RU2071321C1 - Method of prophylaxis of white-muscle calf disease - Google Patents

Abstract

FIELD: veterinary science. SUBSTANCE: method involves administration of a mixture consisting of sodium selenite (7-10 mg), thiamine (100-150 mg) and niacin (50-100 mg) to newborn calves orally, twice at the age 24 h and 5 days. EFFECT: enhanced effectiveness of method.

Description

 The invention relates to veterinary medicine, and in particular to methods of preventing white muscle disease of farm animals.

 A known method for the prevention of white muscle disease by daily feeding to animals feeding, containing 0.1 mg / kg of selenium in the form of sodium selenite. Sodium selenite is mixed with grain sap.

 There is also known a method of injection of a solution of sodium selenite in a dose of 2-3 mg / kg body weight and vitamin E 136-750 I.E.

 A disadvantage of the known methods is the lack of effectiveness of disease prevention.

 The closest in technical essence and the achieved result (prototype) to the proposed technical solution is the oral administration of sodium selenite at a dose of 0.05 mg / kg body weight and 50 mg of niacin per lamb. The disadvantage of this method is lower efficiency than the proposed one.

 Comparative studies of the myocardium and skeletal muscle of patients with white muscle disease and healthy calves showed that the key pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase complexes in the Krebs cycle have a deficiency of thiamine pyrophosphate and nicotinamide adenine dinucleotide co-enzymes, the synthesis of which is the precursor of thiamine and niamine.

 The invention is aimed at solving the problem of improving the prevention of white muscle disease in farm animals.

 To achieve this goal, in a known mixture, which includes sodium selenite and niacin, according to the invention, thiamine is administered orally at a dose of 100-150 mg in combination with sodium selenite at a dose of 7-10 in addition to newborn calves mg and niacin in a dose: 50-100 mg.

 Doses of injected drugs are known, sodium selenite is used at a dose of 0.3 mg per 10 g of live weight (see Slanina L. Elechka I. et al. Prince. Health and morbidity of calves in industrial production M. Urajay, 1982, p. 286- 290). Niacin is administered at a dose of 50-100 mg per calf (see Mozgov I.E. Pharmacology, Publishing House Kolos; 1985, p. 218-220).

 Thiamine is used intramuscularly at a dose of 50-100 mg to calves, and 1.5 times more by mouth (see Karput IM et al. Prince. Non-communicable diseases of young animals. Mn. Urajay, 1989, p. 163).

 The method is illustrated by the following examples.

 Example 1. Tests were performed on 640 calves. Each cow from the second half of pregnancy was injected subcutaneously with a 0.5% aqueous solution at a dose of 40-50 mg of sodium selenite every 40-50 days and the injections were stopped 14-20 days before calving. Newborn calves were divided into two groups. A mixture in the form of a powder in the form of a powder of 7-10 mg of sodium selenite, 10) -150 mg of thiamine and 50-100 mg of niacin was administered orally to each calf of one group (experimental) twice a day at the age of 5 days. The calves of the second group (control) were orally administered (prototype) sodium selenite at a dose of 0.05 mg / kg body weight and 50 mg of niacin per calf, with a repetition after 20 days.

 Fell from white muscle disease in the control group of 13 calves, and in the experimental group 3 calves. The prevented damage under the new option amounted to 19.37 rubles. on the calf (see the act of production verification of the method).

 Example 2. Tests were performed on 600 calves. Each cow from the second half of pregnancy was injected subcutaneously. A 0.5% aqueous solution at a dose of 40-50 mg of sodium selenite every 40-50 days and the injection was stopped 14-20 days before calving. Newborn calves were divided into two groups. A mixture in the form of a powder of 7-10 mg of sodium selenite, 100-150 mg of thiamine and 50-100 mg of niacin was administered orally twice to each calf of one group (experimental) twice a day at 5 days of age. The calves of the second group (control) were injected subcutaneously with an aqueous solution of 0.1% sodium selenite at a dose of 4 mg and vitamin E at a dose of 30 mg, with repetition after 20 days. Fell from white muscle disease in the control group of 13 calves, and in the experimental group 3 calves. The prevented damage under the new option amounted to 18.61 rubles per calf. The proposed method is most effective in the prevention of white muscle disease in animals. In this disease, in addition to the violation of the antioxidant protection of body cells, there is a violation of the pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase complexes, due to a lack of thiamine and niacin. The introduction of thiamine in combination with niacin and sodium selenite normalizes metabolic processes in the body preventing the development of the disease.

Claims (1)

 A method for the prevention of white muscle calf disease, comprising introducing into the body a mixture in the form of a powder of sodium selenite and niacin, characterized in that the mixture additionally contains thiamine in a dose of 100 to 150 mg, and its administration to animals is carried out twice in a day and five days old.