RU2325197C1 - Ionized solution making device - Google Patents

Abstract

FIELD: medicine; medical equipment.

SUBSTANCE: invention can be applied in contaminated surgery for suppurative infections of soft tissues of any etiology and localization, as well as for pyoinflammatory processes in closed cavities. Ionized solution making device contains active electrode made of silver wire. One end of electrode is connected to electric cell terminal. Electrode made of silver wire is designed as a spiral and placed into ionization chamber containing cylinder and cover. Cover has conical opening aside designed to electrode output for connection to electric cell terminal. Upper side of cover contains opening for ionization chamber connection to infusion system. Lower part of cylinder contains sleeve for silicone or drain tube connection.

EFFECT: allows placing the device outside of human body, and delivering active ions saturated medicine directly to pathologic focus.

2 cl, 1 ex, 1 dwg

Description

The invention relates to medical equipment and can be used in purulent surgery for the treatment of purulent diseases of soft tissues of various etiologies and localizations, as well as for the treatment of purulent-inflammatory processes in closed cavities.

The most promising treatment of purulent wounds is currently considered the use of devices whose operation is based on the use of ultrasonic cavitation, focused and defocused laser radiation [1].

However, such equipment is very expensive and not available in all medical institutions.

Devices for conducting drug electrophoresis are more accessible, and the technique for conducting it is relatively simple, but effective. The main advantage of drug electrophoresis is the combination of the action of galvanic current and ions of the drug substance on the body. Ionic shifts affect the vital activity of cells, changing the course of biophysical, electro- and biochemical processes in them. Circulatory and metabolic processes improve, biologically active substances (in particular, histamine) are intensely formed, which leads to improved metabolism and enhanced reparative processes.

However, the use of "standard" electrophoresis in the treatment of wounds is not always possible, since it is recommended to apply electrodes only to intact skin integuments. In addition, the epidermis of the skin has great resistance, and the duration of the procedure is limited in time, and the ions of the drug are introduced only into the epidermis, forming a depot in it, from where they gradually spread with blood and lymph flow throughout the body. As a result, only 2-3% of the drug used in the procedure enters the body. In addition, during electrophoresis using antibiotics to prevent the damaging effect of electrolysis products on the tissue between the human body and metal electrodes, along with the hydrophilic (electrode) gasket, it is necessary to additionally use gaskets with protective solutions (5% glucose solution or 1% glycanol solution), which delivers some inconvenience in use and further reduces the amount of drug substance delivered to the body [2, 3, 4].

Known devices that allow the method of direct delivery of ionized drugs to the site of exposure using a catheter for infusion of a drug into which an active electrode is inserted [5, 6]. These devices for ionizing drug solutions contain an infusion system, a catheter with an active electrode inserted into it, which is connected to the pole of a galvanizing apparatus or a constant current source that has the same charge sign as the active ion of the drug, as well as a second (passive) electrode.

For example, the device according to patent No. 20166553 for the treatment of postpartum and postabortion endometritis contains a two-channel catheter, into one of the channels of which an electrode is inserted, connected to a constant current source. The device is designed for sequential washing with solutions of biological adsorbents, antibiotics of a wide spectrum of action of the uterine cavity with simultaneous exposure to the focus of inflammation and surrounding tissues with a constant electric current of 0.2-5.0 mA / cm ² . The disadvantage of this method is the need to introduce an electrode into the channel of the catheter immediately before use with the condition that the electrode should not reach the outlet of the channel of the catheter by 5-10 mm, because however, the sterility of the catheter may be impaired.

Inaccurate insertion of the catheter can either disrupt the integrity of the catheter itself or lead to organ damage by the electrode. In addition, sterilization of the entire device is problematic.

Closest to the claimed device is the patent No. 2159640 for preoperative preparation of patients with chronic lower limb ischemia. The device contains a catheter with two cannulas, one of which is designed to be connected to the infusion system, and a silver wire connected to the terminal of the galvanizing apparatus is introduced into the catheter as an active electrode through the second cannula.

The disadvantage of this device is that the installation of a catheter requires surgical intervention. In addition, an active electrode must be introduced into the lumen of the catheter after catheterization, which can disrupt the integrity and sterility of the catheter.

The objective of the invention is to provide a device for implementing a safe method of introducing into a purulent wound of an ionized solution of a drug substance.

The technical result is the possibility of creating directly in the pathological focus a high therapeutic concentration of highly active ions of the drug substance using lower doses of the drug substance, for example antibiotics, than with other treatment methods (oral, parenteral), which avoids negative side reactions, promotes accelerated wound cleansing, recovery microcirculation and oxygenation of tissues, increase regenerative activity, and therefore, shorten the life treatment of purulent wounds. It also eliminates the risk of damage to the organ or catheter by the electrode.

To achieve this objective, a device is proposed in the form of an ionization chamber containing a cylinder made of glass and a lid, ground at the junction, an electrode made of silver wire in the form of a spiral located inside the ionization chamber, and one end of the electrode is brought out through a conical hole on the lid devices for connecting to the terminal of the galvanizing apparatus.

The analysis of patent and technical literature did not reveal such a device, which confirms the compliance of the proposed technical solution with the criterion of "novelty."

Compliance with the criterion of "inventive step" is confirmed by the fact that:

- the device is made in the form of an ionization chamber, which contains a cylinder and a cover made of glass, while the glass at the junction is ground to better “grind” the parts relative to each other (it is necessary to slightly rotate relative to each other), which makes it easy to disassemble the device for sterilization and for processing (for example, in a steam-formalin chamber);

- the electrode is made of a coiled silver wire and is located inside the ionization chamber, which allows the device to be made more compact and eliminates the need to insert the electrode into the catheter, i.e. the risk of damage to the organ or catheter is excluded;

- the aforementioned electrode is configured to be removed from the device, which allows it to be sterilized;

- the device comprises a conical hole located on the side of the device cover, through which one end of the electrode is brought out to connect with the terminal of the galvanizing apparatus;

- the hole for connection to the infusion system is located in the upper part of the device cover;

- a pipe for connecting to it a silicone or drainage tube for supplying the ionized solution directly to the purulent wound is located in the lower part of the cylinder.

Due to the above characteristics, the proposed ionization chamber allows you to submit the obtained highly active ionized solutions of drugs directly to the site of inflammation, i.e. receive in the pathological focus a high therapeutic concentration of highly active ions of the drug using lower doses than with other methods of treatment (oral, parenteral), which contributes to the accelerated cleansing of wounds, the restoration of microcirculation and oxygenation of tissues, increase regenerative activity, and therefore, shorten the treatment time for purulent wounds. And also, due to its location outside the body, it avoids negative side reactions and eliminates the danger of organ damage by the electrode. In addition, it is easy to use.

The invention is illustrated in the drawing, which shows the ionization chamber.

The device — the ionization chamber — contains a cylinder (1) and a cover (2) made of glass, while the glass at the junction is ground to better “grind” the parts relative to each other (it is necessary to slightly rotate relative to each other). On the cover (2) there is a conical hole (3) for the output of the silver electrode (4), made of a silver wire coiled into a spiral. A sealing sleeve (5) is inserted inside the hole (3) for fastening the silver electrode (4), sealing and sealing the structure. On the cylinder (1) and the cover (2), there are brackets-holders (6) that can be interconnected and designed to prevent spontaneous separation of the cylinder (1) and the cover (2). The crustons 6 of the cylinder (1) and the cover (2) are interconnected using, for example, an elastic closed tape or regular rubber. The bracket 6 of the cylinder (1) is also designed to hold the entire structure on a tripod (7). The top hole (8) of the cover (2) is intended to be connected to the infusion system (9), and the hole (10) of the cylinder (1) is connected to a silicone tube (11) to bring the drug to the pathological focus (purulent wound) or directly from drainage tube (11) located in the purulent cavity.

The device operates as follows.

An electrode (4) made of a spiral-coiled silver wire is placed in the cylinder (1). The cover (2) and the cylinder (1) are connected, leading the end of the electrode (4) through the conical hole (3) and slightly turning the cover (2) and the cylinder (1) relative to each other. Connect the brackets (6) of the cylinder (1) and the cover (2), for example, with an elastic band. Mount the device on a tripod (7) using the bracket (6) located on the cylinder (1). To the silver electrode (4) attach the terminal of the apparatus for galvanization type "Potok-1". The advantage of this device is operation not only from a 220 V network, but also from mini-accumulators, which ensures greater safety during use. An infusion system (9) containing a drug substance is connected to the upper opening (8) on the lid (2). A silicone tube (11) is connected to the lower hole (10) of the cylinder (1) to bring the drug to the purulent wound or a drainage tube (11) located in the purulent cavity is attached in compliance with aseptic and antiseptic rules. The second passive electrode in the form of a lead plate is placed on the opposite side to healthy tissues (if the wound is on the front surface of the lower leg, then the passive electrode is placed on the back surface of the lower leg and proximal).

When you turn on the apparatus for galvanization under the influence of direct current, any drug in solution dissociates into oppositely charged ions. However, the specific therapeutic effect expected of this drug has a very specific ion having a charge of a certain sign. For most drugs, the sign of the charge of the active ion is known, therefore, the pole of the galvanizing apparatus having the same sign of charge as the active ion is connected to the active electrode, respectively, the passive electrode is connected to the opposite charge. Thus, ballast ions are deposited on the active electrode, and the drug is saturated with active ions, which are delivered directly to the area of the pathological focus. In addition, the effect of direct current on tissues causes a variety of cell-tissue and molecular-metabolic reactions, which leads to the activation of trophic and energy processes.

Example. Patient Matarykina M.N., 66 years old, was admitted to the purulent surgery department of Moscow City Clinical Hospital No. 1 on March 14, 2006.

Dz: Trophic ulcer of the left leg (after radiation therapy for skin diseases). Hypertension II Art., Risk IV. Type II diabetes mellitus, stage of compensation.

From the anamnesis: about 1 year ago, combined treatment (surgical and radiation therapy) was performed for a skin disease. The appearance of a trophic ulcer marks about 9 months ago. She was treated on an outpatient basis and in the hospital, the ulcer did not decrease in size. Status localis: the left tibia is somewhat swollen, on the front surface in the middle third of the trophic ulcer is 5.0 * 4.0 cm in size with uneven, torn edges, the bottom is covered with fibrin, the skin is hyperemic around the ulcer. Bacteriological examination: Staphylococcus aureus sensitive to gentamicin, rafampicin, lincomycin, cefoperazone, tarivid, amikacin, cefataxime, cefipime, meronem was isolated. Not sensitive: erythromycin, streptomycin, chloramphenicol, tetracycline, cefazolin, cephalexin, pefloxacin, ciprofloxacin.

Antispastic, antiplatelet antihypertensive therapy, glycemia correction were carried out. Given the inefficiency of the previously conducted methods of treatment, it was decided to apply electrical stimulation using the proposed device. Dose 4-5 mA once a day for about 60 minutes. 14 sessions.

03/17/06, hyperemia of the skin, swelling decreased, the wound is cleaned. 03/22/06, Islets of granulation tissue appeared at the bottom of the ulcer. An ulcer measuring 2.5 × 1.5 × 0.5.

03/30/06, an ulcer measuring 2.3 × 1.0 × 0.3 cm, granulations rise from the bottom, epithelization from the edges.

Discharged in satisfactory condition under the supervision of a surgeon at the place of residence.

Bibliography

1. Bulynin V.I. Treatment of wounds / V.I. Bulynin, A.A. Glukhov, I.P. Moshurov // Publishing house of the Voronezh State University - 1998 - 248 p.

2. Kuzin M.I. Wounds and wound infection / M.I. Kuzin, B.M. Kostyuchenok // M .: Medicine, 1990 - 591 p.

3. Nazarenko G.I. Wound, dressing, patient / G.I.Nazarenko, I.Yu. Sugurova, S.P. Glossy // M .: Medicine, 2002 - 469 p.

4. Catcher B.C. Theory and practice of drug electrophoresis // Ed. “Belarus”: Minsk, 1976 - 206 p.

5. Patent No.2016553. "The method of postpartum and postabortion endometritis."

6. Patent No. 2159640. "A method of preoperative treatment of patients with chronic critical lower limb ischemia."

Claims (2)

1. A device for producing ionized solutions containing an active electrode made of silver wire, one of the ends of which is connected to a terminal of a galvanic cell, characterized in that the electrode of silver wire is made in the form of a spiral and placed in an ionization chamber containing a cylinder and a cover, on the side of the lid of the device there is a conical hole for leading the end of the electrode outward for connection with the terminal of the galvanizing apparatus, and in the upper part of the cover there is a hole for connecting tions of the ionization chamber to the infusion system, in the lower part of the cylinder tube is located for connection thereto of silicone or the drainage tube. 2. The device according to claim 1, characterized in that the cylinder and the cover of the ionization chamber are made of glass, and the electrode is removable from the ionization chamber.