RU2018143005A - METHOD FOR FORMING TUMOR CELL CULTURE RESISTANT TO PROTONS - Google Patents

METHOD FOR FORMING TUMOR CELL CULTURE RESISTANT TO PROTONS Download PDF

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Publication number
RU2018143005A
RU2018143005A RU2018143005A RU2018143005A RU2018143005A RU 2018143005 A RU2018143005 A RU 2018143005A RU 2018143005 A RU2018143005 A RU 2018143005A RU 2018143005 A RU2018143005 A RU 2018143005A RU 2018143005 A RU2018143005 A RU 2018143005A
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RU
Russia
Prior art keywords
cell culture
protons
tumor cell
forming tumor
culture resistant
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RU2018143005A
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Russian (ru)
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RU2691853C2 (en
RU2018143005A3 (en
Inventor
Евгений Евгеньевич Бекетов
Елена Васильевна Исаева
Надежда Валерьевна Наседкина
Степан Евгеньевич Ульяненко
Петр Викторович Шегай
Сергей Анатольевич Иванов
Андрей Дмитриевич Каприн
Original Assignee
Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России)
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Priority to RU2018143005A priority Critical patent/RU2691853C2/en
Publication of RU2018143005A publication Critical patent/RU2018143005A/en
Publication of RU2018143005A3 publication Critical patent/RU2018143005A3/ru
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Publication of RU2691853C2 publication Critical patent/RU2691853C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (1)

Способ формирования культуры опухолевых клеток, резистентной к протонам, включающий облучение в дозе 6 Гр⋅экв, с учетом величины относительной биологической эффективности, отличающийся тем, что культуру клеток подвергают облучению электронами 1 раз в неделю до суммарной дозы 60 Гр или протонами 1 раз в неделю до суммарной дозы 70 Гр (84 Гр⋅экв).A method of forming a proton-resistant tumor cell culture comprising irradiation at a dose of 6 Gy-Eq, taking into account the relative biological effectiveness, characterized in that the cell culture is irradiated with electrons 1 time per week to a total dose of 60 Gy or protons 1 time per week up to a total dose of 70 Gy (84 Gy в eq).
RU2018143005A 2018-12-05 2018-12-05 Method for proton-resistant tumor cell culture RU2691853C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2018143005A RU2691853C2 (en) 2018-12-05 2018-12-05 Method for proton-resistant tumor cell culture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2018143005A RU2691853C2 (en) 2018-12-05 2018-12-05 Method for proton-resistant tumor cell culture

Publications (3)

Publication Number Publication Date
RU2018143005A true RU2018143005A (en) 2019-01-15
RU2018143005A3 RU2018143005A3 (en) 2019-05-22
RU2691853C2 RU2691853C2 (en) 2019-06-18

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RU2018143005A RU2691853C2 (en) 2018-12-05 2018-12-05 Method for proton-resistant tumor cell culture

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RU (1) RU2691853C2 (en)

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Publication number Publication date
RU2691853C2 (en) 2019-06-18
RU2018143005A3 (en) 2019-05-22

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