RU2078561C1 - Cosmetic agent for preventing skin aging - Google Patents

Abstract

FIELD: cosmetology, particularly, biocremes for prevention skin aging. SUBSTANCE: cosmetic agent contains ferment preparation of pancreatin and hyaluronic acids as active ingredients. As fat base are used hydrogenated cotton oil, olive oil, and glycerin, while as preservative, antiseptic and oxidant are used sodium benzoate, zinc oxide and α-tocopherol. Ratio of ingredients is the following, mas.%: hydrogenated cotton oil, 25-27; olive oil, 12-17; hydrolyne, 6-8; glycerin, 6-8; zinc oxide, 2-3; α-tocopherol, 0.1-0.2; sodium benzoate, 1-2; pancreatin, 0.1-0.2; hyaluronic acid, 0.5-1; flavor, 1-1.5; water, up to 100. EFFECT: higher efficiency.

Description

 The invention relates to cosmetology, and in particular, to a cosmetic product in the form of bio-cream that prevents skin aging.

 Known cosmetic anti-aging agents containing as active ingredients various antibiotics, sulfonamides, corticosteroids and other compounds. However, these funds in some cases have a negative effect on the skin, causing allergic and other congestion phenomena.

 In recent years, enzyme preparations of various spectrum of action are increasingly being introduced into cosmetics for aging skin.

 Closest to the claimed, adopted as a prototype, is the composition of the cosmetic product in the form of bio-cream that prevents skin aging, containing as an active ingredient 2-5% transglutaminase enzyme distributed in a fat basis / lanolin, petrolatum, glycerin / and also including calculated amounts of preservatives / nipagin, nipazole /, antiseptics / various antibiotics /, antioxidants / β ionol /, perfumes and water.

 The disadvantages of the known bio-cream is that the transglutaminase enzyme included in it does not have a specific depolymerizing effect on the structure of the collagen molecule, which is largely responsible for skin aging processes, which necessitates the introduction of this enzyme in high concentrations / 2 5% /. In addition, the inclusion of Vaseline (about 30) in the composition of the fat base worsens the rheological and thixotropic characteristics of biocream, its digestibility when applied to the skin.

 It should also be noted that the action of the known bio-cream is of a short-term nature due to the rapid destruction of the enzyme, as a result of which it is necessary to use this agent at least 3-4 times a day.

 The invention solves the problem of creating a highly effective cosmetic product in the form of a cream that prevents skin aging, has a prolonged effect and does not cause side effects.

This result is achieved through the use of pancreatin and hyaluronic acid / HA / as an active ingredient in the enzyme preparation (using the domestic HA preparation called "Giallux" according to TU 9185-003-17204830-93), introducing hydrogenated cottonseed oil / GCM into the fat base /, olive oil, hydroline and glycerin and use as a preservative, antiseptic and antioxidant, respectively, sodium benzoate, zinc oxide and a tocopherol / in the form of a pharmacopoeial 10% solution of tocopherol acetate one containing 100 mg / ml synthetic tocopherol acetate. In this case, the ratio of components in wt. make up:
GCM 25 27
Olive oil 12 17
Hydroline 6 8
Glycerol 6 8
Zinc Oxides 2 3
a-tocopherol 0.1-0.2
Sodium benzoate 1 2
Pancreatin 0.1 -0.2
Hyaluronic acid 0.5 1
Fragrances 1 1.5
Water up to 100
The claimed composition of the cosmetic product has advantages over the known one in that the preparation pancreatin is a complex of pancreatic enzymes in slaughtered animals / 9 /, including proteases / chirotripnin, trypsin and lipases, which have a pronounced anti-inflammatory, wound healing and tissue regenerating effect, which allows you to use it in low concentrations / 0.1-0.2% /.

 The absence of vaseline in the inventive cream and the introduction of GCM in the fat base in combination with olive oil and glycerin significantly increase its bioavailability and storage stability. These properties are especially enhanced by introducing into the base, instead of the usual lanolin, a hydroline of a domestic product obtained by hydrogenation of lanolin and characterized by a higher emulsifying ability.

 As for the other components of the claimed drug, the inclusion of zinc oxide as an antiseptic in it, and tocopherol as an antioxidant and sodium benzoate as a preservative is due to their pronounced specific properties, confirmed by the results of many years of pharmacological and clinical trials, complete harmlessness and economic factors.

 Particular attention should be paid to the use of a combination of pancreatin and HA in the cream. The logical nature of this combination is primarily due to the fact that the depolymerizing effect of the enzyme on the native collagen configuration is of short duration, due to which technical solutions aimed at transdermal use of pancreatin were not known until now, and its use was limited only by oral administration in the treatment of pancreatitis and related diseases.

 At the same time, HA, which is a high molecular weight polysaccharide, acts as a prolongator of pancreatin action, which allows to reduce the use of the claimed drug up to once in the grid.

 However, the role of HA is not limited to the creation of a “depot” of the enzyme. It is known that HA regulates the homeostasis system in connective tissues, prevents the excessive secretion of hyaluronidase and, thus, has a rejuvenating and anti-inflammatory effect.

 However, it should be emphasized that in order to achieve such an effect, strict adherence to both quantitative ratios of active ingredients and auxiliary agents in the claimed composition is necessary. With a decrease or increase in the mass ratio of pancreatin and HA, a change in one direction or another of the content of the components of the fat base, antiseptic, antioxidant, preservative and perfume, the optimal effect of the cream on aging skin is not achieved, its stability during storage decreases, and the appearance worsens.

 The technological aspects of obtaining a cosmetic product are also important. To obtain a cream that meets modern requirements, fat components are introduced into its composition according to the recipe, which are homogenized during melting, after which the aqueous phase containing the dissolved or suspended active ingredients, antiseptic, preservative is gradually added, the mixture is cooled to room temperature, homogenized and aromatized.

 The invention is illustrated by the following examples of its implementation.

Example 1. The mixture / wt./ 25 GCM, 12 olive oil, 6 hydrolin, 6 glycerol and 0.1 a tocopherol straighten in a water bath at 45 50 ^o . A suspension of 1 sodium benzoate, 0.1 pancreatin, 0.5 GK in a small amount of water is prepared separately, 2 zinc oxides are added, the suspension is poured in portions with stirring into the fat base, the mixture is diluted with water to 100, cooled to room temperature, 1 perfume is added , cream mass is homogenized and packaged in jars.

 The resulting cream has a pleasant appearance and smell, is easily absorbed, has a positive effect on aging skin of the face and neck, expressed in smoothing wrinkles, reducing peeling of the skin and eliminating inflammation when applied with a thin layer 1 time per day, does not cause side effects with prolonged use .

Example 2. Into a mixture (w / w) of 26 GCM melted at 45 ^{° to} 50 ^° , 15 olive oils, 7 hydrolytes, 7 glycerol and 0.15 α-tocopherol, an aqueous suspension containing 1.5 sodium benzoate is added in portions with stirring. 15 pancreatin, 0.75 HA and 2.5 zinc oxides, the mixture is diluted with the remaining amount of water to 100, cooled to room temperature, 1.25 perfumes are added, the cream mass is homogenized, packaged in jars and a cream is obtained with properties similar to example 1 .

Example 3. Into the mixture molten at 45 ^{° to} 50 ^° C / wt. / 27 GCM, 17 olive oils, 8 hydrolytes, 8 glycerol and 0.2 alpha tocopherol, an aqueous suspension containing 2 sodium benzoates, 0.2 pancreatin is added in parts with stirring , 1 HA and 3 zinc oxides, the mixture is diluted with the remaining amount of water to 100, cooled to room temperature, 2 perfumes are added, the cream mass is homogenized, packaged in jars and a cream is obtained with properties similar to example 1.

 The results of a comparative analysis of the technical and economic indicators of the known and claimed cosmetic products obtained by triple testing the analyzed samples in experiments in vivo and in vivo are presented in the table.

 T. about, the claimed cosmetic product differs from the known higher rheological characteristics and greater stability during storage. Despite a decrease in the concentration of the enzyme by a factor of 20, the claimed cream has a more prolonged effect and can be applied to the skin only 1 time per day, while there are no side effects associated with its use.

Claims (1)

 Anti-aging bio-cream cosmetic product, including an enzyme as an active ingredient, a fat base, preservative, antioxidant, antiseptic, perfume and water, characterized in that it contains pancreatin as an enzyme, hydrogenated cottonseed oil, olive oil as a fat base , the hydrolysis product of lanolin, hydroline and glycerin, and as a preservative, antiseptic and antioxidant, respectively, sodium benzoate, zinc oxide and alpha-tocopherol and additionally it contains hyaluronic islotu the following component ratio, wt. Hydrogenated Cottonseed Oil 25 27
Olive oil 12 17
Hydroline 6 8
Glycerin 6 8
Zinc oxide 2 3
alpha tocopherol 0.1 0.2
Sodium benzoate 1 2
Pancreatin 0.1 0.2
Hyaluronic acid 0.5 1.0
Fragrance 1.0 1.5
The rest of the water

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