex of therapeutic measures was carried out using the proposed composition.

All symptoms of this disease disappeared on the fifth day from the start of treatment. The patient was discharged in satisfactory condition at normal levels of a general blood test.

Example 2. Patient Z., 38 years old, was referred for inpatient treatment to the surgical department of the Meleuzov Central District Hospital of the Republic of Belarus with a diagnosis of post-extraction putrefactive-necrotic alveolitis of the hole of the 35th tooth of the lower jaw on the left. Concomitant diagnosis: diabetes mellitus. The duration of the disease is 5 days. Objectively: during an external examination, a slightly pronounced asymmetry of the face due to swelling of soft tissues in the left buccal region is noted. Examination of the oral cavity: a putrid odor from the mouth, the mucosa of the transitional fold of the lower jaw in the area of the extracted tooth is slightly painful and thickened due to periosteal inflammatory changes, the post-extraction hole is empty, its bottom and edges are sharply painful and covered with a gray-dirty coating. The patient notes evening rises in body temperature to an average of 38 ° C.

Data from clinical and laboratory blood tests upon admission:

General blood test - e. - 3.9 · 10 ⁶ μl; Hb. - 115 g / l; l - 7 · 10 ³ μl; ESR - 18 mm / h, blood sugar - 2.9 mmol / L.

On the day of admission, the patient underwent a series of measures aimed at stopping the local inflammatory process, namely: under local conduction anesthesia with 2% novocaine solution, thorough curettage of the socket of the removed 35 tooth of the lower jaw is performed with the evacuation of necrotic tissue, the alveoli cavity is sanitized with an antiseptic solution (hydrogen peroxide ) and then fill with the proposed composition for the treatment of alveolitis with the application of one suture from catgut on the edges of the wound.

On the 3rd day of inpatient treatment, along with the normalization of the general condition of the patient, relief of the local inflammatory process was noted with the elimination of acute pain in the area of post-extraction inflammation. Objectively, at a local examination on the 7th day: the wound edges are completely cleared of necrotic altered tissues, the appearance of fresh foci of newly formed granulation tissue is noted; in addition, there was a positive trend in hematological indicators e. - 3.9 · 10 ⁶ μl; Hb - 116 g / l; l - 5 · 10 ³ μl; ESR - 11 mm / h, sugar - 2.88 mmol / L.

The patient was discharged in satisfactory condition on the 10th day of inpatient treatment.

Tests of the proposed composition showed its high efficiency in the treatment of alveolitis and its ability to activate regenerative healing processes.

Claims (1)

An ointment for the treatment of alveolitis containing an ointment base and an active substance, characterized in that it contains a mixture of lanolin and petrolatum as an ointment base, crystalline iodine, an aqueous solution of potassium iodide, pectin and anestezin in the following ratio, wt. %: A mixture of lanolin and petroleum jelly 46.2-46.6 Crystalline iodine 0.2-0.6 Aqueous solution of potassium iodide 0.7-0.9 Pectin 46.2-46.6 Anestezin 4.6-4.9 Distilled water Rest