CN117018110A - Medicament for removing necrotic tissue and promoting tissue regeneration and preparation method thereof - Google Patents

Medicament for removing necrotic tissue and promoting tissue regeneration and preparation method thereof Download PDF

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Publication number
CN117018110A
CN117018110A CN202311230816.9A CN202311230816A CN117018110A CN 117018110 A CN117018110 A CN 117018110A CN 202311230816 A CN202311230816 A CN 202311230816A CN 117018110 A CN117018110 A CN 117018110A
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medicine
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vaseline
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矫秀君
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
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Abstract

The invention belongs to the field of traditional Chinese medicines, and discloses a medicine for removing necrotic tissue and promoting granulation, and a preparation method and application thereof. The invention discloses a medicine raw material comprising: 20-30 parts of rubber, 20-30 parts of blood pressure, 20-30 parts of red halloysite, 20-30 parts of frankincense, 20-30 parts of dragon bone, 20-30 parts of myrrh, 20-30 parts of catechu, 2-5 parts of borneol, 2-5 parts of lithospermum oil and 5-10 parts of vaseline. The ointment prepared by the compatibility of nine traditional Chinese medicine components has the effects of clearing heat and detoxicating, reducing swelling and relieving pain, can effectively inhibit wound infection, has strong antibacterial and anti-inflammatory forces, can stop bleeding and relieve pain, can promote skin repair, and has quick curative effect and low cost.

Description

Medicament for removing necrotic tissue and promoting tissue regeneration and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a medicine for removing putrefaction and promoting granulation and a preparation method thereof.
Background
In recent years, the incidence rate of anorectal diseases is higher and higher, and many people in life suffer from anorectal diseases, namely various diseases occurring on anus and large intestine, which are typical and frequently occurring diseases of human beings, and commonly include internal hemorrhoids, external hemorrhoids, mixed hemorrhoids, anal fissure, anal fistula, perianal abscess, hematochezia, anal sinusitis and the like. Clinical presentation shows that most perianal diseases are caused by bad life.
Most people have the experience that the delay and forgetting to defecation are bad habits of many people when sitting on buses and when working is tension. Thus, the feces can be accumulated in the intestinal tract for a long time, and the feces are dry along with water loss, so that the feces are more difficult to discharge again, and the constipation is marked. Constipation for a long period of time can easily cause hemorrhoids. Newspaper reading and mobile phone playing are habits of many people when squatting and toilet. Research shows that after ten minutes of squatting toilet, anus will receive certain oppression, produces the influence to anus health. Or the anus health is possibly influenced by little drinking water, bad dressing habit, insufficient exercise quantity and long standing and sitting in life.
Currently, the art is primarily concerned with perianal disease by saline irrigation, topical medications, oral medications, infrared therapy or surgery. However, the saline water washing has general therapeutic effect on perianal diseases; the topical medicine is suitable for patients with mild symptoms; oral administration of the drug can only help recovery of the disease by reducing the inflammatory response of the body, and the effect is not ideal; the infrared treatment requires professional operation of doctors and is complicated; although the operation treatment can effectively relieve the perianal diseases, the operation treatment still has the defects of easy recurrence, high price and the like. Therefore, how to provide a method for treating perianal diseases, which has low price, simple use and can effectively treat perianal diseases, diminish inflammation and sterilize and promote skin regeneration, becomes the problem to be solved by the invention.
Disclosure of Invention
In view of the above, the invention provides a medicament capable of removing necrotic tissue and promoting tissue regeneration and a preparation method thereof, and the medicament is prepared into ointment by matching nine Chinese herbal medicines, has the advantages of convenient use, low price, rapid curative effect, and effective hemostasis, pain relieving and tissue regeneration promoting.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the medicine for removing the necrotic tissue and promoting tissue regeneration comprises the following components in parts by weight:
20-30 parts of rubber, 20-30 parts of blood pressure, 20-30 parts of red halloysite, 20-30 parts of frankincense, 20-30 parts of dragon bone, 20-30 parts of myrrh, 20-30 parts of catechu, 2-5 parts of borneol, 2-5 parts of lithospermum oil and 5-10 parts of vaseline.
The beneficial effects of the technical scheme are that:
the prescription of the invention is mainly formed by combining natural medicines, does not exclude the use of artificial synthetic medicines, and is formed by organically combining various medicines. The preparation method is fixed, the use method is clear, the preparation is designed for unspecified people, and the effect is obvious.
The traditional Chinese medicine formula is relatively complex in components, and from the perspective of traditional Chinese medicine, the traditional Chinese medicine formula takes the basic theory of traditional Chinese medicine as a principle, blood force as monarch drug, rubber, red halloysite, dragon bone and catechu as ministerial drugs, frankincense, myrrh, borneol and lithospermum oil as adjuvant drugs, and after a plurality of drugs are organically combined into a traditional Chinese medicine preparation, the composition drugs are mutually coordinated and the curative effect is obviously enhanced, and meanwhile, the toxicity of certain drugs is reduced or alleviated, so that the drug treatment effect is better exerted. In addition, the medicines are combined into a prescription, so that the medicine can be better suitable for complex diseases.
And (3) rubber: salty taste, warm taste, functional indications: promoting blood circulation, stopping bleeding, healing sore and all wounds, and the ulcers are not closed for a long time;
blood force: sweet, salty, flat, mainly: removing blood stasis, relieving pain, promoting blood circulation, and promoting granulation, and can be used for treating traumatic hemorrhage;
halloysitum rubrum: sweet and sour nature, astringency and warmth, and mainly treats: astringing to stop bleeding, promoting granulation, astringing intestine, and relieving diarrhea;
keel: sweet, astringent and flat nature, and has the main functions of: tranquillizing, arresting sweating, astringing essence, promoting tissue regeneration, and healing sore, and treating chronic ulcer without healing by external application;
catechu: bitter, astringent and slightly cold in nature, and mainly treats: clearing heat and resolving phlegm, healing sore and stopping bleeding, activating blood and promoting tissue regeneration, and treating sores and ulcers for a long time without healing;
mastic gum: pungent, bitter and slightly warm in nature, and mainly treats: promoting blood circulation, activating qi-flowing, dredging channels, relieving pain, detumescence, promoting granulation, relieving pain of heart and abdomen, rheumatalgia, traumatic stasis, carbuncle, swelling and toxic substance, and promoting wound healing;
myrrh: bitter and flat nature, and mainly treats: promoting blood circulation, relieving pain, detumescence, promoting granulation, removing blood stasis and pain of chest and abdomen, traumatic injury, carbuncle, swelling, pain, acute appendicitis, conjunctival congestion and swelling and pain;
borneol: pungent and pungent. Bitter and slightly cold, mainly functions: inducing resuscitation, refreshing mind, clearing heat, and relieving pain, and can be used for treating fever unconsciousness, convulsion, apoplexy, phlegm syncope, speckle and conjunctival congestion, aphtha, and laryngopharynx swelling and pain;
arnebia oil: dry nature, salty taste, cold nature, and its main indications: clearing heat and cooling blood, promoting blood circulation and removing toxic substances, promoting eruption and eliminating ecchymoses, and also can be used as a lubricant.
Further, the ratio of the raw materials is preferably as follows: 30 parts of rubber, 30 parts of blood force, 30 parts of red halloysite, 30 parts of frankincense, 30 parts of dragon bone, 30 parts of myrrh, 30 parts of catechu, 2 parts of borneol, 2 parts of lithospermum oil and 5 parts of vaseline.
A preparation method of a medicine for removing necrotic tissue and promoting granulation comprises the following steps:
(1) Weighing the raw materials according to the weight part of claim 1;
(2) Grinding the nine raw materials into fine powder respectively;
(3) Mixing the powder obtained in step (2) uniformly, adding vaseline, mixing uniformly, and making into ointment.
Further, the concentration ratio of the ointment Chinese medicinal ointment to the vaseline is 10% -30%.
The application method of the ointment for removing the necrotic tissue and promoting tissue regeneration prepared by the invention comprises the following steps: the patient is cleaned by clear water before defecation, 1 to 1.5 g of the medicine is applied or received on the anus, 2 times a day, ten days is a treatment course.
The beneficial effects of the technical scheme are that:
the ointment prepared by the invention has the effects of clearing heat and detoxicating, detumescence and relieving pain, can effectively control wound infection, accelerate wound healing, has strong antibacterial and anti-inflammatory forces, can stop bleeding, relieve pain, promote granulation, and has low cost and convenient use.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A medicine for removing putrefaction and promoting granulation comprises the following components:
20 parts of rubber, 20 parts of blood force, 20 parts of red halloysite, 20 parts of frankincense, 20 parts of dragon bone, 20 parts of myrrh, 20 parts of catechu, 2 parts of borneol, 2 parts of lithospermum oil and 5 parts of Vaseline.
Example 2
A medicine for removing putrefaction and promoting granulation comprises the following components:
25 parts of rubber, 25 parts of blood force, 25 parts of red halloysite, 25 parts of frankincense, 25 parts of dragon bone, 25 parts of myrrh, 25 parts of catechu, 4 parts of borneol, 4 parts of lithospermum oil and 7 parts of Vaseline.
Example 3
A medicine for removing putrefaction and promoting granulation comprises the following components:
30 parts of rubber, 30 parts of blood force, 30 parts of red halloysite, 30 parts of frankincense, 30 parts of dragon bone, 30 parts of myrrh, 30 parts of catechu, 5 parts of borneol, 5 parts of lithospermum oil and 10 parts of vaseline.
Verification of clinical treatment effect
Case 1: some Liu, men, 63 years old, the patient starts to have a small amount of hematochezia in 2010, has no pain, is not cared at that time, and does not take therapeutic measures; symptoms aggravate after 2017, and the long-term hematochezia and anus pain.
After the ointment prepared by the invention is applied, pain is relieved within 1h, the hematochezia amount is reduced, and after the ointment is continuously applied for 5 days, the symptoms disappear, and the ointment has obvious treatment effect and no hematochezia and pain.
Case 2: some plum, men, 90 years old, the patient has no cause of perianal swelling pain, crumbling and pus flowing, postoperative wound pain and occasional bleeding in 2019.
After the ointment prepared by the invention is smeared, pain is relieved within 1 hour, the blood volume is reduced, the wound is lubricated and glossy, the operation wound is basically healed after being smeared for ten days, the ointment is in a normal state, no hematochezia and pain are caused, and the treatment effect is obvious.
Case 3: a man, 85 years old, the patient had hematochezia before and after 2008, and had no other symptoms, but was not treated; in 2015, the symptoms are aggravated, hematochezia is increased, and pain is hard to be felt; wound edema and pain after operation.
After the ointment prepared by the invention is applied, pain is gradually relieved, bleeding amount is gradually reduced within 2 hours, edema disappears after ten days of continuous application, wound is free from infection, hematochezia and pain are avoided, and the ointment is basically cured and has remarkable treatment effect.
Case 4: some men in Song, 84 years old, the patient had hematochezia in 2010, the symptoms were light, and the hematochezia was increased in 2023, and the patient had pain and distention feeling.
After the ointment prepared by the invention is coated, the pain is relieved, the pain is free from falling and swelling feeling after three days of continuous coating, the hematochezia amount is relieved, and the ointment is coated for five days again, and has obvious treatment effect without pain, hematochezia and disappearance of symptoms.
Case 5: some men are born for 83 years, the patient has no cause of anal pain, no hematochezia and hard anus in 2020.
After the ointment prepared by the invention is applied, pain is relieved within 2 hours, symptoms disappear after the ointment is continuously applied for one week, pain is avoided, the package blocks become soft, and the treatment effect is obvious.
200 cases of clinical cases were summarized and the results shown in Table 1 were summarized.
TABLE 1
Through years of clinical application, the effective rate of the ointment for treating hematochezia, pain, anus Zhou Zhongzhang and difficult sore healing can reach more than 92.5%.
In the present specification, each embodiment is described in a progressive manner, and each embodiment is mainly described in a different point from other embodiments, and identical and similar parts between the embodiments are all enough to refer to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (5)

1. The medicine for removing the necrotic tissue and promoting tissue regeneration is characterized by comprising the following components in parts by weight:
20-30 parts of rubber, 20-30 parts of blood pressure, 20-30 parts of red halloysite, 20-30 parts of frankincense, 20-30 parts of dragon bone, 20-30 parts of myrrh, 20-30 parts of catechu, 2-5 parts of borneol, 2-5 parts of lithospermum oil and 5-10 parts of vaseline.
2. The medicine for removing putrefaction and promoting tissue regeneration according to claim 1, wherein the ratio of the raw materials is preferably as follows:
30 parts of rubber, 30 parts of blood force, 30 parts of red halloysite, 30 parts of frankincense, 30 parts of dragon bone, 30 parts of myrrh, 30 parts of catechu, 2 parts of borneol, 2 parts of lithospermum oil and 5 parts of vaseline.
3. The preparation method of the medicine for removing the necrotic tissue and promoting tissue regeneration according to claim 1 or 2, which is characterized by comprising the following steps:
(1) Weighing raw materials according to the weight portion;
(2) Grinding the nine raw materials into fine powder respectively;
(3) Mixing the powder obtained in step (2) uniformly, adding vaseline, mixing uniformly, and making into ointment.
4. The method for preparing a medicine for removing necrotic tissue and promoting granulation according to claim 3, wherein the concentration ratio of the ointment to the vaseline is 10% -30%.
5. The method for using the medicament for removing the necrotic tissue and promoting tissue regeneration prepared by the claims 3 to 4 is characterized by comprising the following steps:
the patient is cleaned by clear water before defecation, 1 to 1.5 g of the medicine is applied or received on the anus, 2 times a day, ten days is a treatment course.
CN202311230816.9A 2023-09-22 2023-09-22 Medicament for removing necrotic tissue and promoting tissue regeneration and preparation method thereof Pending CN117018110A (en)

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