RU2149645C1 - Method of treatment of children with pollinosis - Google Patents

Abstract

FIELD: medicine, pediatry, allergology. SUBSTANCE: method involves administration of allergen aqueous-saline extracts before season in granulated form by sublingual route, 30 min before eating, once per a day and increasing amount of granules from 1 to 10 for a single intake. At allergen dilution 1: 1000000 and 1:100000 granules are intaken every day, at dilution 1: 1000 - each other day and at dilution 1:100 - twice per a week. EFFECT: enhanced effectiveness of specific immunotherapy in pollinosis, decreased treatment period, decreased complications and adverse effects. 4 cl, 1 ex

Description

 The invention relates to medicine, pediatrics, specifically to methods for treating hay fever in children.

 There is a method of treating hay fever, which consists in prescribing a causally significant allergen in gradually increasing doses in the form of water-salt extracts orally, which is simple to use, easy to tolerate, but due to the partial destruction of the allergen extract in the gastrointestinal tract, is not effective enough. The closest in effectiveness to the proposed method is the method of parenteral administration of water-salt extracts of allergens, however, it has a number of significant drawbacks (1, 2). The method is traumatic, requires the administration of a large number of injections, differs in duration and often gives side effects in the form of local and general allergic reactions.

 A new technical result - reducing the time, reducing the morbidity, reducing the number of complications during treatment is achieved by a new method of treating hay fever in children, which consists in the appointment of water-salt extracts of allergens in gradually increasing doses preseasonally, and allergens are used in granular form sublingually 30 minutes before meals 1 time per day, increasing the number of granules from 1 to 10 at a time, and when diluting allergen 1: 1,000,000 and 1: 100,000, granules are taken daily, when diluted 1: 1000 - every other day, and once administered 1: 100 - 2 times a week.

The method is as follows:
To obtain the drug intended for treatment, commercial water-salt extracts of allergens from birch pollen, a mixture of meadow herbs (fescue, timothy grass, hedgehog, bluegrass, ryegrass), a mixture of weed herbs (wormwood, quinoa) were used.

 The preparations were made in a homeopathic pharmacy N53 in Tomsk (license N1 dated 01/05/95) in the form of granules (small balls of milk sugar) that are impregnated with a diluted allergen so that each granule corresponds to a drop of liquid allergen in an adequate dilution, which ensures accuracy of dosing of the drug. During the manufacture of granules, the method of dynamization or potentiation is applied (a system of shaking and grinding as the substance is diluted), which, according to some authors (3, 4), contributes to a significant increase in the activity of drugs due to the energy generated in this process.

 Granules prepared in this way are dried in closed jars during the day, then packaged in 5 grams using precautionary measures - in a respirator and avoiding skin contact. For specific immunotherapy the following dilutions of allergens were used: 1: 1 000 000, 1:10 000. 1: 1 000, 1: 100.

 Specific immunotherapy for patients with hay fever begins pre-seasonally: in January-February and ends in March-April 2-3 weeks before the expected start of flowering. A causally significant allergen is prescribed in gradually increasing doses according to the following scheme.

Treatment scheme:
Dissolve the drug under the tongue 1 time per day 30 minutes before meals.

 1. Dilution 1: 1 000 000. Start with 1 granule, increasing by one per day, bring up to 10 granules for 1 reception. Take daily.

 2. A dilution of 1: 100,000. Start with 1 granule, increasing by one per day, bring up to 10 granules in 1 dose. Take daily.

 3. A dilution of 1: 1,000. Start with 1 granule, bring to 10 granules at a time. Take every other day.

 4. A dilution of 1: 100. Start with 1 granule, bring up to 10 granules in 1 dose. Take 2 times a week.

 The entire course of treatment takes an average of 2.5 months. Control examinations of children are carried out once every 14 days, in addition, all patients fill out special observation sheets, which record the date of the introduction of allergens, their dilution and dose, the presence of a local or general reaction, changes in the condition of the child, and taking medications. The rate of dose increase in the proposed method for the treatment of hay fever in children is slower than in previously used ones, which provides an adequate protective rearrangement of the immune system and prevents allergic reactions during treatment, which is confirmed by a phased examination of sick children.

 Using the method described above, 60 children with pollinosis at the age of 3 to 14 years were treated. Good and excellent results were obtained in 73.4% of children after the first course of treatment, after two courses the effectiveness increased to 80.0%. There were practically no allergic reactions to the administered drug. Only one child at a dilution of 1: 1000 allergen had complaints of itchy skin, as a result of which the therapy was suspended for 2 days. After the disappearance of complaints, treatment was continued with an increase in the intervals between doses of the drug and subsequently proceeded smoothly.

 In the comparison group according to the prototype method (children who received specific immunotherapy by injection), local allergic reactions were observed in 35% of patients, the duration of treatment was 4-4.5 months.

Example
Patient S., 6 years old. He turned to an allergist in May 1994 with complaints of itching, redness and swelling of the eyes, nasal congestion, frequent sneezing, paroxysmal cough, shortness of breath. An allergist was diagnosed with Pollinosis, rhinoconjunctivitis, pollen asthma. During the entire period of exacerbation, the child received antihistamines, bronchodilators and vasoconstrictor drugs, but the symptoms of the disease did not completely stop. An allergological examination using the method of scarification tests conducted in winter revealed a sensitization to birch pollen. Since February 1995, the child was given specific immunotherapy with a birch pollen allergen prepared in the form of granules in a sublingual way. The treatment went smoothly and was completed by mid-April. When examining a child during the flowering period of birch, the condition was assessed as satisfactory, slight difficulty in nasal breathing, mild conjunctival hyperemia was noted. Cough, shortness of breath was not. During the flowering period of birch, the child received a short course of antihistamines, against which the symptoms of the disease disappeared.

 The following year, the child underwent 2 courses of specific immunotherapy in winter, after which no symptoms of conjunctivitis, cough, shortness of breath were observed during the flowering period of the birch, only for 2 days the child was bothered by a slight nasal congestion, which did not require the use of additional drugs. Against the background of the treatment, in addition to reducing the intensity of the clinical symptoms of the disease, positive changes were noted in the local immunity system - the eosinophilia of the nasal mucosa decreased from 13% to 1%, the content of immunoglobulins A, G and SIgA in the nasal secretion increased and approached normal values.

 Thus, the advantages of this specific immunotherapy method are: simplicity and ease of use, non-invasiveness, which is especially important in pediatric practice, reduction of treatment time, low percentage of side effects from treatment. The method does not require hospitalization of patients, gives a high clinical effect and has a stimulating effect on local immunity, which allows us to recommend the developed treatment regimen for use in pediatric allergological practice for the treatment of hay fever.

LIST OF USED LITERATURE
1. Balabolkin I. I. Pollinosis in children. - M .: KRON- PRESS, 1996 .-- 272 p.

 2. Ziselson A. D. Pollinosis in children. - L .: Medicine, 1989 .-- 160 p.: Ill. - (B-ka practical doctor).

 3. L. D. Frenkel Homeopathic Pharmacology: a Reference Guide. - Kharkov: "Eleum", "Veles", 1993. -584 p.

 4. Charette J. Practical Homeopathic Pharmacology: A Guide: Per. with fr. - 2nd ed. - N .: Vico Association, 1992 - 223 p.

Claims (4)

 1. A method of treating hay fever in children is to prescribe water-salt extracts of allergens in gradually increasing doses preseasonally, characterized in that allergens are used in granular form in a dilution from 1: 1,000,000 to 1: 100 sublingually 30 minutes before meals 1 time per day , increasing the number of granules from 1 to 10 at a time.  2. The method according to p. 1, characterized in that when diluting the allergen 1: 1,000,000 and 1: 1: 100,000 granules are taken daily.  3. The method according to p. 1, characterized in that when diluting the allergen 1: 1000 granules are taken every other day.  4. The method according to claim 1, characterized in that when diluting the allergen 1: 100, the granules are taken 2 times a week.