RU2257906C2 - Method of treating acute nonspecific suppurative pulmonary and pleural diseases - Google Patents

Abstract

FIELD: thoracic surgery and pulmonology.

SUBSTANCE: method comprises complex therapy utilizing ecdysterone-containing preparation, namely 0.005-0.01% ecdysterone solution prepared by dissolving ecdysterone in mixture of equal portions of 70% alcoholic tinctures of calendula and eucalyptus. Preparation is administered orally in dose of 30-40 drops before meal.

EFFECT: activated formation of antibodies, function of phagocytes and T cells, protein synthesis processes, including surfactant synthesis, and stabilized alveolocyte membranes.

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Description

The invention relates to medicine, namely to thoracic surgery, pulmonology, therapy.

Suppurative diseases of the lungs and pleura (acute and chronic empyema of the pleura, acute and chronic abscess of the lung, lung gangrene, etc.) remain one of the leading pathologies among all diseases of the respiratory system. In these patients, the difficulties of therapy are associated with hypoxia, pronounced endotoxemia, loss of protein, trace elements, present in all patients with secondary immunodeficiency [1].

The purpose of the invention is to improve the results of treatment of acute nonspecific suppurative diseases of the lungs and pleura by using an original preparation, which is a mixture of equal parts of 70% alcohol tinctures of calendula and eucalyptus in which ecdysterone is dissolved to obtain a 0.005-0.01% solution. Ecdysteroids are a relatively new class of natural compounds with valuable biological properties [2].

We obtained ecdysterone from many plants of the clove family [3].

The proposed method of treatment is as follows.

Patients daily 20-30 minutes before meals were taken orally by 30-40 drops of the drug. Experimental studies have shown that the drug has an immunostimulating effect, affecting T-cell immunity and phagocyte activity, activates antibody formation, stimulation of non-specific immunity. Anabolic action, activation of protein synthesizing processes is noted, a positive nitrogen balance in the body is created. Activation of type II alveolocytes and synthesis of surfactant is observed, the membrane of type I alveolocytes stabilizes, microcirculation improves due to the active formation of blood capillaries. Clinical studies (the drug was used in 40 cases of acute suppurative diseases of the lungs and pleura) showed that the use of this drug led to a rapid decrease in endotoxemia, normalization of protein and other types of metabolism, pronounced stimulation of immunity, abacilation and purification of purulent cavities. The foregoing is illustrated by the following examples:

Example 1. Patient G., 45 years old, was admitted to the department of thoracic surgery 05/23/02 20 days after the onset of the disease. He was treated at the local central hospital for poisoning with alcohol substitutes, acute hepatic-renal failure, bleeding from varicose veins of the esophagus, anemia, bilateral lower lobar pneumonia with abscess and pleuritic pleurisy on the right. Upon admission to the ward, the patient's condition is severe, intoxication phenomena are expressed (body temperature 39-39.8 ° C, hectic in nature). Clinical diagnosis: acute pleural empyema on the right, bilateral lower lobar pneumonia, purulent intoxication, DN II-III stage, renal-hepatic insufficiency, encephalopathy. Thoracocentesis was performed, the empyema cavity was drained 05/27/02 phlegmon of soft tissues of the chest developed - opened, drained. Prescribed drug. Against the background of the therapy, a significant improvement was observed: the temperature decreased to subfebrile numbers (on the 2nd day), the consciousness was clear, there was no shortness of breath. Objectively: the condition is relatively satisfactory. In a control study, normalization of perioclinic analyzes is noted. Postoperative wounds healed. Diuresis is adequate. On drainage from the pleural cavity there is no discharge, removed. Discharged in satisfactory condition.

Example 2. Patient X., 62 years old, was admitted to the Department of Thoracic Surgery OKB 05/22/2002, after 1.5 months from the onset of the disease. Upon receipt, pronounced intoxication phenomena (body temperature 39 ° C), cough with discharge of purulent sputum (up to 100 ml / day), shortness of breath with slight physical exertion. Objectively: a state of moderate severity. Clinical diagnosis: acute bilateral lung abscesses. Performing thoracocentesis and drainage of abscess cavities is technically not feasible due to their small size and central location. Prescribed drug. On the 3rd day from the start of the drug, a subjectively significant improvement was observed: the body temperature decreased to subfebrile numbers and returned to normal on the 5th day. During the control study, normalization of general clinical tests is noted. The outcome of the disease is limited pneumofibrosis, was discharged in satisfactory condition.

Thus, the proposed method for the treatment of acute nonspecific suppurative diseases of the lungs and pleura allows in a short time to achieve a decrease in endotoxemia, restoration of impaired metabolism and immunological status, and, ultimately, a faster clinical and radiological recovery.

Sources of information:

1. Surgery of the lungs and pleura. Ed. Kolesnikova I.S. - L., Medicine, 1988 - 382 p.

2. Syrov V.N. // Experiment. and clinic. pharmacology. - 1994. - T.57, No. 5. - S.66-72.

3. Boltaev U.A., Darmograi V.N., Abubakirov N.K. Phytoecdysteroids of plants of the genus Silene // Chemistry of Natural Compounds - 1987. - No. 1. - S. 850-852.

Claims (1)

A method for the treatment of acute nonspecific suppurative diseases of the lungs and pleura, which consists in using an ecdisterone-containing preparation in complex therapy, which is a 0.005-0.01% solution of ecdisterone obtained by dissolving ecdisterone in a mixture of equal parts of 70% alcohol tinctures of calendula and eucalyptus, moreover taken orally 30-40 drops before meals.