RU2149005C1 - Method for treating viral and chlamydia infections - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves administering per os preparations of blood as drops in the form of autonosode in progressively growing doses with 2-4 days long time intervals between applications, daily. Strictly prescribed time being the time of taking blood for producing autonosode is to be selected. EFFECT: enhanced effectiveness in treating severe forms of gynecological diseases.

Description

 The invention relates to medicine and can be used in gynecology for the treatment of viral and chlamydial infections of urogenital localization, as well as chronic inflammatory diseases of the pelvic organs (chronic endometritis, chronic saltingoophoritis) and their complications, accompanied by a decrease in the resistance of the immune system (for example, chroniosepsis).

 A known method of treating vasomotor rhinitis (A.S. N 1438797, USSR, MKI 4 A 61 K 35/16, 09/29/86) by introducing autoserum in microdoses in the usual mode.

 The disadvantage of this method is the inability for the patient to independently carry out autoserotherapy, since the drug must be administered by an otolaryngologist using a syringe and needle at the base of the attachment of the front ends of both lower nasal concha. The method has limited use only in otolaryngology.

 A known method of treating patients often recurring psoriasis (A.S. N 1220661, USSR, MKI 4 A 61 K 35/16, 12/13/83) by administering intravenously autoplasma previously prepared during the period of remission of 50-200 ml 1 time in 5- 7 days for a course of 1-4 infusion.

 The disadvantage of this method is that autoplasma must be harvested in advance, strict storage conditions must be observed and the drug administered intravenously, which reduces its accessibility to widespread use. The method in the proposed form cannot be used for the treatment of chronic inflammatory diseases of the pelvic organs of viral and chlamydial etiology.

 There is also known a method for the treatment of allergic diseases (a.s. N 1793923, USSR, MKI 5 A 61 K 35/14, 02/12/91 - prototype) by administering to the patient a blood preparation in gradually increasing doses with an administration interval of 2-4 days.

 The disadvantage of this method is that autolymphocytosis can lead to an unpredictable immune response due to the content of biologically active substances in them, as well as a technically difficult way to prepare the drug, the need for empirical selection of the initial dose. Treatment of viral and chlamydial infections in this way is impossible, since complications in the form of the development of various allergic reactions are possible.

 The aim of the invention is to develop a method for the treatment of viral and chlamydial infections of urogenital localization and chronic nonspecific inflammatory diseases of the pelvic organs and their complications, accompanied by a decrease in the resistance of the immune system.

 This goal is achieved by the fact that the patient is administered orally a blood product in the form of an autonosode in the form of drops daily at a strictly defined time - the time of blood sampling for the manufacture of an autonosode.

 Currently, there are no methods for treating chlamydia and chronic nonspecific diseases of the pelvic organs, giving a lasting long-term positive effect or leading to complete healing. Existing methods - antibacterial and immunomodulating therapies have several disadvantages, give a temporary positive effect, and after a short period of time the treatment has to be repeated.

 The disadvantage of antibiotic therapy is its immunosuppressive effect. The action of antibiotics is insufficient due to the ability of bacteria to form L-forms that are not sensitive to antibiotics, and the presence in the life cycle of chlamydia of the intracellular phase, when they are not available for exposure to antibiotics.

 Due to the fact that the microflora in the upper and lower genital tracts may not coincide, laparoscopy may be required to take the material, in order to determine the sensitivity to antibiotics.

 The lack of effectiveness of antibiotic therapy is also associated with an adhesion process that develops with chlamydia and nonspecific salivophore and makes it difficult for antibacterial drugs to penetrate the focus of inflammation.

 Antiviral drugs such as acyclovir used in the treatment of viral infections have a number of side effects: nausea, vomiting, diorrhea, an increase in the content of bilirubin in the blood plasma, an increase in the activity of liver enzymes, etc., which narrows the range of patients in whom they can be used.

 Of the methods of immunomodulating therapy in the treatment of chronic non-specific saltingoophoritis, immunostimulants (pyrogenal, gonovaccine, staphylococcal toxoid, etc.) are used, which can cause hyperstimulation of the immune system and triggering autoimmune reactions. It is difficult to avoid such complications, as it is impossible to accurately calculate the individual dose of an immunostimulant.

 Autohemotherapy, used as an immunomodulator, technically requires each time an intravenous blood sampling and its intramuscular administration, which is inconvenient for the patient and staff. In addition, normal post-injection complications (abscess, etc.) are possible.

 The essence of the proposed method lies in the fact that the immunological characteristics of the blood and the whole body have their daily biorhythm, and therefore, differ in the same patient at different times of the day. The prepared autonozode carries information about the state of the immune system at the time when blood was taken for its preparation. Immunological status at this point in time is the interference of biorhythmic and pathological changes. Accordingly, when prescribing an autonomose blood at a time when blood was taken for its preparation, it will be eliminated precisely pathological shifts in immune homeostasis.

 The method is as follows. 0.1 ml of capillary or venous blood is taken from the patient. Fresh blood is dissolved and dynamized in 10 ml of a solution of 40% ethanol. This dilution corresponds to 1 CH, it is considered as a basic solution for subsequent dilutions. Then the resulting solution was poured, and the tube was filled with 10 ml of 10% alcohol. The result is a dilution, considered 1K (the first hundredth dilution according to Korsakov). Next, the drug is prepared to the desired dilution on 10% alcohol (according to the Korsakov method). It is important when preparing blood autosodes that solutions of 40% and 10% alcohol are prepared from 96% alcohol and distilled water and are obtained in a test tube at the same time and for each potency separately, since when mixing water and alcohol energy is released that enhances the process of potentiation and, accordingly, the activity of the drug. The drug is prescribed 8 drops per 1 / 4-1 / 2 pieces of sugar at the same time of the day when a blood sampling was done to prepare an autonozode. Preference is given to the morning hours from 8.00 to 12.00. It is recommended not to eat 2 hours before and 30 minutes after taking the drug, and shake the drug itself before use. In the process of treatment, the state of the blood, the immune system and the whole organism changes, so it is necessary to re-prepare the autonomozodes that carry new information about the state of the blood (the need to prepare a new autonomozoda is determined by the state of immunity). Treatment begins with a potency of 6K daily, with a one-day break for a week. In this case, the day free from the use of the drug is the day of preparation of the autonozoda. With the normalization of the immunological status, a gradual transition to fixing therapy with autonomozodes of blood is carried out in a potency of 12K every other day for one to three weeks. The duration of treatment is 1.5-2 months with subsequent fixing therapy.

Example 1. Patient Z., 27 years old, was admitted for treatment on 12/25/90 with complaints of progressively increasing general weakness, lack of appetite, weight loss - 10 kg in 4 months, daily chills - lasting up to 4-5 hours, with an increase body temperature up to 37.7 ^o C for four months, sweating, increased hair loss, copious discharge from the genital tract. Life story. She was born on time, grew and developed normally. Past diseases: chickenpox, SARS, flu. Heredity is not burdened. An allergic history without features. Menses from 14 years, established immediately for 4-5 days after 21 days, heavy, painful, regular. Pregnancy - 1, childbirth - 0, abortion - 1 in 1985

 The history of this disease: considers himself a patient for 5 years (since 1985), when an artificial abortion in the period of 8-9 weeks of pregnancy was complicated by endometritis, acute bilateral salpingo-oophoritis, about which conventional anti-inflammatory therapy with a short-term effect was carried out. Over the next three years, monthly exacerbations of chronic bilateral salpingoophoritis were observed, accompanied by an increase in general weakness, a decrease in appetite, and weight loss. Constant subfebrile condition was noted. From 1985 to 1988 inpatient treatment was carried out (antibiotics taking into account the sensitivity of microflora, detoxification therapy, vitamin therapy, stimulation of immunity with prodigiosan, thymalin, levamisole) with a short-term effect or lack thereof. In 1988 and 1989 separate diagnostic curettage of the uterus was performed twice - in scraping, the endometrium corresponded to the phase of the menstrual cycle without pathological changes. Given the increase in the phenomena of intoxication, the lack of effect from the therapy, bimanual and ultrasound data confirming the localization of the primary focus of infection in the uterine appendages, the patient was offered surgical treatment. The clinical diagnosis before surgery is chronic bilateral salpingo-oopritis with frequent exacerbations, chroniosepsis.

 In December 1989, an operation was performed to extirpate the uterus with tubes. The postoperative period was uneventful. There was an improvement in general condition, normalization of temperature, an increase in weight of 10 kg, the disappearance of all phenomena of intoxication. In August 1990, after a two-week stay in the south with excessive insolation, the patient noted a worsening condition - weakness, subfebrile condition, sweating, chills at different times of the day, loss of appetite, weight loss of 8 kg per 1 month, the appearance of profuse watery whites with a herring odor standing out in portions, the development of mental depression. In October 1990, a course of anti-inflammatory therapy was carried out with stimulation of the immune system with thymalin, which led to a short-term improvement in the general condition, the disappearance of intoxication symptoms, and improvement of the immunogram indices. In November 1990, after two physiotherapeutic procedures were performed on an outpatient basis (electrophoresis with zinc sulfate), there was a sharp deterioration with the return of all the previous symptoms, which were joined by tugging (like an abscess) of pain in the lower abdomen and the appearance of a tumor-like formation in the region of the left ovary, varying in the observation process from 4 to 11 cm in diameter, which was confirmed by the ultrasound conducted in dynamics. Conservative therapy did not give effect, in connection with which the operation was performed to remove the ovaries. The patient's condition after surgery for a short period of time has improved.

Objective observation: the patient has the correct physique, although nutrition is low. The skin is pale, blue circles under the eyes, brittle hair, fall out intensely. In the lungs - vesicular breathing, no wheezing. Respiratory rate - 19 in 1 min. Heart sounds are clear, rhythmic. Pulse 82 beats per minute, rhythmic, weak filling. HELL - 11/70 mm RT. Art. The tongue is dry, covered with a whitish coating. The abdomen is soft, does not swell, participates in the act of breathing, painless on palpation. The liver is not enlarged. The spleen is slightly enlarged, painless on palpation. There is a tendency to constipation. Urination is free, painless, non-frequent. The symptom of striking is negative on both sides. According to the immunograms, phagocytosis is 16 nF% (normal - 30-90 nF%), loading index 0.8 (normal - 2-5), immunoglobulins M, G, and A were not detected, the number of undifferentiated lymphocytes (O-lymphocytes) increased up to 32% (normal - up to 12%), white blood cells - 4 • 10 ⁹ d / l (normal - 4 • 10 ⁹ - 10 • 10 ⁹ d / l), all other indicators are on the lower border of the norm.

Considering the lack of effect from allopathic therapy, the increase in intoxication symptoms, it was decided to start therapy with autologous blood in a 6K potency daily, parenterally, 8 drops per 1/2 piece of sugar with weekly preparation of a new autonomozod. 2 hours after the first dose of the drug, the patient noted exacerbation of weakness, severe internal anxiety, sweating, fever up to 37.6 ^o C. The period of the primary drug reaction lasted for 3 days. From the fourth day of therapy, weakening of the general symptoms and an increase in local (pain) was observed in accordance with Goering's law. Immunity indicators improved simultaneously with positive changes in clinical symptoms - phagocytosis - 64 nf%; load index - 1.6; IgG - 9.0 g / l (normal - 6-18 g / l): IgA - 1.95 g / l (normal - 1-5 g / l); the number of O-lymphocytes decreased to 23%; the number of total and active T-lymphocytes increased. This therapy was continued for 3 months with a 7-day forced break (the patient was leaving for family reasons), which led to a short-term deterioration in the general condition and immunity indices. This deterioration was quickly eliminated with the resumption of therapy with autonomous blood. After 3 months of treatment, the woman considers herself healthy, has passed weakness, chills have disappeared, weight has recovered, temperature has returned to normal, immunity indicators are stably consistent with normal values. The patient was monitored for a year. Her condition and well-being remained consistently good. There are no repeated calls.

 Example 2. Patient M., 24 years old, suffers from genital herpes from 22 years (within 2 years at the time of treatment). The last year marks monthly exacerbations associated with menstruation, clinically manifested as burning in the vagina and vulva, vesicles on the inner surface of the labia minora. Among the diseases noted, chickenpox, mumps, tonsillitis (at 14 years old), SARS, flu (1 time in 2-3 years). Menses from 13 years, established immediately for 4-5 days after 27-28 days, moderate, painful on the first day, regular. Sexual life since 19 years old, single. There were no pregnancies. It is protected from pregnancy with a condom. Gynecological diseases transferred: at the age of 19 - acute gonorrhea and trichomoniasis, about which antibacterial therapy was carried out, the positive effect of which was confirmed by negative results of bacterioscopic examination after three provocations. An objective study showed general and gynecological status — without features, indicators of clinical blood and urine tests within normal limits, vaginal purity — the second, cytological findings revealed cell-specific changes in the herpes virus.

 Therapy with autologous blood was started on the 10th day of the menstrual cycle in the absence of visible clinical signs of genital herpes in 6K potency (with a subsequent increase in potency: 12K and 30K). The patient received 8 drops dissolved in two tablespoons of boiled water. Autonozode was produced weekly. On the third day of therapy, herpetic eruptions appeared over 4 days (usually the manifestations of herpes in this patient were clearly associated with menstruation). Herpetic eruptions that appeared during the next menstruation were accompanied by insignificant in relation to the usual clinical manifestations. After a month with menstruation, there were no clinical manifestations of herpes, but cytological signs persisted. After 3 months from the start of treatment, the cytological signs of herpes infection disappeared. During the control period, which lasted 8 months, the patient did not observe clinical manifestations of genital herpes, and with a triple cytological examination, specific hermetic cellular changes were not found.

 Example 3. Patient K., 25 years old, turned 14.09.94, with complaints of aching pain in the lower abdomen, worse after menstruation. From the anamnesis it is known: heredity is not burdened, allergoanalysis without features. Past diseases: measles, rubella, acute respiratory viral infections, influenza, appendectomy at age 12. Menses from 14 years, established immediately for 4-5 days after 26-28 days, moderate, painful on the first day, regular. Sex life since 19 years, married. Pregnancy - 2, childbirth - 1, artificial abortion - 1 in the period of 8-9 weeks. Childbirth and abortion were not accompanied by complications. Gynecological diseases: cervical erosion after childbirth, for which cryodestruction was performed. The history of this disease: considers himself ill for 3 years, when the aching pain for the first time appeared in the lower abdomen. I turned to the antenatal clinic, where she was diagnosed with subacute salpingoophoritis. The patient was hospitalized and underwent a course of antibacterial, desensitizing anti-inflammatory therapy and physiotherapy. After 2 months, the pain in the lower abdomen again resumed. The hospital treatment of chronic salpingo-oophoritis with a short-term effect was repeatedly carried out. In October 1993, she was examined for chlamydia, which was detected. Repeatedly underwent treatment for chlamydia without significant effect.

 An objective examination of the general status without features. With bimanual gynecological examination, appendages on both sides are heavy, sensitive to palpation. Chlamydia was detected in a smear from the cervical canal using an immunofluorescence reaction. The titer of specific chlamydial IgG was 1: 128.

 The patient underwent a course of treatment with autonomozodes with triple preparation of a new autonomozoda. The patient took the drug daily, 8 drops under the tongue, or dissolved this amount in 2 tablespoons of boiled water at room temperature. The pain syndrome went through 10 days of therapy. At the end of the course of chlamydia in the smear was not detected, the titer of specific antibodies was less than 1:32. Chlamydia was not detected during control studies performed on the 6-7th day of the menstrual cycle for 3 months.

 The examples show that the proposed method is a highly effective therapeutic method for the treatment of viral and chlamydial infections.

Claims (1)

 A method for the treatment of viral and chlamydial infections of urogenital location and chronic non-specific inflammatory diseases of the pelvic organs and their complications, accompanied by a decrease in the resistance of the immune system, comprising administering to the patient a blood preparation in gradually increasing doses and an administration interval of 2 to 4 days, characterized in that the blood preparation is administered orally in the form of an autonozode in the form of drops daily at a strictly defined time - the time of blood sampling for the manufacture of an autonozode.