RU2218168C2 - Immunomodulating vegetable agent "zvezda baikala" - Google Patents

Abstract

FIELD: medicine, phytotherapy, pharmacology. SUBSTANCE: invention proposes immunomodulating set consisting of five different by composite vegetable species that are prescribed in sequence. Proposed set is useful for severe and recidivating forms of immune insufficiency. Except for, agent doesn't cause habituation to immunomodulating therapy in the process of prolonged treatment. EFFECT: valuable medicinal properties of agent. 1 ex

Description

 The invention relates to medicine, namely to the pharmacology of immunodeficiency states.

 Due to the wide spread of immunodeficiencies, the most important task of modern medicine is the search for new means and methods of immunocorrection.

 Treatment with immunomodulatory fees is a relatively new area in domestic medicine and immunology.

 However, the situation has changed over the past ten years. Many authors have proposed various plant fees for immunocorrection.

 1. For the treatment of immune deficiency, a collection consisting of blueberry leaves, centaury grass, yarrow grass, birch leaves, elecampane root, nettle grass, tricolor grass, woodruff grass, lemon balm leaves, burdock root is taken equally (1).

 2. The collection of the Blouse KI, for 10 years tested and used to reduce the incidence in children. It consists of: perforated St. John's wort grass, field horsetail grass, yarrow grass, flowering heather tops, coltsfoot leaf, linden flowers, black elderberry flowers, medicinal calendula flowers (2).

 3. Plant collection, which reduces the frequency of colds by 2.67 times, and the duration of recurrent diseases by 2.2 times; which includes: medicinal calendula flowers, medicinal sage leaf, large plantain leaf, grass of a three-part succession, bare licorice root, marsh rosemary leaves (2).

 The duration of the course of treatment with such fees, according to their authors, is from 1.5 to 2 months. (2).

 For one calendar year, it is not recommended to carry out treatment with one immunomodulating collection more than 2 times (2).

 Treatment with one immunomodulating collection is indicated for mild forms of immune deficiency associated, for example, with antibiotic treatment or during periods of seasonal hypovitaminosis.

 The disadvantage of the above immunomodulating fees is that their therapeutic efficacy is limited by a fairly short course of treatment - 1.5-2 months.

 It is noted in relation to chemical drugs (antibiotics, sulfonamides, drugs, analgesics, sleeping pills, laxatives, diuretics), the reaction of addiction and lowering the sensitivity of the body, there is also a time for long-term treatment with medicinal plants.

 If only immunomodulating collection is used in the treatment of severe immunodeficiency, which is characterized by a long-term course and is associated, for example, with repeated courses of long-term treatment with chemical immunosuppressants, then canceling after 2 months of immunomodulating collection leads to a gradual decrease in the level of non-specific immune defense: and before the time will come for re-treatment with the same immunomodulatory collection, in patients there comes an immune breakdown in the form of an infectious-inflammatory process.

 At the same time, if immunomodulating fees that are new to the body are used consistently, then they can be used to increase or maintain non-specific immunity in a patient for a long time at a high level.

The closest technical solution, selected as a prototype, is a multi-component collection with immunomodulating action, registered under the name "Tatiana" (3)
Composition of the collection:
Rosehips - 20.0
Eleutherococcus root - 20.0
Stinging Nettle Grass - 10.0
Calendula officinalis flowers - 10.0
Rhizome of calamus swamp - 10.0
Blackcurrant leaf - 10.0
Fruits of red mountain ash - 10.0
Fruits of anise ordinary - 10.0
Red clover flowers - 15.0
Oregano grass - 10.0
The main disadvantages of the Tatyana immunomodulating collection is that this collection cannot be used for a long time, for example, for a whole year, to treat a severe or continuously recurring form of immune deficiency, as this leads to addiction and weakening of the stimulating plant collection for immunity.

 The objective of the invention is the introduction into practice of the treatment of serious diseases and recurring forms of immune deficiency of an immunomodulating herbal set, which does not become addictive to immunomodulating therapy during long-term treatment.

This task is achieved in that the immunomodulatory herbal remedy "Baikal Star" consists of five immunomodulatory fees of different composition, assigned sequentially, where collection 1 includes 10 medicinal plants in the following ratio of components, mass., G:
Red clover, flowers - 15.0
Siberian penny, grass - 15.0
Astragalus is webbed, grass - 7.5
Kuril tea, leaf - 15.0
Hair pulp, grass - 7.5
Lungwort softest, flowers - 10.0
Salvia officinalis, leaf - 7.5
Chamomile pharmaceutical, flowers - 7.5
White birch, leaf - 10.0
Eyebright, grass - 5.0
2. Collection 2 includes 10 medicinal plants in the following ratio of components, mass., G:
Red clover, flowers - 15.0
Alfalfa yellow, grass - 10.0
Red raspberries, leaf - 10.0
Small day, grass - 7.5
Tuberous tuber, leaf - 15.0
Plotted meadowsweet, leaf - 10.0
Bell deer, grass - 10.0
Odorhead, odorous, grass - 10.0
Belozor swamp, grass - 5.0
White lamb, grass - 7.5
3. Collection 3 includes 10 medicinal plants in the following ratio of components, mass., G:
Red clover, flowers - 15.0
Ural licorice, root - 10.0
Goldenrod Daurian, grass - 5.0
Veronica longifolia, grass - 15.0
Bearded gentian, grass - 5.0
Cyanosis blue, grass - 10.0
Melilotus officinalis, grass - 5.0
Sossurey controversial, sheet - 10.0
Lacquer speckled, leaf - 15.0
Three-part sequence, grass - 10.0
4. Collection 4 includes 10 medicinal plants in the following ratio of components, mass., G:
Red clover, flowers - 15.0
Sainfoin sand, grass - 7.5
Tansy, flowers - 5.0
Real bedstraw, grass - 10.0
Lyubov bifolia, leaf - 5.0
Creeping thyme, grass - 10.0
Kuril tea, leaf - 15.0
Siberian Istod, grass - 15.0
Horsetail, grass - 7.5
Common flax, grass - 5.0
5. Collection 5 includes 10 medicinal plants in the following ratio of components, mass., G:
Red clover, flowers - 15.0
Rising astragalus, grass - 7.5
Field mint, leaf - 5.0
Large plantain, leaf - 10.0
Yarrow, grass - 15.0
Bell bell, grass - 15.0
Goat-like hairbrush, grass - 10.0
Cinquefoil marsh, grass - 15.0
Elecampane loosestrife, grass - 5.0
Hemophilus officinalis, leaf - 7.0
Lush cloves, grass - 10.0
All plant fees that are part of the Baikal Star immuno-modulating agent are prepared as follows: all components of the plant harvest must be dried, taken in certain proportions and crushed with a 100 W power grinder.

Treatment of immune deficiency is carried out sequentially: fees 1, 2, 3, 4, 5. After treatment, each collection requires a break of 7 days, after which they begin treatment again. The treatment uses water infusions of herbal preparations. Dose of medicinal fees for adults: 1 teaspoon of chopped collection is taken, 200 ml of boiling water is poured, infused at room temperature for 40 minutes, filtered. Drink 1 cup of infusion 2-3 times a day 30 minutes before meals. The course of treatment with one immunomodulatory collection is not more than 2 months. Doses for children dosage charges by taking _^1/2 teaspoon collection and filled with 200 ml of boiling water, infused at room temperature for 30-40 min, filtered. Drink for children aged 3-7 years old in _^1/2 cup of infusion 2 times a day 30 min before meal, children over 7 years: 1 cup of infusion 2 times a day for 30 minutes before eating.

Example for clinical use:
Patient Yuri A., 35 years old, lives in the city of Baikalsk, turned on 24.04.2000 with complaints of weakness of the body's defenses, which manifests itself as frequent and long-term diseases of the upper respiratory tract. Weakening of his immunity has been noted since the spring of 1999, when the patient completed a course of chemotherapy for the disease: lymphogranulomatosis, activity III b. He took chemotherapy drugs: cyclophosphamide, vinblastine, natulene, prednisone, cefazolin, biseptol.

Examined March 25, 00 - immunogram. Conclusion: a low content of leukocytes and lymphocytes, an imbalance of the T-system - a decrease in percentage and absolute E-ROCK, a decrease in the E-ROCK of theophylline sensitive, a decrease in the phagocytic activity of neutrophils. 04/07/00 - general blood test: lake. - 2.4 • 10 ⁹ ; er. - 3.6 • 10 ¹² ;
Hb-105%; E-1; p-4; s-58; l-32; m-3. Platelets - 103 thousand

04/11/00 - An. feces for dysbiosis: inhibition of the growth of bifidobacteria to 10 ² , there is an abundant growth of black mold.

 04/01/00 - computed tomography. Axillary l / nodes small 3-7 mm, paraortal lymph nodes small up to 6 mm, paratracheal and bifurcation l / nodes up to 1 cm.

 Thus, on the basis of laboratory and instrumental examinations, the patient showed inhibition of white blood sprout, which was manifested by severe leukopenia and immune disorders in the form of an imbalance of the T-system, and a decrease in the phagocytic activity of neutrophils.

 An increase in the group of l / nodes suggests that the patient's lymphatic system did not return to normal after chemotherapy.

 In addition, as a result of chemotherapy - intestinal dysbiosis.

 Based on the foregoing, the patient was prescribed immunomodulating therapy with the fees included in the Baikal Star kit to treat secondary immune deficiency.

 By 08/17/00. the patient completed treatment with immunodulatory collection 2.

08.17.00 - An. Blood - total: lake - 3.1 • 10 ⁹ ; er. - 4.0 • 10 ¹² ; Hb - 121%; E-1; p-1; c-51; l-44; m-5; platelets - 124 thousand

 09/06/00 - Computed tomography. Conclusion: Compared with the previous study, there is a pronounced positive dynamics, manifested by a decrease in the number and size of l / nodes of the anterior mediastinum, bronchopulmonary and paratracheal l / nodes were not detected.

 Thus, for four months of continuous treatment with immunomodulatory fees 1 and 2, the patient improved not only blood circulation function, but also the state of the lymphatic system. By 05/04/01 - the patient completed treatment with immunomodulatory fees 1, 2, 3, 4, 5. During the treatment, he was practically not ill. 05/04/01 - Immunogram. Conclusion: Increased phagocytic activity of neutrophils.

05/04/01 - Blood test - general; lake. - 4.0 • 10 ⁹ ; er. - 4.1 • 10 ¹² ; Нb - 136%; e-3; p-2; s-45; l-47; m-4. Platelets - 180 thousand

 Thus, after 1 year from the treatment with the Baikal Star immunomodulating agent, the previously noted immune disorders disappeared in this patient, the leukocyte count in the blood rose to normal, and the lymphatic system returned to normal.

 In total, 358 patients received the immunomodulatory agent Baikal Star, of which 47 used all 5 immunomodulating collections for the treatment of immune deficiency for a whole year or more.

 Patients who took water infusions of immunomodulatory fees noted good tolerance of ready-made herbal remedies, improvement of clinical and laboratory indicators of immune status.

Sources of information
1. Vinogradov V.M., Vinogradova T.A., Gazheev B.N. et al. Handbook of herbal medicine for children and adults. St. Petersburg, 1996, p. 164.

 2. Barnaulov O. Herbal medicine for colds. St. Petersburg, 1998, p. 25, 26, 27.

 3. Application for I. 98103284/14, A 61 K 35/00, O.B. "Invention, utility models", M., 2000 3, pp. 91-92 - prototype.

Claims (1)

An immunomodulatory herbal remedy, including red clover flowers, characterized in that the remedy is a set of five medicinal preparations, while collection No. 1 additionally contains Siberian penny grass, Astragalus membranous grass, a leaf of Kuril tea, hairy pulp grass, softest lungwort flowers, leaf medicinal sage, chamomile flowers, white birch leaf, herb euphrasia officinalis in the following ratio of components, g: Red clover, flowers 15.0 Siberian penny, grass 15.0 Astragalus webbed, grass 7.5 Kuril tea, leaf 15.0 Hair pulp, grass 7.5 Lungwort softest, flowers 10.0 Salvia officinalis, leaf 7.5 Chamomile, flowers 7.5 White birch, leaf 10.0 Eyebright, grass 5.0 collection No. 2 additionally contains yellow alfalfa grass, red raspberry leaf, small reddish grass, club grasshopper leaf, common grassland leaf, red deer bellflower grass, fragrant snakehead grass, white-grass swamp grass, white walnut grass in the following ratio of components, g: Red clover, flowers 15.0 Alfalfa yellow, grass 10.0 Red raspberries, leaf 10.0 Small day, grass 7.0 Tuberous tuber, leaf 15.0 Plotted meadowsweet, leaf 10.0 Bell deer leaf 10.0 Odorhead, odorous, grass 10.0 Belozor swamp, grass 5.0 Lamb white grass 7.5 collection No. 3 additionally contains Ural licorice root, Daurian goldenrod grass, Veronica longifolia grass, beard gentian grass, blue cyanosis grass, medicinal sweet clover grass, disputed saussure leaf, speckled caclia leaf, three-parted grass series in the following ratio of components, g: Red clover, flowers 15.0 Ural licorice, root 10.0 Goldenrod Daurian, grass 5.0 Veronica longifolia, grass 15.0 Bearded gentian, grass 5.0 Cyanosis blue, grass 10.0 Melilotus officinalis, grass 5.0 Sossurey controversial, sheet 10.0 Lacquer speckled, leaf 15.0 Three-part sequence, grass 10.0 collection No. 4 additionally contains sandy quartet grass, common tansy flowers, real bedstraw grass, bifolia leaf, creeping thyme leaf, Kuril tea leaf, Siberian source grass, field horsetail grass, common flax grass, with the following ratio of components, g: Red clover, flowers 15.0 Sainfoin sand, grass 7.5 Tansy, flowers 5.0 Real bedstraw, grass 10.0 Lyubov bifolia, leaf 5.0 Creeping thyme, grass 10.0 Kuril tea, leaf 15.0 Siberian Istod, grass 15.0 Horsetail, grass 7.5 Lyanka ordinary, grass 5.0 collection No. 5 additionally contains rising astragalus grass, field mint leaf, large plantain leaf, common yarrow grass, prefabricated bell grass, goat-bellied grass grass, marsh cinquefoil grass, elecampane loosy grass, medicinal blood-crust leaf, clove grass of the following cloves : Red clover, flowers 15.0 Astragalus rising, grass 7.5 Field mint leaf 5.0 Large plantain leaf 10.0 Yarrow, grass 15.0 Bell bell, grass 15.0 Goat-grassy grass, grass 10.0 Cinquefoil marsh, grass 15.0 Elecampane loosestrife, grass 5.0 Hemophilus officinalis, leaf 7.5 Lush cloves, grass 10.0