RU2236859C2 - Preparation "fitoomolazhivajuschie" - Google Patents

Abstract

FIELD: medicine, pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to an agent promoting to prolongation of active longevity. Preparation for prophylaxis of body premature aging comprises mother bee milk, flower pollen, saffron infusion dry concentrate, ginger roots, cinnamon, nutmeg, vitamin E, succinic acid, ascorbic acid, citric acid, starch, calcium stearate, talk and sugar taken in the definite ratio. The preparation is made as tablet with weight 0.36 g. Preparation promotes to prolongation of active longevity and useful in using.

EFFECT: valuable properties of preparation.

2 tbl

Description

The invention relates to medicine, in particular to the parapharmaceutical industry, producing drugs for therapeutic and prophylactic purposes, and can be used as a means of prolonging active longevity.

Known drug "Bee Pollen granules" / Pilate T.L. and others. Kazakhstan registry of biologically active food additives, Almaty, Leovit, 2000, p.193 /, containing flower pollen. It is used for high blood pressure, diseases of the nervous and endocrine systems, allergies, anemia, increases energy, vitality, improves memory, activity, slows down the aging process, improves appetite, supports the immune system, relieves drowsiness, helps with diseases of the prostate gland, promotes general recovery organism. It has anti-inflammatory, antitumor, anti-tuberculosis, general tonic effects.

A disadvantage of the known drug is the individual intolerance to certain components of the drug observed in individual patients.

Known drug (BAA) herbal tea "The secret of youth (for women)" / Pilate T. (Ed.), Federal Register of Dietary Supplements, M., Kogelet, 2001, p. 354 /, which includes motherwort herb, licorice root, hawthorn fruit, oregano grass, marigold flowers, and laminaria thalli. It has a calming effect with pathologically menopause, relieves a painful condition.

A disadvantage of the known drug is the individual intolerance to certain components of the drug observed in individual patients.

Known drug / Pilate T.L. etc. Kazakhstan registry of biologically active food additives, Almaty, Leovit, 2000, p.126 /, which includes royal jelly and pollen and excipients (excipients and fillers): starch, sugar, calcium stearate, talc. The drug is available in tablet form and has a general strengthening effect due to the strengthening of the immune system and normalization of metabolism, increases mental and physical performance, relieves depression, improves overall status. Replenishes the deficiency of the body in vitamins, improves appetite, promotes growth, normalization of weight. Strengthens the walls of capillaries, blood vessels, including the brain, prevents the appearance of cerebral hemorrhage, stimulates blood formation. Increases the body's resistance to infectious diseases, has a bactericidal, viralolytic effect. Normalizes the activity of the genitourinary system in diseases of the prostate gland. They are used as a general strengthening agent for hysteria, overwork, vitamin deficiency, increased physical exertion, after diseases.

A disadvantage of the known drug is the individual intolerance to certain components of the drug observed in individual patients.

The objective of the invention is the development of a new affordable drug, available in tablet form, convenient for use, recommended as a restorative tonic, which has a rejuvenating effect, strengthens all systems and organs of the body, contributing to the prolongation of active longevity.

The invention is aimed at expanding the arsenal of drugs that contribute to the extension of active longevity.

This is achieved by the fact that a preparation is proposed for the prevention of premature aging of the body, which has a restorative, tonic and anti-aging effect, including royal jelly, pollen and excipients: starch, calcium stearate, talc and sugar.

However, unlike the known, the proposed preparation additionally contains a dry concentrate of saffron infusion, ginger, cinnamon, nutmeg, vitamin E, succinic acid, ascorbic acid, citric acid in the following ratio of components per tablet weighing 0.36 g, g:

Royal jelly 0.0005-0.0040

flower pollen 0.0100-0.0800

dry concentrate of saffron infusion 0.000004-0.00015

ginger root 0.0025-0.0100

cinnamon 0.0025-0.0100

nutmeg 0.1000-0.2000

Vitamin E 0.0025-0.0100

succinic acid 0.0025-0.0100

ascorbic acid 0.0100-0.0800

citric acid 0.0025-0.0100

starch 0.0200-0.0500

calcium stearate 0.0050-0.0100

talcum powder 0.0050-0.0100

sugar rest

The drug is called - “Phyto-Rejuvenating”.

The drug "Phyto-Rejuvenating" - a tonic, tonic, has a rejuvenating effect, strengthens all systems and organs of the body, helps prolong active longevity, stimulates sexual and reproductive functions; biochemical processes in the body, energy metabolism. It has a general tonic effect, improves memory, vision, mood. Increases mental and physical performance. It has a beneficial effect on the condition of the skin and hair. It is used as an auxiliary and healing agent to prevent premature aging of the body; with exhaustion, weakness, after diseases and operations.

The preparation “Phyto-Rejuvenating” in the form of tablets is prepared as follows.

Saffron in an amount of 0.0145 kg is loaded into an enameled container of 10 l, pour 7 kg of room temperature water, insist on a boiling water bath for 35 minutes with frequent stirring, cooled for 45 minutes at room temperature. The infusions are filtered, squeezing the plant material, filtered through 4 layers of gauze.

The yield of infusion (1.5% dry) is 7 kg.

Sugar in the amount of 71.3 kg is weighed in a bag on a scale, visually checked for mechanical impurities, then, in the absence of impurities, crushed in a mill. To do this, sugar from the bag is loaded in portions into the loading hopper. Crushed sugar through the lower nozzle of the mill is collected in a plastic bag, the ends of which are previously fixed on the nozzle. The bag is placed in the receiver.

The yield of crushed sugar is 70.6 kg.

Flower pollen in the amount of 5.8 kg is weighed in bags on a scale, visually checked for mechanical impurities, then, in the absence of impurities, crushed in a mill. To do this, flower pollen from the bag is loaded in portions into the loading hopper. The crushed pollen flower through the lower nozzle of the mill is collected in a plastic bag, the ends of which are previously fixed on the fitting. The bag is placed in the receiver.

The yield of shredded flower pollen is 5.72 kg.

Ginger roots in the amount of 1.5 kg are weighed on a scale, visually checked for mechanical impurities, then, in the absence of impurities, crushed in a mill. To do this, ginger roots from the bag are loaded in portions into the loading hopper. The crushed ginger roots through the lower nozzle of the mill are collected in a plastic bag, the ends of which are previously fixed on the nozzle. The bag is placed in the receiver.

The yield of crushed ginger root is 1.45 kg.

Cinnamon bark in the amount of 1.5 kg is weighed on a scale, visually checked for mechanical impurities, then, in the absence of impurities, crushed in a mill. To do this, the cinnamon bark from the bag is loaded in portions into the loading hopper. The crushed cinnamon bark through the lower nozzle of the mill is collected in a plastic bag, the ends of which are previously fixed on the nozzle. The bag is placed in the receiver.

The yield of crushed cinnamon bark is 1.45 kg.

Nutmeg in the amount of 1.5 kg is weighed in bags on a scale, visually checked for mechanical impurities, then, in the absence of impurities, crushed in a mill. To do this, nutmeg from the bag is loaded in portions into the loading hopper. The crushed nutmeg through the lower nozzle of the mill is collected in a plastic bag, the ends of which are previously fixed on the nozzle. The bag is placed in the receiver.

The yield of chopped nutmeg is 1.43 kg.

In a 10 liter enameled container, 6 kg of saffron infusion are brought to a boil. A suspension of starch is prepared separately. To do this, take 0.5 kg of starch and 1 kg of infusion, mix and add to a boiling solution, bring to a boil with constant stirring.

The yield of the finished product is 7.45 kg.

In an enameled container of 5 l load 2 kg of water, bring to a boil, add 1.43 kg of citric acid, mix until the acid is completely dissolved.

The yield of the finished product is 3.4 kg.

1 kg of water and 18 kg of sugar are loaded into an enameled 3-liter container, brought to a boil, boiled for 5 minutes, cooled to 95 ° C, and 0.29 kg of royal jelly is added. The solution is brought to a temperature of 95 ° C in a boiling water bath and incubated for 5 minutes. The solution is filtered through 4 layers of gauze.

The product yield is 3.05 kg.

Crushed sugar, pollen, ginger root, cinnamon bark, nutmeg, starch, ascorbic acid, succinic acid, citric acid, vitamin E are sieved through a sieve with a hole diameter of 1 mm, talc and calcium stearate through a sieve with a hole diameter of 0.5 mm Water, succinic acid solution is filtered through 4 layers of gauze.

With the lid open, load 15 kg of crushed sugar, 0.143 kg of succinic acid, mix for 5 minutes, add ginger root 1.43 kg, cinnamon bark powder 1.43 kg, nutmeg 1.43 kg, mix for 10 minutes, then add starch 9.8 kg and flower pollen 5.72 kg. The mixture is stirred for 10 minutes. Then a sugar residue of 53.8 kg is added. The whole mixture is stirred for another 10 minutes. Moisturize with a solution of citric acid 3.4 kg, mix for 5 minutes, add a solution of royal jelly in syrup 3.05 kg, mix for 5 minutes and add starch paste in an amount of 7.45 kg. Stirred for 10 minutes.

The yield of finished product is 103.94 kg.

The wet mass in the amount of 103.94 kg is loaded in portions into the installation to obtain granulate from wet tablets. Turn on a screw device, with which the mixture is pressed through a mesh with holes with a diameter of 4-5 mm. Wet granulate is collected in a receiver. Wet granulate is transferred from the receiver to the dryer.

The yield of the product is 103.44 kg.

Moistened tablet mass in the amount of 103.44 kg is laid out on paper in trays with a layer thickness of 1.5-2 cm. The trays are installed in an oven. The system for supplying hot air to the switchgear of the drying cabinet is switched on. The drying temperature is set at 40-45 ° C, with an increase in which the supply of hot air is automatically turned off. The drying process is carried out for 10 hours to constant weight with periodic stirring (at least 3 times). Drying control is carried out in the laboratory by weighing product samples from trays to a constant weight. Product humidity - no more than 2%. The dry tablet mass is sent to dry granulation.

The yield of dry tablet mass is 93.3 kg.

The dried mixture in the amount of 93.3 kg is loaded in portions into the installation to obtain granulate from dry tablets. Turn on the screw device, with which the mixture is rubbed through a mesh with holes, with a diameter of 1.5 mm. Dry granulate is collected in a receiver. From the receiver, dry granulate is loaded with the lid open into the mixer.

To a dry granular tablet mixture in an amount of 93.3 kg, a mixture of vitamin E in an amount of 1.43 kg and ascorbic acid 5.8 kg is added to the mixers. The mixture is stirred for 10 minutes and 1.03 kg of talc and 1.03 kg of calcium stearate are added, and stirred for another 10 minutes. The finished granulate is transferred to tableting.

The yield of finished granulate is 102 kg.

From the mixer, dry granules in the amount of 101 kg are sent for tabletting into the loading hopper of the tabletting machine.

Turn on the engine. Pre-set engine speed in accordance with the bulk density, the pressing zone and the height of the tablet. When the machine starts, the vacuum cleaner turns on.

The diameter of the tablet is 10.0 ± 0.2 mm.

The height of the tablet is 3.6 ± 0.3 mm.

The average tablet weight is 0.36 g ± 0.02.

During tabletting, they monitor the operation of the machine and the quality of the tablets. Every 30 minutes, the disintegration, strength and average weight of the tablets are checked. Inadequate tablets are discarded and sent for recycling. At the end of the process, the machine is turned off in the reverse order. The tablets are collected in a receiver and sent for dust removal.

The product yield is 101.5 kg.

Finished tablets in the amount of 101.5 kg are sieved on a vibrating screen through a hole with a diameter of 8 mm, weighed on an 8 kg scale and loaded into clean, dry plastic buckets. Samples of the finished tablets are transferred to the control and analytical laboratory for analysis. When the tablets comply with the technical documentation standards, the finished tablets are transferred to the packaging stage.

The output of the finished tablets is 101 kg.

The sequence of operations is the same regardless of the number of prepared composition.

The “Phyto-Rejuvenating” preparation contains well-known medicinal products approved for use in medical practice, which in the indicated combination (see table 1, examples 1-4) provide for the reduction or disappearance of the symptoms of premature aging of the body, with exhaustion, weakness, after diseases and operations .

Starch, sugar were used as auxiliary components ensuring the reliability of preservation of the shape of the pressed tablets in a dry form and their short disintegration time in a humid environment, and calcium stearate and talc were used to improve the fluidity of the granulate.

Available in the form of tablets, which is convenient for use, has a long shelf life (2 years).

Clinical trials were conducted on volunteers.

During clinical trials, the Phyto-Rejuvenating drug was prescribed to patients older than 45 years with progressive signs of aging.

According to the bicycle ergometry test, the initial average tolerance threshold was 25 W, which was only 50% of the normal level for healthy untrained women. The reason for the stop was fatigue. There were no threshold signs of pathology from the cardiovascular system.

Before therapy with Phyto-Rejuvenating drug (against the background of basic therapy for 6 months), 100% of patients complained of irritability, 80% of them were anxiety, increased irritability, and 70% had emotional lability. Complaints of weakness and severe fatigue were presented by 100% of patients. Complaints about a decrease in physical activity were presented by 80% of women, which was objectively confirmed by a bicycle ergometry test.

The results of the ITO personality survey revealed that the most common combination of multidirectional trends, indicating disadaptive internal conflict (40%). The second most frequent was the sensitive type of response (30%), in addition, it was possible to distinguish anxious and aggressive personalities (20%), characterized by pronounced emotional instability. 1 woman, due to poor self-understanding and reduced criticality, showed inadequate self-esteem with a high degree of insincerity.

Only 20% regarded the "quality of life" as "good", as "satisfactory" 70% and "poor" 10% of the observed patients.

The dynamics of clinical symptoms against the background of the intake of dietary supplements (see table 2) reliably confirmed an improvement in the general clinical status and autonomic symptoms. When conducting a bicycle ergometric test, it was objectively confirmed that the average tolerance threshold was 50 W, i.e. working capacity doubled and amounted to 75% of the norm for healthy untrained women. The reason for the stop was the achievement of the calculated submaximal pulse.

According to the results of the ITO personality survey, it was revealed that maladaptive internal conflict persisted in 20%, the sensitive type of response did not change (30%), anxious and aggressive traits persisted in 10%, which are characterized by pronounced emotional instability. Inadequate self-esteem with a high degree of insincerity was not recorded. 40% were assigned to the standard option. So, by the 60th day only 60% of patients complained of irritability, of which 40% - anxiety, increased irritability, 40% remained emotional lability. Complaints of weakness and fatigue persisted only in 50% of patients. A decrease in physical activity persisted in 40% of women. “Quality of life” was considered “good” by 70% of patients, and “satisfactory” by 30%.

60% of patients subjectively noted improvement in turgor and complexion.

Claims (1)

A preparation for the prevention of premature aging of the body, which has a restorative, tonic and anti-aging effect, including royal jelly, flower pollen and excipients: starch, calcium stearate, talc and sugar, characterized in that it additionally contains a dry concentrate of saffron infusion, ginger root, cinnamon , nutmeg, vitamin E, succinic acid, ascorbic acid and citric acid in the following ratio of components, g per tablet weighing 0.36 g: Royal Jelly 0.0005-0.0040 Flower pollen 0.0100-0.0800 Dry concentrate of saffron infusion 0.000004-0.00015 Ginger Root 0.0025-0.0100 Cinnamon 0.0025-0.0100 Nutmeg 0.1000-0.2000 Vitamin E 0.0025-0.0100 Succinic acid 0.0025-0.0100 Ascorbic acid 0.0100-0.0800 Citric acid 0.0025-0.0100 Starch 0.0200-0.0500 Calcium Stearate 0.0050-0.0100 Talcum 0.0050-0.0100 Sugar Else