RU2189242C1 - Agent for normalization of intestine function - Google Patents

Abstract

FIELD: medicine, gastroenterology. SUBSTANCE: invention proposes an agent comprising the following components, g: dried apricots, 200; kernel free prune, 200; figs, 200; sunflower oil, 100; senna herb, 25. All components are passed through a meat chopper and mixed. The intake dose is one tea-spoon before sleep. The agent normalizes an intestine function and fecal discharge and can be used in treatment of chronic constipations. EFFECT: enhanced effectiveness of agent. 1 cl, 1 ex

Description

 The present invention relates to the field of gastroenterology and will find application in the treatment of disorders of the intestines.

 Constipation is a problem of the century. 30-50% of the adult population suffers from constipation. The increasing prevalence of chronic constipation every year is associated with urbanization and inactivity, a deterioration in the quality of life, a change in the stereotype of nutrition - a lack of plant fiber, an abundance of flour foods. There are acute and chronic constipation. In acute constipation, there is a sudden absence of stool for more than two days. The most common causes of acute constipation are impaired intestinal patency (tumors, inflammation, diverticulitis), anorectal pathology, acute cerebrovascular accident, traumatic brain injury, bed rest and side effects of drugs. Suddenly developed constipation requires the elimination of a neoplasm of the left half of the colon. For constipation, which is based on inflammatory processes, the presence of fever is characteristic, and for constipation associated with neoplasm, a gradual increase in clinical symptoms and an elongation of the intervals between bowel movements. In patients with chronic constipation, dysbiosis must be excluded. In patients suffering from constipation due to decreased motor function of the intestine, as a rule, it is necessary to exclude the organic pathology of the gastrointestinal tract (gastritis, duodenitis, peptic ulcer).

 To normalize the work of the intestine, a large number of various drugs and agents are currently used.

 Conducted research on the medical-scientific and patent literature revealed various means used to normalize the activity of the intestine.

 The most physiological effect on the intestines is possessed by laxatives, which increase the volume of intestinal contents and lower its viscosity. In general terms, the mechanism of action of laxatives is as follows - drugs of this group, either inhibiting the absorption of water, or stimulating intestinal secretion, lead to the accumulation of fluid in the intestine. However, most laxatives also accelerate the transit of intestinal contents. Treatment of constipation begins with the appointment of small doses of laxatives and for a short time (Zlatkina AR Treatment of chronic diseases of the digestive system. M., Medicine, 1994.).

The rate of onset of the effect when using laxatives depends on what level of the intestine they act (Grigoryev P.Ya., Yakovenko A.V. Clinical gastroenterology: A textbook for medical students, doctors and cadets of postgraduate education. M: Medical Information Agency, 2001. 704 p.):
- at the level of the small intestine (oil, salt laxatives) - the effect develops after 4-5 hours;
- at the level of the colon (derivatives of anthraquinone and diphenyl) - the effect develops after 8-12 hours;
- at the level of the rectum (suppository, enema) - the effect develops after 10-20 minutes.

 In the complex treatment of constipation against the background of hypomotor dyskinesia and intestinal atony, prokinetics (drugs that enhance intestinal motility) are used. The most effective of these is cisapride (prepulside, cordinax), which is prescribed at 20 mg 3 times a day. Metoclopramide (10 mg 3 times a day) can also be used for this purpose. However, its clinical efficacy is lower and the incidence of side effects is significantly higher. In addition, the drug should be used with great care in the elderly. With spastic dyskinesia, myotropic antispasmodics or M-anticholinergics are included in the treatment complex. High efficacy in this condition, as well as in irritable bowel syndrome, was shown by the new drugs Pinaverium bromide (dicetel) and otilonium bromide (lubricant). The use of drugs with a high content of bile acids (allochol, lyobil, henofalk) is justified in cases where there is hypofunction of the gallbladder. Recently, the most physiological corrector of bile formation seems to be Odeston (1-2 tablets 3 times a day).

Classification of laxatives:
osmotic laxatives
- macrogol (forlax);
- synthetic polysaccharides (lactulose, pormaza, lysalac, portalac, duphalac, sorbitol);
softening feces (feces)
- petroleum jelly, almond and castor oil;
- liquid paraffin;
- docusate sodium;
intestinal motility stimulants
- saline laxatives (inorganic salts: phosphates, magnesia, Glauber's salt);
- increasing the volume of the intestinal contents: vegetable laxatives (bran, seaweed), indigestible fibers (methyl cellulose, agar);
- containing anthranoids: preparations of buckthorn, senna, rhubarb, purssenide, thiassen, regulax, x-prep;
- not containing anthranoids: diphenylmethane derivatives (phenolphthalein, bisacodyl, dulcolax, laxodyl, laxabene, stalax), sodium picosulfate (guttalax, laxigal);
- herbal preparations - Agiolax, Regulax, Califig, Mussinum, Depuraflux, plantain seeds, becunis;
laxatives used for intestinal lavage
- macrogol (fortrans).

 The most common and giving some positive effect are senna preparations.

As a prototype taken grass senna, which is used as follows:
a brew is brewed (10%) and applied orally by 3-5 tablespoons per day.

The disadvantage is that, firstly, taking a decoction of senna leads to a decrease in the concentration of K ⁺ ions in the mucosa of the large intestine. This fact underlies the decrease in the effectiveness of treatment as the duration of receiving decoction of senna grass increases and leads to a steady decrease in the chances of restoring normal "work" of the colon (Grigoryev P.Ya., Yakovenko A.V. Clinical gastroenterology: A textbook for students of medical schools, doctors and cadets of institutions of postgraduate education.M .: Medical News Agency, 2001. 704 p.). It is significant that the effectiveness of the action of laxatives decreases after three years of regular intake to 73%, after 5 years - to 50%, and after 10 years only 11% of patients respond to laxatives. Secondly, the vast majority of patients taking senna decoction as a laxative, note increased pain in the abdomen, there is melanosis of the colon mucosa, and dyskinesia is increasing, and 1/3 of the patients have an “inert” colon. Atrophic changes in the mucosa and inflammatory changes due to local irritating effect of laxatives containing anthracoglycosides are observed in many patients with laxative therapy.

 This tool is taken as a prototype.

 The aim of the present invention is to normalize the intestines and restore normal daily stool.

 This goal is achieved by the fact that on the basis of senna grass a remedy is prepared, which includes the following components: dried apricots without stones; pitted prunes, figs; sunflower oil and senna grass.

 The product is prepared as follows: 200 g of dried seedless dried apricots are taken. After thorough washing with boiled water, dried apricots are passed through a meat grinder measuring 0.3-0.5 cm, then 200 g of prunes are taken, also seedless, and after washing, they are also passed through a meat grinder. Then 200 g of figs are also washed after passing through a meat grinder. After that, 25 g of granules of dry senna leaves are crushed in a coffee grinder to a powdery form. All components are mixed, after which 100 g of sunflower oil is added to this mixture. After thorough mixing, the product is ready for use, it is placed in a glass dish and stored in the refrigerator.

 It is applied daily at night for 1 teaspoon. In the morning, stool is normalized without any complications.

The presence of dried apricots, prunes and figs in this product helps to normalize the intestinal microflora and provides it with the necessary amount (K ⁺ , glucose, Ca ²⁺ ).

Clinical Examples
Patient S. turned to the clinic with complaints of prolonged, for several years, constipation, which were localized by taking a large number of laxatives.

 After taking the proposed remedy, the stool returned to normal.

Compared with the prototype, the proposed tool allows you to normalize the intestines, does not cause an imbalance of K ⁺ ions in the intestinal mucosa.

Claims (1)

Means for the normalization of the intestine on the basis of senna grass, characterized in that it consists of the following components, g:
Dried apricots - 200
Pitted prunes - 200
Figs - 200
Sunflower oil - 100
Senna grass in granules - 25