RU2223770C2 - Method for preventing and treating the cases of gastrointestinal and urinary tract diseases - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves diluting natural bischofite pickle with natural or tap water to reach 1.2-2.8 g/dm³ mineralization level and producing in this way mineral water having anions and cations in the following proportion in mg/dm³: HCO₃ - 250-450, SO $\genfrac{}{}{0ex}{}{\text{2}}{\text{4}}$ not less than 150, Cl - 700-1700, Br - 5-25, Ca²⁺ - less than 100, Mg²⁺ 200- 500, (Na⁺+K⁺) - 100-400, the rest is completed with water. The so prepared mineral water is administered at a dose of 1\2 of glass 30- 60 min before taking meals daily during 24-30 days at 37-40 C. EFFECT: enhanced effectiveness of treatment. 2 cl

Description

 The invention relates to medicine, to the prevention and treatment of diseases of the gastrointestinal tract, hepatitis, postcholecystectomy syndrome and diseases of the genitourinary system.

 There is a method of treating diseases of the gastrointestinal tract and genitourinary system by prescribing the intake of mineral water prepared by diluting with water a natural bischofite brine (RF Patent, 2076713, class A 23 L 2/00, 1997) / 1 / - prototype.

The natural mineral bischofite is a magnesium chloride produced in the form of brine in the Narimanov section of the Volgograd field. It is an oily liquid with a total salinity of 415-460 g / l. The density of bischofite is 1.3-1.32 g / cm ³ , pH 4.5-4.7. Bischofite contains magnesium chloride - up to 434.5 g / l, magnesium bromide - 4-9 g / l, calcium sulfate - up to 1 g / l, calcium hydrogen carbonate - 0.5 g / l, potassium chloride - up to 5 g / l, sodium chloride - up to 5 g / l, calcium chloride - up to 5 g / l.

 According to the known method for the treatment of diseases of the gastrointestinal tract and genitourinary system, it is recommended to prescribe therapeutic water with a total mineralization of 8-12 g / l, prepared by diluting bischofite with distilled water in a ratio of 1: (38-58). It is also recommended to appoint medicinal table water with a total salinity of 2-8 g / l, prepared by diluting bischofite with distilled water in a ratio of 1: (58-230), as well as medicinal table water with a total salinity of 5.0-6, 0 g / l prepared by diluting bischofite with distilled water in a ratio of 1: (76-92). In addition, this information source describes table water (a refreshing drink) with a total mineralization of 1-2 g / l and less than 1 g / l, which is prepared by diluting bischofite with distilled water in a ratio of 1: (230-460) and which is recommended for use inside systematically, without prescribing a doctor as table mineral water. This information source indicates that the dose and duration of use of water prepared by diluting bischofite in the specified ratio of bischofite to water are not limited.

 However, the prolonged use of water prepared by diluting bischofite in the conditions of the Dubovka sanatorium in the Volgograd region and on an outpatient basis at the Moscow Medical University of 18 Volgograd showed that only a narrow range of total mineralization is applicable for treating diseases of the gastrointestinal tract and genitourinary system.

 The technical result achieved by the present invention is to increase the effectiveness of the treatment of diseases of the gastrointestinal tract and genitourinary system through the use of mineral water with an optimal narrow range of total mineralization prepared by diluting bischofite with drinking water.

The specified technical result is achieved by the fact that in the method for the prevention and treatment of diseases of the gastrointestinal tract and genitourinary system by the appointment of mineral water prepared by diluting with water a natural bischofite brine to obtain mineral water containing anions HCO ₃ ^- , SO ₄ ^2- , Cl ^- , Br ^- , cations Ca ²⁺ , Mg ²⁺ , (Na ⁺ + K ⁺ ) and water, a distinctive feature is that bischofite is diluted with natural or tap drinking water to a total mineralization of 1.2-2.8 g / dm ³ to obtain mineral water containing anions and cations in their following ratio, mg / DM ³ :
NSO ₃ ^- - 250 - 450
SO ₄ ^2- - Less than 150
Cl ^- - 700 - 1700
Br ^- - 5 - 25
Ca ²⁺ - Less than 100
Mg ²⁺ - 200 - 500
(Na ⁺ + K ⁺ ) - 100 - 400
Water - Else
and the prepared mineral water is prescribed for daily intake of 1/2 cup 30-60 minutes before meals for 24-30 days.

Allowed the appointment to receive mineral water with a temperature of 37-40 ^o C.

 Given the value of the level of total mineralization and predominantly magnesium cationic composition, the mineral water used by the method according to the invention for treating diseases of the gastrointestinal tract and genitourinary system is treatment-table water and occupies an intermediate position among the known, industrially bottled mineral waters XVI, XX and XXVII groups (GOST 13273-88). The name "Aqua-Bi" has been assigned to water.

 The following are examples illustrating the invention.

 Example 1. At the Department of Histology of the Volgograd Medical Academy, the effect of water prepared according to examples 1-3 on the processes of reparative regeneration in the stomach was studied.

Experimental studies were performed on 40 white Wistar male rats. We studied the effect of sodium chloride-magnesium water prepared by diluting bischofite with natural drinking water. The water variants used had a total salinity of 1.2 g / dm ³ , 2.0 g / dm ³ and 2.8 g / dm ³ , which corresponded to three compositions, mg / dm ³ :
NSO ₃ ^- - 250; 350; 450
SO ₄ ^2- - 100; 120; 140
Cl ^- - 700; 1200; 1700
Br ^- - 5; fifteen; 25
Ca ²⁺ - 50; 70; 90
Mg ²⁺ - 200; 350; 500
(Na ⁺ + K ⁺ ) - 100; 250; 400
Water - Else
We studied the effect of three samples of prepared water on the acetate model of gastric ulcer. A group of 40 rats was divided into 4 subgroups. In 10 rats, tap water was used as a control. 30 experimental rats were divided into three subgroups and investigated, respectively, the effect on them of three samples of prepared water. All experimental rats were orally administered once daily with 3 ml of water through a needle with olive at the end for 21 days. Histological studies were performed after the animals were killed, after 15 drinking procedures and on the 6th day of the aftereffect. The objective parameters for evaluating the effectiveness of the action of mineral water were the sizes (indices) of ulcerative defects, their complete epithelization, mitotic activity of the epithelium at the edges of ulcers, and the development of granulation tissue.

It was shown that after 15 animal watering procedures with mineral water heated to 37-40 ^° C (all three variants), activation of cell proliferation in the connective and epithelial tissues of the stomach was noted with the development of blood vessels and granulation tissue and the initial effects of epithelization at the edges of ulcerative defects. A tendency to a decrease in the size of ulcerative defects was noted.

 In general, at that time, against the background of a weakening of inflammatory and dystrophic-necrotic phenomena, there was an increase in biosynthetic processes, which are the basis for the development of protective and adaptive-compensatory reactions.

 During the aftereffect, on the 6-10th days after the end of the course of drinking, there was a decrease in the size of ulcerative defects compared to the control by 64.5%, with fully healed ulcers being 53.1%.

 Example 2. A clinical examination of 120 patients (55 men, 65 women) was carried out, which were divided into two groups of 60 people each.

 The first group included 40 patients with peptic ulcer of the stomach and duodenum and 20 patients with erosive gastritis outside the stage of exacerbation. Among the patients of the group, women aged 38-42 years prevailed. Concomitant pathology in this group was represented by chronic cholecystitis, hepatitis, pancreatitis, gastritis and hypertension. The second group included 60 patients with a similar underlying and concomitant pathology. The average age of patients is 38-43 years.

Patients of the first group received drinking treatment with water prepared according to the invention: diluting bischofite with natural drinking or tap drinking water to produce mineral table water with a total salinity of 1.5 g / dm ³ , 2.2 g / dm ³ and 2, respectively 5 g / dm ³ . The water was used heated to 37-40 ^o C. The treatment was carried out in the conditions of the sanatorium "Dubovka" in the Volgograd region. and outpatient at MMU 18, Volgograd.

 Patients of the second group received treatment with Smirnovskaya sulphate-magnesium mineral water.

 Patients of both groups underwent a traditional general clinical examination. The diagnosis of gastric ulcer and duodenal ulcer was established using generally accepted diagnostic criteria: complaints, survey data, objective examination of laboratory and instrumental studies: radiological and endoscopic. According to FGS, in patients with a moderate amount of fluid, thickening of folds with edematous spotted mucosa was determined in the stomach. In some patients, erosion was observed on average 0.5-0.8 cm with the tips pulled in, as well as ulcerative defects along the lesser curvature of the stomach with an average diameter of 0.6-0.9 cm with a bottom covered with fibrin and an inflammatory shaft around. Peptic ulcer in the duodenal bulb was 0.3-0.5 cm in diameter.

Patients of both compared groups took 1/2 cup of water in 3 divided doses 30-60 minutes before meals for 24-30 days. Water temperature 37-40 ^o C.

 After treatment, patients of the two compared groups showed a subjective improvement: increased appetite, decreased heartburn, the disappearance of epigastric pain. According to an endoscopic study, 72% of patients of the first group showed the disappearance of mucosal edema, a decrease in the size of erosion by an average of 1.9 times and their number by 1.5 times. Peptic ulcers decreased on average 2.0 times, their pronounced epithelization appeared.

 63% of patients of the second group noted the disappearance of mucosal edema, a decrease in the size of erosion by an average of 1.5 times and their number by 1.2 times. Peptic ulcers decreased on average by 1.8 times, while their moderate epithelization was noted.

 Thus, clinical studies have shown that patients taking mineral water according to the invention, compared with patients taking mineral water Smirnovskaya, have more pronounced antispasmodic, analgesic, tonic and regenerating effects, as well as improved somatic status.

Example 3. A group of patients from 200 people with gastric ulcer and erosive gastritis was divided into three subgroups: 20, 90 and 90 people, respectively. Patients of the first, second and third subgroups received water with a total salinity of 1.0 g / dm ³ , 2.2 g / dm ³ and 3.2 g / dm ³ , respectively, prepared by diluting bischofite with natural drinking water or drinking tap water . All patients were prescribed water in the amount of 1/2 cup in three divided doses 30-60 minutes before meals for 24-30 days. Water temperature 37-40 ^o C.

 After a course of treatment, the three compared groups received different results.

 In patients of the second subgroup receiving mineral water prepared according to the invention, a subjective improvement was noted: increased appetite, decreased heartburn, and the disappearance of epigastric pain. In 80% of patients of this group, the disappearance of edema of the mucosa, a decrease in the size of erosion by an average of 1.9 times. Peptic ulcers decreased on average by 2 times, their pronounced epithelization appeared.

 Patients of the first and third subgroups did not show a pronounced therapeutic effect and changes for the better. Moreover, in three patients of the first subgroup and in seven patients of the third subgroup, a deterioration was noted. Some patients of the third subgroup had pronounced loose stools, which may be associated with a high level of magnesium in water exceeding its level recommended by the present invention.

Example 4. Water according to the invention with a total salinity of 1.2-2.8 g / dm ³ was prescribed as an additive to therapeutic nutrition for women with diseases of the gastrointestinal tract with concomitant fibrocystic mastopathy with pain. The water was heated to 37-40 ^o C and was appointed in the amount of 1/2 cup three times a day for 30-60 minutes before meals for 24-30 days. Water intake was accompanied by a decrease in pain, a decrease in turgor of breast tissue.

Example 5. In contrast to the well-known sulfate-sodium waters ("Jermuk", "Smirnovskaya", "Essentuki-17") mineral water "Aqua-Bi", prepared by diluting bischofite with natural or tap water to a total mineralization of 1.2-2, 8 g / dm ³ , is magnesium chloride water with a significant content of magnesium ions, which actively influence the bile excretory function, enhance cystic reflux, change the physicochemical properties of bile, and increase the content of bile pigments and acids. Calcium ions present in Aqua-Bi water have an anti-inflammatory effect, reduce the permeability of cell membranes, and reduce the tendency to bleed mucous membranes. According to the Scientific Research Institute of Pharmacology of the Volgograd Medical Academy, when applying magnesium preparations, cardioprotection develops with myocardial infarction, cardiac arrhythmia is stopped, antihypertensive effect is manifested, chronic fatigue syndrome is eliminated. Magnesium preparations are used for cerebrovascular accidents, urolithiasis, and osteoporosis.

 When studying Aqua-Bi mineral water prepared by diluting bischofite with natural drinking water, it was shown at the Department of Pharmacology of the Volgograd Medical Academy that water has hypocholesterolemic activity. When using water in the treatment of the liquidators of the Chernobyl accident, normalization of the psychophysiological state was observed, its immunomodulatory effect and a decrease in the production of histamine, serotonin, and bradykinins were noted.

 Example 6. Mineral water "Aqua-Bi", prepared according to the invention from bischofite, was used to treat patients with chronic diseases of the genitourinary tract. Observations were made of 17 patients suffering from urolithiasis, chronic pyelonephritis in remission, chronic prostatitis in remission. Patients took Aqua-Bi mineral water 1/2 cup 30-60 minutes before meals for 24-30 days. Beginning with a two-, three-day course of taking mineral water, all patients noted improvement in well-being, all patients showed positive clinical and laboratory dynamics (general urine analysis, general blood analysis, urine analysis according to Nechiporenko).

Example 7. Since May 1999, chloride-magnesium mineral water "Aqua-Bi" with a total salinity of 1.2-2.8 g / dm ³ , prepared by diluting bischofite with tap drinking water, is used in a complex of therapeutic measures in patients of the sanatorium rehabilitation department Dubovka, Volgograd Region, who underwent surgery on the organs of the hepatobiliary zone or on the intestine. Studies have shown the following:
1. Mineral water "Aqua-Bi" does not adversely affect the course of diseases.

 2. Water has excellent organoleptic properties and is readily consumed by patients.

 3. Water has a positive effect on patients suffering from chronic hepatitis, dyskinesia of the gallbladder according to the hypotonic type, chronic colitis and spastic dyskinesia of the intestine.

 4. Water helps to improve overall well-being, normalize laboratory parameters and speedy rehabilitation of patients who underwent surgery on the organs of the biliary system and on the intestine.

 5. Water helps to more quickly reduce the inflammatory processes of the liver, gall bladder and biliary tract, as well as the colon.

 6. Water provides positive dynamics (general blood count, general urine analysis, urinalysis according to Nechiporenko) in patients with chronic diseases of the urogenital sphere (urolithiasis, chronic pyelonephritis, chronic prostatitis).

During the use of Aqua-Bi mineral water in the sanatorium the following was treated:
1. In 1999 - 320 people, of which 319 (99.7%) had a positive result. An unexpressed result was observed in only one person (0.3%).

 2. In 2000 - 547 people, of which 540 people (98.7%) had a positive result. An unexpressed result was observed in 7 people (1.3%).

 3. In 2001, for the period from January to August, inclusive - 577 people. A positive result was observed in 566 people (98.1%). An unexpressed result was observed in 11 people (1.9%).

Example 8. By diluting bischofite with tap drinking water, several samples of mineral water were prepared, differing from one another in general mineralization; 1.2 g / dm ³ , 2.8 g / dm ³ , 3.2 g / dm ³ , 5 g / dm ³ , 6 g / dm ³ , 7 g / dm ³ . Patients willingly consumed the first two samples of mineral water. Patients who consumed a third sample of mineral water noted its unpleasant bitter-salty taste. The use of this water sample on the second or third day led to loose stools, which was accompanied by pain in the intestines. On the second or third days of use, patients refused to drink water of this sample. Samples the fourth, fifth and sixth had a too pronounced bitter-salty taste. All patients refused their use.

 Analysis of the information set forth in the well-known information source / 1 / that supposedly patients took for a period of 1.5 months three times a day a quarter cup of mineral water obtained by diluting bischofite to a total mineralization of 5.0-6.0 g / l, it makes us think that patients took this water only in diluted form, since their own observations show that water with such a level of general mineralization causes a gag reflex, and its organoleptic characteristics cause disgust in patients. In addition, the use by patients of water with such a high level of general mineralization will certainly lead to a steady, tiring, difficult to normalize loose stool. And the intake of such water by patients in diluted form makes it non-standard, different from the reception for admission, but nevertheless, approaching the water according to the present invention in terms of total mineralization.

Thus, the chloride-magnesium treatment and table mineral water "Aqua-Bi" with a total salinity of 1.2-2.8 g / dm ³ obtained by diluting natural or tap drinking water with natural bischofite brine can be recommended as a therapeutic and prophylactic agent persons suffering from chronic hepatitis, biliary dyskinesia of the hypokinetic type, patients with chronic colitis and patients who underwent cholecystectomy and intervention in the biliary tract, as well as people suffering from chronic diseases genitourinary sphere (urolithiasis, chronic pyelonephritis, chronic prostatitis). Appointment of chloride-magnesium mineral water "Aqua-Bi" as an additive to therapeutic nutrition is advisable for hepatitis, biliary dyskinesia, postcholecystectomy syndrome and colitis of various origins. In addition, it is advisable to recommend water for use to women with diseases of the gastrointestinal tract with concomitant fibrocystic mastopathy with pain.

 Mineral medicinal-table water prepared from bischofite in accordance with the present invention corresponds to the principle of spa treatment of patients with gastric ulcer, duodenal ulcer, erosive gastritis: it has an antispasmodic, analgesic and tonic effect. When going beyond the parameters recommended by the invention, mineral water does not show the healing properties that it exhibits within the parameters recommended by the invention.

Sourse of information
1. RF patent 2076713, MKI A 23 L 2/00, 1997.

Claims (2)

1. A method for the prevention and treatment of diseases of the gastrointestinal tract and genitourinary system by appointing to receive mineral water prepared by diluting with water a natural bischofite brine to obtain mineral water containing NSO anions $\genfrac{}{}{0ex}{}{\text{-}}{\text{3}}$ SO $\genfrac{}{}{0ex}{}{\text{2-}}{\text{4}}$ , Cl ^- , Br ^- , Ca ²⁺ Mg ²⁺ cations, (Na ⁺ + K ⁺ ) and water, characterized in that the bischofite is diluted with natural or tap drinking water to a total mineralization of 1.2-2.8 g / dm ³ to obtain mineral water containing anions and cations in the following ratio, mg / DM ³ : NSO $\genfrac{}{}{0ex}{}{\text{-}}{\text{3}}$ 250-450 SO $\genfrac{}{}{0ex}{}{\text{2-}}{\text{4}}$ Less than 150 Cl ^- 700-1700 Br ^- 5-25 Ca ²⁺ Less than 100 Mg ²⁺ 200-500 (Na ⁺ + K ⁺ ) 100-400 Water Else mineral water and cooked for prescribed daily intake of _^1/2 cup for 30-60 minutes before meals for 24-30 days. 2. The method according to claim 1, characterized in that it is prescribed to receive mineral water with a temperature of 37-40 ° C.