CN117045675A - Mineral ion composition and application thereof in preparation of products with therapeutic effect on prostate diseases - Google Patents

Mineral ion composition and application thereof in preparation of products with therapeutic effect on prostate diseases Download PDF

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CN117045675A
CN117045675A CN202311176380.XA CN202311176380A CN117045675A CN 117045675 A CN117045675 A CN 117045675A CN 202311176380 A CN202311176380 A CN 202311176380A CN 117045675 A CN117045675 A CN 117045675A
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parts
manganese
potassium
zinc
calcium
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黄雄文
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Guangzhou Weina Cosmetics Co ltd
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Guangzhou Weina Cosmetics Co ltd
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Abstract

The application belongs to the technical field of mineral materials, and particularly discloses a mineral ion composition and application thereof in preparing a product with a therapeutic effect on prostate diseases, wherein the mineral ion composition comprises the following components in parts by weight: potassium ion solution, calcium ion solution, zinc ion solution, and manganese ion solution; the volume ratio of the potassium ion solution to the calcium ion solution to the zinc ion solution to the manganese ion solution is (2-4): (3-6): (2-5): (2-5). The mineral ion composition has a certain effect of treating the prostate diseases, and can treat abscess, urgent urination, frequent urination and painful urination caused by prostatitis, chronic prostatic hyperplasia and hypertrophy.

Description

Mineral ion composition and application thereof in preparation of products with therapeutic effect on prostate diseases
Technical Field
The application relates to the technical field of mineral materials, in particular to a mineral ion composition and application thereof in preparing a product with a therapeutic effect on prostate diseases.
Background
Prostatitis is one of the most common diseases of urology and men, generally refers to a group of diseases with symptoms such as pain or discomfort, abnormal urination and the like which are caused in a pelvic area for more than 3 months under the condition that other lower urinary tract symptoms are not generated, and a prostate patient is often accompanied with depression, anxiety, fear of pain, sexual dysfunction and the like, so that physical and mental health of the patient is seriously affected and a great social and economic burden is brought.
The literature 'clinical effect of nano silver hydrogel combined with alpha-receptor blocker for treating IIIA type prostatitis' discusses the clinical effect of nano silver hydrogel combined with alpha-receptor blocker for treating IIIA type prostatitis, and the result shows that the effect of combining nano silver for treating prostatitis can be achieved with half effort. The nano silver has obvious inhibition effect on the growth of pathogen microorganisms such as staphylococcus aureus, escherichia coli, gonococcus, candida albicans, fungi, saccharomycetes and the like. The III A type prostatitis patient is treated by adopting the nano silver hydrogel combined with the alpha-receptor blocker, the treatment effect is definite and safe, and the preparation is worthy of wide application and popularization.
The clinical curative effect of the traditional Chinese medicine combined with the nano silver gel for treating the chronic prostatitis is evaluated in the literature 'observation of the curative effect of the traditional Chinese medicine combined with the nano silver gel', and the result shows that the nano silver gel has strong penetrability, so that the medicine can quickly penetrate through the prostate capsule, and the higher effective concentration is maintained in the diseased prostate, thereby generating ideal curative effect.
Patent CN104208242a discloses an external patch for treating prostatitis and a preparation method thereof, wherein nano silver and various traditional Chinese medicine components are combined, nano silver gel can slowly and permanently permeate skin and internalize into prostate tissue cells, so that an excellent and durable antibacterial effect is achieved, and a certain treatment effect is achieved on bacterial prostatitis. In addition, 5% (mass volume ratio) of aminoketone and ammonio leaf oil are added into the patch as a transdermal enhancer, honey (refined) is added into the patch as a humectant, and a black plaster matrix is added into the patch, so that the patch has a good effect of treating the prostate.
How to provide an improved therapeutic effect on prostate diseases is a technical problem to be solved by those skilled in the art.
Disclosure of Invention
The application provides a mineral ion composition and application thereof in preparing a product with a therapeutic effect on prostate diseases, which can treat abscess, urgent urination, frequent urination and painful urination caused by prostatitis, chronic prostatic hyperplasia and hypertrophy.
The application solves the technical problems by adopting the following technical scheme:
a mineral ion composition comprising: potassium ion solution, calcium ion solution, zinc ion solution, and manganese ion solution;
the volume ratio of the potassium ion solution to the calcium ion solution to the zinc ion solution to the manganese ion solution is (2-4): (3-6): (2-5): (2-5).
As a preferred embodiment of the present application, the potassium ion solution comprises a potassium salt and water, wherein the mass ratio of the potassium salt to the water is 1: (5-20); the potassium-containing salt comprises at least one of potassium malate, potassium citrate, potassium chloride, potassium acetate, potassium phosphate, potassium citrate, and potassium bicarbonate.
As a preferred embodiment of the present application, the calcium ion solution comprises calcium salt and water, wherein the mass ratio of the calcium salt to the water is 1: (5-20); the calcium-containing salt comprises at least one of calcium lactate, calcium gluconate, calcium citrate, calcium fruit acid, calcium carbonate, calcium hydrogen phosphate, tricalcium phosphate, calcium chloride, and emulsified calcium carbonate.
As a preferred embodiment of the present application, the zinc ion solution comprises zinc salt and water, wherein the mass ratio of the zinc salt to the water is 1: (5-20); the zinc-containing salt comprises at least one of zinc lactate, zinc gluconate, zinc citrate, zinc sulfate, zinc oxide, zinc acetate and zinc dimalt-phenoxy.
As a preferred embodiment of the present application, the manganese ion solution comprises manganese-containing salt and water, wherein the mass ratio of the manganese-containing salt to the water is 1: (5-20); the manganese-containing salt comprises at least one of manganese glycinate, rice chelated manganese, manganese ascorbate, manganese carbonate, manganese lactate, citric acid chelated manganese, amino acid chelated manganese, manganese gluconate, manganese sulfate and manganese chloride.
As a preferred embodiment of the application, the application also comprises traditional Chinese medicine extract, nano silver gel liposome, chitosan quaternary ammonium salt, poloxamer 407 and sodium carboxymethyl cellulose;
the dosage ratio of the potassium ion solution to the traditional Chinese medicine extract to the nano silver gel liposome to the chitosan quaternary ammonium salt to the poloxamer 407 to the sodium carboxymethyl cellulose is (2-4) mL: (8-20) g: (0.5-2) g: (0.2-1) g: (0.2-1) g: (0.1 to 0.6) g.
As a preferred embodiment of the application, the preparation method of the traditional Chinese medicine extract comprises the following steps:
(1) Weighing the following components in parts by mass: 20-40 parts of giant knotweed, 10-30 parts of platycodon grandiflorum, 10-30 parts of szechwan chinaberry fruit, 10-20 parts of white paeony root, 5-15 parts of gorgon fruit and 2-8 parts of borneol;
(2) Boiling giant knotweed rhizome, platycodon root, szechwan chinaberry fruit, white paeony root, gorgon fruit and borneol for 2 times by using an ethanol solution with the volume concentration of 50-80%, and concentrating each time for 4-8 hours to obtain the traditional Chinese medicine extract.
As a preferred embodiment of the application, the nano silver gel liposome is of a core-shell structure, the core of the core-shell structure is nano silver gel, and the shell of the core-shell structure comprises the following components in parts by mass: 100 parts of dimyristoyl phosphatidylcholine, 10-30 parts of hydrogenated soybean lecithin, 40-100 parts of cholesterol chloroformate, 10-30 parts of methyl glucose sesquistearate, 5-20 parts of N, N-dimethylformamide, 5-20 parts of sodium hyaluronate, 20-80 parts of polyethylene glycol 1000, 20-60 parts of citrate buffer and 2-10 parts of tocopheryl acetate.
As a preferred embodiment of the present application, the preparation method of the nano silver gel liposome comprises the following steps:
uniformly mixing dimyristoyl phosphatidylcholine, hydrogenated soybean lecithin and cholesterol chloroformate, adding N, N-dimethylformamide, sodium hyaluronate, polyethylene glycol 1000, citrate buffer solution, tocopheryl acetate and nano silver gel, and uniformly mixing to obtain the nano silver gel liposome.
The application also provides application of the mineral ion composition in preparing a product with a therapeutic effect on the prostate diseases.
The application has the beneficial effects that: the mineral ion composition has a certain effect of treating the prostate diseases, and can treat abscess, urgent urination, frequent urination and painful urination caused by prostatitis, chronic prostatic hyperplasia and hypertrophy.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
In the application, the technical characteristics described in an open mode comprise a closed technical scheme composed of the listed characteristics and also comprise an open technical scheme comprising the listed characteristics.
In the present application, the numerical ranges are referred to as continuous, and include the minimum and maximum values of the ranges, and each value between the minimum and maximum values, unless otherwise specified. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range description features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to include any and all subranges subsumed therein.
In the present application, the specific dispersing and stirring treatment method is not particularly limited.
The reagents or apparatus used in the present application are conventional products commercially available without the manufacturer's knowledge.
Embodiments of the present application provide a mineral ion composition comprising: potassium ion solution, calcium ion solution, zinc ion solution, and manganese ion solution;
the volume ratio of the potassium ion solution to the calcium ion solution to the zinc ion solution to the manganese ion solution is (2-4): (3-6): (2-5): (2-5).
The potassium ion channel disclosed by the application is very widely distributed in various tissues of a human body such as skeletal muscle, nerves, heart, blood vessels, blood, kidneys, reproductive system, glands and the like, and is an ion channel with the widest distribution and the largest variety in the human body. Potassium has effects of promoting gland secretion, cell repolarization, terminating action potential, maintaining cell resting potential, regulating cell volume, assisting substance transmembrane transport and intercellular signal transduction, including cell cycle proliferation, differentiation, apoptosis and cytokine secretion.
The calcium activated potassium channel can couple cell electric activity and cell metabolism, is a main ion channel for regulating the contraction activity of cavernous smooth muscle, can promote endothelial cells to synthesize endothelial cell dilating factors and endothelial source hyperpolarizing factors, dilate blood vessels and increase blood supply, and plays an important role in the extracellular secretion of epithelial cells. Calcium signaling occurs in all cell death types and even plays an extremely important role in controlling the "life and death", apoptosis, necrosis, autophagy mechanisms of cellsActing as a medicine. Many important physiological metabolic activities of the prostate are related to intracellular calcium ion concentration, such as voltage-dependent Ca on cell membranes 2+ Opening of channels to allow extracellular Ca 2+ Inner flow, thereby increasing intracellular Ca 2+ Concentration. In addition, changes in the level of androgens and androgens can lead to abnormalities in genes that ultimately lead to proliferation and apoptosis of cells, mainly loss of control of cell proliferation, through second messengers, leading to prostate disease.
Zinc belongs to trace elements in body fluid, and normal prostate liquid contains a Powerful Antibacterial Factor (PAF), which is a zinc-containing compound, and the zinc content is lower than normal when chronic prostatitis occurs. The zinc ion content in the prostatic fluid corresponds to about 100 times that in plasma. Indicating that the tissue cells of the prostate gland can actively uptake zinc from plasma or tissue.
Manganese is involved in synthesis or activation of many hormones and enzymes, constitutes a transmission of genetic information, is an indispensable factor in biochemical processes such as redox phosphorylation, promotes synthesis of cholesterol, and is involved in vitamin E synthesis. The total amount of manganese in the adult is 12-20 mg, and the manganese is more contained in liver, brain and pituitary. Mainly absorbed in duodenum, most of manganese is combined with plasma and globulin, and a small part of manganese enters erythrocytes to form manganese She Lin, and the manganese She Lin is transported into cells containing rich mitochondria, and 3.8mg of manganese is required to be taken by adults every day.
Under the interaction of the potassium ion solution, the calcium ion solution, the zinc ion solution and the manganese ion solution, the mineral ion composition has a certain effect of treating the prostate diseases, and can treat abscess, urgent urination, frequent urination and painful urination caused by prostatitis, chronic prostatic hyperplasia and hypertrophy.
In one embodiment, the potassium ion solution comprises potassium salt and water, wherein the mass ratio of the potassium salt to the water is 1: (5-20); the potassium-containing salt comprises at least one of potassium malate, potassium citrate, potassium chloride, potassium acetate, potassium phosphate, potassium citrate, and potassium bicarbonate.
In one embodiment, the calcium ion solution comprises calcium salt and water, wherein the mass ratio of the calcium salt to the water is 1: (5-20); the calcium-containing salt comprises at least one of calcium lactate, calcium gluconate, calcium citrate, calcium fruit acid, calcium carbonate, calcium hydrogen phosphate, tricalcium phosphate, calcium chloride, and emulsified calcium carbonate.
In one embodiment, the zinc ion solution comprises zinc salt and water, wherein the mass ratio of the zinc salt to the water is 1: (5-20); the zinc-containing salt comprises at least one of zinc lactate, zinc gluconate, zinc citrate, zinc sulfate, zinc oxide, zinc acetate and zinc dimalt-phenoxy.
In one embodiment, the manganese ion solution comprises manganese-containing salt and water, wherein the mass ratio of the manganese-containing salt to the water is 1: (5-20); the manganese-containing salt comprises at least one of manganese glycinate, rice chelated manganese, manganese ascorbate, manganese carbonate, manganese lactate, citric acid chelated manganese, amino acid chelated manganese, manganese gluconate, manganese sulfate and manganese chloride.
In one embodiment, the composition also comprises traditional Chinese medicine extract, nano silver gel liposome, chitosan quaternary ammonium salt, poloxamer 407 and sodium carboxymethyl cellulose;
the dosage ratio of the potassium ion solution to the traditional Chinese medicine extract to the nano silver gel liposome to the chitosan quaternary ammonium salt to the poloxamer 407 to the sodium carboxymethyl cellulose is (2-4) mL: (8-20) g: (0.5-2) g: (0.2-1) g: (0.2-1) g: (0.1 to 0.6) g.
The inventor of the application discovers in a great deal of researches that on the basis of the mineral ions, the traditional Chinese medicine extract and the nano silver gel liposome are added, so that the treatment effect on prostatitis is further improved.
The nano silver gel has excellent antibacterial activity, has strong permeability, can play an obvious antibacterial role at low concentration, can quickly permeate into subcutaneous 2 mm, can play an obvious bactericidal effect on deep infected tissues, can accelerate wound healing, is beneficial to promoting repair and regeneration of damaged cells, improves microcirculation around wounds, and further effectively activates cell growth.
In one embodiment, the preparation method of the traditional Chinese medicine extract comprises the following steps:
(1) Weighing the following components in parts by mass: 20-40 parts of giant knotweed, 10-30 parts of platycodon grandiflorum, 10-30 parts of szechwan chinaberry fruit, 10-20 parts of white paeony root, 5-15 parts of gorgon fruit and 2-8 parts of borneol;
(2) Boiling giant knotweed rhizome, platycodon root, szechwan chinaberry fruit, white paeony root, gorgon fruit and borneol for 2 times by using an ethanol solution with the volume concentration of 50-80%, and concentrating each time for 4-8 hours to obtain the traditional Chinese medicine extract.
The application creatively combines giant knotweed, platycodon grandiflorum, szechwan chinaberry fruit, white paeony root, gorgon fruit and borneol, and prepares the traditional Chinese medicine composition for treating the prostate diseases.
Wherein, in the traditional Chinese medicine composition, the giant knotweed is a monarch drug, and the giant knotweed has the characteristic taste: slightly bitter and slightly cold. It enters liver, gallbladder and lung meridians. The main functions are as follows: dispelling wind and promoting diuresis, removing blood stasis and relieving pain, relieving cough and reducing sputum, and the giant knotweed can bidirectionally regulate the estrogen level, balance the proportion of estrogen and androgen and alleviate the hyperplasia of prostate; radix platycodi and fructus toosendan are ministerial drugs, and the fructus toosendan has the flavor of: bitter and cold. The Chinese medicinal composition has the effects of regulating qi-flowing and relieving pain after entering liver, small intestine and bladder channels, and has a good inhibition effect on main pathogenic bacteria of prostatitis; platycodon root smell: bitter and pungent in flavor, flat in property, enter lung meridian. The main functions of the traditional Chinese medicine are lung diffusing, sore throat relieving, phlegm eliminating and pus discharging, and the traditional Chinese medicine has the effect of killing various tumor cells; white peony root and gorgon fruit are adjuvant drugs, white peony root is good in taste: : bitter and acidic taste and slight cold, has effects of replenishing blood and nourishing blood, suppressing liver yang, astringing yin and suppressing sweat; gorgon fruit nature taste: the product has the effects of invigorating kidney, stopping nocturnal emission, invigorating spleen, relieving diarrhea, removing dampness, and stopping leukorrhagia; borneol is used as a guiding drug, and added with the fragrance of borneol to play the role of a transdermal absorption promoter, so that the drug can directly reach the affected part.
In one embodiment, the nano silver gel liposome is of a core-shell structure, the core of the core-shell structure is nano silver gel, and the shell of the core-shell structure comprises the following components in parts by mass: 100 parts of dimyristoyl phosphatidylcholine, 10-30 parts of hydrogenated soybean lecithin, 40-100 parts of cholesterol chloroformate, 10-30 parts of methyl glucose sesquistearate, 5-20 parts of N, N-dimethylformamide, 5-20 parts of sodium hyaluronate, 20-80 parts of polyethylene glycol 1000, 20-60 parts of citrate buffer and 2-10 parts of tocopheryl acetate.
According to the application, the nano silver gel is added into the formula system in a liposome form, so that the stability of the nano silver gel can be effectively improved, the aggregation of the nano silver gel in the formula system is avoided, meanwhile, the targeting property of the nano silver gel is improved, the permeability of the nano silver gel is further improved, the nano silver gel can be more rapidly permeated into the skin, and the treatment effect on the prostate diseases is further improved.
The nano silver gel is purchased from Shanghai Zheng Utility Co., ltd., product model: AGS-NM20C with granularity of 2-5 NM and main component content of more than or equal to 20ppm.
In one embodiment, the preparation method of the nano silver gel liposome comprises the following steps:
uniformly mixing dimyristoyl phosphatidylcholine, hydrogenated soybean lecithin and cholesterol chloroformate, adding N, N-dimethylformamide, sodium hyaluronate, polyethylene glycol 1000, citrate buffer solution, tocopheryl acetate and nano silver gel, and uniformly mixing to obtain the nano silver gel liposome.
In the present application, the method for preparing the mineral ion composition is not limited, and those skilled in the art know how to prepare the mineral ion composition, and exemplary methods for preparing the mineral ion composition are: mixing potassium ion solution, calcium ion solution, zinc ion solution, manganese ion solution, chinese medicinal extract, nanometer silver gel liposome, chitosan quaternary ammonium salt, poloxamer 407, and sodium carboxymethyl cellulose.
The application also provides application of the mineral ion composition in preparing a product with a therapeutic effect on the prostate diseases.
For example, the mineral ion composition of the present application may be applied as a patch for external application, or may be introduced by a transdermal introduction method.
Exemplary, the steps of transdermal delivery of the mineral ion composition are as follows:
(1) An ultra-micro permeation health decoder (such as the ultra-micro permeation health decoder shown in CN 208770668U) is used for tightly attaching the negative electrode patch with negative electrons to the Shenque acupoint of a patient, and then the skin is smeared with an emollient for massaging the back skin for 5 minutes.
(2) 15 parts of mineral ion composition and 40 parts of blending agent are mixed, the mixed solution is smeared on the skin of a patient, and then the mixed solution is continuously introduced into a place with the back coated with the mixed solution by using an ultra-micro permeation decoder and a positive electrode massage head for about 40 minutes, different gears and temperatures are selected according to different sensitivity of individual differences of the patient, and 1 time and 9 times are taken as a treatment course.
More specifically, the method for introducing the mineral ion composition of the present application comprises the steps of:
the first step is negative ion dredging:
1. dredging governor vessel, 5 times from Dazhui acupoint to Baliao acupoint, 5 times from left bladder channel to right bladder channel;
2. the waist area is reinforced, the horizontal line of the twelfth thoracic vertebra is taken as the upper limit, the upper edge of the buttocks is taken as the lower limit, and the governor vessel, the left bladder meridian and the right bladder meridian are dredged in sequence from top to bottom;
3. dredging the outer sides of the belt veins at two sides to the buttocks, and leading the gallbladder channels of the legs to go upwards to the buttocks;
4. the thigh bladder channel is dredged downwards, and the kidney channel is dredged downwards.
And the second step, composition introduction:
1. leading-in governor vessel, looping anticlockwise from Baliao to Dazhui for 3 times;
2. the bladder channels on two sides are led in, and the bladder channels are circled anticlockwise to the shoulder and neck acupoints for 3 times;
3. the waist area is reinforced, the horizontal line of the twelfth thoracic vertebra is taken as the upper limit, the lower edge of the buttocks is taken as the lower limit, and the governor vessel and the left bladder channel and the right bladder channel are dredged for 5 times by using an introducer in sequence;
4. the pulse is lifted to Baliao, the gallbladder meridian of the leg reaches the buttocks for 5 times respectively;
and a third step of: acupoint location
1. Shenshu;
2. qihishu;
3. dachangshu;
4. guanyuanshu;
5. small intestine Shu;
6. bladder Shu;
7. lower liao;
8. supporting;
9. baliao;
10. the length is strong;
11. perineum;
fourth step: abdominal composition introduction
1. The probe is pushed up and down for 5 times along the meridian from the probe under the Shenque acupoint (navel) to directly reach the Shenque acupoint along the abdomen midline direct bent bone acupoint ┈ ┈ (without fixed point);
2. dredging kidney meridian on both sides, cavitation ┈ ┈, blind Shu acupoint (without fixed point), is pushed up and down along the meridian for 5 times;
3. dredging stomach meridian on both sides, and pushing the water channel ┈ ┈ to the acupoints (without fixed point) for 5 times along the channels;
4. dredging spleen channels on two sides, fu house ┈ ┈ Daxiong acupoint (without fixed point), and cruising up and down along channels for 5 times;
5. dredging liver meridian on both sides, and pulling up and down 5 times along the meridian from the urgent pulse ┈ ┈ to the outside of the belt pulse;
6. dredging gallbladder meridian on both sides, five-axis ┈ ┈ with pulse acupoint without fixed point), and pulling up and down for 5 times along the meridian
Fifth step: fixed point reinforced acupoints
1. Shenque acupoint;
2. closing the element;
3. curved bone
4. Groin, yinlar, acupoint and kidney meridian.
The following examples are provided to facilitate an understanding of the present application. These examples are not provided to limit the scope of the claims.
Example 1
A mineral ion composition comprising: 3mL of potassium ion solution, 5mL of calcium ion solution, 4mL of zinc ion solution, 4mL of manganese ion solution, 11g of traditional Chinese medicine extract, 1.5g of nano silver gel liposome, 0.5g of chitosan quaternary ammonium salt, 0.5g of poloxamer 407 and 0.5g of sodium carboxymethyl cellulose.
The potassium ion solution comprises potassium salt and water, wherein the mass ratio of the potassium salt to the water is 1:9, a step of performing the process; the potassium-containing salt is potassium malate.
The calcium ion solution comprises calcium salt and water, wherein the mass ratio of the calcium salt to the water is 1:9, a step of performing the process; the calcium salt is calcium gluconate.
The zinc ion solution comprises zinc salt and water, wherein the mass ratio of the zinc salt to the water is 1:9, a step of performing the process; the zinc-containing salt is zinc lactate.
The manganese ion solution comprises manganese-containing salt and water, wherein the mass ratio of the manganese-containing salt to the water is 1:9, a step of performing the process; the manganese-containing salt is manganese lactate.
The preparation method of the traditional Chinese medicine extract comprises the following steps:
(1) Weighing the following components in parts by mass: 30 parts of giant knotweed, 20 parts of platycodon grandiflorum, 20 parts of szechwan chinaberry fruit, 15 parts of white paeony root, 10 parts of gorgon fruit and 5 parts of borneol;
(2) Boiling giant knotweed rhizome, platycodon root, szechwan chinaberry fruit, white paeony root, gorgon fruit and borneol for 2 times by using an ethanol solution with the volume concentration of 50-80% (the ratio of feed to liquid is 4mL:1g each time) for 6 hours, collecting the boiling liquid twice, and concentrating to obtain the traditional Chinese medicine extract.
The nano silver gel liposome is of a core-shell structure, the core of the core-shell structure is nano silver gel, and the shell of the core-shell structure comprises the following components in parts by mass: 100 parts of dimyristoyl phosphatidylcholine, 20 parts of hydrogenated soybean lecithin, 50 parts of cholesterol chloroformate, 20 parts of methyl glucose sesquistearate, 10 parts of N, N-dimethylformamide, 10 parts of sodium hyaluronate, 40 parts of polyethylene glycol 1000, 30 parts of citrate buffer and 5 parts of tocopheryl acetate.
Wherein, the mass ratio of the nano silver gel to the dimyristoyl phosphatidylcholine is 20:100.
the preparation method of the nano silver gel liposome comprises the following steps:
uniformly mixing dimyristoyl phosphatidylcholine, hydrogenated soybean lecithin and cholesterol chloroformate, adding N, N-dimethylformamide, sodium hyaluronate, polyethylene glycol 1000, citrate buffer solution, tocopheryl acetate and nano silver gel, and uniformly mixing to obtain the nano silver gel liposome.
Example 2
A mineral ion composition comprising: 2mL of potassium ion solution, 6mL of calcium ion solution, 3mL of zinc ion solution, 5mL of manganese ion solution, 11g of traditional Chinese medicine extract, 1.2g of nano silver gel liposome, 0.4g of chitosan quaternary ammonium salt, 0.8g of poloxamer 407 and 0.6g of sodium carboxymethyl cellulose.
The potassium ion solution comprises potassium salt and water, wherein the mass ratio of the potassium salt to the water is 1:9, a step of performing the process; the potassium-containing salt is potassium malate.
The calcium ion solution comprises calcium salt and water, wherein the mass ratio of the calcium salt to the water is 1:9, a step of performing the process; the calcium salt is calcium gluconate.
The zinc ion solution comprises zinc salt and water, wherein the mass ratio of the zinc salt to the water is 1:9, a step of performing the process; the zinc-containing salt is zinc lactate.
The manganese ion solution comprises manganese-containing salt and water, wherein the mass ratio of the manganese-containing salt to the water is 1:9, a step of performing the process; the manganese-containing salt is manganese lactate.
The preparation method of the traditional Chinese medicine extract comprises the following steps:
(1) Weighing the following components in parts by mass: 30 parts of giant knotweed, 20 parts of platycodon grandiflorum, 20 parts of szechwan chinaberry fruit, 15 parts of white paeony root, 10 parts of gorgon fruit and 5 parts of borneol;
(2) Boiling giant knotweed rhizome, platycodon root, szechwan chinaberry fruit, white paeony root, gorgon fruit and borneol for 2 times by using an ethanol solution with the volume concentration of 50-80% (the ratio of feed to liquid is 4mL:1g each time) for 6 hours, collecting the boiling liquid twice, and concentrating to obtain the traditional Chinese medicine extract.
The nano silver gel liposome is of a core-shell structure, the core of the core-shell structure is nano silver gel, and the shell of the core-shell structure comprises the following components in parts by mass: 100 parts of dimyristoyl phosphatidylcholine, 15 parts of hydrogenated soybean lecithin, 40 parts of cholesterol chloroformate, 15 parts of methyl glucose sesquistearate, 12 parts of N, N-dimethylformamide, 8 parts of sodium hyaluronate, 30 parts of polyethylene glycol 1000, 40 parts of citrate buffer and 5 parts of tocopheryl acetate.
Wherein, the mass ratio of the nano silver gel to the dimyristoyl phosphatidylcholine is 20:100.
the preparation method of the nano silver gel liposome comprises the following steps:
uniformly mixing dimyristoyl phosphatidylcholine, hydrogenated soybean lecithin and cholesterol chloroformate, adding N, N-dimethylformamide, sodium hyaluronate, polyethylene glycol 1000, citrate buffer solution, tocopheryl acetate and nano silver gel, and uniformly mixing to obtain the nano silver gel liposome.
Example 3
A mineral ion composition comprising: 4mL of potassium ion solution, 3mL of calcium ion solution, 5mL of zinc ion solution, 2mL of manganese ion solution, 10g of traditional Chinese medicine extract, 1.4g of nano silver gel liposome, 0.8g of chitosan quaternary ammonium salt, 0.4g of poloxamer 407 and 0.4g of sodium carboxymethyl cellulose.
The potassium ion solution comprises potassium salt and water, wherein the mass ratio of the potassium salt to the water is 1:9, a step of performing the process; the potassium-containing salt is potassium malate.
The calcium ion solution comprises calcium salt and water, wherein the mass ratio of the calcium salt to the water is 1:9, a step of performing the process; the calcium salt is calcium gluconate.
The zinc ion solution comprises zinc salt and water, wherein the mass ratio of the zinc salt to the water is 1:9, a step of performing the process; the zinc-containing salt is zinc lactate.
The manganese ion solution comprises manganese-containing salt and water, wherein the mass ratio of the manganese-containing salt to the water is 1:9, a step of performing the process; the manganese-containing salt is manganese lactate.
The preparation method of the traditional Chinese medicine extract comprises the following steps:
(1) Weighing the following components in parts by mass: 30 parts of giant knotweed, 20 parts of platycodon grandiflorum, 20 parts of szechwan chinaberry fruit, 15 parts of white paeony root, 10 parts of gorgon fruit and 5 parts of borneol;
(2) Boiling giant knotweed rhizome, platycodon root, szechwan chinaberry fruit, white paeony root, gorgon fruit and borneol for 2 times by using an ethanol solution with the volume concentration of 50-80% (the ratio of feed to liquid is 4mL:1g each time) for 6 hours, collecting the boiling liquid twice, and concentrating to obtain the traditional Chinese medicine extract.
The nano silver gel liposome is of a core-shell structure, the core of the core-shell structure is nano silver gel, and the shell of the core-shell structure comprises the following components in parts by mass: 100 parts of dimyristoyl phosphatidylcholine, 25 parts of hydrogenated soybean lecithin, 45 parts of cholesterol chloroformate, 25 parts of methyl glucose sesquistearate, 18 parts of N, N-dimethylformamide, 12 parts of sodium hyaluronate, 35 parts of polyethylene glycol 1000, 25 parts of citrate buffer and 5 parts of tocopheryl acetate.
Wherein, the mass ratio of the nano silver gel to the dimyristoyl phosphatidylcholine is 20:100.
the preparation method of the nano silver gel liposome comprises the following steps:
uniformly mixing dimyristoyl phosphatidylcholine, hydrogenated soybean lecithin and cholesterol chloroformate, adding N, N-dimethylformamide, sodium hyaluronate, polyethylene glycol 1000, citrate buffer solution, tocopheryl acetate and nano silver gel, and uniformly mixing to obtain the nano silver gel liposome.
Comparative example 1
Comparative example 1 is different from example 1 in that comparative example 1 does not contain nano silver gel liposome, and the other are the same.
A mineral ion composition comprising: 3mL of potassium ion solution, 5mL of calcium ion solution, 4mL of zinc ion solution, 4mL of manganese ion solution, 11g of traditional Chinese medicine extract, 0.5g of chitosan quaternary ammonium salt, 0.5g of poloxamer 407 and 0.5g of sodium carboxymethyl cellulose.
Comparative example 2
Comparative example 2 is different from example 1 in that sodium hyaluronate is not contained in the preparation method of nanoliposome of comparative example 2, and all other matters are the same.
The nano silver gel liposome is of a core-shell structure, the core of the core-shell structure is nano silver gel, and the shell of the core-shell structure comprises the following components in parts by mass: 100 parts of dimyristoyl phosphatidylcholine, 20 parts of hydrogenated soybean lecithin, 50 parts of cholesterol chloroformate, 20 parts of methyl glucose sesquistearate, 10 parts of N, N-dimethylformamide, 40 parts of polyethylene glycol 1000, 30 parts of citrate buffer and 5 parts of tocopheryl acetate.
Wherein, the mass ratio of the nano silver gel to the dimyristoyl phosphatidylcholine is 20:100.
comparative example 3
Comparative example 3 is different from example 1 in that comparative example 3 does not contain a Chinese medicinal extract, and all the other are the same.
A mineral ion composition comprising: 3mL of potassium ion solution, 5mL of calcium ion solution, 4mL of zinc ion solution, 4mL of manganese ion solution, 1.5g of nano silver gel liposome, 0.5g of chitosan quaternary ammonium salt, 0.5g of poloxamer 407 and 0.5g of sodium carboxymethyl cellulose.
Test case
1. 70 SPF-grade SD male rats (weighing 200+ -20 g) were selected and evenly divided into 7 groups, namely a blank group, a model group, a positive control group and 4 test groups.
Wherein, after the rats are adaptively fed for 1 week, the rats in the blank group are subcutaneously injected with 10mg of physiological saline/(kg.d), and the rats in the other groups are subcutaneously injected with 10mg of testosterone propionate/(kg.d), and then are continuously injected for 7 days, and then the original dose of testosterone propionate (the physiological saline is injected into the blank group) is subcutaneously injected at intervals of two days; then, the grouping treatment is performed.
Wherein the blank group is normal untreated rats and the model group is untreated rats, wherein the positive control group is subjected to gastric lavage with finasteride 1.0 mg/(kg.d), and the test group is respectively applied to pubic bone by the patches of examples and comparative examples 1-3 once a day for 2 weeks.
After the last treatment, fasted water was used for 24 hours, weighed, 3mL/kg of chloral hydrate was used for anesthesia, prostate tissue was isolated, wet weight was measured, and prostate index was calculated as follows: prostate index = wet prostate weight (mg)/rat body weight (g).
The experimental data were statistically analyzed using SPSS 13.0 statistical software, and single-factor analysis of variance was used. P < 0.05 is statistically significant, and P < 0.01 is statistically significant.
TABLE 1
Model group was compared with blank group, P < 0.05, P < 0.01; the test group was compared with the model group, # P＜0.05， ## P＜0.01。
as can be seen from Table 1, the composition of the present application is effective in inhibiting and alleviating prostatic hyperplasia.
2. Hu Mou, sex: men, age 69 years, were treated with surgery for prostate hyperplasia 12 years, 2018, 3 times of postoperative nocturnal urination, 23:00, 2:00, 4:00, respectively. Daily sleep time was 21:00-5:00, and the sleeping quality is poor due to nocturia.
2023 1 month 3 color Doppler ultrasound: the size of the prostate is 5.3 x 4.6 x 3.7cm, the prostate protrudes into the bladder by 1.1cm, and the residual urine of the bladder after urination is about 30ml. After 9 application treatments with the composition of the application, 2023, 1, 11 days color ultrasound: the size of the prostate is 5.1 x 4.6 x 3.7cm, the prostate protrudes into the bladder by 1.1cm, the residual urine of the bladder after urination is about 15ml, the frequency of nocturia is reduced to 1, the pain of urination is relieved, and the sleeping quality is greatly improved.
With the above-described preferred embodiments according to the present application as an illustration, the above-described descriptions can be used by persons skilled in the relevant art to make various changes and modifications without departing from the scope of the technical idea of the present application. The technical scope of the present application is not limited to the description, but must be determined according to the scope of the claims.

Claims (10)

1. A mineral ion composition comprising: potassium ion solution, calcium ion solution, zinc ion solution, and manganese ion solution;
the volume ratio of the potassium ion solution to the calcium ion solution to the zinc ion solution to the manganese ion solution is (2-4): (3-6): (2-5): (2-5).
2. The mineral ion composition of claim 1, wherein the potassium ion solution comprises a potassium salt and water, and the mass ratio of the potassium salt to the water is 1: (5-20); the potassium-containing salt comprises at least one of potassium malate, potassium citrate, potassium chloride, potassium acetate, potassium phosphate, potassium citrate, and potassium bicarbonate.
3. The mineral ion composition of claim 1, wherein the calcium ion solution comprises a calcium salt and water, the mass ratio of the calcium salt to the water being 1: (5-20); the calcium-containing salt comprises at least one of calcium lactate, calcium gluconate, calcium citrate, calcium fruit acid, calcium carbonate, calcium hydrogen phosphate, tricalcium phosphate, calcium chloride, and emulsified calcium carbonate.
4. The mineral ion composition of claim 1, wherein the zinc ion solution comprises zinc-containing salt and water, and the mass ratio of the zinc-containing salt to the water is 1: (5-20); the zinc-containing salt comprises at least one of zinc lactate, zinc gluconate, zinc citrate, zinc sulfate, zinc oxide, zinc acetate and zinc dimalt-phenoxy.
5. The mineral ion composition of claim 1, wherein the manganese ion solution comprises a manganese-containing salt and water in a mass ratio of 1: (5-20); the manganese-containing salt comprises at least one of manganese glycinate, rice chelated manganese, manganese ascorbate, manganese carbonate, manganese lactate, citric acid chelated manganese, amino acid chelated manganese, manganese gluconate, manganese sulfate and manganese chloride.
6. The mineral ion composition of claim 1, further comprising a traditional Chinese medicine extract, a nano silver gel liposome, a chitosan quaternary ammonium salt, poloxamer 407, sodium carboxymethyl cellulose;
the dosage ratio of the potassium ion solution to the traditional Chinese medicine extract to the nano silver gel liposome to the chitosan quaternary ammonium salt to the poloxamer 407 to the sodium carboxymethyl cellulose is (2-4) mL: (8-20) g: (0.5-2) g: (0.2-1) g: (0.2-1) g: (0.1 to 0.6) g.
7. The mineral ion composition of claim 6, wherein the method for preparing the traditional Chinese medicine extract comprises the following steps:
(1) Weighing the following components in parts by mass: 20-40 parts of giant knotweed, 10-30 parts of platycodon grandiflorum, 10-30 parts of szechwan chinaberry fruit, 10-20 parts of white paeony root, 5-15 parts of gorgon fruit and 2-8 parts of borneol;
(2) Boiling giant knotweed rhizome, platycodon root, szechwan chinaberry fruit, white paeony root, gorgon fruit and borneol for 2 times by using an ethanol solution with the volume concentration of 50-80%, and concentrating each time for 4-8 hours to obtain the traditional Chinese medicine extract.
8. The mineral ion composition according to claim 6, wherein the nano silver gel liposome is of a core-shell structure, the core of the core-shell structure is nano silver gel, and the shell of the core-shell structure comprises the following components in parts by mass: 100 parts of dimyristoyl phosphatidylcholine, 10-30 parts of hydrogenated soybean lecithin, 40-100 parts of cholesterol chloroformate, 10-30 parts of methyl glucose sesquistearate, 5-20 parts of N, N-dimethylformamide, 5-20 parts of sodium hyaluronate, 20-80 parts of polyethylene glycol 1000, 20-60 parts of citrate buffer and 2-10 parts of tocopheryl acetate.
9. The mineral ion composition of claim 8, wherein the method of preparing the nano-silver gel liposome comprises the steps of:
uniformly mixing dimyristoyl phosphatidylcholine, hydrogenated soybean lecithin and cholesterol chloroformate, adding N, N-dimethylformamide, sodium hyaluronate, polyethylene glycol 1000, citrate buffer solution, tocopheryl acetate and nano silver gel, and uniformly mixing to obtain the nano silver gel liposome.
10. Use of a mineral ion composition according to any one of claims 1 to 9 for the preparation of a product having a therapeutic effect on prostate disorders.
CN202311176380.XA 2023-09-13 2023-09-13 Mineral ion composition and application thereof in preparation of products with therapeutic effect on prostate diseases Pending CN117045675A (en)

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