RU2285550C2 - Method for reducing abstinence syndrome in opium addiction patients - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves administering self-controlled energy-neuro-adaptive regulation therapy in individually or subjectively dosed modes and their combinations performed in three stages beginning from haired portion of the head to the coccyx along spinal processes of the vertebral column to the right and left of paravertebral lines from the seventh cervical vertebra level to the coccyx. The second stage involves acting upon six points corresponding to trigeminus nerve exits. Liver projection skin region is treated at the third stage applying frequencies within the range of 60-90 Hz with total treatment time being equal to 30-40 min in one session daily during 10-14 days.

EFFECT: reduced abstinence period.

2 dwg, 1 tbl

Description

The invention relates to medicine, namely to the field of narcology, and is intended for the treatment of patients with drug addiction.

It is known that addiction is based on cyclic disturbances in the activity of the supporting system of the brain. With the use of narcotic drugs, such violations progressively increase and lead to the continued use of drugs, as well as to a decrease in control over their use. Prolonged abuse of opium drugs is often accompanied by damage to internal organs and especially the liver. The use of various drugs (analgesics, antipsychotics, tranquilizers, nootropics, opiate receptor blockers, calcium channel blockers, adrenotropic drugs, α- and β-blockers, antidepressants) during an exacerbation of the disease can alleviate the condition of patients. However, to achieve stabilization of the state requires a sufficiently long period of time. Of no small importance is the fact that many patients have a drug allergy that limits the range of medicines used. In addition, the use of these drugs does not affect the most important pathogenetic aspects of the disease, in particular, lipid peroxidation processes, accompanied by the accumulation of excess free radicals that contribute to the progression of damage to internal organs.

In this regard, the use of central and local regulation of homeostasis disorders, in particular lipid peroxidation, for the treatment of physical factors is of particular interest. For this, it is advisable to use physical factors of various modality and frequency to address them to different hierarchical levels of the body to obtain a more pronounced synchronizing effect. A prerequisite for using a combination of physical factors is also a number of general patterns in the reactions of regulatory systems (Lebedev NI, 1995), which create the basis for the directed regulation of homeostasis.

There is a method of complex treatment of drug addiction and alcoholism, Vrublevsky A.G., Rokhlina M.L., Radchenko A.F., Voronin K.E., Badikov S.V. Clinical pathomorphism of opium withdrawal syndrome. - Issues of addiction. - 1990. - 2, - 23-25 s., Including relief of withdrawal symptoms (clonidine from the first day at a dose of 0.6 to 0.9 mg / day for 3 doses) and removal of the allergic syndrome (using the LENAR apparatus for 2 sessions in day lasting 60 minutes, while the frequency and current are selected individually). The actualization of the pathological attraction to the drug is prevented with the help of prolonged-acting antipsychotics - pipmitiazine palmitate and haloperidol - decanoate in doses of 50-75 mg once every 4 weeks. To normalize sleep in the first few days, the use of intramuscular injection of a combination of tizercin and relanium. In cases of resistance of the combination, sodium oxybutyrate is added orally, but not more than 3-5 days (10-20 ml of a 10% solution). Subsequently, leponex or chloro-protexene (12.5 and 50 mg, respectively) is taken orally for agripnia. The method allows to reduce somatovegetative manifestations of withdrawal symptoms, as well as pain. However, with this method of treatment, frequent complications (extrapyramidal disorders, impaired liver function) are observed. A significant drawback is the use of a large number of drugs when acting on the mental sphere.

In the patent of the Russian Federation No. 2205665, IPC A 61 M 21/00, A 61 N 1/32, 5/06, publ. 2003 described a method for the treatment of drug and alcohol dependence by exposing the patient to both a pulsed current of voltage from 0.1 to 20 ± 4 V, pulse duration of 0.15-0.75 ms, and their repetition rate from 150 ± 30 to 2000 ± 400 Hz from electrodes located in the forehead, with light pulses of 8-12 ms duration, lying in the wavelength range of the visible part of the spectrum; sound signals from infrasound up to 15 kHz in intensity from the auditory threshold to 80 dB. Suggestive effect is carried out at the end of the session against the background of a relaxing melody. In this case, a suggestion is carried out with a view to abandoning narcotic substances that cause mental dependence. The session lasts 40 minutes, the number of sessions from 1 to 10.

In the patent of the Russian Federation No. 2135149, IPC A 61 H 39/00, publ. 1999 described a method for the treatment of drug dependence, carried out by exposing patients to an electric pulse rectangular current of negative polarity. Affect the biologically active points of predominantly wonderful meridians. Affect 15 points simultaneously. The duration of the session is 50-70 minutes. The method allows you to remove mental dependence.

There is also a method for the rehabilitation of patients at various stages of drug addiction (RF application No.2000112324, IPC A 61 H 39/00, publ. 05.20.2002), which consists in exposure to a pulsed current frequency of 20-320 Hz with an asymmetric bipolar pulse shape characterized by a short high-amplitude cathode ejection followed by a prolonged low-amplitude anode phase onto the segmental zones of the spinal cord region, reflexogenic zones and biologically active points associated with the manifestations of the disease, due to the application of electrodes on them, and ctrodes are applied to the collar zone in anesthesia mode, paravertebrally to the adrenal zone in stimulation mode, and they act on biologically active zones of sedative and antidepressant effects by applying electrodes to the posterior surfaces of the lower third of the legs — in stimulation mode, the duration of electrical stimulation is 20-30 minutes, with a break of 4-6 hours, until the relief of the phenomenon of withdrawal symptoms, simultaneously with electrical stimulation, they gradually cleanse and restore body functions due to normal malization and additional nutrition of cells, due to the intake of infusions of medicinal herbs.

A common drawback of these methods of treatment is the subjective use of electrostimulating devices, without taking into account feedback from the patient, as well as the lack of control over biochemical homeostasis, in particular the state of the oxidative-antioxidant system of the body.

The objective of the invention is the creation of a highly effective method that provides improved immediate results with the relief of withdrawal symptoms, an improvement in withdrawal of patients with opiate addiction, activation of the antioxidant defense of the body and improved long-term prognosis of the disease.

This object is achieved by the fact that in the method of relieving withdrawal symptoms in patients with opium addiction, against the background of traditional treatment, SCENAR therapy is carried out in individually dosed (IDR) or in subjectively dosed (SDR) modes and their combination in three stages: at the first stage, the effect on the patient’s skin surface: from the border of the scalp to the coccyx along the spinous processes of the spine, to the right and left along paravertebral lines from the level of the seventh cervical vertebra to the coccyx; in the second stage, they act on six points corresponding to the places of the trigeminal nerve exit, in the third stage they affect the projection of the liver on the skin, with a frequency within 60-90 Hz, the total duration of exposure is 30-40 minutes in one session, daily for 10-14 days .

The claimed method meets the criteria of the invention of "novelty", since there is no source of information that would describe the claimed combination of symptoms or mention the possibility of stopping withdrawal symptoms in patients with opium addiction using SCENAR-therapy.

The claimed method has an inventive step, because for a specialist drug addiction does not explicitly follow from the level of medicine in this area, limited to the use of various means without the use of directional regulation of homeostasis. The proposed application of SCENAR-therapy using the indicated frequencies prevents the dominance of stress syndrome by addressing the central and peripheral mechanisms of homeostasis regulation with an adequate functional load and launches a system that prevents excessive accumulation of free radicals.

The claimed method is industrially applicable, as it can be used both in specialized narcological departments and in general hospitals. The compact and reliable apparatus for SCENAR-therapy makes it possible to work with large groups of patients.

The proposed method is illustrated by schematic drawings, where Fig. 1 shows the zones and points of action on the human body with a SCENAR apparatus, and in Fig. 2, the direction of action of the electrode of the SCENAR apparatus.

SCENAR is an abbreviation of the name of the device and method of treatment - a self-controlled energy-neuroadaptive regulator, which is designed for therapeutic, non-invasive effects on the skin and mucous membranes of a person in order to provide a general regulatory effect on physiological systems.

One of the main principles of treatment with the SCENAR device is “work on an actual complaint”. This is due to the fact that any stereotypical reaction of a living organism that arose during evolution is genetically defined and has a multi-level mechanism of self-healing. If it is disrupted and / or dominates at the moment, it will “try” to attract the attention of all organs and tissues of the body, with the formation of functional systems from them for a speedy recovery.

The claimed method of relieving withdrawal symptoms in patients with opium addiction is implemented as follows. When stopping withdrawal symptoms, the patient is exposed to the skin using pulses of a continuous frequency of 60–90 Hz using a SCENAR-97.4 apparatus (GOST R 50444, class B as per RD 50-707). The signal parameters during the procedure are set automatically (IDR) due to the action of the biological feedback of the device-patient. The SCENAR electrode is pressed to the skin surface near the future exposure site and the optimal exposure energy is selected by patient-doctor feedback, i.e. the doctor applies an electrode to the area of the skin of the patient’s back and increases the force of exposure until the patient feels a slight tingling under the electrode. During treatment, a comfortable mode of exposure is used, when the patient feels a slight tingling and vibration.

The impact of SCENAR is produced by moving the device along a selected area of the patient’s body (Fig. 1, a). At the beginning of the first stage of exposure, the SCENAR electrode is applied vertically below the seventh cervical vertebra to the surface of the patient’s skin, after a light and sound signal, it is moved, without tearing off the skin surface, to a distance equal to the length of the electrode. The specified effect is carried out along the spinous processes of the spine to the coccyx. Then the electrode is torn off the skin surface, placed on the border of the scalp and moved as described above to the seventh cervical vertebra.

Next, the effect is carried out on the paravertebral line on the left and on the right, stepping back a distance equal to the length of one vertical electrode from the line of the spine, also from the level of the seventh cervical vertebra to the tailbone.

In the process of exposure to the skin under the electrode and / or on other parts of the body, skin areas may appear that differ in discoloration, the appearance of itching or rash. These are the so-called asymmetries.

The characteristic features of SCENAR - therapy are:

- “sticking” (the electrode as if ceases to “move on the skin”, or there is a feeling that the skin under the electrode is sticky);

- a change in the color of the skin (hyperemia or pallor) or a change in the patient's sensations (painful or insensitive area);

- change in the sound of the apparatus when moving the electrode over the skin (amplification or absence of sound).

It is on these signs that special attention should be paid, providing an additional effect on the places of their manifestation in a subjectively dosed mode (SDR) until the disappearance or appearance of dynamic changes.

The second stage is the impact on six points on the face corresponding to the trigeminal nerve exit points (Fig. 1, b). The electrode is applied similarly to the image in figure 1. b. The optimal exposure energy is selected, as a rule, 2-3 times less than on the back. The exposure time in the IDR, the moment the exposure ends is indicated by the light and sound signal that the device emits.

The third stage is the effect of SCENAR on the skin over the projection of the liver, which is determined percussion, starting from the middle axillary line and to the anterior midline. The impact vector from top to bottom, from left to right (figure 2). The device slides, snuggling, over the skin slowly. The exposure time is at least 10 minutes.

Before starting, in the process, and also after completing the course of treatment, the dynamics of the body's reactions are taken into account: a questionnaire determination of well-being is carried out, the parameters of the oxidative - antioxidant systems of the body are investigated.

Examples of the implementation of the proposed method.

1. Matveev AG, age 26 years, opium addiction 2 stages. Entered in a state of abstinence. On admission, muscle pain in the legs, rhinorrhea, diarrhea, tachycardia, and restless sleep were noted. At the same time as the traditional treatment, SCENAR-therapy was carried out according to the method described above lasting 40 minutes, daily for 10 days. Immediate results of treatment: withdrawal from withdrawal on day 6, improvement of well-being, disappearance of muscle pain in the legs, rhinorrhea, diarrhea, tachycardia, restoration of balance in the system of prooxidants-antioxidants (diene conjugates, malondialdehyde, Schiff bases, superoxide dismutase, catalase). Long-term results: disappearance of "craving" for a drug, normalization of sleep.

2. Live A.V., age 19 years, opium addiction, 2 stages. Entered in a state of abstinence. On admission, headaches, irritability, short temper, body aches, and sleep disturbance were noted. Against the background of traditional treatment, SCENAR-therapy was carried out according to the method described above lasting 40 minutes, daily for 10 days. Immediate results of treatment: withdrawal from withdrawal on day 7, the antioxidant system improved, body aches, headache disappeared, and the general condition improved significantly. Long-term results: the disappearance of "traction". The proposed method was carried out the treatment of 28 patients with opium addiction.

Control (traditional treatment without SCENAR-therapy):

1. Dontsov VV, age 28 years, opium addiction 2 stages. Entered in a state of abstinence. On admission, abdominal cramps, headache, nausea, insomnia, and periodic chills were noted. Against the background of traditional treatment, withdrawal was withdrawn on the 10th day of treatment. Immediate results of treatment: abdominal cramps, chills, nausea were removed. Nevertheless, headaches persisted for a long time, there was no restoration of balance in the antioxidant-prooxidant system, craving for a drug decreased, but the attraction remained.

2. Koval D.N., age 26 years, opium addiction 2 stages. Entered in a state of abstinence. At admission, muscle pains were observed throughout the body, tachycardia, dysphoria, chills, sleep disturbance. Against the background of traditional treatment, withdrawal was withdrawn on the 10th day of treatment. Immediate results of treatment: relieved muscle pain throughout the body, tachycardia, dysphoria, chills. After treatment, poor tolerance of physical activity was observed, indicators of the antioxidant system of the body did not undergo significant changes in 10 days.

The data obtained allow us to draw the following conclusion. The use of SCENAR-therapy in complex treatment leads to:

1) to reduce the period of withdrawal from an average of 10 to 6-7 days;

2) there is a decrease in dose or cancellation of non-narcotic analgesics and tranquilizers;

3) during the treatment with SCENAR, there is a faster normalization of sleep and suppression of the somato-vegetative component of withdrawal symptoms;

4) there is a relief of oxidative stress by activating antioxidant systems and normalizing the intensity of free radical processes, restoring antioxidant-prooxidant balance in the body;

5) a significant suppression of autoimmune reactions in the patient’s body is recorded.

Claims (1)

A method of relieving withdrawal symptoms in patients with opium addiction, characterized in that, against the background of traditional treatment, SCENAR-therapy is carried out in individually or subjectively dosed modes and their combination in three stages: from the border of the scalp to the coccyx along the spinous processes of the spine, left and right along paravertebral lines from the level of the seventh cervical vertebra to the coccyx; at the second stage, they act on six points corresponding to the trigeminal nerve exit sites; at the third stage, they affect the projection of the liver on the skin with a frequency within 60-90 Hz, with a total duration of exposure of 30-40 minutes in one session, daily for 10-14 days.

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