RU2017130257A - A method of treating lung cancer - Google Patents

A method of treating lung cancer Download PDF

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Publication number
RU2017130257A
RU2017130257A RU2017130257A RU2017130257A RU2017130257A RU 2017130257 A RU2017130257 A RU 2017130257A RU 2017130257 A RU2017130257 A RU 2017130257A RU 2017130257 A RU2017130257 A RU 2017130257A RU 2017130257 A RU2017130257 A RU 2017130257A
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RU
Russia
Prior art keywords
days
photosensitizer
lung cancer
treating lung
dose
Prior art date
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RU2017130257A
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Russian (ru)
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RU2682293C2 (en
RU2017130257A3 (en
Inventor
Юрий Александрович Рагулин
Виктория Николаевна Капинус
Михаил Александрович Каплан
Данил Вячеславович Гоголин
Николай Григорьевич Горбушин
Андрей Дмитриевич Каприн
Сергей Анатолиевич Иванов
Юрий Сергеевич Романко
Original Assignee
Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский радиологический центр" Министерства здравоохранения Российской Федерации" (ФГБУ "НМИРЦ" Минздрава России)
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Priority to RU2017130257A priority Critical patent/RU2682293C2/en
Publication of RU2017130257A3 publication Critical patent/RU2017130257A3/ru
Publication of RU2017130257A publication Critical patent/RU2017130257A/en
Application granted granted Critical
Publication of RU2682293C2 publication Critical patent/RU2682293C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/267—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Anesthesiology (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (1)

Способ лечения рака легкого, включающий проведение фотодинамической терапии путем введения фотосенсибилизатора внутривенно, капельно в течение от 30 до 40 минут, с последующим сеансом лазерного облучения внутрибронхиального/внутритрахеального компонента опухоли через 3 часа после введения фотосенсибилизатора, отличающийся тем, что в качестве фотосенсибилизатора вводят «Фотолон» в дозе от 1,1 до 1,6 мг/кг массы тела больного, через 1-2 дня после ФДТ проводят цитостатическую химиотерапию по схемам Цисплатин 120 мг в первый день и Этопозид 200 мг в 1, 2, 3 дни или Карбоплатин 600 мг в первый день и Этопозид 200 мг в 1, 2, 3 дни, при этом цикл лечения повторяют 2-3 раза с интервалом от 21 до 28 дней, затем проводят дистанционную лучевую терапию в разовой очаговой дозе от 2 до 2,4 Гр до суммарной очаговой дозы от 60 до 70 Гр.A method of treating lung cancer, including conducting photodynamic therapy by introducing a photosensitizer intravenously, drip for 30 to 40 minutes, followed by a laser session of laser irradiation of the intrabronchial / intratracheal component of the tumor 3 hours after administration of the photosensitizer, characterized in that "Photolon is administered as a photosensitizer "At a dose of 1.1 to 1.6 mg / kg of patient’s body weight, 1-2 days after PDT, cytostatic chemotherapy is carried out according to the Cisplatin 120 mg regimens on the first day and Etoposide 200 mg in 1, 2, 3 days or Carboplatin 600 mg on the first day and Etoposide 200 mg on 1, 2, 3 days, while the treatment cycle is repeated 2-3 times with an interval of 21 to 28 days, then remote radiation therapy is performed once focal dose from 2 to 2.4 Gy to a total focal dose of 60 to 70 Gy.
RU2017130257A 2017-08-28 2017-08-28 Method for treating lung cancer RU2682293C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2017130257A RU2682293C2 (en) 2017-08-28 2017-08-28 Method for treating lung cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2017130257A RU2682293C2 (en) 2017-08-28 2017-08-28 Method for treating lung cancer

Publications (3)

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RU2017130257A3 RU2017130257A3 (en) 2019-03-01
RU2017130257A true RU2017130257A (en) 2019-03-01
RU2682293C2 RU2682293C2 (en) 2019-03-18

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RU2017130257A RU2682293C2 (en) 2017-08-28 2017-08-28 Method for treating lung cancer

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RU (1) RU2682293C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2724480C2 (en) * 2019-07-18 2020-06-23 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации" (ФГБУ "НМИЦ радиологии" Минздрава России) Method of combined radiotherapy and photodynamic therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050090732A1 (en) * 2003-10-28 2005-04-28 Triton Biosystems, Inc. Therapy via targeted delivery of nanoscale particles
RU2372119C1 (en) * 2008-05-15 2009-11-10 Федеральное государственное учреждение "Научно-исследовательский институт онкологии имени Н.Н. Петрова Федерального агентства по высокотехнологичной медицинской помощи" Method of integrated treatment of locally advanced malignant bronchial and/or tracheal tumours

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RU2682293C2 (en) 2019-03-18
RU2017130257A3 (en) 2019-03-01

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Effective date: 20190829