RU2020111785A - Antibodies for laboratory diagnosis of interleukin-11 concentration - Google Patents

Antibodies for laboratory diagnosis of interleukin-11 concentration Download PDF

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Publication number
RU2020111785A
RU2020111785A RU2020111785A RU2020111785A RU2020111785A RU 2020111785 A RU2020111785 A RU 2020111785A RU 2020111785 A RU2020111785 A RU 2020111785A RU 2020111785 A RU2020111785 A RU 2020111785A RU 2020111785 A RU2020111785 A RU 2020111785A
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RU
Russia
Prior art keywords
antibodies
concentration
derivatives
interleukin
fragments
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RU2020111785A
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Russian (ru)
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RU2020111785A3 (en
RU2763178C2 (en
Inventor
Тажиб Ахмедханович Мирзабеков
Роман Вячеславович Михайлов
Андрей Романович Яковенко
Сергей Евгеньевич Пермяков
Людмила Викторовна Ермолина
Андрей Сергеевич Соколов
Екатерина Владимировна Павлова
Евгений Анатольевич Пермяков
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Акционерное Общество "Р-Фарм"
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Priority to RU2020111785A priority Critical patent/RU2763178C2/en
Publication of RU2020111785A3 publication Critical patent/RU2020111785A3/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Claims (4)

1. Антитела, специфичные к ИЛ-11 человека и модельных животных, таких как яванская макака, или их производные, или антигенсвязывающие фрагменты антител, в которых вариабельные домены тяжелой и легкой цепей содержат одну из следующих комбинаций аминокислотных последовательностей гипервариабельных участков:1. Antibodies specific to human IL-11 and model animals, such as cynomolgus, or their derivatives, or antigen-binding antibody fragments, in which the variable domains of the heavy and light chains contain one of the following combinations of amino acid sequences of the hypervariable regions:
Figure 00000001
Figure 00000002
Figure 00000001
Figure 00000002
Figure 00000003
Figure 00000003
 2. Способ определения в пробах наличия и концентрации ИЛ-11 человека и модельных животных, таких как яванская макака, заключающийся в том, что 1) исследуемый образец, содержащей ИЛ-11, приводят в контакт с антителами, или их фрагментами, или производными по п. 1 и 2) оценивают наличие и концентрацию иммунных комплексов антител, или их фрагментов, или производных по п. 1 с антигеном (ИЛ-11).2. A method for determining the presence and concentration of IL-11 in humans and model animals, such as cynomolgus monkey, in samples, which consists in the fact that 1) the test sample containing IL-11 is brought into contact with antibodies, or their fragments, or derivatives of p. 1 and 2) assess the presence and concentration of immune complexes of antibodies, or their fragments, or derivatives of p. 1 with an antigen (IL-11).
RU2020111785A 2020-03-23 2020-03-23 Antibodies for laboratory diagnostics of the concentration of interleukin-11 RU2763178C2 (en)

Priority Applications (1)

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RU2016151730A Previously-Filed-Application RU2016151730A (en) 2016-12-28 2016-12-28 Antibodies for laboratory diagnosis of interleukin-11 concentration

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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274547B1 (en) * 1996-06-14 2001-08-14 Genetics Institute, Inc. Methods comprising the use of human interleukin-11 receptor proteins
US6407218B1 (en) * 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
CN101370525B (en) * 2005-08-19 2013-09-18 Abbvie公司 Dual variable domain immunoglobin and uses thereof

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RU2763178C2 (en) 2021-12-28

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