RU2147242C1 - Method for treating the cases of tobacco smoking - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves injecting liquid aloe extraction. Maximum treatment course duration is 6-7 days. The treatment is indicated to wide set of patients. Paired and symmetric injections are administered into patient posterior stomatopharynx wall submucosa. The procedure is done at least twice with 2-3 days pause. Drug dose is 0.5-1.0 ml per each injection. EFFECT: quickly manifested therapeutic effectiveness; no contraindications found.

Description

 The invention relates to medicine, and specifically to medicinal preparations from plants for therapeutic purposes.

 A number of drugs are known for the treatment of tobacco smoking, for example, gamma-pyrone (US Pat. No. 4,276,890, class 131/270, 1981), various pharmaceutical compositions (US Pat. No. 5,643,905, class 514/215, 1997, EP 0680326, A 61 K 31/55, 1995, WO 9300083, A 61 K 31/19, 1993).

 Also known are drugs that, when created for other purposes, are used as a treatment for smoking, for example, galantamine (patent WO 9416708, A 61 K 31/55, 1994), 2-pyrimidinyl-1-piperazine (US patent N 4871738, CL 514/252), 3,5-diamino-6- (2,3-dichlorophenyl) -1,2,4-triazine (RF application N 94046273, A 61 K 31/53, 1993) Cotinine preparation (US Pat. No. 5,612,357, CL 514/343, 1997 and US Pat. No. 5,747,512, CL 514/343, 1998).

 The therapeutic effect of the use of these drugs is low, and the duration of the course of treatment is very long (3-6 months).

 All of the above drugs are chemically synthesized substances, the introduction of which into the human body may be accompanied by undesirable side effects.

 There are a sufficient number of contraindications to the use of these drugs, and therefore, not everyone who wants to stop smoking can be treated with the use of these drugs.

 Medicines based on nicotine are also known, for example, Nicorette chewing gum (Karon B.I. Modern views on tobacco control // Military Medical Journal. - 1988. - N 8. - P. 66-68) and transdermal patches (Rose at all. // Clin. Pharmacol. Ther. - 1985. - N 38. - P. 450-456).

 These agents can also cause a variety of undesirable side effects, require a long course of treatment, and have low efficacy.

 Closest to the proposed invention is a tool "Antinik" (US Pat. RF N 2066196, A 61 K 35/78, 1995) on a plant basis. The tool includes two compositions of collections of medicinal plants and has virtually no contraindications.

 The use of this agent through the gastrointestinal tract in the form of tea or a food supplement to various dishes is associated with the destruction of many active components by its gastric enzymes, which weakens the therapeutic effect.

 The second disadvantage of this tool is a very long course of treatment - 3-4 months, which requires high self-discipline from the patient. The lack of a quick result in treatment contributes to the emergence of distrust in many patients of the effectiveness of Antinika and the rejection of its use.

 An object of the present invention is to provide an effective plant-based product for a sufficiently rapid treatment of tobacco smoking (treatment duration is 3-6 days).

 The problem is solved by the use of liquid aloe extract for injection as a means for the treatment of smoking.

 Aloe extract liquid for injection (Extractum Aloes fluidum pro injectionibus) is a well-known biogenic stimulant, which is an aqueous extract of crushed aloe leaves, preserved in the dark at certain temperatures. Transparent sterile liquid from light yellow to yellowish red, bitter taste; pH 5.0-6.0. Manufactured in ampoules of 1 ml.

 It is used in the treatment of a number of eye diseases, peptic ulcer and duodenal ulcer, bronchial asthma and other diseases (MD Mashkovsky. Medicines: Pharmacotherapy manual for doctors. Part 2. - 8th ed., Revised and additional . - M .: Medicine, 1978. - S. 101).

 Aloe extract is a complex physicochemical compound with a large number of microelements, the chemical-biological mechanism of the effect of the drug on the human body during the treatment of smoking has not been investigated, and therefore it is impossible to indicate an essential feature of this drug, providing a therapeutic effect according to the present invention.

 The use of liquid aloe extract for injection as a means for the treatment of smoking is carried out by pairwise and symmetric injection of the drug into the submucosa of the posterior oropharynx of the patient. This procedure is carried out by a known method at least twice with an interval of 2-3 days. The dose of the drug per procedure is 0.5-1.0 ml, depending on the length of smoking, gender and weight of the patient.

 Examples of the use of liquid aloe vera injectable as a treatment for smoking are described in the following case reports.

 Example 1. Patient F., 55 years old, weight 87 kg, smoking experience 32 years. The last 4 years he smoked 50 cigarettes a day. According to the well-known technique, on April 5, 1994, a pair symmetric injection of Extr was made. Aloes fluidi 1.0 to the submucosa of the posterior wall of the oropharynx. Two hours after the injection, the patient developed an unexpressed feeling of nausea with second-hand smoke, which persisted for 2 days. The craving for smoking was significantly reduced, but not completely, but was overcome by the patient with some effort. On April 8, 1994, the patient underwent a second treatment session using the same method. After 4 hours, the patient's craving for smoking almost completely disappeared, and the feeling of nausea with second-hand smoke intensified. The patient is under observation. Until now, she has not smoked, and over the years has felt an increase in aversion to smoking and the smell of tobacco smoke. There are no complications.

 Example 2. Patient K., 28 years old, weight 48 kg, smoking experience 11 years, smoked 20 cigarettes per day. According to the well-known method, on May 13, 1996, a pair symmetric injection of Extr was made. Aloes fluidi 0.5 to the submucosa of the posterior wall of the oropharynx. Craving for smoking after injection did not decrease, but the number of cigarettes smoked in the next two days decreased to 3 to 4 pieces per day. On May 15, 1996, the patient received a second treatment session using the same method. After 2 hours I felt a slight muscle pain during movements, which lasted 1.5 - 2 hours. There was an aversion to tobacco smoke. There was no desire to smoke, but the patient, deciding to check the effectiveness of the treatment, made an attempt to smoke a cigarette. After the second puff, there was a feeling of nausea followed by a single vomiting. A day later, there was a faint desire to smoke, as reported by the attending physician. On the same day, the patient underwent a third treatment session using this method. Three days later, the craving for smoking disappeared completely. To date, does not smoke. There are no complications.

 The use of liquid aloe extract for injection as a means for the treatment of smoking provides a quick therapeutic effect in the vast majority of patients. The duration of treatment is 3-6 days, depending on the length of smoking and the patient's gender. The practical absence of contraindications makes it possible to cover a wide range of patients with treatment.

Claims (1)

 The use of liquid aloe extract for injection as a means for the treatment of smoking.