RU2195319C2 - Disinfecting agent - Google Patents

Abstract

FIELD: disinfectants. SUBSTANCE: invention, in particular, relates to agents for sterilization and washing off biological fluids and can be, for example, used for treatment of hemodialysis equipment and dialyzers. Agent contains peracetic acid, hydrogen peroxide, acetic acid, stabilizing additive, and water and is distinguished by additionally containing concentrated sulfuric acid as catalyst and by that said stabilizing additive is orthophosphoric acid and ethylenediaminetetraacetic acid sodium salt, all components being taken at specified proportions. EFFECT: increased stability and reduced destructive effect of agent on metallic parts of equipment.

Description

 The invention relates to medicine, namely to means for sterilization and washing from biological fluids, and can be, for example, used for the treatment of hemodialysis equipment and dialyzers.

 A disinfectant is known (SU 1333338, A 61 L 2/16, priority 20.06.83). It contains, wt.%: Peracetic acid 12.5-13.3%; cityl chloride chloride 13.3-18.75%; sodium sulfate 18.75-20% and water - the rest. The tool has a relatively low disinfectant activity.

A known method of obtaining a disinfectant preparation (SU 1755802, A 61 L 2/16, priority 02.21.90,). The method involves mixing a solution of stabilized 50% hydrogen peroxide with a mixture of acetic anhydride and sulfuric acid at 26-30 ^{° C.} for 5-6 hours. The solution is left to stand for 10-12 hours. Then, a stabilizer and water are added.

 Known tool for sterilization and laundering of biological fluids (RU 2077890, A 61 L 2/16, priority 04/27/97). It contains peracetic acid, hydrogen peroxide, acetic acid, ethylenediaminetetraacetic acid and water, taken in certain quantitative proportions. The tool is obtained by mixing an aqueous solution of ethylenediaminetetraacetic acid with glacial acetic acid, followed by the addition of the remaining components to the indicated concentrations.

 The disadvantages of the above funds are not sufficiently high indicators of stability of the funds.

 The technical result consists in the creation of a disinfectant with higher stability, reduced destructive effect on the metal elements of the equipment, increased shelf life.

The technical result is achieved as follows:
The disinfectant contains peracetic acid, hydrogen peroxide, acetic acid, a stabilizing additive and water, and is characterized in that it additionally contains a catalyst, which uses concentrated sulfuric acid, and as a stabilizing additive contains phosphoric acid and Na EDTA in the following ratio of components:
Peracetic acid - 0.1-2.5
Hydrogen Peroxide - 5.0-12.0
Acetic acid - 1.5-10.5
Phosphoric acid and Na EDTA - 0.05-0.2
Concentrated Sulfuric Acid - 0.05-0.2
Water - Else
The preparation of the disinfectant is carried out in two stages. First stage. A 35% hydrogen peroxide solution (GOST 177-88) and 100% glacial acetic acid (GOST 61-75) are poured into the container while stirring. Then, a stabilizer and a catalyst are added to the resulting mixture and stirred at a temperature of 20-30 ^° C. Na EDTA and / or phosphoric acid can be used as a stabilizer. Concentrated sulfuric acid is used as a catalyst. The introduction of the catalyst into the mixture can significantly reduce the formation time of the final product.

 The resulting mixture was incubated for at least 10 hours. The content of peracetic acid (NAA) was from 5 to 10%.

 Second stage. To increase the NAA, a 35% hydrogen peroxide solution was added to the aged reaction mixture, and the resulting mixture was kept for one day.

 The content of NAA in the finished product is from 15 to 20%. The drug can be stored for a year while maintaining high stabilizing qualities.

 The following are examples of a disinfectant with different levels of NAA in the finished product.

Example 1
The content of NAA in the prepared tool is 2.2 mol / g (about 15%) with the following specific amounts of the starting components of the synthesis, mol / l:
Hydrogen Peroxide - 5.9
Acetic acid - 10.1
Stabilizer - (phosphoric acid and Na EDTA) - 0.13
Catalyst - Sulfuric Acid - 0.1
Water - 83.77
Example 2
The content of NAA in the prepared tool is 2.2 mol / g (about 15%) with the following specific amounts of the starting components of the synthesis, mol / l:
Hydrogen Peroxide - 5.9
Acetic acid - 10.1
Stabilizer - (phosphoric acid and Na EDTA) - 0.13
Catalyst - Sulfuric Acid - 0.1
Water - 83.87
The exposure time is 5-7 days (without catalyst).

Example 3
The content of NAA in the prepared tool is 2.2 mol / g, (about 15%) with the following specific amounts of the starting components of the synthesis, mol / l:
Hydrogen Peroxide - 5.9
Acetic acid - 10.1
Stabilizer - (phosphoric acid and Na EDTA) - 0.13
Catalyst - Sulfuric Acid - 0.1
Water - 83.77
The exposure time is 12 hours.

Example 4
The content of NAA in the prepared product is 1.1 mol / g with the following specific amounts of the starting components of the synthesis, mol / l:
Hydrogen peroxide - 9.1
Acetic acid - 3.6
Stabilizer - (phosphoric acid and Na EDTA) - 0.13
Catalyst - Sulfuric Acid - 0.1
Water - 87.07
Example 5
The content of the NAA in the prepared product is 0.6 mol / g with the following specific amounts of the starting components of the synthesis, mol / l:
Hydrogen Peroxide - 12.0
Acetic acid - 1.7
Stabilizer - (phosphoric acid and Na EDTA) - 0.13
Catalyst - Sulfuric Acid - 0.1
Water - 86.07
As the results show, when exposed to a disinfectant, microorganisms and viruses are deactivated during oxidation. Contaminants of biogenic origin are oxidized and degraded, pass into a soluble form.

 The table shows data on the activity of the drug.

 The present invention will find application as a highly effective disinfectant for processing equipment in the food industry, in the medical industry for the disinfection of medical equipment, tools and facilities, etc.

Claims (1)

A disinfectant containing peracetic acid, hydrogen peroxide, acetic acid, a stabilizing additive and water, and characterized in that it further comprises a catalyst, which uses concentrated sulfuric acid, and as a stabilizing additive contains phosphoric acid and Na EDTA in the following ratio components, mol / l:
Peracetic acid - 0.1-2.5
Hydrogen Peroxide - 5.0-12.0
Acetic acid - 1.5-10.5
Phosphoric acid and Na EDTA - 0.05-0.2
Concentrated Sulfuric Acid - 0.05-0.2
Water - Else

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