RU2235558C1 - Antiseptic preparation - Google Patents

Abstract

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to disinfecting agents eliciting bactericidal, fungicide and virucidal effect. Antiseptic preparation comprises ethyl alcohol, alkyldimethylbenzyl ammonium chloride, propylene glycol, distilled glycerol, grape kernel oil, tocopherol acetate and water. Combination of components in the definite ratio provides preparing the preparation eliciting broad spectrum of effect and high degree of protection, safety in using and no inducing allergic responses.

EFFECT: enhanced effectiveness, valuable properties of preparation.

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Description

The invention relates to the satisfaction of vital needs, namely to the food industry, as an antimicrobial, disinfectant and sterilizing agent, used, for example, as a skin antiseptic for treating hands, treating an injection field, elbow bends of donors, having a bactericidal, fungicidal and virucidal effect.

Known antimicrobial agent with a wide spectrum of antimicrobial activity, containing active substances, excipients and water (patent RU No. 2113862, class A 61 L 25/18, 1998).

As active substances are used:

- alkyldimethylbenzylammonium chloride, ethyl alcohol;

as auxiliary:

- glycerin and castor oil.

The objective of the invention is the creation of an antiseptic drug with a wide spectrum of action, having bactericidal and antiseptic properties. In addition, the objective of the invention is to provide a drug that is safe to use, does not cause allergic reactions, with a high degree of protection and preservation of the skin.

The problem is solved in that the antiseptic preparation contains alkyldimethylbenzylammonium chloride, ethyl alcohol, propylene glycol, glycerin and grape seed oil, a 5.0-33.5% solution of tocopherol acetate and water in the following proportions, wt.%:

ethyl alcohol 75.0-80.0

Alkyldimethylbenzylammonium chloride 0.05-0.15

distilled glycerin 0.01-0.3

propylene glycol 0.01-0.3

grape seed oil 0.1-0.3

tocopherol acetate 0.005-0.1

water rest

Analysis of the claimed object and its comparison with the prototype allow us to conclude that the proposed object contains new components, the totality of which allows us to solve the problem.

The combination of ingredients and their quantitative ratio allows to provide an antiseptic and bactericidal effect and to protect the skin when using the drug.

A high degree of protection and preservation of the skin is achieved, firstly, by the use of grape seed oil, which, due to its alpha hydroxy acid content, is easily absorbed by the skin and combines moisture, holding it for a long time in the cells, and secondly, by the use of tocopherol acetate, which is the strongest antioxidant - protects the skin from the harmful effects of the environment. Thanks to the use of a solution of tocopherol acetate in grape seed oil, the effect of ethyl alcohol is reduced in combination with other active ingredients that dry the skin, destroying the components of intercellular substances, collagen, lipids, which are the basis of the skin, which are important for the normal functioning of the skin. The technical result of the invention is to minimize the harmful effects on the skin of the active ingredients of the composition.

The proposed composition is prepared as follows:

An aqueous solution of alkyl dimethylbenzylammonium chloride is added to ethyl alcohol with stirring, then the required amount of distilled and propylene glycol glycerol is added. Tocopherol acetate is added to the grape seed oil to obtain a 5.0-33.5% solution. An oil solution is added to a pre-prepared ethanol-based solution and water is added to 100% with stirring. The safety indicators of the drug are determined according to the guidelines "Assessment of the effects of harmful chemical compounds on the skin and the justification of the maximum permissible levels of skin pollution", USSR Ministry of Health, Moscow, 1980

The resulting preparation has the following safety indicators: when applied to the skin more than 10,000 mg / k corresponds to hazard class 4.

There is no local irritant effect on the skin when applying 10 applications.

Performance indicators are determined in accordance with the testing methods of disinfectants to assess their safety and effectiveness (Moscow, 1996).

The effectiveness of the disinfecting effect on the skin in the mode of application when processing the skin of the surgical field according to the total microflora is at least 100%, according to the test culture with artificial contamination, at least 100.0%.

The effectiveness of the disinfecting effect on the skin in the mode of application when processing the skin of the surgical field according to the total microflora is at least 95%.

The drug is active against gram-negative and gram-positive bacteria (including tuberculosis microbacteria), fungi of the genera Candida and Trichophyton, viruses (pathogens of parenteral viral hepatitis, HIV infection, herpes, rotavirus gastroenteritis, enterovirus infections, hepatitis A, poliomyelitis acute and influenza, and influenza. viral infections).

Example 1

To prepare 1000 g of the drug, 780 g of ethanol are taken in terms of 100%; 1.5 g of distilled glycerol, 1.5 g of propylene glycol are added. In 2.0 g of grape seed oil, add 0.1 g of tocopherol acetate to obtain a 5% solution, then add a 50% aqueous solution of alkyl dimethylbenzylammonium chloride - 1 g in terms of 100% and adjust the composition with water to 1000 g. The drug is bottled with a capacity of 0.1, 1, 5 dm ³ .

Example 2

To prepare 1000 g of the drug, take 750 g of ethyl alcohol in terms of 100%; add 0.1 g of distilled glycerol, 3 g of propylene glycol. In 3.0 g of grape seed oil, add 1 g of tocopherol acetate to obtain a 33.5% solution, then add a 75% aqueous solution of alkyldimethylbenzylammonium chloride, i.e. 1.5 g in terms of 100% and adjusted the composition with water to 1000 g. The drug is poured into bottles with a capacity of 0, 1, 1, 5 dm ³ .

Example 3

To prepare 1000 g of the drug, 800 g of ethyl alcohol are taken in terms of 100%; add 3 g of distilled glycerol, 3.0 g of propylene glycol. In 2.0 g of grape seed oil, add 0.1 g of tocopherol acetate to obtain a 5% solution, then add a 50% aqueous solution of alkyl dimethylbenzylammonium chloride - 1 g in terms of 100% and adjust the composition with water to 1000 g. The drug is bottled with a capacity of 0.1, 1, 5 dm ³ . Physico-chemical characteristics of the drug are shown in the table.

The drug belongs to hazard class 4: low-hazard substances.

The shelf life of the drug is 3 years.

The drug is a ready-to-use solution. It is applied to the hands and rubbed into the skin.

The drug has antimicrobial activity against gram-positive and gram-negative bacteria (including pathogens of nosocomial infections; Mycobacterium tuberculosis); Candida fungi and viruses (including hepatitis B virus and HIV)

After using the drug, dry skin is not observed. The skin of the hands retains its natural state.

Thus, tests showed that the drug provides a disinfecting effect with a low content of active substances.

Claims (1)

An antiseptic preparation, including ethyl alcohol, alkyldimethylbenzylammonium chloride, glycerin and water, characterized in that it additionally contains propylene glycol and a 5.0-33.5% solution of tocopherol acetate in grape seed oil, and distilled glycerin is used as glycerin the following ratio of ingredients, wt.%: Ethyl alcohol 75 - 80 Alkyldimethylbenzylammonium chloride 0.05 - 0.15 Propylene glycol 0.01 - 0.3 Distilled glycerin 0.01 - 0.3 Grape Seed Oil 0.1 - 0.3 Tocopherol acetate 0.005 - 0.1 Water Else