RU2019108242A3 - - Google Patents

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Publication number
RU2019108242A3
RU2019108242A3 RU2019108242A RU2019108242A RU2019108242A3 RU 2019108242 A3 RU2019108242 A3 RU 2019108242A3 RU 2019108242 A RU2019108242 A RU 2019108242A RU 2019108242 A RU2019108242 A RU 2019108242A RU 2019108242 A3 RU2019108242 A3 RU 2019108242A3
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RU
Russia
Application number
RU2019108242A
Other languages
Russian (ru)
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RU2019108242A (ru
RU2782794C2 (ru
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed filed Critical
Publication of RU2019108242A publication Critical patent/RU2019108242A/ru
Publication of RU2019108242A3 publication Critical patent/RU2019108242A3/ru
Application granted granted Critical
Publication of RU2782794C2 publication Critical patent/RU2782794C2/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
    • C12N9/224—Class 1 CAS enzyme complex, e.g. multi-enzyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21004—Type II site-specific deoxyribonuclease (3.1.21.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
RU2019108242A 2016-08-24 2017-08-24 Сконструированные мишень-специфические нуклеазы RU2782794C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662378978P 2016-08-24 2016-08-24
US62/378,978 2016-08-24
US201762443981P 2017-01-09 2017-01-09
US62/443,981 2017-01-09
PCT/US2017/048409 WO2018039448A1 (en) 2016-08-24 2017-08-24 Engineered target specific nucleases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2022127957A Division RU2022127957A (ru) 2016-08-24 2017-08-24 Cконструированные мишень-специфические нуклеазы

Publications (3)

Publication Number Publication Date
RU2019108242A RU2019108242A (ru) 2020-09-25
RU2019108242A3 true RU2019108242A3 (cg-RX-API-DMAC7.html) 2021-04-09
RU2782794C2 RU2782794C2 (ru) 2022-11-02

Family

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Also Published As

Publication number Publication date
WO2018039448A1 (en) 2018-03-01
EP3964573A1 (en) 2022-03-09
US20200340016A1 (en) 2020-10-29
US20210024958A1 (en) 2021-01-28
JP2019528073A (ja) 2019-10-10
BR112019003327A2 (pt) 2019-07-02
AU2017315414A2 (en) 2020-03-12
AU2017315414A9 (en) 2019-07-18
JP2023100751A (ja) 2023-07-19
KR20220145913A (ko) 2022-10-31
SG10202007392SA (en) 2020-09-29
EP3504327A4 (en) 2020-02-12
IL264792B1 (en) 2023-06-01
AU2024203182A1 (en) 2024-08-01
SG11201901364VA (en) 2019-03-28
NZ750943A (en) 2025-06-27
US20210024957A1 (en) 2021-01-28
US20180087072A1 (en) 2018-03-29
IL264792A (cg-RX-API-DMAC7.html) 2019-03-31
KR20240144493A (ko) 2024-10-02
JP7272948B2 (ja) 2023-05-12
US10975393B2 (en) 2021-04-13
WO2018039448A9 (en) 2019-04-25
IL300783A (en) 2023-04-01
ES2901989T3 (es) 2022-03-24
SG10201913948PA (en) 2020-03-30
RU2019108242A (ru) 2020-09-25
US11827900B2 (en) 2023-11-28
IL300783B2 (en) 2026-03-01
IL264792B2 (en) 2023-10-01
KR20190039955A (ko) 2019-04-16
EP3504327A1 (en) 2019-07-03
US20240229079A9 (en) 2024-07-11
KR102455249B1 (ko) 2022-10-17
US20240132917A1 (en) 2024-04-25
CN110418841A (zh) 2019-11-05
AU2017315414B2 (en) 2024-02-15
CN120248076A (zh) 2025-07-04
CA3034884A1 (en) 2018-03-01
AU2017315414A1 (en) 2019-03-14
EP3504327B1 (en) 2021-10-06
IL300783B1 (en) 2025-11-01

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