RU2020115905A - METHOD FOR INTRAOPERATIVE PHOTODYNAMIC THERAPY IN COMBINED TREATMENT OF LOCAL DISTRIBUTED BY SARCK SOFT TISSUES - Google Patents

METHOD FOR INTRAOPERATIVE PHOTODYNAMIC THERAPY IN COMBINED TREATMENT OF LOCAL DISTRIBUTED BY SARCK SOFT TISSUES Download PDF

Info

Publication number
RU2020115905A
RU2020115905A RU2020115905A RU2020115905A RU2020115905A RU 2020115905 A RU2020115905 A RU 2020115905A RU 2020115905 A RU2020115905 A RU 2020115905A RU 2020115905 A RU2020115905 A RU 2020115905A RU 2020115905 A RU2020115905 A RU 2020115905A
Authority
RU
Russia
Prior art keywords
photodynamic therapy
combined treatment
sarck
soft tissues
local distributed
Prior art date
Application number
RU2020115905A
Other languages
Russian (ru)
Other versions
RU2020115905A3 (en
RU2737704C2 (en
Inventor
Елена Викторовна Ярославцева-Исаева
Алексей Леонидович Зубарев
Александр Александрович Курильчик
Михаил Александрович Каплан
Вячеслав Евгеньевич Иванов
Алексей Леонидович Стародубцев
Андрей Дмитриевич Каприн
Сергей Анатольевич Иванов
Ирина Сергеевна Спиченкова
Виктория Николаевна Капинус
Original Assignee
Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России) filed Critical Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России)
Priority to RU2020115905A priority Critical patent/RU2737704C2/en
Publication of RU2020115905A publication Critical patent/RU2020115905A/en
Publication of RU2020115905A3 publication Critical patent/RU2020115905A3/ru
Application granted granted Critical
Publication of RU2737704C2 publication Critical patent/RU2737704C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Claims (3)

Способ интраоперационной фотодинамической терапии в комбинированном лечении местно-распространенных сарком мягких тканей, включающий внутривенное введение фотосенcибилизатора хлорин Е6, отличающийся тем, что пациенту за 2-3 часа до операции вводят фотосенcибилизатор хлорин Е6 в водорастворимой лекарственной форме однократно в виде внутривенной капельной инфузии 0,8-1,5 мг/кг, проводят хирургическое удаление опухоли, после чего ложе опухоли облучают с помощью волоконно-оптического катетера с микролинзой, мощность лазерного излучения на выходе катетера от 1 до 2,5 Вт, плотность мощности лазерного излучения 0,08-0,28 Вт/см², длина волны 662 нм, и если у пациента:A method of intraoperative photodynamic therapy in the combined treatment of locally distributed soft tissue sarcomas, including intravenous administration of a chlorin E6 photosensitizer, characterized in that the patient is administered a chlorin E6 photosensitizer 2-3 times before surgery in a water-soluble dosage form once in the form of an intravenous drip infusion of 0.8 -1.5 mg / kg, surgical removal of the tumor is performed, after which the tumor bed is irradiated with a fiber optic catheter with a microlens, the laser radiation power at the catheter exit is from 1 to 2.5 W, the laser radiation power density is 0.08-0 , 28 W / cm², wavelength 662 nm, and if the patient: - первичные новообразования, то доза лазерного облучения составляет 80 Дж/см², - primary neoplasms, the dose of laser irradiation is 80 J / cm², - рецидивные новообразования - 80-100 Дж/см².- recurrent neoplasms - 80-100 J / cm².
RU2020115905A 2020-05-15 2020-05-15 Method of intraoperative photodynamic therapy in combined treatment of locally advanced soft tissue sarcomas RU2737704C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2020115905A RU2737704C2 (en) 2020-05-15 2020-05-15 Method of intraoperative photodynamic therapy in combined treatment of locally advanced soft tissue sarcomas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2020115905A RU2737704C2 (en) 2020-05-15 2020-05-15 Method of intraoperative photodynamic therapy in combined treatment of locally advanced soft tissue sarcomas

Publications (3)

Publication Number Publication Date
RU2020115905A true RU2020115905A (en) 2020-06-25
RU2020115905A3 RU2020115905A3 (en) 2020-08-13
RU2737704C2 RU2737704C2 (en) 2020-12-02

Family

ID=71135534

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2020115905A RU2737704C2 (en) 2020-05-15 2020-05-15 Method of intraoperative photodynamic therapy in combined treatment of locally advanced soft tissue sarcomas

Country Status (1)

Country Link
RU (1) RU2737704C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2767272C2 (en) * 2021-08-17 2022-03-17 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации Method for treatment of rat m-1 transferable connective tissue sarcoma under combined impact of photodynamic therapy and radiation therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2691549C2 (en) * 2018-12-05 2019-06-14 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) Method of organ-preserving treatment of urothelial cancer of renal pelvis
RU2704202C1 (en) * 2019-07-03 2019-10-24 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) Method of photodynamic therapy of growth surface solid connective-tissue sarcoma of m-1 rats

Also Published As

Publication number Publication date
RU2020115905A3 (en) 2020-08-13
RU2737704C2 (en) 2020-12-02

Similar Documents

Publication Publication Date Title
EP0947222B1 (en) Method of activating photosensitive agents
Okunaka et al. A comparison between argon‐dye and excimer‐dye laser for photodynamic effect in transplanted mouse tumor
Gomer et al. The effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis
Cheng et al. Effects of photoradiation therapy on normal rat Brian
JP2014171882A (en) Use of photosensitizer in preparation of virus-inactivating medicaments for treating diseases
US5163898A (en) Medical treatment of tumors with phycocyanin
RU2020115905A (en) METHOD FOR INTRAOPERATIVE PHOTODYNAMIC THERAPY IN COMBINED TREATMENT OF LOCAL DISTRIBUTED BY SARCK SOFT TISSUES
Rovers et al. Significantly increased lesion size by using the near‐infrared photosensitizer 5, 10, 15, 20‐tetrakis (m‐hydroxyphenyl) bacteriochlorin in interstitial photodynamic therapy of normal rat liver tissue
Lee et al. Wireless power transfer for glioblastoma photodynamic therapy
RU2022134620A (en) METHOD FOR INTRAOPERATIVE PHOTODYNAMIC THERAPY FOR LOCAL ADVANCED SCALP CANCER
SOUDANT et al. The use of photodynamic therapy and photochemotherapy with lasers for palliative treatment of head and neck carcinomas: An initial human case report
RU2146159C1 (en) Method for applying photodynamic therapy of malignant neoplasms
KR20090108071A (en) Treatment of esophageal high grade dysplasia using photodynamic therapy
RU2797433C1 (en) Method of intraoperative photodynamic therapy in combined treatment of primary locally advanced tongue cancer
McCaughan Lasers in photodynamic therapy
KR20090108069A (en) Treatment of Barrett's esophagus using photodynamic therapy
RU2146160C1 (en) Method for applying anesthesia in carrying out photodynamic therapy of malignant neoplasms
ES2301480T3 (en) INHIBITION OF VASCULAR RESENOSIS AFTER ANGIOPLASTIA.
WO2014097208A2 (en) Method of combined treatment of maligant tumors
RU2297859C1 (en) Method for treating disseminated forms of melanoma
RU2236270C2 (en) Method for treating the cases of malignant cerebral tumors having multifocal growth pattern
Theodossy et al. Anaesthetic considerations for patients receiving photodynamic therapy in head and neck surgery
Furukawa et al. Photodynamic therapy using a diode laser with mono-L-aspartyl chlorin e6 (NPe6)
Jerjes et al. Spinal metastasis subjected to photodynamic therapy: an update
Gossner et al. Verapamil and hematoporphyrin derivative for tumour destruction by photodynamic therapy.