RU2192876C2 - Method of lipid level decrease - Google Patents

Abstract

FIELD: medicine, medicinal biochemistry, phytotherapy. SUBSTANCE: invention proposes method of decrease of lipids level that involves prescription to patient 42% alcoholic extract of Unabi date fruits, medlar fruits, swampy sweet flag, common anise, sandy common immortelle, medicinal valerian, common marjoram, fragrant holy-grass, perforate Saint-John's wort, sown coriander, horse chestnut fruits, pot-marigold, linden flowers, laurel leaves, lovage, peppermint, matricary, medicinal common balm, common milfoil, caraway seeds, sage, thyme, fragrant dill,, chicory, dry grape vine taken in dilution with water 1:5, 3 times per a day for 8-10 days. Method ensures to avoid unpleasant adverse effects arising in prescription of medicinal hypolipidemic agents and can be used in any cases to decrease and eliminate lipids from body. EFFECT: enhanced effectiveness of agent, valuable medicinal property. 1 cl, 9 ex

Description

 The invention relates to medicine, biology, biophysics and can be used to reduce lipid levels, as well as to monitor the progress of lipid metabolism for therapeutic and prophylactic purposes.

 A known method of reducing lipid levels by taking an extract of: leaves of hay 10, bearberry leaves 10, fruits of hawthorn 10, peppermint leaves 15, common motherwort grass 15, grass of a series of three-parted 15, rose hips 25 / patent RU 2150286 "Collection of medicinal plants having hypolidemic action ", adopted by us as a prototype / Authors: Glyzin V.I., Sokolskaya T.A., Kolher V.K., Kosenko N.V.

 Disadvantages: low effect on the level of lipids in the body, the complexity of the method, the duration of exposure.

 A known method of reducing lipid levels using pharmacological agents / Okorokov A.N. In the book: Treatment of diseases of internal organs. Medical correction of atherogenic dyslipoproteinemia (nicotinic acid). Minsk-Vitebsk, 1996, p. 24-270 /.

 The method involves the administration of nicotinic acid (NK) in a dose of 100 mg in 3 divided doses for 1 week, then for 2 weeks, 200 mg in 3 divided doses per day, for 3 weeks, 400 mg in 3 divided doses per day, 4 weeks 1000 mg in 3 divided doses per day. Shortly before taking nicotinic acid, 325 mg of aspirin is taken. Treatment is designed for a long period.

The disadvantages of the method:
- The presence of side effects in the treatment of NK (impaired liver function).

 - Irritant effect on the stomach, which can cause exacerbation of chronic hepatitis, peptic ulcer.

 - Hyperemia of the skin, hot flushes at the beginning of treatment.

 - Perhaps the development of hyperglycemia, the need to check the level of glucose in the blood during treatment.

 - Increased uric acid levels.

 - Itchy skin.

 - The appearance of brown spots on the skin.

 - Appointment of aspirin 30 minutes before taking NK.

 - The duration of the course of treatment.

 - Lack of ability to visually control metabolic restructuring in the body during treatment in order to reduce the dose of NK.

The objectives of the invention are:
Enhanced effect.

 A simplification of the method of lowering lipid levels.

 Reducing the timing of the removal of lipids from the human body.

 Elimination of complications arising from the appointment of lipid-lowering drugs.

 Increasing the information content of the proposed method.

 Lower cost of treatment.

 Improving the reliability of control.

 The essence of the invention lies in the fact that the patient is prescribed an extract from natural components, including as the main active principle, Unaby dates and medlar, as well as marsh cinnamon, common anise, immortelle sandy, medicinal valerian, common oregano, aromatic bison, pierced St. John's wort, sowing coriander , horse chestnut fruits, calendula, linden blossom, bay leaf, lovage, cinquefoil, peppermint, medicinal chamomile, lemon balm, yarrow, caraway seeds (fruits), sage, thyme, odorous dill, chicory, dry vine grape course, with a dilution of 10 ml of 42% alcohol extract in 50 ml of water, three times a day for 8-10 days according to indications.

 The method is as follows.

 Prepare the first portion of the alcoholic extract: take 1 liter of alcoholic 50% solution: 15 g of Unaby date fruits, 10 g of medlar, pour the solution and incubate for 12 days, then the solution is drained.

Prepare a second portion of the alcoholic extract based on 1 liter of alcoholic 50% solution taken, g:
Calamus Root Marsh - 0.2
The fruits of anise ordinary - 0.1
Immortelle sand - 0.1
Valerian officinalis - 0.03
Origanum ordinary - 0.3
Scented dentition - 0.6
St. John's wort pierced - 0.8
The fruits of the coriander seed - 0.5
Conkers - 0.18
Calendula flowers - 0.05
Linden flowers - 0.05
Noble Laurel (leaf) - 0.03
Lovage (leaves and tops of flowering stems) - 0.25
Bloodroot (rhizome) - 0.2
Peppermint - 0.25
Melissa officinalis - 0.3
Yarrow (tops of stems) - 0.25
Chamomile officinalis - 0.25
Caraway seeds - 0.2
Sage - 0.2
Thyme - 0.3
Dill odorous (fruits) - 0.05
Chicory - 0.2
Grape Dry Vine - 0.4
pour in the solution, incubated for 12 days, then the solution is drained.

 Combine the first and second servings and bring to 42% strength with 96.4% alcohol.

 The obtained extract from natural components is prescribed in a course, when diluting 10 ml of 42% alcohol extract in 50 ml of water (1: 5), three times a day for 8-10 days according to indications.

 The healing properties of the natural components included in the proposed 42% alcoholic extract are: Unabi dates (Chinese dates) - fruits. Use in raw, dried, smoked, canned form; contain organic acids, steroids, saponins, triterpenoids, vitamins C, B1, P, PP, K, folic acid, beta-carotene, phenolcarboxylic acids, flavonoids. Unabi preparations have an antisclerotic, antihypertensive effect, regulate the metabolism in the body, and are a powerful antioxidant.

 Medlar (fruits) is a rich source of vitamin C. The set of other ingredients used by us stimulates the activity of the liver, gall bladder, and intestines. At the same time, cholesterol and triglycerides are excreted with human bile through feces.

 The method was tested on 168 patients.

 The treatment results are controlled in dynamics by quantitatively determining the level of cholesterol and triglycerides in the blood serum (SC) of the test person, before and after the course of treatment (quantitative control).

 For reliability of control, the exchange structure of the blood serum of the test person is studied under a polarized light microscope before and after the course of treatment. (Savina L.V., Chirvinsky N.P., Tuev A.V. Avt. St. 1559262 // discovery, 1990. 15. Method for the diagnosis of atherosclerosis; Savina L.V., Doronina T.A., Botchenko L. .L. Patent 2144188. Method for controlling the administration of parapharmaceuticals and pharmaceuticals, 2000). (Quality control).

 The basis of the study is the detection of optically active crystals in the blood serum: cholesterol, represented by radial radiant spherulites and triglycerides, made by dendrites of tangled-fiber aggregates (DSVA). After a course of treatment, the crystals of cholesterol and triglycerides disappear.

 We present samples of SC of a healthy person (photo 1a) and samples of patients with hyperlipidemia (photo 1b, c).

 Photo 1a shows the structure of the SC of a healthy person, there are filiform, dichotomously (dividing in two) branching crystals.

 Figure 1b shows the structure of the SC of patient I. with hypercholesterolemia, cholesterol - 5.8 mmol / L (norm 4.4 mmol / L). There is a cholesterol crystal - radial radiant spherulite.

 Photo 1c shows the structure of the patient's C.'s SC with hypertriglyceridemia. There is a TG crystal - a dendritic tangled-fiber aggregate (DSVA).

EXAMPLES
Example 1 (photo 2 a-c). Patient L., 45 years old, medical history (IB) 3198. Diagnosis: obesity, III stage, exogenous. In photos 2a, b, the initial structure of the patient's SC is visible. In photo 2a, the TG crystal is visible in the form of DSVA, in photo 2b - a radially radiant XC crystal.

 In photo 2c - the restored structure of SC after a course of treatment with alcohol extract (SE). Filamentous dichotomous branching crystals are present.

 Technology: blood was taken from the finger of a patient L. before treatment for quantitative and qualitative determination of hyperlipidemia. Then, the subject was prescribed 10 ml of SC three times in 50 ml of water for 8 days. Its initial level of cholesterol is 6.8 mmol / L, and TG is 1.27 mmol / L. Microscopy of a preparation prepared from a patient’s SC of L. found crystals of cholesterol and TG.

 After 8 days, with a second study of cholesterol and TG indices, their level turned out to be normal and amounted to 4.6 mmol / L and 1.08 mmol / L, respectively. No CS and TG crystals were found in the SC structure studied in polarized light. Filamentous dichotomously branched crystals were present.

 The hypolipidemic effect of SE is confirmed.

 Example 2 (photo 3 a-c). Patient J., 55 years old. Diagnosis: latent diabetes mellitus. Menopausal syndrome. IB 3112. The initial structure of the SC is represented by DSVA and spherulites (photo 3a, b).

 On photo 3c - the restored structure of SC after a course of treatment for SE. Threadlike dichotomously branched crystals are visible.

 Technology. Before starting treatment of SE in patient J., a quantitative and qualitative determination of hyperlipidemia was made. Then she was prescribed 10 ml of SC three times a day in 50 ml of water for 10 days. The initial level of cholesterol is 7.1 mmol / l, TG is 1.11 mmol / l, and the crystals of cholesterol and TG are present in the SC structure.

 10 days after treatment, the level of cholesterol and TG turned out to be normal and amounted to 4.6 and 1.07 mmol / L. The SC structure was made by whisker dichotomously branching (NDV) crystals.

 The hypolipidemic effect of SE is confirmed.

 Example 3 (photo 4 a-c). Patient N., 50 years old. Diagnosis: atherosclerosis with a primary lesion of the vessels of the brain and lower extremities. IB 729. The initial structure of the SC is represented by spherulites and their relics (a, b). Photo 4c shows the restored structure of SC after a course of treatment for SE. NDV crystals are visible.

 Technology. Before starting taking SE in patient N., a quantitative and qualitative determination of hyperlipidemia was made. Then, 10 ml of SC is prescribed three times a day in 50 ml of water for 10 days. The initial level of cholesterol was increased - 5.5 mmol / l, TG - 1.06 mmol / l (normal). Chloride crystals and their relics are present in the SC structure. 10 days after treatment, the level of cholesterol is 4.4 mmol / l, TG - 1.04 mmol / l.

 The structure of the SC is made by NDV crystals. The hypolipidemic effect of SE is confirmed.

 Example 4 (photo 5 a-c). Patient M., 38 years old. Diagnosis: chronic cholecystitis. Obesity III tbsp. IB 2117. The initial structure of the SC is represented by triglyceride crystals and their relics, DSVA (a, b). Figure 5c shows the SC recovery structure. NDV crystals are visible.

 Technology. Before taking SE in patient M., a quantitative and qualitative determination of hyperlipidemia was carried out. Then, 10 ml of SC is prescribed three times a day in 50 ml of water for 10 days.

 The initial level of cholesterol is normal and equal to 4.5 mmol / L, the level of TG is increased and equal to 2.8 mmol / L (normal - 1.09 mmol / L). The SC structure contains TG crystals and their relics in the form of dendritic, tangled-fiber aggregates. 10 days after treatment, the level of cholesterol is 4.1 mmol / l, TG - 1.08 mmol / l. The SC structure is made by whisker dichotomously branching (NDV) crystals. The hypolipidemic effect of SE is confirmed.

 Example 5 (photo 6 a-c). Patient V., 39 years old. Diagnosis: diabetes mellitus, insulin dependent. IB 3149. The initial structure of SC is represented by cholesterol crystals, relicts of radially radiant spherulites (a, b). Photo 6c shows the recovery structure of SC after a course of treatment for SE.

 Technology. Before starting treatment of SE, patient V. underwent a quantitative and qualitative determination of hyperlipidemia. Then, 10 ml of SC is prescribed three times a day in 50 ml of water for 8 days. The initial level of cholesterol is 7.3 mmol / L (N - 4.4 mmol / L). In the initial structure of the SC, there are cholesterol crystals, their relics (semi-finished radially radiant spherulites). After 8 days from the start of treatment, the level of cholesterol was normalized (4.6 mmol / l), the structure of the SC was performed by NDV crystals.

 The hypolipidemic effect of SE is confirmed.

 Example 6 (photo 7 a-c). Patient 3., 45 years old. Diagnosis: coronary heart disease. Angina pectoris II functional class. IB 818. The initial structure of SC is represented by spherulites (a), DSVA (b).

 Figure 7c shows the restoration structure of SC after a course of treatment for SE.

 Technology. Before starting treatment of SE, patient Z. had a quantitative and qualitative determination of hyperlipidemia. Then, 10 ml of SC is prescribed three times a day in 50 ml of water for 10 days. In the initial structure of SC, there are: cholesterol crystals (cholesterol - 6.1 mmol / l, with N - 1.09 mmol / l) in the form of DSVA. After 10 days from the start of taking SE, the level of cholesterol and triglycerides normalized to 4.5 and 1.06 mmol / l, respectively), the structure of the SC is made by NDV crystals. The hypolipidemic effect of SE is proven.

 Example 7 (photo 8 a-c). Patient U., 64 years old. Diagnosis: gout. IB 2116. The initial structure of SC is represented by cholesterol crystals (spherulites, their relics) (photo 8 a, b). Figure 8c shows the normal structure of SC obtained after a course of treatment for SE.

 Technology. Before starting treatment of SE, patient U. underwent a comprehensive study of SC to determine hyperlipidemia (HLP). Then, 10 ml of SC is prescribed three times a day in 50 ml of water for 10 days. In the initial SC structure, there is an abundance of cholesterol crystals (cholesterol - 6.9 mmol / L) made by spherulites and their relics. After 10 days from the start of taking SE, the level of cholesterol was normalized (4.5 mmol / L), the structure of SC is represented by NDV crystals.

 The hypolipidemic effect of SE is confirmed.

 Example 8 (photo 9 a-c). Patient A., 39 years old. Diagnosis: osteoarthropathy. IB 2418. The initial structure of the SC is represented by TG crystals made by DSVA (photo 9a).

 In photo 9b - the SC recovery structure after 8 days from the start of the SC administration.

 Technology. Before starting treatment of SE, patient A. carried out a comprehensive determination of hyperlipidemia. Then, 10 ml of SC is prescribed three times a day in 50 ml of water for 8 days. The initial structure of SC contains TG and CS crystals (TG - 2.04 and CS - 6.1 mmol / L, exceeding the norm). After 8 days from the start of treatment, the level of cholesterol is 4.6, TG - 1.08 mmol / L. The structure of SC is represented by NDV crystals.

 The hypolipidemic effect of SE is confirmed.

 Example 9 (photo 10 a-c). Patient G., 49 years old. Diagnosis: osteochondrosis of the spine. IB 595. The initial structure of the SC is represented by spherulites and their relics (photo 10 a, b). The recovery structure of the SC after taking SE in the photo of the 10th century.

 Technology. Before starting treatment for SE, patient G. underwent a comprehensive determination of HFL. Then, 10 ml of SC is prescribed three times a day in 50 ml of water for 10 days. In the initial structure of SC, cholesterol crystals are present (cholesterol - 6.9 mmol / L). After 10 days, the level of cholesterol returned to normal - 4.8 mmol / L. The structure of SC is represented by NDV crystals.

 The hypolipidemic effect of SE is confirmed.

The method provides:
- No side effects.

 - The use of natural ingredients in the preparation of alcohol extract.

 - Shortening the course of lipid-lowering therapy.

 - Reducing economic costs, ensuring control over the effect of treatment.

Claims (1)

 A method of reducing lipid levels by administering an extract of natural components to a patient, characterized in that they prescribe 42% alcoholic extract of Unaby date fruits, medlar, marsh calf, common anise, sandwort immortelle, medicinal marjoram, common oregano, scented St. John's wort, seed coriander, horse chestnut, calendula, linden blossom, bay leaf, lovage, cinquefoil, peppermint, chamomile, lemon balm, yarrow, caraway seeds (fruit s), sage, thyme, odorous dill, chicory, grape dry vine diluted with water 1: 5, 3 times a day for 8-10 days.

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