CN110327427A - It is a kind of to treat morning, the Chinese medicine composition of mid-term high blood pressure and preparation method - Google Patents

It is a kind of to treat morning, the Chinese medicine composition of mid-term high blood pressure and preparation method Download PDF

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CN110327427A
CN110327427A CN201910662895.8A CN201910662895A CN110327427A CN 110327427 A CN110327427 A CN 110327427A CN 201910662895 A CN201910662895 A CN 201910662895A CN 110327427 A CN110327427 A CN 110327427A
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parts
weight
water
blood pressure
chinese medicine
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钟广伟
姚佳梅
罗艳红
于平平
陈琼
邱新建
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Xiangya Hospital of Central South University
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Abstract

Morning, the Chinese medicine composition of mid-term high blood pressure and preparation method are treated the invention discloses a kind of, which is made of the bulk pharmaceutical chemicals of following proportion: Rhizoma Gastrodiae 8-20 parts by weight, uncaria 10-20 parts by weight, shell of seaear 22-35 parts by weight, oyster 25-35 parts by weight, radix achyranthis bidentatae 8-20 parts by weight, Radix Salviae Miltiorrhizae 5-20 parts by weight, herba taxilli 5-20 parts by weight, Rhizoma Chuanxiong 5-20 parts by weight, dried orange peel 3-12 parts by weight, rhizoma pinellinae praeparata 3-12 parts by weight.The technical issues of raw materials of traditional Chinese medicine composition ingredient that drug prepared by the present invention solves treatment high blood pressure at present is more, preparation process is cumbersome, slow effect, uncertain therapeutic efficacy are cut, drug of the present invention has effects that nourishing and suppressing Yang, calming the liver to stop the wind, dissipating phlegm and removing blood stasis, compatibility is reasonable, mutually there is synergistic effect, it can heighten the effect of a treatment, and then reach and treat early, mid-term high blood pressure, have many advantages, such as that safe and reliable, no dependence, clinical efficacy is significant, stable and controllable for quality, preparation process is simple.

Description

It is a kind of to treat morning, the Chinese medicine composition of mid-term high blood pressure and preparation method
Technical field
The invention belongs to technical field of traditional Chinese medicine, are related to a kind of Chinese medicine composition for treating morning, mid-term high blood pressure And preparation method.
Background technique
The high blood pressure course of disease is longer, and clinical manifestation is changeful, is difficult to be classified as a certain specific illness of Chinese medicine.Chinese medicine Though, according to its performance, ancient physician generally falls into scopes such as " dizziness " " headaches " without hypertension name of disease.According to " Plain Questions To very discussing greatly " in " all wind trembling and dizziness, come under liver ", it is indicated that disease located in liver, root are in kidney, it is believed that it is in the nature asthenia in origin and asthenia in superficiality, Imbalance of yin and yang；One word of dizziness sees Prescriptions Worth Thousand Gold for Emergencies earliest, and Zhang Zhongjing also proposes in treatise on Febrile Diseases " Synopsis Golden Chamber " The name of " dizzy " " dizzy ".Ancient physician substantially thinks the etiology and pathogenesis of high blood pressure nothing more than following several: one says because void is caused a disease, " Ling Shu Miraculous Pivot or Divine Axis defends gas " is said: " deficiency of the upper causing dizziness ", Zhang Jingyue think that lower empty cause is dizzy, and " the miscellaneous card of Jing Yue's complete work " is said: " though on dizzy category Coke, so cannot be without relating under.Cover empty person, the yang aspect of yang void；Lower void person, the yang aspect of yin void." secondly being caused for wind fire phlegm retention Disease, ZHU Dan-xi have " dizziness must be caused by phlegm, phlegm are dynamic because of fire " at " danxi's experiential therapy ", propose " wind in Sui Dynasty Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " Dizzy person, by deficiency of qi and blood, ailment said due to cold or exposure enters internal organs ", it is believed that caused by liver and kidney deficiency, insufficiency of vital energy and blood, violate on inside and outside heresy wind in brain be cause it is dizzy Dizzy main pathogenesis.Thirdly stagnant obstructed for the blood vessels stasis of blood.Doctor's Wang Kentang thinks zang-fu differentiation qi and blood superinverse, upsets clear key, causes Blood stops up stagnant passages through which vital energy circulates and sends out dizziness headache, and clearly proposition hemostasis is pathogenic etiology and pathogenesis.Majority doctor thinks hypertension at present The etiology and pathogenesis of disease essentially consists in visceral dysfunction caused by improper diet and overtiredness, emotional factors, native endowment, major pathogenetic factor For wind, fire, phlegm, the stasis of blood, void, sick position is mainly related to liver and spleen kidney.In recent years face card during and investigation of clinical epidemiology knot Fruit shows syndrome of upper hyperactivity of liver yang and the turbid syndrome of blood stasis of phlegm is the highest card of composition ratio in hypertension each phase (early, mid-term) and the different courses of disease It waits, accounts for 62.36%；It is with a long history that traditional Chinese medicine treats high blood pressure, and most results of study show: traditional Chinese medicine prevention is high Blood pressure diseases significant effect, the evidence of " Chinese hypertension prevention and control guide " Zeng Yinyong tcm clinical research illustrate that traditional Chinese medicine is treated The toxic side effect of high blood pressure is small, and curative effect is obvious, and this advantage is just got growing concern for.
In the clinically used six big hypotensors pointed out in " Chinese hypertension prevention and control guide ", the effect of single drug is past Toward bad, most of patients needs drug combination, and Long-term taking medicine, and Western medicine is while reducing blood pressure, inevitably There is various adverse reactions, such as flush, dry cough, ankle and foot oedema, liver and kidney dysfunction, some drugs can also be because of decompression It is too fast and cause the excessive appearance of fluctuation of blood pressure is dizzy the uncomfortable reaction such as to aggravate.And many drug prices are expensive in Western medicine, have Drug long-term use there is also drug resistance, and the compliance that the above factor all will lead to patient's medication is poor, certainly will will affect The treatment of high blood pressure control the state of an illness cannot well.
Currently, there are many drug products currently on the market about treatment high blood pressure, especially Western medicine, but these drugs are all It is symptomatic treatment, lacks the characteristics of taking safety, no dependence for a long time；Also Chinese medicine compound prescription and monomer in treating hypertension there are many, But the technical problem that there are raw materials of traditional Chinese medicine composition ingredients is more, preparation process is cumbersome, slow effect, uncertain therapeutic efficacy are cut etc., really Can be used in it is clinical and few, especially in morning, mid-term patients with hypertension (syndrome of upper hyperactivity of liver yang and the turbid syndrome of blood stasis of phlegm) Western medicine research is still in blank at present.In addition for morning, mid-term hypertensive patient, traditional Chinese medicine is controlled in fact in terms of simple decompression Therapeutic effect is strong unlike Western medicine, it does not have Western medicine rapid-action, convenient to take.But the diagnosis and treatment based on an overall analysis of the illness and the patient's condition of traditional Chinese medicine, Overall View is considering controlling The theories such as non-disease can effectively improve the cardinal symptom and simultaneous phenomenon of patient, so as to improve the quality of life of patient, and Chinese medicine for lowering high blood pressure curative effect is stablized, and mitigation is compared in decompression.
Summary of the invention
In order to solve currently on the market about treatment high blood pressure raw materials of traditional Chinese medicine composition ingredient is more, preparation process is numerous The technical issues of trivial, slow effect, uncertain therapeutic efficacy are cut, the present invention provide a kind of Chinese medicine composition for treating morning, mid-term high blood pressure, Solve problems of the prior art.
It is a further object of the present invention to provide the preparation methods of above-mentioned Chinese medicine composition.
In order to solve the above technical problems, the invention adopts the following technical scheme:
A kind of Chinese medicine composition for treating morning, mid-term high blood pressure, the Chinese medicine composition by following proportion bulk pharmaceutical chemicals group At: Rhizoma Gastrodiae 8-20 parts by weight, uncaria 10-20 parts by weight, shell of seaear 22-35 parts by weight, oyster 25-35 parts by weight, radix achyranthis bidentatae 8-20 Parts by weight, Radix Salviae Miltiorrhizae 5-20 parts by weight, herba taxilli 5-20 parts by weight, Rhizoma Chuanxiong 5-20 parts by weight, dried orange peel 3-12 parts by weight, rhizoma pinellinae praeparata 3- 12 parts by weight.
Preferably, which is made of the bulk pharmaceutical chemicals of following proportion: Rhizoma Gastrodiae 10-17 parts by weight, uncaria 12-18 weight Measure part, shell of seaear 25-33 parts by weight, oyster 28-33 parts by weight, radix achyranthis bidentatae 12-18 parts by weight, Radix Salviae Miltiorrhizae 8-15 parts by weight, herba taxilli 12-17 parts by weight, Rhizoma Chuanxiong 9-15 parts by weight, dried orange peel 6-10 parts by weight, rhizoma pinellinae praeparata 7-10 parts by weight.
It is highly preferred that the Chinese medicine composition is made of the bulk pharmaceutical chemicals of following proportion: 15 parts by weight of Rhizoma Gastrodiae, 15 weight of uncaria Part, 30 parts by weight of the shell of seaear, 30 parts by weight of oyster, 15 parts by weight of radix achyranthis bidentatae, 12 parts by weight of Radix Salviae Miltiorrhizae, 15 parts by weight of herba taxilli, Rhizoma Chuanxiong 12 parts by weight, 9 parts by weight of dried orange peel, 9 parts by weight of rhizoma pinellinae praeparata.
Another technical solution of use of the invention is, it is a kind of treat morning, mid-term high blood pressure Chinese medicine composition system Preparation Method, comprising the following steps:
Step S1, weigh each bulk pharmaceutical chemicals Rhizoma Gastrodiae, uncaria, the shell of seaear, oyster, radix achyranthis bidentatae, Radix Salviae Miltiorrhizae, herba taxilli, Rhizoma Chuanxiong, dried orange peel, Rhizoma pinellinae praeparata, it is spare；
Step S2 takes formula ratio Rhizoma Gastrodiae to clean, is ground into superfine powder, is sieved through 100 mesh, spare；
Step S3 takes formula ratio uncaria, radix achyranthis bidentatae, herba taxilli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, dried orange peel, rhizoma pinellinae praeparata, cleans, adds water to cook 3 Secondary, for the first time plus the water of crude drug amount 8-10 volume times, decoction 4-6h extract 2-4h；Add crude drug amount 7-9 volume times for the second time Water decocts 3-4h, extracts 2-3h；The water of third time plus crude drug amount 4-6 volume times decocts 2-3h, extracts 1-2h；Collecting decoction, Filtering, filter vacuum are concentrated into the clear cream that relative density is 1.15-1.20, and clear cream is spray dried to dry powder, spare；
Step S4 takes the formula ratio shell of seaear, oyster crude drug to clean, broken thick block mixing, after the water retting 2h for adding 3 volumes times, It decocts 3 times；Add the water decoction 4h of 5 times of volumes of water for the first time, for the second time plus the water of 3 times of volumes of water decocts 2h, adds 2 times of water for the third time The water of volume decocts 1h, merges medical filtration three times, and 60-80 DEG C is condensed into medicinal extract, adds the 90-95% ethyl alcohol of 3-4 volume times, cold Leaching 4-6 times, filtering, is recovered under reduced pressure ethyl alcohol, obtains medicinal extract, dries, and is broken into smalls, and No. five are sieved through 100 mesh；
Step S5, by superfine powder obtained, dry powder, smalls and even, dry pressing granulation is made the dosage form of clinical receiving, has Tablet, capsule, powder, soft capsule, dripping pill, honeyed bolus, pill, granule, soft extract with bee honey agent, sustained release preparation, controlled release preparation.
The traditional chinese medicine composition of the invention selects ten kinds of components, in which:
(1) Rhizoma Gastrodiae has effects that suppressing liver-YANG, Inflammation Zhijing, dispelling wind and removing obstruction in the meridians, uncaria have The flat liver of heat-clearing, dispelling wind and relieving convulsion Effect, the two share can The flat liver of heat-clearing, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. and relieve pain improving eyesight, the effect of calming the liver to stop the wind can be reinforced, be entire prescription in Monarch drug in a prescription is alleviated because of clinical symptoms such as liver-yang uplink has a headache caused by head, hot eyes, irritability and dysphoria with smothery sensation；
(2) shell of seaear has calming the liver to stop the wind, checking exuberance of yang, removes hot improving eyesight effect, and oyster, which has, holds back negative checking exuberance of yang, and hidroschesis arresting seminal emission is changed Phlegm softening hard masses effect；The salty-cold matter weight of the two, share can promote it is calming the liver, and can remove hot improving eyesight, assist the calming the liver to stop the wind of monarch drug in a prescription The effect of, it is the ministerial drug in entire prescription, the clinical symptoms such as headache, hot eyes, alliteration, spiritlessness and weakness of reduction of patient；
(3) radix achyranthis bidentatae has nourishing liver and kidney, strengthening the bones and muscles, and dispelling stasis of blood and stimulating the menstrual flow is ensuringd proper downward flow of the blood, and can activating blood and promoting diuresis；And herba taxilli has Nourishing liver and kidney, strengthening bones and muscles, dispelling wind and dampness, miscarriage prevention member and other effects, the two, which shares, draws liver-yang downlink, and can tonify the liver and kidney, activating blood and promoting diuresis, reaches To nourishing and suppressing Yang, yin and yang in equilibrium is the ministerial drug in entire prescription, the diseases such as the flushing of reduction of patient, insomnia, amnesia, soreness and weakness of waist and knees Shape.
(4) Radix Salviae Miltiorrhizae: having promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness and other effects, and Rhizoma Chuanxiong has promote breath and open depression, dispels wind The effect of eliminating dampness, promoting blood circulation and stopping pain, the two is shared with promoting blood circulation analgesic；Because it is stagnant obstructed that there are the blood vessels stasis of bloods, internal organs is caused to pass through Network qi and blood superinverse, upsets clear key, and blood is caused to stop up stagnant passages through which vital energy circulates and send out dizziness headache, thus can the analgesic of promoting blood circulation access, alleviation faces Bed symptom.
(5) dried orange peel has effects that regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm, and rhizoma pinellinae praeparata have effects that it is eliminating dampness and eliminating phlegm；The two shares tool There is eliminating dampness and eliminating phlegm, regulating qi-flowing for activating stagnancy, is adjutant with Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong.Because there are eating and drinking without temperance for patients with hypertension, overfeeding is plump, Cause weakness of the spleen and the stomach, phlegm wet is obstructed, and causes to blind clear key, heaviness of the head as if it were tightly bandaged, giddy, uncomfortable in chest, abundant expectoration, absent minded etc. occurs Symptom.
Ten kinds of components in above-mentioned Chinese medicine composition share, and reach nourishing and suppressing Yang, calming the liver to stop the wind, dissipating phlegm and removing blood stasis function jointly Effect, compatibility is reasonable, mutually has synergistic effect, can heighten the effect of a treatment；The Chinese medicine composition that the present invention is researched and developed is mainly for inverse It is significant in efficacy in terms of turning the reconstruct of patient's main artery blood vessel and improving patient clinical symptom, it can steadily be depressured.
The beneficial effects of the present invention are: the traditional chinese medicine composition of the invention uses several kinds of Chinese medicinal materials, there is nourishing and suppressing Yang, calming the liver to put out Wind, dissipating phlegm and removing blood stasis effect, compatibility is reasonable, mutual to have synergistic effect, can heighten the effect of a treatment, and then reaches and treat early, mid-term height Blood pressure diseases have headache, heaviness of the head as if it were tightly bandaged, giddy, alliteration, uncomfortable in chest, abundant expectoration, flushing, hot eyes, insomnia, amnesia, spiritlessness and weakness, waist and knee The symptoms such as aching and limp, absent minded, irritability and dysphoria with smothery sensation；The traditional chinese medicine composition of the invention treatment is early, mid-term high blood pressure effect is aobvious It writes, can not only reduce blood pressure, and blood lipid, hemorheology and Carotid Vascular Remodeling can be improved, correct and suffer from Person's disorders of lipid metabolism and blood pressure rhythm imbalance；And preparation method is simply conducive to produce, and it is without side-effects, it can be used for morning, the high blood of mid-term Press the treatment of patient.Chinese medicine composition of the invention is with safe and reliable, no dependence, clinical efficacy is significant, quality is stable Controllably, the advantages that preparation process is simple.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described, Obviously, the described embodiment is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the reality in the present invention Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to In the scope of protection of the invention.
Embodiment 1
A kind of Chinese medicine composition for treating morning, mid-term high blood pressure, is made of the raw material of following weight parts: 8 parts of Rhizoma Gastrodiae, hook 10 parts of rattan, 22 parts of the shell of seaear, 25 parts of oyster, 8 parts of radix achyranthis bidentatae, 5 parts of Radix Salviae Miltiorrhizae, 5 parts of herba taxilli, 5 parts of Rhizoma Chuanxiong part, 3 parts of dried orange peel, rhizoma pinellinae praeparata 3 parts.
The preparation method of early, mid-term high blood pressure the Chinese medicine composition of the treatment, comprising the following steps:
Step S1, weigh each bulk pharmaceutical chemicals Rhizoma Gastrodiae, uncaria, the shell of seaear, oyster, radix achyranthis bidentatae, Radix Salviae Miltiorrhizae, herba taxilli, Rhizoma Chuanxiong, dried orange peel, Rhizoma pinellinae praeparata, it is spare；
Step S2 takes formula ratio Rhizoma Gastrodiae to clean, is ground into superfine powder, is sieved through 100 mesh, spare；
Step S3 takes formula ratio uncaria, radix achyranthis bidentatae, herba taxilli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, dried orange peel, rhizoma pinellinae praeparata, cleans, adds water to cook 3 Secondary, for the first time plus the water of 8 volume of crude drug amount times, decoction 4h extract 2h；The water for adding 7 volume of crude drug amount times for the second time, decocts 3h, Extract 2h；The water of third time plus 4 volume of crude drug amount times decocts 2h, extracts 1h；Collecting decoction, filtering, filter vacuum are concentrated into phase The clear cream for being 1.15 to density, clear cream is spray dried to dry powder, spare；
Step S4 takes the formula ratio shell of seaear, oyster crude drug to clean, broken thick block mixing, after the water retting 1h for adding 3 volumes times, It decocts 3 times, first time 2h, second of 2h, third time 1h, merges medical filtration three times, 60 DEG C are condensed into medicinal extract, add 3 volumes times 90% ethyl alcohol, cold soaking 4 times, filtering is recovered under reduced pressure ethyl alcohol, obtains medicinal extract, dries, is broken into smalls, and No. five are sieved through 100 mesh；
Superfine powder obtained, dry powder, smalls and even, dry pressing granulation are added conventional step S5 according to common process Capsule is made in auxiliary material.
Embodiment 2
A kind of Chinese medicine composition for treating morning, mid-term high blood pressure, is made of the raw material of following weight parts: 15 parts of Rhizoma Gastrodiae, 15 parts of uncaria, 30 parts of the shell of seaear, 30 parts of oyster, 15 parts of radix achyranthis bidentatae, 12 parts of Radix Salviae Miltiorrhizae, 15 parts of herba taxilli, 12 parts of Rhizoma Chuanxiong part, 9 parts of dried orange peel, 9 parts of rhizoma pinellinae praeparata.
The preparation method of early, mid-term high blood pressure the Chinese medicine composition of the treatment, comprising the following steps:
Step S1, weigh each bulk pharmaceutical chemicals Rhizoma Gastrodiae, uncaria, the shell of seaear, oyster, radix achyranthis bidentatae, Radix Salviae Miltiorrhizae, herba taxilli, Rhizoma Chuanxiong, dried orange peel, Rhizoma pinellinae praeparata, it is spare；
Step S2 takes formula ratio Rhizoma Gastrodiae to clean, is ground into superfine powder, is sieved through 100 mesh, spare；
Step S3 takes formula ratio uncaria, radix achyranthis bidentatae, herba taxilli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, dried orange peel, rhizoma pinellinae praeparata, cleans, adds water to cook 3 Secondary, for the first time plus the water of 9 volume of crude drug amount times, decoction 5h extract 3h；The water for adding 8 volume of crude drug amount times for the second time, decocts 3.5h extracts 2.5h；The water of third time plus 5 volume of crude drug amount times decocts 2.5h, extracts 1.5h；Collecting decoction, filtering, filtrate It is concentrated in vacuo to the clear cream that relative density is 1.17, clear cream is spray dried to dry powder, spare；
Step S4 takes the formula ratio shell of seaear, oyster crude drug to clean, broken thick block mixing, after the water retting 2h for adding 3 volumes times, It decocts 3 times；Add the water decoction 4h of 5 times of volumes of water for the first time, for the second time plus the water of 3 times of volumes of water decocts 2h, adds 2 times of water for the third time The water of volume decocts 1h, merges medical filtration three times, and 70 DEG C are condensed into medicinal extract, adds 93% ethyl alcohol of 3 volumes times, and cold soaking 5 times, Filtering, is recovered under reduced pressure ethyl alcohol, obtains medicinal extract, dries, and is broken into smalls, and No. five are sieved through 100 mesh；
Superfine powder obtained, dry powder, smalls and even, dry pressing granulation are added conventional step S5 according to common process Capsule is made in auxiliary material.
Embodiment 3
A kind of Chinese medicine composition for treating morning, mid-term high blood pressure, is made of the raw material of following weight parts: 20 parts of Rhizoma Gastrodiae, 20 parts of uncaria, 35 parts of the shell of seaear, 35 parts of oyster, 20 parts of radix achyranthis bidentatae, 20 parts of Radix Salviae Miltiorrhizae, 20 parts of herba taxilli, 20 parts of Rhizoma Chuanxiong part, dried orange peel 12 Part, 12 parts of rhizoma pinellinae praeparata.
The preparation method of early, mid-term high blood pressure the Chinese medicine composition of the treatment, comprising the following steps:
Step S1, weigh each bulk pharmaceutical chemicals Rhizoma Gastrodiae, uncaria, the shell of seaear, oyster, radix achyranthis bidentatae, Radix Salviae Miltiorrhizae, herba taxilli, Rhizoma Chuanxiong, dried orange peel, Rhizoma pinellinae praeparata, it is spare；
Step S2 takes formula ratio Rhizoma Gastrodiae to clean, is ground into superfine powder, is sieved through 100 mesh, spare；
Step S3 takes formula ratio uncaria, radix achyranthis bidentatae, herba taxilli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, dried orange peel, rhizoma pinellinae praeparata, cleans, adds water to cook 3 Secondary, for the first time plus the water of 10 volume of crude drug amount times, decoction 6h extract 4h；The water for adding 9 volume of crude drug amount times for the second time, decocts 4h, Extract 3h；The water of third time plus 6 volume of crude drug amount times decocts 3h, extracts 2h；Collecting decoction, filtering, filter vacuum are concentrated into phase The clear cream for being 1.20 to density, clear cream is spray dried to dry powder, spare；
Step S4 takes the formula ratio shell of seaear, oyster crude drug to clean, broken thick block mixing, after the water retting 2h for adding 3 volumes times, It decocts 3 times；Add the water decoction 4h of 5 times of volumes of water for the first time, for the second time plus the water of 3 times of volumes of water decocts 2h, adds 2 times of water for the third time The water of volume decocts 1h, merges medical filtration three times, and 80 DEG C are condensed into medicinal extract, adds 95% ethyl alcohol of 4 volumes times, and cold soaking 6 times, mistake Filter, is recovered under reduced pressure ethyl alcohol, obtains medicinal extract, dries, and is broken into smalls, and No. five are sieved through 100 mesh；
Superfine powder obtained, dry powder, smalls and even, dry pressing granulation are added conventional step S5 according to common process Capsule is made in auxiliary material.
Embodiment 4
A kind of Chinese medicine composition for treating morning, mid-term high blood pressure, is made of the raw material of following weight parts: 10 parts of Rhizoma Gastrodiae, 12 parts of uncaria, 25 parts of the shell of seaear, 28 parts of oyster, 12 parts of radix achyranthis bidentatae, 8 parts of Radix Salviae Miltiorrhizae, 12 parts of herba taxilli, 9 parts of Rhizoma Chuanxiong part, 6 parts of dried orange peel, method 7 parts of the tuber of pinellia.
The preparation method of early, mid-term high blood pressure the Chinese medicine composition of the treatment, comprising the following steps:
Step S1, weigh each bulk pharmaceutical chemicals Rhizoma Gastrodiae, uncaria, the shell of seaear, oyster, radix achyranthis bidentatae, Radix Salviae Miltiorrhizae, herba taxilli, Rhizoma Chuanxiong, dried orange peel, Rhizoma pinellinae praeparata, it is spare；
Step S2 takes formula ratio Rhizoma Gastrodiae to clean, is ground into superfine powder, is sieved through 100 mesh, spare；
Step S3 takes formula ratio uncaria, radix achyranthis bidentatae, herba taxilli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, dried orange peel, rhizoma pinellinae praeparata, cleans, adds water to cook 3 Secondary, for the first time plus the water of 8 volume of crude drug amount times, decoction 4h extract 2h；The water for adding 7 volume of crude drug amount times for the second time, decocts 3h, Extract 2h；The water of third time plus 4 volume of crude drug amount times decocts 2h, extracts 1h；Collecting decoction, filtering, filter vacuum are concentrated into phase The clear cream for being 1.16 to density, clear cream is spray dried to dry powder, spare；
Step S4 takes the formula ratio shell of seaear, oyster crude drug to clean, broken thick block mixing, after the water retting 1h for adding 3 volumes times, It decocts 3 times, first time 2h, second of 2h, third time 1h, merges medical filtration three times, 60 DEG C are condensed into medicinal extract, add 3 volumes times 90% ethyl alcohol, cold soaking 4 times, filtering is recovered under reduced pressure ethyl alcohol, obtains medicinal extract, dries, is broken into smalls, and No. five are sieved through 100 mesh；
Superfine powder obtained, dry powder, smalls and even, dry pressing granulation are added conventional step S5 according to common process Capsule is made in auxiliary material.
Embodiment 5
A kind of Chinese medicine composition for treating morning, mid-term high blood pressure, is made of the raw material of following weight parts: 17 parts of Rhizoma Gastrodiae, 18 parts of uncaria, 33 parts of the shell of seaear, 33 parts of oyster, 18 parts of radix achyranthis bidentatae, 15 parts of Radix Salviae Miltiorrhizae, 17 parts of herba taxilli, 15 parts of Rhizoma Chuanxiong part, dried orange peel 10 Part, 10 parts of rhizoma pinellinae praeparata.
The preparation method of early, mid-term high blood pressure the Chinese medicine composition of the treatment, comprising the following steps:
Step S1, weigh each bulk pharmaceutical chemicals Rhizoma Gastrodiae, uncaria, the shell of seaear, oyster, radix achyranthis bidentatae, Radix Salviae Miltiorrhizae, herba taxilli, Rhizoma Chuanxiong, dried orange peel, Rhizoma pinellinae praeparata, it is spare；
Step S2 takes formula ratio Rhizoma Gastrodiae to clean, is ground into superfine powder, is sieved through 100 mesh, spare；
Step S3 takes formula ratio uncaria, radix achyranthis bidentatae, herba taxilli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, dried orange peel, rhizoma pinellinae praeparata, cleans, adds water to cook 3 Secondary, for the first time plus the water of 10 volume of crude drug amount times, decoction 6h extract 4h；The water for adding 9 volume of crude drug amount times for the second time, decocts 4h, Extract 3h；The water of third time plus 6 volume of crude drug amount times decocts 3h, extracts 2h；Collecting decoction, filtering, filter vacuum are concentrated into phase The clear cream for being 1.19 to density, clear cream is spray dried to dry powder, spare；
Step S4 takes the formula ratio shell of seaear, oyster crude drug to clean, broken thick block mixing, after the water retting 2h for adding 3 volumes times, It decocts 3 times；Add the water decoction 4h of 5 times of volumes of water for the first time, for the second time plus the water of 3 times of volumes of water decocts 2h, adds 2 times of water for the third time The water of volume decocts 1h, merges medical filtration three times, and 70 DEG C are condensed into medicinal extract, adds 93% ethyl alcohol of 3 volumes times, and cold soaking 5 times, mistake Filter, is recovered under reduced pressure ethyl alcohol, obtains medicinal extract, dries, and is broken into smalls, and No. five are sieved through 100 mesh；
Superfine powder obtained, dry powder, smalls and even, dry pressing granulation are added conventional step S5 according to common process Capsule is made in auxiliary material.
By screening three times, ten kinds of composition dose are gradually reduced, finally determines and plays the specific of ten kinds of component optimum medicine efficacies Dosage is the drug component proportion in embodiment 2:
It is the primary efficacy drug of prescription, while according to Rhizoma Gastrodiae and uncaria because (1) Rhizoma Gastrodiae and uncaria are monarch drug in a prescription jointly Pharmaceutical properties, matter is lighter, 15 parts by weight of common choice；(2) and the shell of seaear and oyster are ministerial drug, be the shell of animal, it is carbon containing Hydrochlorate is more, and quality is heavier, and to reach checking exuberance of yang effect, therefore dosage is bigger than normal, selects 30 parts by weight, is 2 multiple doses of monarch drug in a prescription；(3) Radix achyranthis bidentatae and herba taxilli are ministerial drug, and common nourishing and suppressing Yang effect draws liver-yang downlink, therefore selects 15 parts by weight；(4) Radix Salviae Miltiorrhizae and Rhizoma Chuanxiong are Adjutant stops up stagnant passages through which vital energy circulates mainly for blood stasis liquid and sends out dizziness headache symptom, thus can the analgesic of promoting blood circulation access, wherein Rhizoma Chuanxiong and ox Knee drug one rise and one drop reaches qi and blood balance jointly, therefore selects 12 parts by weight.(5) dried orange peel and rhizoma pinellinae praeparata are also ministerial drug, because of taste Weakness, phlegm wet are obstructed, and cause to blind clear key, the symptoms such as heaviness of the head as if it were tightly bandaged, giddy, uncomfortable in chest, abundant expectoration, absent minded occur, therefore Select 9 parts by weight.
Drug used in following tests example 1-3 is Chinese medicine composition prepared by embodiment 2
Test example 1: pharmacology test
(1) materials and methods:
WKY rat (is originated from the individual for not having hypertension feature and blood pressure stabilization in same population with SHR), and 10, It is male, 230-250g is purchased from Beijing Vital River Experimental Animals Technology Co., Ltd.；
SHR rat (spontaneous hypertensive rat), 30, be male, 230-250g, purchased from the experiment of Beijing dimension tonneau China Zoo technical Co., Ltd；Rat blood pressure is surveyed using BESN-II multichannel animal non -invasivetesting system.
(2) zoopery is grouped: 10 WKY rats are Normal group；SHR rat is divided into 3 groups, every group according to systolic pressure 10, respectively model control group, positive controls and medicine group of the present invention.
(3) medication:
Drug of the present invention is provided by Xiangya Hospital, Central-South China Univ., is administered by 10 multiple doses of clinical drug dosage of the present invention, I.e. 0.75g/Kg/d is dissolved in physiological saline, the gastric infusion after experimental animal grouping, and continuous 6 weeks.Positive controls give ammonia Flordipine piece, trade name Amlodipine Besylate Tablet, is produced by pfizer inc, dosage 1.67mg/Kg, is clinical dosage 10 times；Normal group and model control group rat give same amount of normal saline stomach-filling in same time point.
(4) Indexs measure:
The measurement of systolic pressure: rat blood pressure measurement: rat is surveyed using BESN-II multichannel animal non -invasivetesting system and is shunk Blood pressure is pressed, measures a blood pressure after administration weekly, measurement takes mean value three times, reduces operating error.
Vaso-active substance (blood plasma NO and ET-1) detection: taking jugular vein blood, is centrifuged, and radioimmunoassay illustrates according to kit Book operation.
Thoracic aortic tissue morphological observation: after administration, Animal Anesthesia fixation is taken into fresh aorta pectoralis, in Property fixer it is fixed after carry out HE and Masson dyeing, microscopically observation aorta pectoralis vascular wall collagen-type and difference.It surveys Media thickness (MT), internal diameter (LD), thickness and internal diameter ratio (MT/LD).
(5) statistical method: carrying out data processing and analysis using SPSS17.0 statistical software, measurement data with mean ± Standard deviationIt indicates.Comparison among groups are examined using t.It is that difference is statistically significant with P < 0.05.
As a result:
(1) variation of rat blood pressure:
Compared with Normal group, model control group systolic pressure is significantly raised (P < 0.01)；Positive controls and model pair Compare according to group, systolic pressure is decreased obviously, and difference has conspicuousness (P < 0.05)；Medicine group of the present invention compared with model control group, Systolic pressure is decreased obviously, and difference has conspicuousness (P < 0.05)；But medicine group of the present invention is compared with positive controls, These parameters No significant difference (P > 0.05), is shown in Table 1.
The comparison of 1 four groups of rat blood pressures of table
Group Before administration 1 week after administration 3 weeks after administration 5 weeks after administration 6 weeks after administration
Normal group 142.6±15.8 145.5±17.5 148.8±15.4 146.4±16.6 151.3±16.2
Model control group 183.4±21.6★ 185.6±19.4★ 187.8±18.5★ 185.8±21.1★ 190.3±19.7★
Positive controls 186.9±20.7★ 167.2±15.6△ 163.2±16.4△ 158.6±17.6▲ 151.3±17.2▲
Medicine group of the present invention 181.8±20.5★ 171.4±18.7△ 167.1±17.6△ 161.2±16.3▲ 156.7±16.9▲
Note: compared with Normal group,★P < 0.01；Compared with after model control group,△P < 0.05,▲P < 0.01.
(2) variation of vaso-active substance (blood plasma NO and ET-1):
Compared with Normal group, model control group NO content in plasma is decreased obviously, and ET-1 content is significantly raised, difference With conspicuousness (P < 0.01)；Positive controls are compared with model control group, and NO content in plasma is significantly raised, and ET-1 content is bright Aobvious decline, difference have conspicuousness (P < 0.01)；Compared with model control group, NO content in plasma obviously rises medicine group of the present invention Height, and ET-1 content is decreased obviously, difference has conspicuousness (P < 0.01)；But medicine group of the present invention is compared with positive controls, These parameters no significant difference (P > 0.05), is shown in Table 2.
2 rat plasma vaso-active substance of table compares
Group NO(pg/ml) ET-1(pg/ml)
Normal group 163.07±16.83 43.23±8.45
Model control group 87.25±9.25☆★ 73.26±10.14☆★
Positive controls 132.53±12.34▲ 57.97±8.52▲
Medicine group of the present invention 128.24±14.57▲ 61.05±9.34▲
Note: compared with Normal group,★P < 0.01；Compared with model control group,▲P < 0.01.
(3) vascular remodeling of aorta pectoralis vascular wall tissue changes:
After being administered 6 weeks, model control group rat aorta MT [(112.5 ± 12.6) μm] and Normal group [(82.4 ± 8.7) μm] (P < 0.01) is increased compared to significant；Model control group rat aorta MT/LD (7.13 ± 0.72) and Normal group (4.58 ± 0.58) (P < 0.01) is increased compared to significant；Compared with model control group, positive controls rat aorta MT/LD, MT [(98.3 ± 9.8) μm] and medicine group rat aorta MT/LD, MT of the present invention [(96.7 ± 10.3) μm] are substantially reduced (P <0.05).Test end, 3 groups of rat aorta LD and no significant difference (P > 0.05), are shown in Table 3.
3 rat chest aorta vascular wall Morphological comparison of table
Group MT(μm) MT/LD
Normal group 82.4±8.7 4.58±0.58
Model control group 112.5±12.6★ 7.13±0.72★
Positive controls 98.3±9.8☆ 5.22±0.56☆
Medicine group of the present invention 96.7±10.3☆ 4.85±0.67☆
Note: compared with normal control,★P < 0.01；Compared with model control group,☆P < 0.05.
(4) each group rat aorta morphological observation:
HE is dyed under histotomy light microscopic, Normal group SD rat chest aorta vascular wall inner membrance, middle film, 3 layers of outer membrane Structure is obvious, and nothing thickens；Elongated middle film vascular smooth muscle is in shuttle shape, nucleus indigo plant dye, concentric circles marshalling.Model pair According to rat aorta wall thickening, middle film vascular smooth muscle is disorganized, and unit area nucleus amount increases.Positive controls and Medicine group Aortic Wall of Rats of the present invention slightly thickens, and rule, unit area cell nucleus number are owed in middle film vascular smooth muscle arrangement Mesh slightly increases.Masson dyeing, vascular smooth muscle cells dyeing take on a red color, and interstitial collagen is in blue-green.Rats in normal control group Tube wall collagen tissue is evenly distributed, middle film elastic fibers plate marshalling.Model control group rat tube wall collagen component significantly increases More, stiff straighten of middle film elastic fibers plate is even broken, and quantity is reduced, and smooth muscle cell hyperplasia is obvious.With model comparison Group is compared, and positive drug group collagen component does not have significant change, and medicine group of the present invention and tube wall collagen component then significantly reduce, Middle film elastic fibers plate arrangement is more regular.
Test example 2: toxicologic study
Content 7.48g/Kg, 3.74g/Kg, 1.86g/Kg of Chinese medicine composition of the invention (are respectively equivalent to 54.48,27.24,13.62 crude drugs/kg) three dosage to rat oral gavage, continuous 6 months, then observe the general state of animal Situation: appearance signs, behavioral activities, breathing, and periodically dosage weight, food-intake in administration 3 months, are administered 6 months and deactivate 15 days afterwards, difference 1/3 animal of each execution, and carry out hematology, blood biochemical and organ coefficient and histopathologic examination.
As a result: during administration, groups of animals has no adverse reaction, raw in weight increment, food-intake, hematology and blood Chemical indices compare in control group, are significant difference, and animal main organs histopathologic examination removes a small number of animals Lung's chronic interstitial is scorching outer, remaining does not find obvious abnormal pathologic Histological change.
Test example 3: clinical test
1. case source
Case is from June, 2018 in July, 2015-in Xiangya Hospital, Central-South China Univ.'s Internal Medicine-Cardiovascular Dept. and traditional Chinese and western medicine knot Close internal medicine, Hunan Province, First People's Hospital, Chenzhou Internal Medicine-Cardiovascular Dept., Hunan Province's the second the People's Hospital Internal Medicine-Cardiovascular Dept. and Hunan Province The Internal Medicine-Cardiovascular Dept. outpatient service of Xiangxi Autonomous Prefecture institute of traditional Chinese medicine and inpatient are grouped using the method for stratified random, i.e., first press hypertension The case for meeting the standard of being included in is divided into I grade, II grade of 2 sub-layer by classification, and then it is random (mono blind method) to carry out lottery for each sub-layer It is divided into treatment group and control group.Treatment group 135, male 87, women 48, year at age (51.6 ± 12.4), the course of disease 2.6~ 19.4, average (10.5 ± 4.8) year, hypertension grading: I grade 46, II grade 99.Control group 155, male 102, female Property 53, the age (52.4 ± 10.5) year, the course of disease 2.3~20.7 years, average (11.2 ± 5.9) year, hypertension grading: I grade 51 Example, II grade 104.2 groups of data are statistically analyzed no significant difference, are comparable.
2. being included in standard:
1) it doctor trained in Western medicine diagnosis and grade scale: is executed by the hypertension diagnosis formulated of WHO/ISH in 1999 and grade scale.
2) TCM syndrome diagnostic criteria: the syndrome of upper hyperactivity of liver yang and phlegm in reference " new Chinese medicine guideline of clinical investigations " are turbid Syndrome of blood stasis takes the two cardinal symptom performance, formulates high blood pressure early stage main clinic symptoms.Main symptom be dizziness, headache, it is irritated easily Anger, uncomfortable in chest, soreness and weakness of waist and knees, secondary card are heaviness of the head as if it were tightly bandaged, palpitaition, insomnia, thirsty, abundant expectoration, flushing, tinnitus, spiritlessness and weakness, tongue nature Red, whitish tongue is greasy, wiry and rolling pulse or heavy.Main symptom has 3 or 2, i.e. diagnosable with 2 cards.
3) case is included in standard: meeting Diagnosing Hypertension standard, and hypertension grading belongs to I, II grade.
4) case exclusion criteria: 1. the age is in under-18s or 70 years old or more；2. it is tight to be associated with liver, kidney, hemopoietic system etc. Weight primary disease, mental patient；3. intentionally, renal failure and fundus hemorrhage person；4. secondary to hyperthyroidism, The secondary hypertensions such as primary aldosteronism and renal hypertension；5. systolic pressure (SBP) >=180mmHg and/or diastole Press (DBP) >=110mmHg person.
3. criterion of therapeutical effect:
1) efficacy of antihypertensive treatment standard: according to Chinese hypertension alliance revision in 1999 " Chinese hypertension prevention and control guide is controlled Treat target " it executes.Effective: diastolic pressure (DBP) decline >=10mmHg simultaneously reaches normal range (NR)；Though or do not drop to it is normal, under 20mmHg or more drops.It is effective: diastolic pressure (DBP) decline < 10mmHg, but have reached normal range (NR)；Or diastolic pressure (DBP) decline >=10mmHg, but do not drop to normal；Or systolic pressure (SBP) decline >=30mmHg.It is invalid: not up to above-mentioned efficiency index person.
2) clinical treatment standard: effective: original symptom completely disappears or significantly mitigates, and syndrome integral reduces >=70%.It is effective: Original symptom is improved or is mitigated, and syndrome integral reduces >=30%.It is invalid: original symptom without improvement, syndrome integral reduces < 30%.
4. statistical method:
Using t inspection and X2It examines.
6. specific implementation process
(1) Chinese medicine composition prepared by embodiment 2 is prepared into capsule, drug containing 0.4g in every capsule.
(2) above-mentioned two groups of patients, be divided into treatment group and control group, wherein treatment group patient daily the present embodiment 2 Chinese medicinal composition capsules agent 3 times, 2-3 each, half an hour takes after meal daily, and 4 weeks are 1 course for the treatment of, and 3 courses for the treatment of are a treatment Period, every half a year are an observation period；Control group takes levamlodipine (2.5mg/ piece, Levamlodipine medicine company group (Jilin) Co., Ltd's production), each 2.5mg, once a day；Other drugs are deactivated during taking this medicine, emphasize low-salt and low-fat diet, are adjusted Spirit is taken the photograph, appropriate activity avoids fatigue.
(3) two groups of patients of routine observation medication, the index of correlation of observation are as follows:
1) blood pressure: before medication and the 4th weekend surveyed seat right upper arm blood pressure.Use vertical water silver blood pressure measuring amount, measuring blood pressure Preceding rest 15min answers measuring blood pressure 3 times every time, is averaged record result.
2) symptom: observation dizziness, headache, palpitaition, soreness and weakness of waist and knees, vexed dry, insomnia, tinnitus, tongue picture, pulse condition, weekly Record 1 time evaluates degrees of symptoms using point-score according to document.The Syndrome Scale quantitative criteria of high blood pressure, each is pressed Gently, in, remember 1,2,3 point respectively again.Inquiry observation item by item before and after treatment, calculates and records total mark.
3) variation of Carotid intima-media's thickness (IMT) before and after treatment: Sonography uses U.S. VIVID3 Color ultrasonic devices, normal value < 1.0mm.
4) hemorheology changes, including whole blood high shear viscosity, whole blood low shear viscosity, Plasma Viscosity, Rigidity of red cells refer to Number.
5) microdose urine protein changes.
6) blood lipid level: measurement total cholesterol (TC), triglycerides (TG), lipoprotein, apolipoprotein etc..
7) blood pressure rhythm: 24 h ABPs monitoring.Any discomfort or symptom occurred in therapeutic process is by bad Reaction record.
(4) result: it is shown in Table 4-11.
Efficacy of antihypertensive treatment compares (n, %) after 4 two groups of patients of table intervene
Group Number of cases It is effective Effectively In vain Total effective rate (%)
Control group 155 45(29.03) 85(54.84) 25(16.13) 83.87
Treatment group 135 48(35.56)☆ 78(57.77) 9(6.67)☆ 93.33☆
Note: compared with the control group,☆P < 0.05.Illustrate: the numerical value in bracket is percentage, according to number of cases divided by total example
The percentage that number obtains is the numerical value obtained by 45 divided by 155 such as effective 29.03 in control group.
TCM symptom score compares after 5 two groups of patients of table intervene
Note: compared with before each group treatment,☆P < 0.05,★P < 0.01；Compared with after control group treatment,△P < 0.05,▲P < 0.01.
Tcm syndrome curative effect compares (n, %) after 6 two groups of patients of table intervene
Group It is effective Effectively In vain Total effective rate (%)
Control group (155) 40(25.81) 87(56.13) 28(18.06) 81.94
Treatment group (135) 51(37.78)☆ 73(54.07) 11(8.15)☆ 91.85☆
Note: compared with the control group,☆P < 0.05.Illustrate: the numerical value in bracket is percentage, according to number of cases divided by total number of cases The percentage obtained, 155 and 135 refer to number of cases
Blood lipid level compares after 7 two groups of patients of table intervene
Note: compared with the control group,☆P < 0.05；
Microdose urine protein compares 8 two groups of table for 24 hours before and after treatment
Group Before treatment (mg/L) After treatment (mg/L)
Control group (155) 165.3±29.5 110.8±31.7☆
Treatment group (135) 172.5±32.2 89.1±27.3☆△
Note: compared with before treatment,☆P < 0.01；Compared with the control group,△P < 0.05.
Blood viscosity compares after 9 two groups of patients of table intervene
Note: compared with the control group,△P < 0.05,★P < 0.01.
Vascular remodeling Testing index compares after 10 two groups of patients of table intervene
Group TVA(cm2) PA(cm2) LA(cm2) S (%)
Control group (155) 0.88±0.23 0.22±0.06 0.62±0.16 0.32±0.09
Treatment group (135) 0.84±0.18 0.12±0.04★ 0.76±0.12☆ 0.11±0.05★
Note: compared with the control group,☆P < 0.05,★P < 0.01；
Vascular remodeling Testing index compares after 10 two groups of patients of continued intervene
Group IMT(mm) ID(mm) IMT/ID(mm) baPWV(cm/s)
Control group (155) 0.65±0.17 6.87±1.31 12.76±2.65 1165.12±128.52
Treatment group (135) 0.88±0.21☆ 6.85±1.52 14.35±3.28☆ 1726.93±289.38★
Note: compared with the control group,☆P < 0.05,★P < 0.01.
(TVA, circular blood vessel is horizontal at arterial wall China and foreign countries membrane junction for the Lumen Area (LA) of arteria carotis, the blood vessel gross area Cross-sectional area), plaque area (PA), area stenosis rate (S), Carotid intima-media's thickness (IMT), internal diameter of carotid (ID) Arteria carotis communis IMT and internal diameter (ID) ratio (IMT/ID), arm ankle arterial pulse wave conduction of velocity (baPWV).
Blood circadian compares (n, %) after 11 two groups of patients of table intervene
Group Spoon type Non- spoon type Anti- spoon type Super spoon type Aberration rate (%)
Control group (155) 96(61.93) 33(21.2) 15(9.69) 11(7.0) 38.07
Treatment group (135) 98(72.59)☆ 26(19.2) 7(4.44)★ 5(3.71★ 27.41☆
Note: compared with the control group,☆P < 0.05,★P < 0.01.
Safety indexes and adverse reaction situation: the pretherapy and post-treatment blood routine of 2 groups of patients, routine urinalysis, liver function, renal function, It is unobvious to show that the present invention provides a kind of middle pharmaceutical composition for morning, mid-term high blood pressure for the equal Non Apparent Abnormality of electrocardiogram Toxic side effect.
(5) specific case
Case 1: Cao, male, 52 years old, long-term smoking was drunk medical history, and figure is fat；Because of headache, dizziness 2 years repeatedly, with chest The symptoms such as bored, insomnia, amnesia, spiritlessness and weakness, soreness and weakness of waist and knees, irritability and dysphoria with smothery sensation, in 8 Lai our hospital outpatient clinic May in 2016. Patient's two years ago because after event stimulation unhappy in life and work discontinuity there is headache, dizziness, agitation, through with Chinese and western medical Object is treated 1 month and is improved；Then often because of headache after excited, dizziness, uncomfortable in chest sending out again；Before 3 months because with household Severe headache after quarrelling, then dizziness nausea and vomiting 1 time, measuring blood pressure 152/98mmHg, taken Nitrendipine Tablet and Traditional Chinese herbal decoction (specific drug is unknown) treat one month, symptom slightly improves, blood pressure 145/92mmHg, but have a sleepless night, it is uncomfortable in chest plus Weight continues to take medicine-feeding being not relieved with heaviness of the head as if it were tightly bandaged, abundant expectoration.Quarter examines: severe headache, be in paroxysmal, heaviness of the head as if it were tightly bandaged, It is very dizziness, irritable, soreness and weakness of waist and knees, chest distress and palpitation symptoms, insomnia, thirsty, vomiting abundant expectoration, flushing, tinnitus, mind with overhead Fatigue, red tongue body, whitish tongue is greasy, stringy,thready and rapid pulse；Measuring blood pressure is
155/96mmHg.Chinese medical discrimination is headache, leads to liver-yang hyperactivity for liver depression forming fire, caused by phlegm-blood stasis retardance.The rules for the treatment of: flat Liver checking exuberance of yang, resolving sputum promoting blood circulation, remove obstruction in channels to relieve pain, daily the capsule of the Chinese medicine composition of the present embodiment 3 times, and three every time, every time Take half an hour taken with boiled water.4 weeks as a treatment course.Other drugs are deactivated during taking this medicine, and are emphasized low-salt and low-fat diet, are taken good care of oneself Spirit, appropriate activity, avoids fatigue.After taking 1 course for the treatment of, further consultation on June 3 in 2016: patient tells that headache is relieved, and dizziness subtracts Gently, occasionally have it is uncomfortable in chest and out of strength, diet can, nighttime sleep is fine, and pale tongue with thin fur is white, veins string；Measuring blood pressure is 133/84mmHg, is continued It takes half a year, multiple follow-up blood pressure is normal, and without repeatedly, fluctuation of blood pressure is in 122-135/73-86mmHg range.
Case 2: Mr. Wang, male, 48 years old, cadre；Previously there are more than 20 years of long-term alcohol, daily half jin of white wine, figure is inclined It is fat, BMI 30.4, personality irritability；Patient is because of National Day fatigue, eating and drinking without temperance, addiction delicious food savoury during the vacation, once because in work Unhappy event episodic vertigo 2 times.In 18 Lai our hospital outpatient clinic October in 2017.Quarter examines: severe headache, is in paroxysm Property, heavy such as to wrap up in, dizziness, soreness and weakness of waist and knees, chest distress and palpitation symptoms, insomnia, that nausea is received is poor, dysphoria with smothery sensation is flushing, abundant expectoration, spiritlessness and weakness, tongue Matter is red, and whitish tongue is greasy, wiry and rolling pulse；Measuring blood pressure is 162/95mmHg, blood lipid level: triglycerides 4.6mmol/L, cholesterol 7.32mmol/L.Doctor trained in Western medicine diagnosis: 2 grades of high blood pressure, Chinese medical discrimination is headache, and addiction delicious food savoury, interior raw phlegm wet, phlegm is turbid to be blinded Clear sun is then heavy such as to be wrapped up in, dizziness；Liver-yang hyperactivity is caused then to be had a headache for liver depression forming fire, dysphoria with smothery sensation is flushing；Stagnation of turbid phlegm in middle-JIAO, mechanism of qi is not Freely, thus uncomfortable in chest, nauseous difference of receiving.The rules for the treatment of: calming the liver, eleminating phlegm and freeing channels, promoting blood circulation；The daily Chinese traditional medicine composition of the present embodiment The capsule of object 3 times, three every time, each taking half an hour taken with boiled water.4 weeks as a treatment course.Other are deactivated during taking this medicine Drug emphasizes low-salt and low-fat diet, spirit of taking good care of oneself, and appropriate activity avoids fatigue.After taking 1 course for the treatment of, on November 15th, 2017 is multiple Examine: patient's headache, dizziness, it is uncomfortable in chest, nauseous receive that difference etc. is basic to disappear, it is heavy such as to wrap up in environment, diet can, spiritual amelioration, Still, blood pressure stabilization is in 125/78mmHg or so for sleep；Patient is advised to continue to take 3 months, with after treatment effect, multiple follow-up Blood pressure is normal, and without repeatedly, fluctuation of blood pressure is in 116-130/70-85mmHg range.
Test example 4: Chinese medicine composition primary stability test
According to the technical requirements of traditional Chinese medicine research, the method to be kept sample using room temperature is carried out stability to 5 batches of this capsule samples and examined (capsule that 5 batches of sample capsules herein are embodiment 1-5 preparation) is examined, i.e., under conditions of " bottled ", by three batches of samples, batch Successively are as follows: 0201,0202,0203,0204,0205, it places 4 months at room temperature, respectively at 0 month, 1 month, 2 months, 3 The moon, progress indices examination in 4 months, and be compared with 0 month testing result, the results showed that indices become without obvious Change, shows that this capsule primary stability is good.
Important component in the present invention is indispensable, lacks medicinal material therein, and bring medicinal efficacy also disappears accordingly It loses, and the ingredient in this drug is there is also the effect mutually cooperateed with, it is indispensable.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the scope of the present invention.It is all Any modification, equivalent replacement, improvement and so within the spirit and principles in the present invention, are all contained in protection scope of the present invention It is interior.

Claims (4)

1. a kind of Chinese medicine composition for treating morning, mid-term high blood pressure, which is characterized in that the Chinese medicine composition is by following proportion Bulk pharmaceutical chemicals composition: Rhizoma Gastrodiae 8-20 parts by weight, uncaria 10-20 parts by weight, shell of seaear 22-35 parts by weight, oyster 25-35 parts by weight, Radix achyranthis bidentatae 8-20 parts by weight, Radix Salviae Miltiorrhizae 5-20 parts by weight, herba taxilli 5-20 parts by weight, Rhizoma Chuanxiong 5-20 parts by weight, dried orange peel 3-12 parts by weight, Rhizoma pinellinae praeparata 3-12 parts by weight.
2. a kind of Chinese medicine composition for treating morning, mid-term high blood pressure according to claim 1, which is characterized in that in this Drug composition is made of the bulk pharmaceutical chemicals of following proportion: Rhizoma Gastrodiae 10-17 parts by weight, uncaria 12-18 parts by weight, shell of seaear 25-33 weight Measure part, oyster 28-33 parts by weight, radix achyranthis bidentatae 12-18 parts by weight, Radix Salviae Miltiorrhizae 8-15 parts by weight, herba taxilli 12-17 parts by weight, Rhizoma Chuanxiong 9- 15 parts by weight, dried orange peel 6-10 parts by weight, rhizoma pinellinae praeparata 7-10 parts by weight.
3. a kind of Chinese medicine composition for treating morning, mid-term high blood pressure according to claim 2, which is characterized in that in this Drug composition is made of the bulk pharmaceutical chemicals of following proportion: 15 parts by weight of Rhizoma Gastrodiae, 15 parts by weight of uncaria, 30 parts by weight of the shell of seaear, oyster 30 parts by weight, 15 parts by weight of radix achyranthis bidentatae, 12 parts by weight of Radix Salviae Miltiorrhizae, 15 parts by weight of herba taxilli, 12 parts by weight of Rhizoma Chuanxiong, 9 parts by weight of dried orange peel, method 9 parts by weight of the tuber of pinellia.
4. a kind of Chinese medicine composition preparation method for treating morning, mid-term high blood pressure as described in any one of claims 1-3, It is characterized in that, comprising the following steps:
Step S1 weighs each bulk pharmaceutical chemicals Rhizoma Gastrodiae, uncaria, the shell of seaear, oyster, radix achyranthis bidentatae, Radix Salviae Miltiorrhizae, herba taxilli, Rhizoma Chuanxiong, dried orange peel, method half It is summer, spare；
Step S2 takes formula ratio Rhizoma Gastrodiae to clean, is ground into superfine powder, is sieved through 100 mesh, spare；
Step S3 takes formula ratio uncaria, radix achyranthis bidentatae, herba taxilli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, dried orange peel, rhizoma pinellinae praeparata, cleans, adds water to cook 3 times, the The water of primary plus crude drug amount 8-10 volume times decocts 4-6h, extracts 2-4h；The water for adding crude drug amount 7-9 volume times for the second time, decocts 3-4h extracts 2-3h；The water of third time plus crude drug amount 4-6 volume times decocts 2-3h, extracts 1-2h；Collecting decoction filters, filter Liquid is concentrated in vacuo to the clear cream that relative density is 1.15-1.20, and clear cream is spray dried to dry powder, spare；
Step S4 takes the formula ratio shell of seaear, oyster crude drug to clean, broken thick block mixing, after the water retting 2h for adding 3 volumes times, decocts 3 It is secondary；For the first time plus the water of 5 times of volumes of water decocts 4h, and for the second time plus the water of 3 times of volumes of water decocts 2h, third time plus 2 times of volumes of water Water decoct 1h, merge medical filtration three times, 60-80 DEG C is condensed into medicinal extract, adds the 90-95% ethyl alcohol of 3-4 volume times, cold soaking 4- 6 times, filtering is recovered under reduced pressure ethyl alcohol, obtains medicinal extract, dries, and is broken into smalls, and No. five are sieved through 100 mesh；
Step S5, by superfine powder obtained, dry powder, smalls and even, the dosage form of clinical receiving is made in dry pressing granulation, have tablet, Capsule, powder, soft capsule, dripping pill, honeyed bolus, pill, granule, soft extract with bee honey agent, sustained release preparation, controlled release preparation.
CN201910662895.8A 2019-07-22 2019-07-22 It is a kind of to treat morning, the Chinese medicine composition of mid-term high blood pressure and preparation method Pending CN110327427A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112022977A (en) * 2020-10-20 2020-12-04 河南中医药大学第一附属医院 Traditional Chinese medicine composition for treating hypertension and traditional Chinese medicine preparation and application thereof
CN114931612A (en) * 2022-05-13 2022-08-23 河南中医药大学第一附属医院 Traditional Chinese medicine liquid for treating vestibular migraine
CN115737778A (en) * 2022-12-28 2023-03-07 李海霞 Traditional Chinese medicine preparation with pressure regulating effect

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107648479A (en) * 2017-11-06 2018-02-02 谭元生 A kind of Chinese prescription and its product for being used to treat hypertension
CN110292607A (en) * 2019-08-16 2019-10-01 中南大学湘雅医院 The Chinese medicine composition and preparation method for treating the concurrent left ventricular hypertrophy of high blood pressure

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107648479A (en) * 2017-11-06 2018-02-02 谭元生 A kind of Chinese prescription and its product for being used to treat hypertension
CN110292607A (en) * 2019-08-16 2019-10-01 中南大学湘雅医院 The Chinese medicine composition and preparation method for treating the concurrent left ventricular hypertrophy of high blood pressure

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
冯纯慧等: "痰瘀同治法在心血管疾病治疗中的研究现状", 《疑难病杂志》 *
李湘平等: "平肝潜阳方治疗原发性高血压大鼠的实验研究", 《中华中医药杂志》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112022977A (en) * 2020-10-20 2020-12-04 河南中医药大学第一附属医院 Traditional Chinese medicine composition for treating hypertension and traditional Chinese medicine preparation and application thereof
CN112022977B (en) * 2020-10-20 2022-07-12 河南中医药大学第一附属医院 Traditional Chinese medicine composition for treating hypertension and traditional Chinese medicine preparation and application thereof
CN114931612A (en) * 2022-05-13 2022-08-23 河南中医药大学第一附属医院 Traditional Chinese medicine liquid for treating vestibular migraine
CN115737778A (en) * 2022-12-28 2023-03-07 李海霞 Traditional Chinese medicine preparation with pressure regulating effect
CN115737778B (en) * 2022-12-28 2023-10-27 李海霞 Traditional Chinese medicine preparation with pressure regulating effect

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