RU2189235C2 - Method for performing sodium hypochlorate infusion - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves injecting blood taken from peripheral vein of one arm and sodium hypochlorate into external blood circulation circuit at a rate of 40-70 drops/min. Roller pump is used for supporting blood circulation flow rate in the circuit at the level of 50-120 ml/min. Blood treated with sodium hypochlorate is injected into cubital vein of the other arm. EFFECT: enhanced effectiveness of treatment; avoided harmful sodium hypochlorate action upon peripheral veins. 1 dwg, 2 tbl

Description

 The invention relates to medicine, namely to efferent methods of detoxification.

 Sodium hypochlorite is a carrier of active oxygen, a strong oxidizing agent [1, 2]. Oxidation is one of the main and universal biochemical processes in the human body that ensure the inactivation of exogenous and endogenous blood products. Active oxygen released from sodium hypochlorite has a destructive effect on tissue decomposition products and microorganisms. This shows its detoxifying effect.

 There is a method of introducing into the human body a strong oxidizing agent - sodium hypochlorite, which releases active oxygen, by drip infusion through a catheter into a vein. In this case, use the subclavian, jugular and femoral veins. Recommended concentration of sodium hypochlorite for this method is 300-600 mg / L. The rate of administration is up to 50-70 drops per minute [1, 2].

The disadvantages of this method are:
- complications after catheterization of veins;
- for catheterization of the central vein, operating room conditions, special tools and supplies, and highly qualified specialists are necessary;
- the presence of a catheter in the central vein for a long time limits the patient's mobility, requires round-the-clock monitoring.

 A known method of introducing sodium hypochlorite into large peripheral veins, while the concentration of sodium hypochlorite should be no more than 300 mg / l and the injection rate of 20-40 drops per minute [3, 4]. This concentration of sodium hypochlorite is considered ineffective and does not inhibit the growth of a number of pathogenic microbes.

 Experience shows that with repeated administration of even this concentration of sodium hypochlorite into the peripheral vein, phlebitis, necrosis of the vessel wall, and the formation of paravenous infiltrate are possible [5].

 The purpose of the invention is the prevention of the damaging effects of sodium hypochlorite on peripheral veins.

 This goal is achieved by creating an external blood flow circuit, blood from the cubital vein of one human hand using a roller pump is sent to the external blood flow circuit (outside the human body) at a speed of 50-120 ml / min. Sodium hypochlorite is introduced into the external circuit at a rate of 40-70 drops per minute. Treated with sodium hypochlorite, blood is injected into the cubital vein of the other person’s arm.

 The purification of blood with sodium hypochlorite in the external circuit eliminates the damaging effect of active oxygen on the endothelium of the wall of the peripheral vein at the injection site, therefore, blood treatment with this method can be repeated without fear for the state of the veins. The corresponding blood flow velocity in the circuit and the rate of supply of sodium hypochlorite to the circuit make the method safe for cellular elements of the blood. The multiplicity of infusions and the concentration of sodium hypochlorite are determined by the degree of endotoxemia.

 The drawing shows a diagram of the external blood flow circuit used to introduce sodium hypochlorite into the blood, where 1 is a puncture needle, a) a fence, b) return, 2 is a silicone fragment for connecting a dropper with sodium hypochlorite, 3 is a dropper with sodium hypochlorite, 4 - a roller pump for blood perfusion, 5 - a reservoir of blood treated with sodium hypochlorite, 6 - a dropper with an air trap, 7 - a silicone fragment for administering drugs.

 The method is implemented as follows. On a sterile table, a system for an external blood flow koshura is assembled. Standard disposable droppers 3, 6 are used, and a sterile vial with physiological saline or Gemacon-500 is placed as a blood storage unit 5. The external circuit highway, assembled according to the above diagram, but without a dropper with sodium hypochlorite 3, is charged into the roller pump 4. Using a roller pump, the blood flow system is filled through the needle 1a through the needle 1a, the bloodstream is washed with saline to drain through the needle 1b . At the end of the washing, the external circuit is filled with physiological saline, there are no air bubbles in it, the blood storage unit 5 is filled with physiological saline in a volume of 300-350 ml.

 To obtain excessive venous pressure at the site of blood sampling, a venous tourniquet is applied to the shoulder. A vein is punctured with a single needle 1a to collect blood. A vein is punctured with another needle 1b on the opposite limb to return the blood treated with sodium hypochlorite. Establish blood flow according to the given scheme. A 2 ml bolus dose of heparin (10,000 units) is injected into the silicone fragment 2. Then, a dropper with 10% glucose in a volume of 300-500 ml is placed in the silicone fragment 7 to prevent hypoglycemia. After completion of the intravenous administration of a 10% glucose solution, sodium hypochlorite is fed into the external blood stream through a silicone fragment 2 from a dropper 3 at a rate of 40-70 drops per minute. The concentration of 300-600 mg / l sodium hypochlorite introduced into the system is adequate to the severity of epdotoxicosis in the patient. Silicone fragments 2 and 7 of the external blood circuit can be used to collect blood samples before and after treatment with sodium hypochlorite and, based on the analysis, evaluate the effectiveness of the drug.

 Example 1. Patient Ш, 20 children was admitted to the infectious diseases department on November 24, 1999. Diagnosis: viral hepatitis "A", endotoxicosis I-II art. Due to the lack of a positive effect from traditional therapy, intravenous infusion of sodium hypochlorite was carried out for 3 days. (table 1).

 Example 2

 Patient M., aged 20, was admitted to the infectious diseases department on November 19, 1999. Diagnosis: viral hepatitis "A". Detoxification was carried out due to the lack of positive dynamics from the therapy. The table shows the changes in blood parameters after a single injection of sodium hypochlorite. (table 2).

Sources of information
1. Rosen M., Latto J.P., Sheng W. NG. Percutaneous catheterization of the central veins. - M .: Medicine, 1986.

 2. Nazarov I.P., Popova E.A. and other Intensive care burn injury, "Bulletin of intensive care", 1995, 1, p. 23-26.

 3. Lopatkin N.A., Lopukhin Yu.M. Efferent methods in medicine. - Moscow, 1989, p. 320-340.

 4. Fedorovsky N.M., Sashin S.M. Guidelines for the clinical use of the apparatus for indirect electrochemical detoxification of the body EDO-4 with endotoxemia by the method of intravenous administration of sodium hypochlorite, 1991.

 5. Methodological recommendations "Extra- and intracorporal methods of correction of homeostasis in clinical practice."

Claims (1)

 A method of intravenous infusion of sodium hypochlorite, including the effect of sodium hypochlorite on the blood, characterized in that they create an external circuit for blood flow, into which blood is supplied from the cubital vein of one hand and sodium hypochlorite at a speed of 40-70 drops per minute, with a roller pump the blood speed is a circuit of 50-120 ml / min and blood treated with sodium hypochlorite is poured into the cubital vein of the other hand.

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