RU2021124400A - METHOD FOR TREATMENT OF TRANSLABLE CONNECTIVE TISSUE SARCOMA M-1 IN RATS WITH COMBINED IMPACT OF PHOTODYNAMIC THERAPY AND RADIOTHERAPY - Google Patents

METHOD FOR TREATMENT OF TRANSLABLE CONNECTIVE TISSUE SARCOMA M-1 IN RATS WITH COMBINED IMPACT OF PHOTODYNAMIC THERAPY AND RADIOTHERAPY Download PDF

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Publication number
RU2021124400A
RU2021124400A RU2021124400A RU2021124400A RU2021124400A RU 2021124400 A RU2021124400 A RU 2021124400A RU 2021124400 A RU2021124400 A RU 2021124400A RU 2021124400 A RU2021124400 A RU 2021124400A RU 2021124400 A RU2021124400 A RU 2021124400A
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RU
Russia
Prior art keywords
rats
photodynamic therapy
connective tissue
tissue sarcoma
translable
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RU2021124400A
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Russian (ru)
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RU2021124400A3 (en
RU2767272C2 (en
Inventor
Михаил Александрович Каплан
Валентина Владимировна Дрожжина
Любовь Михайловна Архипова
Ольга Борисовна Абрамова
Татьяна Петровна Чурикова
Екатерина Александровна Козловцева
Сергей Анатольевич Иванов
Андрей Дмитриевич Каприн
Original Assignee
Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации
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Priority to RU2021124400A priority Critical patent/RU2767272C2/en
Publication of RU2021124400A publication Critical patent/RU2021124400A/en
Publication of RU2021124400A3 publication Critical patent/RU2021124400A3/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine

Claims (1)

Способ лечения перевивной соединительнотканной саркомы М-1 крыс при комбинированном воздействии фотодинамической терапии и лучевой терапии, отличающийся тем, что проводят комбинированное воздействие лучевой терапии и фотодинамической терапии по схеме: ЛТ+ФДТ с интервалом времени 48 часов, сеанс ФДТ проводят с фотосенсибилизатором амидоаминхлорином е6 (ААХ), который вводят интраперитонеально в дозе 1,25 мг/кг массы животного, что при экстраполяции на дозу человека составляет 0,21 мг/кг, лекарственно-световой интервал между введением препарата и лазерным облучением составляет 3,0 часа, параметры лазерного воздействия: плотность энергии Е=300 Дж/см2, плотность мощности Ps=0,48 Вт/см2, при проведении лучевой терапии доза γ-излучения составляла 20 Гр. A method of treating transplantable connective tissue sarcoma M-1 of rats with the combined effect of photodynamic therapy and radiation therapy, characterized in that the combined effect of radiation therapy and photodynamic therapy is carried out according to the scheme: LT + PDT with a time interval of 48 hours, a PDT session is carried out with a photosensitizer amidoamine chlorine e6 ( AAX), which is administered intraperitoneally at a dose of 1.25 mg / kg of animal weight, which when extrapolated to a human dose is 0.21 mg / kg, the drug-light interval between drug administration and laser irradiation is 3.0 hours, the parameters of laser exposure : energy density E = 300 J / cm 2 , power density Ps = 0.48 W / cm 2 , during radiation therapy, the dose of γ-radiation was 20 Gy.
RU2021124400A 2021-08-17 2021-08-17 Method for treatment of rat m-1 transferable connective tissue sarcoma under combined impact of photodynamic therapy and radiation therapy RU2767272C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2021124400A RU2767272C2 (en) 2021-08-17 2021-08-17 Method for treatment of rat m-1 transferable connective tissue sarcoma under combined impact of photodynamic therapy and radiation therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2021124400A RU2767272C2 (en) 2021-08-17 2021-08-17 Method for treatment of rat m-1 transferable connective tissue sarcoma under combined impact of photodynamic therapy and radiation therapy

Publications (3)

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RU2021124400A true RU2021124400A (en) 2021-10-01
RU2021124400A3 RU2021124400A3 (en) 2021-12-08
RU2767272C2 RU2767272C2 (en) 2022-03-17

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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2724480C2 (en) * 2019-07-18 2020-06-23 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации" (ФГБУ "НМИЦ радиологии" Минздрава России) Method of combined radiotherapy and photodynamic therapy
RU2737704C2 (en) * 2020-05-15 2020-12-02 Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России) Method of intraoperative photodynamic therapy in combined treatment of locally advanced soft tissue sarcomas

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RU2767272C2 (en) 2022-03-17

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