RU2112536C1 - Medicinal agent for treating endocervicitis - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: agent is made in the form of suppositoria based on lipid complex with bagasse of European cranberrybush fruits introduced twice a day by a single suppository for 10-12 days. Suppositoria possess antiinflammatory action. EFFECT: reduced treatment duration. 1 tbl

Description

 The invention relates to medicine, in particular to means for treating inflammation of the mucous membrane of the cervical canal of the uterus.

 It is known to use antibiotic therapy for the treatment of endocervicitis, namely broad-spectrum antibiotics [1, 2]. Antibiotics are prescribed in an individual dosage of a course of 10 days, depending on the nature and course of the disease, the effectiveness and tolerability of the drug.

 The disadvantage of antibiotic treatment is the need for long-term administration of the drug, because premature cessation of admission can lead to the resumption of the chronic process, up to maceration and desquamation of the uterine epithelium. In some cases, nausea, vomiting, and diarrhea develop. Allergic reactions are possible.

 Known agent for the treatment of endocervicitis [3] in the form of rectal suppositories weighing 1.4 g prepared on the basis of ichthyol (0.2 g) and suppository base (1.2 g). Candles are administered daily in the morning and evening for a month. The disadvantage of this tool is its low efficiency.

 An object of the invention is to reduce the duration of treatment, expanding the range of herbal medicines.

 This goal is achieved by using vaginal and rectal suppositories based on the lipophilic fraction of pulp of common viburnum fruit, administered 2 times a day, one suppository vaginally or rectally for 10-12 days.

 The candles were prepared by pouring a suppository mass consisting of a suppository base (Supporin M) and a lipophilic fraction of pulp of common viburnum fruit, obtained by degreasing vegetable raw materials, crushed to a particle size, passing through a sieve with a hole diameter of 2 mm, with Nefraks food gasoline in the ratio raw material extractant 1:10 for 6 hours, followed by distillation of the extractant, the ratio of base and lipophilic fraction: 1, the mass of candles 3.0 g.

 Suppositories were used as an element of complex therapy in 15 patients suffering from endocervicitis, the age of patients from 18 to 35 years.

 The criteria for establishing a diagnosis and evaluating the effectiveness of treatment were the data of objective research, hematological, bacteriostatic studies, as well as subjective feelings of patients. The course of therapy in this group included antibacterial drugs, biogenic stimulants, physiotherapy, prodigiosan.

 Patients received one suppository containing 10–17% of the lipophilic fraction of pulp of the guelder-rose ordinary 2 times a day vaginally or rectally for 12 days. All patients tolerated the tested drugs well. In no case have any clinically or laboratory revealed any local or general adverse reactions or complications. At the same time, the therapeutic activity of the test candles with endocervicitis, in particular their anti-inflammatory effect, was revealed. In the tested patients, a faster and more stable decrease in negative manifestations or complete normalization of the data of objective gynecological examination, as well as stabilization of laboratory parameters, ultrasound and endoscopic tests, were noted.

Example 1. Patient H., 24 years old. Diagnosis: endopervicitis. She received complex therapy, including prodigiosan, antibacterial drugs, biogenic stimulants, physiotherapeutic treatment, 1 suppository was administered containing 0.3 g (10%) of the lipophilic fraction of pulp of Viburnum ordinary fruit 2 times a day for 12 days. At the end of treatment, a clear positive trend was noted - a decrease in pain, an improvement in objective treatment indicators (see table)
Example 2. Patient K., 30 years old. Diagnosis: cervical erosion. The disease lasts about 8 months. She received complex therapy, including prodigiosan, biogenic stimulants, physiotherapy and suppositories containing 0.5 g (17%) of the lipophilic fraction of pulp beet pulp ordinary, 1 candle 2 times a day, for 12 days. A control study showed a decrease in the inflammatory process at the end of the course of treatment.

 - data from a gynecological examination revealed a clear positive trend (see table).

 Thus, suppositories containing the lipid complex of pulp of Viburnum ordinary fruit in an amount of 10 - 17% (0.3 - 0.5 g) have a clear therapeutic effect in the treatment of inflammatory processes of the female genital organs and can be recommended for widespread use in gynecological practice.

Bibliography
1. Vorobyev A.I. Handbook of a practitioner. - M .: Medicine, 1982, p. 378 - 379.

 2. Mashkovsky M.D. Medicines - M .: Medicine, 1993, t. II, p. 247, 258, 259, 263, 265, 266, 271, 296.

 3. Mashkovsky M.D. Medicines - M .: Medicine, 1993, t. II, p. 480.

Claims (1)

An agent for the treatment of endocervicitis containing a lipophilic suppository base and an active substance of natural origin, characterized in that the lipophilic fraction of beet pulp of common viburnum is used as the active substance in the following ratio, wt.%:
Lipophilic fraction of pulp of the fruits of viburnum ordinary - 10 - 17
Lipophilic suppository base - up to 100

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