RU2053814C1 - Method for treatment of local endobronchitis - Google Patents
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- RU2053814C1 RU2053814C1 SU5026877A RU2053814C1 RU 2053814 C1 RU2053814 C1 RU 2053814C1 SU 5026877 A SU5026877 A SU 5026877A RU 2053814 C1 RU2053814 C1 RU 2053814C1
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Изобретение относится к медицине, а именно к пульмонологии и торакальной хирургии, и может быть использовано для лечения острых и хронических воспалительных бронхолегочных заболеваний. The invention relates to medicine, namely to pulmonology and thoracic surgery, and can be used to treat acute and chronic inflammatory bronchopulmonary diseases.
Известен способ эндобронхиального введения аутологичных макрофагов после их предварительной адгезии и инкубации на среде N 199 в течение 4-8 дней (Чучалин А. Г. Белевский А. С. Трескунов В. К. и др. Аутологичные макрофаги в комплексной терапии больных хроническими обструктивными заболеваниями легких. (Сов. медицина, 1984, N 11, с. 31-34). There is a method of endobronchial administration of autologous macrophages after their preliminary adhesion and incubation on medium N 199 for 4-8 days (Chuchalin A.G. Belevsky A.S. Treskunov V.K. et al. Autologous macrophages in the complex treatment of patients with chronic obstructive diseases lungs (Sov. medicine, 1984, N 11, pp. 31-34).
Недостатки способа сложность методики, длительность инкубации, потери клеточного материала в процессе его выделения из крови, старение клеток и снижение их функциональной активности, отсутствие в трансплантирующем субстрате секреторных иммуноглобулинов и сурфактанта. The disadvantages of the method are the complexity of the method, the duration of the incubation, the loss of cellular material in the process of its isolation from the blood, the aging of cells and a decrease in their functional activity, the absence of secretory immunoglobulins and surfactant in the transplanting substrate.
Задачей изобретения является создание более эффективного и простого способа лечения эндобронхита, который позволяет сократить сроки лечения. The objective of the invention is to create a more effective and simple method for the treatment of endobronchitis, which allows to reduce treatment time.
Эта задача решается путем стимуляции защитных механизмов в донорском участке монохроматическим светом низкоэнергетического гелий-неонового лазера и последующей трансплантации в пораженную зону после ее промывания 0,85%-ным раствором хлорида натрия комплекса активированных защитных легочных факторов и сурфактанта, полученных с помощью селективного бронхоальвеолярного лаважа одного из сегментов донорского участка. This problem is solved by stimulating the protective mechanisms in the donor site with monochromatic light of a low-energy helium-neon laser and subsequent transplantation into the affected area after washing it with a 0.85% sodium chloride solution of a complex of activated protective pulmonary factors and surfactant obtained using selective bronchoalveolar lavage of one from segments of the donor site.
Новизна способа заключается в одномоментной трансплантации всего комплекса защитных легочных факторов, стимулированных облучением низкоэнергетическим гелий-неоновым лазером. The novelty of the method lies in the simultaneous transplantation of the entire complex of protective pulmonary factors stimulated by irradiation with a low-energy helium-neon laser.
Лазерная стимуляция активности защитных легочных факторов донорского участка и замещение всего защитного комплекса, отсутствующего в пораженной зоне, значительно повышают эффективность способа. Исключение фракционирования субстрата и длительность инкубациии макрофагов упрощает методику и сокращает сроки лечения. Laser stimulation of the activity of protective pulmonary factors of the donor site and the replacement of the entire protective complex, which is absent in the affected area, significantly increase the efficiency of the method. The exclusion of fractionation of the substrate and the duration of the incubation of macrophages simplifies the technique and shortens the treatment time.
В результате лечения у всех пациентов с острой пневмонией, осложненной ателектазом, в течение 3-4 дней отмечено расправление легочной ткани, у всех больных с нехирургическими формами ХНВЗЛ полностью исчезли признаки эндобронхита, значительно снизилась активность воспалительного процесса и адгезивные свойства секрета у пациентов с бронхоэктазами. По сравнению с прототипом уменьшилось количество эндобронхиальных процедур с 2-6 до 1-2, сократились сроки лечения с 12-20 до 4-12 дней. В процессе лечения антибактериальная терапия и ингаляционные процедуры не применялись. As a result of treatment, in all patients with acute pneumonia complicated by atelectasis, a spreading of lung tissue was noted within 3-4 days, in all patients with non-surgical forms of chronic obstructive pulmonary disease, the signs of endobronchitis completely disappeared, the inflammatory process and adhesive properties of the secret decreased significantly in patients with bronchiectasis. Compared with the prototype, the number of endobronchial procedures decreased from 2-6 to 1-2, the treatment time was reduced from 12-20 to 4-12 days. During treatment, antibiotic therapy and inhalation procedures were not used.
Способ осуществляют следующим образом. The method is as follows.
Во время бронхоскопии устья сегментарных бронхов донорского участка без признаков эндобронхита облучают светом низкоэнергетического гелий-неонового лазера с выходной мощностью 10-15 мВт при длине волны 630 нм и экспозиции 1 мин. Трансплантат получают путем селективного бронхоальвеолярного лаважа стерильным 0,85%-ным раствором хлорида натрия одного из сегментарных бронхов донорского участка. Субстрат селективно вводят в бронхи пораженной дозы с помощью одноразового шприца через силиконизированный катетер после их промывания 0,85% -ным раствором хлорида натрия. В случае необходимости процедуру можно повторить. During bronchoscopy, the mouths of segmental bronchi of a donor site without signs of endobronchitis are irradiated with a low-energy helium-neon laser with an output power of 10-15 mW at a wavelength of 630 nm and an exposure of 1 min. The graft is obtained by selective bronchoalveolar lavage with a sterile 0.85% sodium chloride solution of one of the segmental bronchi of the donor site. The substrate is selectively injected into the bronchi of the affected dose using a disposable syringe through a siliconized catheter after washing with a 0.85% sodium chloride solution. If necessary, the procedure can be repeated.
Клинический пример 1. Больная В. 2,5 г. Диагноз: Острая сегментарная пневмония, осложненная ателектазом средней доли правого легкого, затяжное течение. В течение 1,5 мес получала антибиотики без эффекта. При бронхоскопии 13.07.91 г. выявлен катаральный эндобронхит ll ст. интенсивности в средней доле правого легкого, региональная капнография показала резкое снижение газообмена в средней доле. Устья бронхов верхней доли правого легкого облучены через стандартную оптическую систему светом гелий-неонового лазера ЛГ-52-2и с выходной мощностью 10 мВт при длине волны 630 нм в течение 1 мин. Селективный бронхоальвеолярный лаваж С2 правого легкого 40 мл 0,85% раствора хлорида натрия, в силиконизированную ловушку аспирировано 20 мл трансплантата. Субстрат одноразовым шприцем введен через силиконизированный катетер в сегментарные бронхи средней доли правого легкого, которые предварительно промыты 30 мл 0,85% раствора хлорида натрия. При контрольной рентгенографии 16.07.91 г, ателектаз средней доли не обнаружен, контрольная бронхоскопия показала отсутствие эндобронхита и восстановление газообмена в средней доле правого легкого.Clinical example 1. Patient C. 2.5 g. Diagnosis: Acute segmental pneumonia complicated by atelectasis of the middle lobe of the right lung, prolonged course. For 1.5 months received antibiotics without effect. When bronchoscopy 07/13/91, revealed catarrhal endobronchitis ll st. intensities in the middle lobe of the right lung; regional capnography showed a sharp decrease in gas exchange in the middle lobe. The mouths of the bronchi of the upper lobe of the right lung are irradiated through a standard optical system with the light of a LG-52-2i helium-neon laser with an output power of 10 mW at a wavelength of 630 nm for 1 min. Selective bronchoalveolar lavage C 2 of the right lung of 40 ml of a 0.85% sodium chloride solution, 20 ml of the graft are aspirated into a siliconized trap. The substrate is injected with a disposable syringe through a siliconized catheter into the segmental bronchi of the middle lobe of the right lung, which are pre-washed with 30 ml of a 0.85% sodium chloride solution. During the control radiography of July 16, 91 g, atelectasis of the middle lobe was not detected, control bronchoscopy showed the absence of endobronchitis and restoration of gas exchange in the middle lobe of the right lung.
Клинический пример 2. Больная Д, 9 л. Диагноз: ХНВЗЛ с деформацией бронхов нижней доли левого легкого, затяжное обострение. При бронхоскопии 23.7.91 г. выявлен гнойный эндобронхит ll ст. интенсивности слева: коэффициент экстинции этидиумбромида (КЭЭ) фракцией В бронхоальвеолярной лаважной жидкости (БАЛЖ) С9 левого легкого 75% показатель реакции с нитросиним тетразолием (НСТ-тест) 0,25 един. оптической плотности-гнойный эндобронхит с умеренной активностью микробного воспаления. Устья сегментарных бронхов базальной пирамиды правого легкого облучены через стандартную оптическую систему светом гелий-неонового лазера ЛГ-52-2 мощностью 10 мВт при длине волны 630 нм в течение 1 мин. Бронхоальвеолярный лаваж С9 правого легкого 60 мл 0,85% раствора хлорида натрия, в силиконизированную ловушку аспирировано 30 мл трансплантанта. Субстрат одноразовым шприцем через силиконизированный катетер введен в сегментарные бронхи нижней доли левого легкого, которые предварительно промыты 40 мл, 0,85% раствора хлорида натрия. После процедуры антибактериальное лечение и ингаляционная терапия не проводилась. При контрольной бронхоскопии 31.7.91 г. признаков эндобронхита не выявлено; КЭЭ фракцией в БАЛЖ С9 левого легкого 5% НСТ-тест 0,07 един. оптической плотности эндобронхита нет.Clinical example 2. Patient D, 9 l. Diagnosis: chronic obstructive pulmonary disease with deformity of the bronchi of the lower lobe of the left lung, prolonged exacerbation. When bronchoscopy 23.7.91, revealed purulent endobronchitis ll st. left intensity: extinction coefficient of ethidium bromide (CEE) fraction B bronchoalveolar lavage fluid (BALF) With 9 left lungs 75% reaction rate with nitro-blue tetrazolium (HCT test) 0.25 units. optical density-purulent endobronchitis with moderate activity of microbial inflammation. The mouths of the segmental bronchi of the basal pyramid of the right lung are irradiated through a standard optical system with the light of an LG-52-2 helium-neon laser with a power of 10 mW at a wavelength of 630 nm for 1 min. Bronchoalveolar lavage With 9 right lungs 60 ml of a 0.85% sodium chloride solution, 30 ml of the graft is aspirated into a siliconized trap. The substrate with a disposable syringe through a siliconized catheter is introduced into the segmental bronchi of the lower lobe of the left lung, which are pre-washed with 40 ml, 0.85% sodium chloride solution. After the procedure, antibacterial treatment and inhalation therapy were not carried out. During control bronchoscopy on 31.7.91, there were no signs of endobronchitis; CEE fraction in the BALJ with 9 left lung 5% HCT test 0.07 single. there is no optical density of endobronchitis.
Клинический пример 3. Больной П. 5 л. Диагноз: ХНВЗЛ с бронхоэктазами нижней доли левого легкого, обострение. При бронхоскопии 25.7.91 г. выявлен гнойный индобронхит ll ст. интенсивности слева; КЭЭ фракцией в БАЛЖ С9 левого легкого 81% НСТ-тест 0,53 един. оптической плотности-гнойный эндобронхит с высокой активностью микробного воспаления. Устья сегментарных бронхитов базальной пирамиды правого легкого облучены через стандартную оптическую систему светом гелий-неонового лазера ЛГ-52-2 с выходной мощностью 10 мВт при длине волны 630 нм в течение 1 мин. Бронхоальвеолярный лаваж С9 правого легкого 40 мл 0,85% раствора хлорида натрия, в силиконизированную ловушку аспирировано 15мл трансплантанта. Субстрат одноразовым шприцем через силиконизированный катетер введен в бронхи нижней доли левого легкого, которые предварительно промыты 40 мл 0,85% раствора хлорида натрия. После процедуры антибактериальное лечение и ингаляционная терапия не проводились. При контрольной бронхоскопии 1.8.91 г. отмечен катарально-гнойный эндобронхит ll ст. интенсивности базальной пирамиды левого легкого; КЭЭ фракции В БАЛЖ С9 левого легкого 37% НСТ-тест, 0,41 един. оптической плотности положительная динамика в сторону уменьшения активности эндобронхита.Clinical example 3. Patient P. 5 l. Diagnosis: CNFVD with bronchiectasis of the lower lobe of the left lung, exacerbation. When bronchoscopy 25.7.91, revealed purulent indobronchitis ll st. intensities on the left; CEE fraction in BALJ C9 of the left lung 81% HCT test 0.53 units. optical density-purulent endobronchitis with high activity of microbial inflammation. The mouths of the segmental bronchitis of the basal pyramid of the right lung are irradiated through a standard optical system with the light of a LG-52-2 helium-neon laser with an output power of 10 mW at a wavelength of 630 nm for 1 min. Bronchoalveolar lavage With 9 right lungs of 40 ml of a 0.85% sodium chloride solution, 15 ml of the graft are aspirated into a siliconized trap. The substrate with a disposable syringe through a siliconized catheter is introduced into the bronchi of the lower lobe of the left lung, which is pre-washed with 40 ml of a 0.85% sodium chloride solution. After the procedure, antibacterial treatment and inhalation therapy were not carried out. At control bronchoscopy on 1.8.91, catarrhal-purulent endobronchitis ll st. the intensity of the basal pyramid of the left lung; CEE fractions of BALGE C9 of the left lung 37% HCT test, 0.41 unit optical density positive dynamics towards a decrease in the activity of endobronchitis.
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-
1992
- 1992-02-11 RU SU5026877 patent/RU2053814C1/en active
Non-Patent Citations (1)
| Title |
|---|
| Ж. Советская медицина. 1984, N 1, с.31. * |
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| US7837679B2 (en) | 2000-10-17 | 2010-11-23 | Asthmatx, Inc. | Control system and process for application of energy to airway walls and other mediums |
| US7854734B2 (en) | 2000-10-17 | 2010-12-21 | Asthmatx, Inc. | Control system and process for application of energy to airway walls and other mediums |
| US8888769B2 (en) | 2000-10-17 | 2014-11-18 | Asthmatx, Inc. | Control system and process for application of energy to airway walls and other mediums |
| US8465486B2 (en) | 2000-10-17 | 2013-06-18 | Asthmatx, Inc. | Modification of airways by application of energy |
| US9033976B2 (en) | 2000-10-17 | 2015-05-19 | Asthmatx, Inc. | Modification of airways by application of energy |
| US8257413B2 (en) | 2000-10-17 | 2012-09-04 | Asthmatx, Inc. | Modification of airways by application of energy |
| US10016592B2 (en) | 2001-10-17 | 2018-07-10 | Boston Scientific Scimed, Inc. | Control system and process for application of energy to airway walls and other mediums |
| US9339618B2 (en) | 2003-05-13 | 2016-05-17 | Holaira, Inc. | Method and apparatus for controlling narrowing of at least one airway |
| US10953170B2 (en) | 2003-05-13 | 2021-03-23 | Nuvaira, Inc. | Apparatus for treating asthma using neurotoxin |
| US8172827B2 (en) | 2003-05-13 | 2012-05-08 | Innovative Pulmonary Solutions, Inc. | Apparatus for treating asthma using neurotoxin |
| US7949407B2 (en) | 2004-11-05 | 2011-05-24 | Asthmatx, Inc. | Energy delivery devices and methods |
| US10076380B2 (en) | 2004-11-05 | 2018-09-18 | Boston Scientific Scimed, Inc. | Energy delivery devices and methods |
| US10398502B2 (en) | 2004-11-05 | 2019-09-03 | Boston Scientific Scimed, Inc. | Energy delivery devices and methods |
| US7853331B2 (en) | 2004-11-05 | 2010-12-14 | Asthmatx, Inc. | Medical device with procedure improvement features |
| US8480667B2 (en) | 2004-11-05 | 2013-07-09 | Asthmatx, Inc. | Medical device with procedure improvement features |
| US8920413B2 (en) | 2004-11-12 | 2014-12-30 | Asthmatx, Inc. | Energy delivery devices and methods |
| US7931647B2 (en) | 2006-10-20 | 2011-04-26 | Asthmatx, Inc. | Method of delivering energy to a lung airway using markers |
| US10368941B2 (en) | 2007-07-12 | 2019-08-06 | Boston Scientific Scimed, Inc. | Systems and methods for delivering energy to passageways in a patient |
| US8235983B2 (en) | 2007-07-12 | 2012-08-07 | Asthmatx, Inc. | Systems and methods for delivering energy to passageways in a patient |
| US11478299B2 (en) | 2007-07-12 | 2022-10-25 | Boston Scientific Scimed, Inc. | Systems and methods for delivering energy to passageways in a patient |
| US12029476B2 (en) | 2007-07-12 | 2024-07-09 | Boston Scientific Scimed, Inc. | Systems and methods for delivering energy to passageways in a patient |
| US8489192B1 (en) | 2008-02-15 | 2013-07-16 | Holaira, Inc. | System and method for bronchial dilation |
| US11058879B2 (en) | 2008-02-15 | 2021-07-13 | Nuvaira, Inc. | System and method for bronchial dilation |
| US9125643B2 (en) | 2008-02-15 | 2015-09-08 | Holaira, Inc. | System and method for bronchial dilation |
| US8731672B2 (en) | 2008-02-15 | 2014-05-20 | Holaira, Inc. | System and method for bronchial dilation |
| US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
| US8961508B2 (en) | 2008-05-09 | 2015-02-24 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US8821489B2 (en) | 2008-05-09 | 2014-09-02 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US10149714B2 (en) | 2008-05-09 | 2018-12-11 | Nuvaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US11937868B2 (en) | 2008-05-09 | 2024-03-26 | Nuvaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US8961507B2 (en) | 2008-05-09 | 2015-02-24 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US8088127B2 (en) | 2008-05-09 | 2012-01-03 | Innovative Pulmonary Solutions, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US9668809B2 (en) | 2008-05-09 | 2017-06-06 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US8226638B2 (en) | 2008-05-09 | 2012-07-24 | Innovative Pulmonary Solutions, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US8808280B2 (en) | 2008-05-09 | 2014-08-19 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US9675412B2 (en) | 2009-10-27 | 2017-06-13 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
| US8932289B2 (en) | 2009-10-27 | 2015-01-13 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
| US9649153B2 (en) | 2009-10-27 | 2017-05-16 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
| US8777943B2 (en) | 2009-10-27 | 2014-07-15 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
| US9005195B2 (en) | 2009-10-27 | 2015-04-14 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
| US9017324B2 (en) | 2009-10-27 | 2015-04-28 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
| US8740895B2 (en) | 2009-10-27 | 2014-06-03 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
| US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
| US10610283B2 (en) | 2009-11-11 | 2020-04-07 | Nuvaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
| US9649154B2 (en) | 2009-11-11 | 2017-05-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
| US11389233B2 (en) | 2009-11-11 | 2022-07-19 | Nuvaira, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
| US9149328B2 (en) | 2009-11-11 | 2015-10-06 | Holaira, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
| US11712283B2 (en) | 2009-11-11 | 2023-08-01 | Nuvaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
| RU2449737C1 (en) * | 2010-11-11 | 2012-05-10 | Министерство здравоохранения и социального развития Российской Федерации Федеральное государственное учреждение "Саратовский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения и социального развития Российской Федерации (ФГУ "СарНИИТО" Минздравсоцразвития Росси | Method of treating diffuse endobronchitis in acute and early periods of cervical-spinal trauma |
| US9770293B2 (en) | 2012-06-04 | 2017-09-26 | Boston Scientific Scimed, Inc. | Systems and methods for treating tissue of a passageway within a body |
| US9592086B2 (en) | 2012-07-24 | 2017-03-14 | Boston Scientific Scimed, Inc. | Electrodes for tissue treatment |
| US9572619B2 (en) | 2012-11-02 | 2017-02-21 | Boston Scientific Scimed, Inc. | Medical device for treating airways and related methods of use |
| US9272132B2 (en) | 2012-11-02 | 2016-03-01 | Boston Scientific Scimed, Inc. | Medical device for treating airways and related methods of use |
| US10492859B2 (en) | 2012-11-05 | 2019-12-03 | Boston Scientific Scimed, Inc. | Devices and methods for delivering energy to body lumens |
| US9283374B2 (en) | 2012-11-05 | 2016-03-15 | Boston Scientific Scimed, Inc. | Devices and methods for delivering energy to body lumens |
| US9974609B2 (en) | 2012-11-05 | 2018-05-22 | Boston Scientific Scimed, Inc. | Devices and methods for delivering energy to body lumens |
| US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
| US9814618B2 (en) | 2013-06-06 | 2017-11-14 | Boston Scientific Scimed, Inc. | Devices for delivering energy and related methods of use |
| US11801090B2 (en) | 2013-08-09 | 2023-10-31 | Boston Scientific Scimed, Inc. | Expandable catheter and related methods of manufacture and use |
| US10478247B2 (en) | 2013-08-09 | 2019-11-19 | Boston Scientific Scimed, Inc. | Expandable catheter and related methods of manufacture and use |
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