RU2171683C1 - Agent for treatment of patients with psoriasis (variants) and method of its treatment - Google Patents

Abstract

FIELD: medicine, dermatology, pharmacy. SUBSTANCE: invention relates to development of agent used for treatment of patients with dermatological diseases, in part, psoriasis and method of its treatment. Invention proposes an agent in the form of medicinal plants infusion and ointment for application on damaged sites involving vegetable raw also. Invention proposes also method of treatment of patients with psoriasis using vegetable-base infusion and ointment with additional intake of peony tincture in the dose 1 ml in 50 ml of water in evening. Treatment by proposed method results to stable therapeutic effect and increase of inter- relapse period of disease in all cases. EFFECT: enhanced effectiveness of agent and method of treatment. 4 cl

Description

 The invention relates to medicine and relates to the creation of tools for the treatment of skin diseases, in particular psoriasis and a method for its treatment.

 It is known the use of biologically active substances and the application of therapeutic ointments to the lesions on the background of diet and normalization of the regime of work and rest (1).

 However, the known tool and method is not effective enough and relapses are possible.

 The objective of the invention is to increase the efficiency and increase the relapse period of the disease.

 The problem is solved by creating a group of inventions, united by a single inventive concept.

 The invention consists in the fact that the proposed infusion of medicinal plants, (wt.%).

Roots of Aralia Manchurian - 5-6
Blood Hawthorn Fruits - 20 - 23
The fruits of mountain ash - 20 - 23
Chokeberry fruits - 18-20
May Rose Hips - Else
Also proposed is an ointment containing, wt.%:
Chaga Water Extract - 5-6
40% alcoholic extract of celandine - 3 - 5
Salicylic Acid - 2 - 3
Vaseline - 42-45
Lanolin - 42-45
A method for the treatment of psoriasis is proposed.

 For 4-6 weeks at the stationary stage of psoriasis, an ointment consisting of an extract of birch fungus, celandine, salicylate on a petrolatum-lanolin base is applied twice a day for rashes and rubbed thoroughly. In addition, daily in the morning and in the afternoon during the entire treatment period, an infusion of medicinal herbs of 100 ml per 70 ml is taken orally, containing rosehips, hawthorn, mountain ash and aronia, aralia roots, 20 minutes before meals. In the evening, the patient receives 1 ml of peony tincture in 50 ml of water 1 hour before bedtime. For children, the dose of galenic preparations is 2 drops for each year of life for one dose with a mandatory intake of 30-50 ml of water.

 To prepare the infusion, dry plants are crushed and used in a dose of 2 g per 200 ml of boiling water.

 An aqueous extract of birch fungus is used in the form of an official drug, befungin, which is approved as an internal treatment for gastroenterological patients (12). Celandine extract is prepared from dry grass on 40% alcohol in a ratio of 1: 4 according to GF 10th edition (11).

 In the treatment of psoriasis, diet and regimen are followed. Fatty foods with a variety of dishes and an abundance of plant-derived vitamins are excluded from the diet. Limit the amount of sugar consumed, spicy foods and seasonings.

 Treatment should not be started during an exacerbation of the disease.

 The disappearance of the disease occurs within 30-40 days from the start of the procedures.

 The basic medicinal plants included in the infusion and ointment dosage form include the following, affecting certain symptoms of the disease and used in the treatment of psoriasis.

 Chaga birch mushroom (Inonotus obliquus) is a parasitic fungus from the fungi family. It contains a water-soluble pigment complex, which has an aromatic nature and is built according to the type of humic acids. The therapeutic effect of chaga to a certain extent is due to the presence of steroid compounds of lanosterol, ergosterol and inotodiol (3), as well as humic like chagic acid and free phenols (4). Chagic acid is a highly polymeric aromatic substance - a product of the oxidation of phenolic substances under the influence of mushroom laccase and their subsequent polymerization. The stimulating effect of chaga preparations on the central and humoral systems of the body, as well as metabolic processes, was noted. They increase the body's resistance and contribute to strengthening the formation of compensatory-adaptive mechanisms (5). Chaga is used in gastroenterology, oncology, dermatology (6). However, there is no information about the use of chaga in the external treatment of psoriasis as a mono- or as part of complex preparations.

 Large celandine (Chelidonium majus) is a perennial herbaceous plant from the poppy family. It refers to alkaloid-containing plants (chelidonin, oxychelidonin, sanguinarine, chelerythrin, homochelidonin, helirubin, koptizin, spartein, etc.). Celandine preparations inhibit the growth of malignant tumors, have antimycotic, antiviral, antispasmodic, local anesthetic, reparative, anti-inflammatory, bactericidal, choleretic, wound healing effects (7). More often, an aqueous extract of the plant is used (7), however, alkaloids are not sufficiently extracted from plant materials with a water extractor, and preferably with water-alcohol in an alcohol concentration of 23 - 40%.

 May rose hips (Rosa majalis) increase the redox processes in the body, participate in the oxidative deamination of aromatic amino acids, activate a number of enzyme systems, stabilize the content of adrenaline and other catecholamines, and stimulate the body's resistance to harmful environmental influences (6). The presence in the fruits of vitamins of group B, E and carotene gives the rosehip herbal preparations the missing links of a stimulating effect on the anaerobic decarboxylation of pyruvic acid with subsequent activation of enzyme systems. Fruits also enhance tissue regeneration, hormone synthesis, favorably affect carbohydrate metabolism and vascular permeability (2).

 Due to the presence of a complex of flavonoids, microelements, and hydroxycinnamic acids, the fruits of hawthorn (Cratagus sanguinea) have a hypocholesterolemic effect, lowering blood cholesterol and increasing the amount of lecithin (10), which is important in the treatment of psoriasis. A significant antiviral effect of hawthorn against herpes virus has been established (9), given the retroviral nature of psoriatic disease (6).

 The fruits of mountain ash (Sorbus aucuparia) contain carotenoids, flavonoids, a complex of vitamins and exhibit a multivitamin and antiviral effect (9).

 Chokeberry fruits (Aronia melanocarpa), due to their flavonoid content and vitamin complex, have a chelostimulating, capillary-strengthening and antiviral effect (6), which makes it possible to recommend them in the treatment of psoriasis.

 Aralia manchurian (Aralia manshurica) contains triterpene saponins - aralosides, which increase the resistance of the main physiological systems of the body to adverse effects, are able to create a state of non-specifically increased resistance in the body, regulate the course of a stressful situation (2), which determines the need to use its drugs in the treatment of psoriasis patients (6).

 The invention is illustrated by the following examples.

 Example 1. Patient P., 46 years old, chief accountant of one of the organizations in Moscow. She complained of pain in the hip, elbow and ankle joints, multiple psoriatic rashes of the skin of the trunk and limbs. Sick with psoriasis for 1.5 years. Staying in the south significantly reduces the number of rashes, but after 2 weeks they return again. I was treated in LLC "Venus" with calcium preparations, aevit and cream. She took Dr. Nonna's dietary supplements, but there was no improvement.

 Locally: on the skin of the trunk and extremities there are multiple rounded infiltrated plaques of psoriasis of various sizes and shapes. Diagnosed with common psoriasis, stationary form. Psoriatic polyarthritis. The claimed treatment was prescribed for treatment for 38 days. The consequences of the treatment - pain in the joints decreased, psoriatic rashes became flattened, their number decreased significantly. In the center of some plaques, the appearance of pink skin with no signs of plate peeling is noted. There are no fresh rashes. Significant improvement in the condition of the skin was noted. Observation continued for 8 months. There was no relapse of the disease.

 Example 2. Patient B., 21, the driver of one of the automobile enterprises of the city of Korolev, Moscow region. He turned on 10/14/1998 with complaints of multiple psoriatic plaques on the scalp, elbows and knees. Sick for 7 years. He was treated many times and by various means: Skin-Cap, psoriatic, radevit, psoricline, psorcutan, etc. The effect occurs in a month, but after 2 to 4 weeks the disease recurs. Hepatitis A, acute gastritis. Obesity 1 tbsp. Locally: on the skin of the scalp multiple infiltrated rounded plaques with abundant lamellar peeling. Some of them protrude from under the edge of the hairline. On elbows and knees, rounded plaques 3 X 5 cm with copious lamellar peeling and cracks. Appointed the claimed method of treatment for 6 weeks. As a result, single flattened plaques remained on the occipital region and right knee. It is observed within 18 months. Relapse occurred after 11 months, but with repeated treatment after 3 weeks, the rash disappeared.

 It is under dispensary observation. During the observation period, he lost 7.5 kg.

 In all cases, treatment with this agent leads to a lasting therapeutic effect.

LITERATURE
1. Korsun V.F. Treatment and rehabilitation of patients with psoriasis. - Mn., 1991 .-- S. 10-29.

 2. Sokolov S. Ya., Zamotaev IP Handbook of Medicinal Plants (Herbal Medicine). - M., 1990.

 3. Dosychev EA, Bystrova V.N. Treatment of psoriasis with preparations of the fungus "chaga" dermatol., 1973. - N 5. - S. 79 - 83.

 4. Kortev A.N., Lyasheva A.P., Dontsov G.I. Microelements in clinical lighting. Sverdlovsk, 1969.

 5. Balitsky K.P., Vorontsova A.P. Medicinal plants and cancer. - Kiev, 1972.- 375 p.

 6. Korsun V.F. Herbal medicine psoriasis. - Mn., 1993 .-- S. 117-125.

 7. Stanets M.P. About the ecclesiastical power of purity of the vale. - Kiev, 1966.

 8. Potopalsky A.I., Potopalskaya A.Ya. Treatment of scaly lichen with celandine preparations // Doctor. business, 1964. - N 8. - p. 129-130.

 9. Modern herbal medicine / Ed. V. Petkova. - Sofia, 1988 .-- 504 p.

 10. Turova A.D., Sapozhnikova E.N. Medicinal plants of the USSR and their use. - M., 1987. - 288 p.

 11. State Pharmacopoeia of the USSR, X edition. - M., 1989.

 12. Mashkovsky M.D. Medicines Ed. 14th - M., 2000.

Claims (2)

1. The treatment for psoriasis, containing extracts of medicinal plants, characterized in that it is an infusion of medicinal plants, including the roots of Manchurian aralia, the fruits of the hawthorn, red mountain ash, chokeberry and Mayrose in the following ratio, wt%:
Roots of Aralia Manchurian - 5 - 6
Blood Hawthorn Fruits - 20 - 23
The fruits of mountain ash - 20 - 23
Chokeberry fruits - 18 - 20
May Rose Hips - Else
2. An agent for treating psoriasis containing medicinal plants, characterized in that it contains an aqueous extract of chaga, 40% alcohol extract of celandine, as well as salicylic acid and a base including medical vaseline and anhydrous lanolin in the following ratio, wt%:
Chaga Water Extract - 5 - 6
40% Celandine Alcohol Extract - 3 - 5
Salicylic Acid - 2 - 3
Medical Vaseline - 42 - 45
Anhydrous lanolin - 42 - 45
3. The tool according to claim 2, characterized in that it is intended for local use and is made in the form of an ointment.  4. A method of treating psoriasis by ingestion of medicinal plants and applying applications to the affected areas of the remedy from medicinal plants, characterized in that the medication is used inside, including the infusion of medicinal plants according to claim 1, twice a day, 100 ml each morning and noon, in the evening an additional 1 ml of peony tincture in 50 ml of water, and the ointment according to claim 2 is applied to the lesion site twice a day.