RU2195347C1 - Method for treatment of hyperlipoidemia, hypercoagulation, peroxidation syndromes - Google Patents

Abstract

FIELD: medicine, applicable for treatment of atherosclerosis, ischemic disease of heart and brain, arterial hypertension, diabetes mellitus. SUBSTANCE: electrode of the Milt apparatus is successively put on the points located in the middle of the left sternoclidomastoid muscle, second intercostal to the right of the breast bone, on the second intercostal of the breast bone, on the second intercostal to the left of the breast bone on the fourth intercostal in the left medioclavicular line, on the point of the middle of the right intercostal, on the left ulnar flexion, right ulnar flexion. Prior to putting the electrode on all the regions of putting, gel "Relict-05" is applied. EFFECT: quickly normalized atherogenic lipoproteins, indices of hemostasis and peroxide of lipids due to acceleration of activation of the lipolysis and antioxidant systems. 1 tbl, 3 ex

Description

 The invention relates to medicine and is intended for the treatment of atherosclerosis, coronary heart and brain disease, arterial hypertension, diabetes mellitus. Known methods of treating peroxidation syndrome by prescribing various drugs: vitamins A, C, E, carotenoids, estrogens, phenolic antioxidants, etc. (J.I. Abramova et al. Man and antioxidants. L: Nauka, 1985). There are drugs: sequestrants of bile acids, fibrates, extracorporeal techniques that normalize the level of atherogenic lipoproteins and hemostasis indicators, however they are expensive, require long-term use, with their cancellation the effect of exposure stops and these indicators increase (A.N. Klimov, N.G. Nikulcheva, Lipids, Lipoproteins, and Atherosclerosis, St. Petersburg, 1995). All of the above drugs have differentiated use, do not have a complex effect on the syndromes of peroxidation, hyperlipidemia, hypercoagulation, the effect of their use is short-lived. In recent years, the attention of researchers has been drawn to a helium-neon laser, which is used in the treatment of patients with various pathologies of internal organs, including the cardiovascular one. (Methodological recommendations. The use of combined helium-neon-laser therapy for NBS. Moscow, 1983; V.E. Illarionov. Technique and methodology of laser therapy procedures. Moscow. 1994; directory "Lasers in Medicine". - M. 1998. P. 112; The use of medical-diagnostic magneto-IR laser devices of the "MILTA" type in medical practice: A manual for doctors. - M. 2000. P. 85).

 As an analogue, the method according to patent 2003363 C1, A 61 N 5/06 of 11/13/89 was selected, the author of which proposes an intravenous technique for irradiating a helium-neon laser with an output power of 1-5 mW at the fiber end with a session duration of 30-45 minutes daily or every other day, for a course of treatment of 5-9 sessions. The disadvantage of this method is: an intravenous technique that poses a threat of infection with hepatitis B virus, C virus, HIV infection and others; use of a mono-effect of a constant flow of a helium-neon laser; obtaining treatment results on the 10th day, by the end of the first course of therapy; the need for prior use of antioxidants.

 The closest analogue, i.e. The prototype is a method of treatment using MIL therapy. (The use of medical-diagnostic magneto-IR laser devices of the MILTA type in medical practice: A manual for doctors. - M. 2000. P. 44, 47). MIL therapy is a combination of a magnetic field, infrared radiation with a pulsed laser beam, carried out using the MILTA apparatus, wavelength 890 nm, output power 1-3 mW, frequency 5 Hz.

 The advantage is the method of cutaneous use without prior use of antioxidants, good tolerance of treatment, however, a decrease in atherogenic lipoproteins is noted by the 5th session of the first course of treatment, the dynamics of the ECG and heart rate by 7-10 sessions, and the values of lipid peroxidation are reduced, but unreliable .

 The objective of the invention is to more quickly normalize the level of atherogenic lipoproteins, indicators of hemostasis and lipid peroxides by accelerating the activation of lipolysis and antioxidant systems.

 This task is achieved by using the MILTA apparatus (wavelength 890 nm, frequency 50.5 Hz, radiation power 3 mW) in combination with applying Relict-05 gel to the heart, liver and vein areas.

 "Relikt-05" contains biologically active substances of the Khabarovsk organomineral deposits in the form of a set of enzymes (oxyreductases, transferases, hydrolases, phosphatases), macro- and microelements in a complex compound with a natural pigment-like substance. Issued by the Distom company, hygienic certificate 3112 of the State Committee for Sanitary and Epidemiological Surveillance of the Russian Federation, protocol 974 of 08/10/97, in the form of a high molecular weight gel, whose acidity corresponds to the acidity of the skin, without causing irritation when applied. Biologically active substances not only activate lipolysis, the natural key antioxidants of enzymes: catalases, superoxide dismutases, but also simultaneously donate many enzymes (catalases, transferases, amylases, etc.), are successfully combined in a complex, enhancing the effect of exposure. Photodissociation of substances is carried out from the MILTA apparatus, which penetrate the skin barrier (photophoresis). As a result of treatment, the level of atherogenic lipoproteins decreases, the syndrome of hypercoagulation, peroxidation is eliminated, a number of many positive effects are noted: normalization of the heart rhythm, stabilization of blood pressure, elimination of refractoriness to nitrates and antiarrhythmic drugs.

 The method is as follows.

 Daily irradiation is carried out sequentially at 4 main and 3 additional points with a radiation power of 3 mW, a frequency of 5 Hz, and at a 5 point frequency of 50 Hz, a wavelength of 890 nm, the time for the main 4 points from 30 seconds to 2 minutes, for additional points - from 2 minutes to 5 minutes.

Key exposure points:
1. The middle of the left sternocleidomastoid muscle.

 2. The second intercostal space to the right of the sternum.

 3. The second intercostal space to the left of the sternum.

 4. The fourth intercostal space on the left mid-clavicular line.

Additional points:
5. The middle of the right hypochondrium.

 6. Left elbow bend.

 7. Right elbow bend.

 The exposure time per point is from 30 seconds to 5 minutes, depending on the age and health of the patient. The total time is from 10 to 20 minutes. Treatment is carried out daily, from 7 to 10 procedures are released for the course. Patients receive 1 to 2 courses at 10-day intervals. During the treatment, Relikt-05 gel is applied to all points, which is added as it is absorbed.

Comparison of the effectiveness of the use of MIL therapy according to the standard method and our proposed one (Table 1) in combination with the application of Relict-05 gel indicates:
- good tolerance of treatment in 100% of cases;
- mild effect on indicators of systolic and diastolic blood pressure, which led to its significant decrease in mild hypertension (76% of observations), to a lesser extent in moderate (54%) and severe (40%);
- disappearance of angina attacks of the second functional class in 86% of cases, angina of the third functional class in 64%, unstable angina in 100% of cases, while the exacerbation of the disease was not observed, as was the case with low-energy GNL;
- improved repolarization according to ECG, the disappearance of giant T waves in the left chest leads, normalization of intraventricular conduction, which was combined with restoration of heart rhythm with rare ZhE (1-2 classes according to B. Laun) with a disease duration of up to 5 years and reduction by 50% of the frequency ZhE at a 3-4 grade according to B. Laun with process duration from 3 to 5 years. The results made it possible to temporarily abandon the use of antiarrhythmic drugs or halve their dose;
- overcoming refractoriness to nitrates and antiarrhythmic drugs, which restores sensitivity to them after treatment;
- a decrease in the level of atherogenic lipoproteins, an increase in HDL cholesterol, which correlated with the normalization of hemostasis, a decrease in lipid peroxidation products and an increase in antioxidant protection enzymes (AOD) - catalase (CT), superoxide dismutase (SOD);
- the advantages of a combined methodology for treating patients, which gives faster results compared to MIL therapy and longer lasting effectiveness (up to 6-12 months).

The advantages of the proposed method include:
- reduction of treatment time for patients with coronary heart disease by 2.5 times in 90% of cases;
- an active effect on many risk factors: hypertension, atherogenic hyperlipidemia, hypercoagulation, peroxidation indicators, which is achieved for up to 3 months after the 1st course and for up to 6-12 months after the 2nd course;
- a positive effect on the processes of repolarization in the myocardium, normalization of intraventricular conduction, restoration of the heart rhythm in rare VE (grade 1-2 according to B. Laun), decrease in frequent and prolonged VET (grade 3-4 in B. Laun), which allowed to refuse from the appointment of antiarrhythmic drugs or reduce their dose;
- overcoming refractoriness to antiarrhythmic drugs and nitrates;
- rapid onset of effect: at 3 sessions of 1 course of treatment;
- the method according to the invention is effective, convenient, does not require retraining of personnel, economical, can be successfully used in outpatient practice.

Example 1
A 63-year-old patient B. was treated in the therapeutic department for coronary heart disease: heart failure, postinfarction cardiosclerosis, grade 3 arterial hypertension, risk 3. After suffering small-focal myocardial infarction, he received antianginal drugs for a long time 1.5 years ago: nitrates, beta-blockers, small doses of aspirin. Recently, nitrates do not help, blood pressure is increased, which is in the range of 150-160 / 95-100 mm Hg, cholesterol levels in the range of 7.2 mmol / L. The patient underwent therapy with low-energy GNL using the cutaneous technique. With this therapy, blood pressure tended to decrease to 150 / 90-140 / 90-135 / 90 mm Hg, the patient became more balanced, normalized sleep, however, in 3 sessions, compressive pain behind the sternum appeared, a high pointed tooth was recorded on the ECG T in the form of a "hairpin" in the septum and the anterior wall of the left ventricle, which indicated the development of unstable angina. GNL treatment is discontinued, heparin is prescribed, intravenous perlinganitis. The patient's condition improved, the coronary blood flow stabilized, was discharged in satisfactory condition under the supervision of a local therapist. A month later, MILtherapy was performed in the clinic with the use of Relict-05 gel. The wavelength is 890 nm, the radiation power is 1 mW, the frequency is 5 Hz, at 5 points - 50 Hz, the exposure time for the main points is 30 seconds. 5 point - 4 minutes, 6, 7 - 2 minutes. Total 10 minutes daily, 10 treatments.

 He transferred the procedures well, the dynamics of blood cholesterol decreased to 5.2 mmol / l, blood pressure to 130/90 mm Hg, hemostasis was in a state of normal coagulation; lipid peroxides: diene conjugates (DC), malondialdehyde (DC), exceeding the control by 2 times, decreased to normal. He received a second session of MIL-therapy with Relict-05 gel a month later. Examined in dynamics after 3 months: feeling good, the above indicators are stable.

 Example 2

 Patient I., 50 years old, suffered from ventricular extrasystole (grade 2 according to B. Laun) for 2 years, took riboxin, antiarrhythmic drugs. He began to note refractoriness to the therapy, "tired" of treatment. A course of MIL therapy was carried out according to a standard method, noted improvement in well-being, disappearance of extrasystoles at the 5th treatment session, and therefore canceled the drugs for a month. When extrasystoles occurred, he reapplied with the mood to continue laser treatment. A course of treatment of MIL-therapy with Relict-05 gel was carried out. The wavelength is 890 nm, the radiation power is 3 mW, the frequency is 5 Hz, at 5 points - 50 Hz, the exposure time at 4 main points is 2 minutes, at 5 points - 5 minutes, 6, 7 - 3 minutes. Total - 19 minutes, daily, 10 procedures. Extrasystoles disappeared in the 5th session, the effect lasts 3 months, the patient rests from antiarrhythmic drugs. Indicators of lipids, hemostasis, DC, MDA within those of the control group. Disability is fully restored, went swimming for a whole year.

 Example 3

 Patient E., 62 years old, has been suffering from IHD: CH2FK, ventricular extrasystole (grade 3 according to B. Laun) for 5 years. He receives constant supportive antiarrhythmic therapy, when contacting a cardiologist he has repeatedly expressed a desire to cancel or reduce it, because there were pressing pains in the stomach, signs of gastritis, probably drug, were revealed on FGDS. He underwent MIL therapy with Relikt-05 gel, power 3 mW, wavelength 890 nm, frequency 5 Hz, 5 points - 50 Hz, exposure time to 4 main points for 1 minute, 5 points - 5 minutes, 6 , 7 for 3 minutes. Total - 15 minutes. After the 1st course of MIL therapy at the 7-10th session, he noted a decrease in ventricular extrasystole, in connection with which he halved the dose of antiarrhythmic drugs, the effect lasted a month, after 2 courses - up to 6 months. Subsequently, a course of MIL-therapy with Relict-05 gel was carried out. At the fourth session, I felt a decrease in ventricular extrasystoles, the effect has been maintained for the third month. The patient returned to normal sleep, even mood, no arterial hypertension, cholesterol levels within 5.4 mmol / l, cholesterol of high density lipoproteins increased 2 times, hemostasis, lipid peroxide, antioxidant defense enzymes: superoxide dismutase, catalase - at the level of those in the group control. Examined after two months. Satisfactory condition, Increased sensitivity to nitrates.

Claims (1)

 A method for the treatment of syndromes of hyperlipidemia, hypercoagulation, peroxidation, which consists in sequentially applying an MILTA electrode to points located in the middle of the left sternocleidomastoid muscle, the second intercostal space to the right of the sternum, the second intercostal space to the left of the sternum, and the fourth intercostal space to the left middle clavicular line, characterized in that the electrode is additionally sequentially installed on the midpoint of the right hypochondrium, on the left elbow bend, the right elbow bend, while before applying the electrode all overlay field is applied to the gel "Relic-05."

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