RU2226103C2 - Способы и композиции для предотвращения развития толерантности к лекарственным средствам - Google Patents
Способы и композиции для предотвращения развития толерантности к лекарственным средствам Download PDFInfo
- Publication number
- RU2226103C2 RU2226103C2 RU2001114522/14A RU2001114522A RU2226103C2 RU 2226103 C2 RU2226103 C2 RU 2226103C2 RU 2001114522/14 A RU2001114522/14 A RU 2001114522/14A RU 2001114522 A RU2001114522 A RU 2001114522A RU 2226103 C2 RU2226103 C2 RU 2226103C2
- Authority
- RU
- Russia
- Prior art keywords
- sulfated polysaccharide
- receptor agonist
- adrenergic receptor
- composition
- agonist
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 28
- 239000000203 mixture Substances 0.000 title claims abstract 12
- 238000011321 prophylaxis Methods 0.000 title abstract 4
- 206010052804 Drug tolerance Diseases 0.000 title abstract 3
- 150000004676 glycans Chemical class 0.000 claims abstract 22
- 229920001282 polysaccharide Polymers 0.000 claims abstract 22
- 239000005017 polysaccharide Substances 0.000 claims abstract 22
- 239000000556 agonist Substances 0.000 claims abstract 8
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims abstract 5
- 229960004017 salmeterol Drugs 0.000 claims abstract 5
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims abstract 3
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims abstract 3
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims abstract 3
- 208000006673 asthma Diseases 0.000 claims abstract 3
- 229960004620 bitolterol Drugs 0.000 claims abstract 3
- FZGVEKPRDOIXJY-UHFFFAOYSA-N bitolterol Chemical compound C1=CC(C)=CC=C1C(=O)OC1=CC=C(C(O)CNC(C)(C)C)C=C1OC(=O)C1=CC=C(C)C=C1 FZGVEKPRDOIXJY-UHFFFAOYSA-N 0.000 claims abstract 3
- 229960002848 formoterol Drugs 0.000 claims abstract 3
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims abstract 3
- 229940039009 isoproterenol Drugs 0.000 claims abstract 3
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 claims abstract 3
- 229960002657 orciprenaline Drugs 0.000 claims abstract 3
- 230000007170 pathology Effects 0.000 claims abstract 3
- 229960002052 salbutamol Drugs 0.000 claims abstract 3
- 229960000195 terbutaline Drugs 0.000 claims abstract 3
- 238000011282 treatment Methods 0.000 claims abstract 2
- 239000000048 adrenergic agonist Substances 0.000 claims 10
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 7
- 239000003055 low molecular weight heparin Substances 0.000 claims 7
- 229940127215 low-molecular weight heparin Drugs 0.000 claims 7
- 150000004044 tetrasaccharides Chemical class 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- HUYWAWARQUIQLE-UHFFFAOYSA-N Isoetharine Chemical compound CC(C)NC(CC)C(O)C1=CC=C(O)C(O)=C1 HUYWAWARQUIQLE-UHFFFAOYSA-N 0.000 claims 2
- VQDBNKDJNJQRDG-UHFFFAOYSA-N Pirbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=N1 VQDBNKDJNJQRDG-UHFFFAOYSA-N 0.000 claims 2
- 230000002429 anti-coagulating effect Effects 0.000 claims 2
- 229960003060 bambuterol Drugs 0.000 claims 2
- ANZXOIAKUNOVQU-UHFFFAOYSA-N bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 claims 2
- 229940124630 bronchodilator Drugs 0.000 claims 2
- 229960001268 isoetarine Drugs 0.000 claims 2
- 229960005414 pirbuterol Drugs 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 239000004479 aerosol dispenser Substances 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229940071648 metered dose inhaler Drugs 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- -1 banbuterol Chemical compound 0.000 abstract 2
- 230000003182 bronchodilatating effect Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Images
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10650798P | 1998-10-30 | 1998-10-30 | |
| US60/106,507 | 1998-10-30 | ||
| US09/362,540 | 1999-07-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001114522A RU2001114522A (ru) | 2003-05-10 |
| RU2226103C2 true RU2226103C2 (ru) | 2004-03-27 |
Family
ID=27804349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001114522/14A RU2226103C2 (ru) | 1998-10-30 | 1999-10-13 | Способы и композиции для предотвращения развития толерантности к лекарственным средствам |
Country Status (3)
| Country | Link |
|---|---|
| RU (1) | RU2226103C2 (enrdf_load_stackoverflow) |
| UA (1) | UA73726C2 (enrdf_load_stackoverflow) |
| ZA (1) | ZA200103375B (enrdf_load_stackoverflow) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2051901C1 (ru) * | 1990-03-27 | 1996-01-10 | Актиеболагет Драко | Производные 1-бензиламинофенил-2-(1-метил-2-фенилэтиламино)-этанола-1 в виде смеси изомеров или рацемата или их фармацевтически приемлемые соли, проявляющие бронхоспазмолитическую активность |
| US5674860A (en) * | 1991-12-18 | 1997-10-07 | Astra Aktiebolag | Combination of a bronchodilator and a steroidal anti-inflammatory drug for the treatment of respiratory disorders |
-
1999
- 1999-10-13 RU RU2001114522/14A patent/RU2226103C2/ru not_active IP Right Cessation
- 1999-10-13 UA UA2001042960A patent/UA73726C2/uk unknown
-
2001
- 2001-04-25 ZA ZA200103375A patent/ZA200103375B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2051901C1 (ru) * | 1990-03-27 | 1996-01-10 | Актиеболагет Драко | Производные 1-бензиламинофенил-2-(1-метил-2-фенилэтиламино)-этанола-1 в виде смеси изомеров или рацемата или их фармацевтически приемлемые соли, проявляющие бронхоспазмолитическую активность |
| US5674860A (en) * | 1991-12-18 | 1997-10-07 | Astra Aktiebolag | Combination of a bronchodilator and a steroidal anti-inflammatory drug for the treatment of respiratory disorders |
Non-Patent Citations (1)
| Title |
|---|
| Справочник практического врача. /Под ред. А.И.Воробъева. - М.: Медицина, 1990, т.1, с. 139-142. * |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200103375B (en) | 2003-02-06 |
| UA73726C2 (enrdf_load_stackoverflow) | 2005-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2348926A1 (en) | Methods and compositions for the prevention of tolerance to medications | |
| JP3263723B2 (ja) | 喘息を治療するための組成物、及び喘息にかかった患者を治療するための気管支内薬物の製造における超低分子量ヘパリンの使用 | |
| EP1003479B1 (en) | Method and compositions for treating late phase allergic reactions and inflammatory diseases | |
| RU2179037C2 (ru) | Баллон для доставки фармацевтического состава, дозирующий ингалятор | |
| JP4570251B2 (ja) | 医薬用エーロゾル製剤 | |
| Leonard et al. | The effects of some hallucinogenic drugs upon the metabolism of noradrenaline | |
| EP2749284A2 (en) | Combination of glycopyrronium and carmoterol | |
| NO336142B1 (no) | Farmasøytisk preparat omfattende glykopyrrolat, tørrpulverinhalator som omfatter preparatet og anvendelse derav | |
| RU2000105383A (ru) | Способ и композиции для лечения аллергических реакций на поздней стадии и воспалительных заболеваний | |
| CZ301305B6 (cs) | Tlakové nádobky pro inhalaci odmerené dávky | |
| RU2226103C2 (ru) | Способы и композиции для предотвращения развития толерантности к лекарственным средствам | |
| RU2001114522A (ru) | Способы и композиции для предотвращения развития толерантности к лекарственным средствам | |
| RU2179445C2 (ru) | Способ и композиция для лечения астмы | |
| EP1462148A2 (en) | Methods and compositions for the prevention of tolerance to bronchodilators | |
| AU775161B2 (en) | Method and compositions for treating late phase allergic reactions and inflammatory diseases | |
| HK1069137A (en) | Methods and compositions for the prevention of tolerance to bronchodilators | |
| Lindbladh et al. | A comparison of the bronchodilator effect of salbutamol inhaled via Turbuhaler® as two consecutive doses or as two divided doses at different time intervals | |
| JP2516542B2 (ja) | 乳酸菌含有瀉下薬組成物 | |
| Steffensen et al. | Formoterol as inhalation powder in the treatment of patients with reversible obstructive lung diseases. A 3-month placebo-controlled comparison of the effects of formoterol and salbutamol, followed by a 12-month period with formoterol alone | |
| MXPA00000992A (en) | Method and compositions for treating late phase allergic reactions and inflammatory diseases | |
| HK1007060B (en) | Ulmwh (ultra-low-molecular weight heparin) for treating asthma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC43 | Official registration of the transfer of the exclusive right without contract for inventions |
Effective date: 20120706 |
|
| PC43 | Official registration of the transfer of the exclusive right without contract for inventions |
Effective date: 20120921 |
|
| PD4A | Correction of name of patent owner | ||
| PC41 | Official registration of the transfer of exclusive right |
Effective date: 20121219 |
|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20171014 |