RU2214830C2 - Method for treating and preventing local skin reactions caused by radiation - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves administering ointment that contains 0.01-0. 001% of ecdisteroids as skin application. EFFECT: enhanced effectiveness in arresting inflammation process, stimulating repair processes and preventing local adverse effects. 5 dwg

Description

 The invention relates to medicine, namely to Oncology and radiation therapy.

 There are many ways to treat and prevent radiation epidermitis: ointments containing methyluracil, solcoseryl, applications with dimethyl sulfoxide, the use of sea buckthorn oil and others. Despite the large selection of drugs, the problem of treating radiation epidermitis remains relevant (1, 2).

 The purpose of the invention is the prevention and treatment of radiation epidermitis by using an original ointment containing ecdysteroids.

 This goal is achieved by applying to the area of radiation changes the total phytoecdysteroids in the form of 0.01-0.001% ointment on a petrolatum-lanolin base (4: 1-9: 1) or by applying the above ointment to areas of the skin exposed to radiation for prophylactic purposes. Ecdysteroids, the hormones of molting and metamorphosis of insects, have high biological activity, including reparative, radioprotective, and others (3).

 The proposed method of treatment is as follows. Before each radiation treatment session, after thorough skin treatment, ointments containing ecdysteroids are applied to areas falling into the irradiation zone. Experimental studies have shown that the drug stimulates the growth of granulation tissue through the activation of biogenic inflammation stimulators produced by mast cells through active hyperemia and proliferation of fibroblasts, which contributes to the proliferation of epithelium and repair of the wound surface. There is an improvement in microcirculation due to the active formation of blood capillaries. Clinical trials: the ointment was used in 18 patients who received pre- or postoperative radiation therapy for various oncological diseases (cancer of the stomach, breast, oral cavity), showed that the use of this ointment for 4-5 days gives a positive effect in in the form of reducing skin hyperemia, its edema, and in the case of exposure with a preventive purpose, reduces the severity of radiation reactions.

 The invention is illustrated by the following examples.

Example 1. Patient B., born in 1947, was admitted to the LOCA ROCODE in March 1999 (amb. Card 3803) with a diagnosis of thyroid cancer T ₂ N ₁ M ₀ , condition after hemithyroidectomy in February 1999. The patient received a postoperative course of distance gamma therapy. After adjusting the dose of 40 Gy (ROD = 2 g) in the cervical-supraclavicular region, dry epidermitis with separate areas of maceration developed. Treatment with traditional means for 5 days without effect. After prescribing an ointment containing ecdysteroids, after 2 days the phenomena of inflammation decreased, and after five days they were almost completely absent.

Example 2. Patient M was admitted to the hospital ROCOD 11.11.99 (i / b 4325-851) with a diagnosis of gastric cancer T ₂ N ₀ M ₀ . November 23, 1999, the operation was performed: distal subtotal resection of the stomach. From December 22, 1999 to February 9, 00 a postoperative course of distance gamma-therapy was carried out in a total dose of 51.16 Gy. During irradiation, in order to prevent the occurrence of radioepidermitis, he received an ointment containing ecdysteroids. The absence of the development of any local reaction on the skin was noted.

 Thus, the proposed method for the treatment of radioepidermitis can quickly improve the skin condition in the irradiation zone by stopping the inflammatory reaction and stimulating reparative processes, and also helps to prevent the development of local radiation reactions on the skin.

Literature
1. Bardychev M.S., Tsyb A.F. Local radiation damage. - M.: Medicine, 1985, - 240 p.

 2. Medicines for the treatment of skin diseases. WHO Information, 1999, pp. 54-56.

 3. Syrov V.N. Phytoecdysteroids: biological effects in the body of higher animals and prospects for use in medicine. Experimental and clinical pharmacology. - 1994. -T.57, 5. S. 61-66.

Claims (1)

 A method for the treatment and prevention of local radiation reactions on the skin, characterized in that an ointment containing 0.01-0.001% ecdysteroids is applied to the skin exposed to radiation.